BRPI0415179A - derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas - Google Patents

derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas

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Publication number
BRPI0415179A
BRPI0415179A BRPI0415179-8A BRPI0415179A BRPI0415179A BR PI0415179 A BRPI0415179 A BR PI0415179A BR PI0415179 A BRPI0415179 A BR PI0415179A BR PI0415179 A BRPI0415179 A BR PI0415179A
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BR
Brazil
Prior art keywords
pharmaceutical compositions
methods
ion channel
employing
amide derivatives
Prior art date
Application number
BRPI0415179-8A
Other languages
English (en)
Inventor
Ravindra B Upasani
Michael G Kelly
Satyanarayana Janagani
Original Assignee
Renovis Inc
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Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Publication of BRPI0415179A publication Critical patent/BRPI0415179A/pt

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    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Abstract

"DERIVADOS DE AMIDA COMO LIGANDOS DE CANAL DE ìON E COMPOSIçõES FARMACêUTICAS E MéTODOS DE EMPREGAR AS MESMAS". Descreve-se compostos que têm a fórmula representada pela seguinte: Fórmula (I) Os compostos podem ser preparados como composições farmacêuticas, e podem ser empregados para a prevenção e tratamento de diversas condições em mamíferos, incluindo humanos, incluindo por meio de exemplo não limitante, dor, inflamação, lesão traumática, e outros.
BRPI0415179-8A 2003-10-07 2004-10-07 derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas BRPI0415179A (pt)

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US7432281B2 (en) 2008-10-07
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