ES2552247T3 - Agentes antibacterianos - Google Patents

Agentes antibacterianos Download PDF

Info

Publication number
ES2552247T3
ES2552247T3 ES10179798.3T ES10179798T ES2552247T3 ES 2552247 T3 ES2552247 T3 ES 2552247T3 ES 10179798 T ES10179798 T ES 10179798T ES 2552247 T3 ES2552247 T3 ES 2552247T3
Authority
ES
Spain
Prior art keywords
amino
hydroxyamino
carbonyl
benzamide
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10179798.3T
Other languages
English (en)
Inventor
Niels H. Andersen
Jason Bowman
Alice Erwin
Eric Harwood
Toni Kline
Khisimuzi Mdluli
Simon Ng
Keith B. Pfister
Ribhi Shawar
Allan Wagman
Asha Yabannavar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOVARTIS VACCINES AND DIAGNOSTICS Inc
University of Washington
Novartis Vaccines and Diagnostics Inc
Original Assignee
NOVARTIS VACCINES AND DIAGNOSTICS Inc
University of Washington
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NOVARTIS VACCINES AND DIAGNOSTICS Inc, University of Washington, Novartis Vaccines and Diagnostics Inc filed Critical NOVARTIS VACCINES AND DIAGNOSTICS Inc
Application granted granted Critical
Publication of ES2552247T3 publication Critical patent/ES2552247T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/16—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/08—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C07C337/08—Compounds containing any of the groups, e.g. thiosemicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. thiosemicarbazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Un compuesto de acuerdo con la fórmula I:**Fórmula** o un estereoisómero, sal farmacéuticamente aceptable o éster de la misma, en el que E está ausente o está seleccionado del grupo que consiste en (1) H, (2) alquilo C1-C6 sustituido o sin sustituir, (3) arilo sustituido o sin sustituir, (4) heterociclilo sustituido o sin sustituir, y (5) heteroarilo sustituido o sin sustituir; L está ausente o está seleccionado del grupo que consiste en (1) alquilo C1-C6 sustituido o sin sustituir, (2) -(NH)0-1-(CH2)j-NR3L-(CH2)k-, (3) -(NH)0-1C(R1L, R2L)-NR3L-C(R1L, R2L)-, (4) -C(R1L, R2L)-O-C(R1L, R2L)-, (5) -(CH2)j-NR3L-C(R1L, R2L-CONH-(CH2)k-, (6) -CO-C(R1L, R2L)-NHCO-, (7) -CONH-, (8) -NHCO-, en las que R1L, R2L y R3L están seleccionados independientemente del grupo que consiste en (a) H, (b) alquilo C1-C6 sustituido o sin sustituir, (c) alquilo C1-C6 sustituido con arilo, (d) alquilo C1-C6 sustituido con heterociclilo, y (e) alquilo C1-C6 sustituido con heteroarilo, o R1L y R3L, junto con los átomos a los que están unidos, pueden formar un anillo heterocíclico sustituido o sin sustituir que tiene de 3 a 8 átomos de anillo, en el que 1-2 átomos de anillo del sistema de anillo heterocíclico están seleccionados de N, O y S; j es un número entero de 0-4; k es un número entero de 0-4; D está ausente o está seleccionado del grupo que consiste en (1) cicloalquilo C3-C8 sustituido o sin sustituir, (2) arilo sustituido o sin sustituir, (3) heterociclilo sustituido o sin sustituir, y (4) heteroarilo sustituido o sin sustituir; G está ausente o está seleccionado del grupo que consiste en (1) -C(>=O)-, (2) -C>=C-, (3) -C≡C-C≡C- and (4) -C>=C-; Y está seleccionado del grupo que consiste en (1) cicloalquilo C3-C8 sustituido o sin sustituir, (2) fenilo sustituido o sin sustituir, X está seleccionado del grupo que consiste en (1) -(C>=O)-, (2) -alquilo C1-C6-(C>=O)-, (3) -alquenilo C2-C6-C>=O)-, (4) -alquinilo C2-C6-(C>=O)-, y (5) -CH2-; B está ausente o en la que R1b y R2b están seleccionados independientemente del grupo que consiste en (a) H, (b) alquilo C1-C6 sin sustituir, (c) alquenilo C2-C6 o sin sustituir, (d) alquinilo C2-C6 o sin sustituir, (e) alquilo C1-C6 sustituido con arilo, (f) alquilo C1-C6 sustituido con heterociclilo, y (g) alquilo C1-C6 sustituido con heteroarilo, q es un número entero de 0-4; R3 es H o alquilo C1-C6 sustituido o sin sustituir, R4 es H o alquilo C1-C6 sustituido o sin sustituir, n es 0; A está seleccionado del grupo que consiste en (1) -(CH2)rC(R1a,R2a)N(R4a,R5a), (2) -(CH2)rC(R1a, R2a)N(R4a)COR3a, (3) -(CH2)rC(R1a,R2a)NHCON(R4a,R5a), y (4) -(CH2)rC(R1a, R2a)NHC(>=NH)N(R4a, R5a), en las que R1a, R2a, R3a, R4a y R5a están seleccionados independientemente del grupo que consiste en (a) H, (b) alquilo C1-C6 sin sustituir, (c) alquilo C1-C6 sustituido con heterociclilo, r es 0; Q es -C(>=O)N(R1, R2), R1 es -OH, R2 es H, en las que B está ausente, o E, L, G y B están ausentes, o E, L y G están ausentes, o E, L y B están ausentes, o E, L, D, G y B están ausentes, en la que la frase "alquilo" se refiere a grupos alquilo que no contienen heteroátomos e incluye grupos alquilo de cadena lineal, isómeros de cadena ramificada de grupos alquilo de cadena lineal, grupos alquilo cíclicos y dichos anillos sustituidos con grupos alquilo de cadena lineal o ramificada como se define con anterioridad, la frase "alquenilo" se refiere a grupos de cadena lineal o ramificada y cíclicos como se describe con respecto a los grupos alquilo como se ha definido con anterioridad, excepto que existe al menos un enlace doble entre dos átomos de carbono, y la frase "alquinilo" se refiere a grupos de cadena lineal y ramificada como se ha descrito con respecto a los grupos alquilo como se ha definido con anterioridad, excepto que hay al menos un enlace triple entre dos átomos de carbono.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
ejemplo, ácido aspártico y ácido glutámico.
Como se usa en este documento, el término “éster farmacéuticamente aceptable” se refiere a ésteres que se hidrolizan in vivo e incluyen aquellos que se degradan fácilmente en el cuerpo humano para dar el compuesto
5 parental o una sal del mismo. Grupos éster adecuados incluyen, por ejemplo, aquellos derivados de ácidos carboxílicos alifáticos farmacéuticamente aceptables, particularmente ácidos alcanoicos, alquenoicos, cicloalcanoicos y alcanodioicos, en los que cada resto alquilo o alquenilo no tienen ventajosamente más de 6 átomos de carbono. Ejemplos representativos de ésteres particulares incluyen formiatos, acetatos, propionatos, butiratos, acrilatos y etilsuccinatos.
10 El término “profármacos farmacéuticamente aceptables” como se usa en este documento se refiere a aquellos profármacos de los compuestos que, dentro del alcance del criterio médico sensato, son adecuados para su uso en contacto con los tejidos de seres humanos y animales inferiores sin excesiva toxicidad, irritación y respuesta alérgica acorde a una relación de beneficio/riesgo razonable, y eficaces para su uso previsto, además de
15 las formas de ión bipolar, cuando sea posible, de los compuestos. El término “profármaco” se refiere a compuestos que se transforman rápidamente in vivo para dar el compuesto parental, por ejemplo, mediante hidrólisis en la sangre. Se proporciona una sólida discusión en T. Higuchi y V. Stella, Pro-drugs as Novel Delivery Systems, vol. 14 de A.C.S. Symposium Series, y en Edward B. Roche, ed., Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987.
20 El término “agente antibacteriano” se refiere a agentes sintetizados o modificados en el laboratorio que tienen actividad tanto bactericida como bacteriostática. Un agente “activo” en este contexto inhibirá el crecimiento de
P. aeruginosa y otras bacterias Gram-negativas. El término “inhibir el crecimiento” indica que la tasa de aumento en los números de una población de una bacteria particular se reduce. Por tanto, el término incluye situaciones en las 25 que la población bacteriana aumenta, pero a una tasa reducida, además de situaciones en las que el crecimiento de la población se detiene, además de situaciones en las que los números de bacterias en la población se reducen o la población incluso se elimina. Si se usa un ensayo de actividad enzimática para cribar inhibidores, pueden hacerse modificaciones en la captación/eflujo, solubilidad, semivida, etc. para los compuestos con el fin de establecer una correlación entre inhibición de enzima e inhibición del crecimiento. La actividad de agentes antibacterianos no está
30 necesariamente limitada a bacterias, pero también puede englobar actividad contra parásitos, virus y hongos.
La invención objeto también incluye inhibidores de LpxC isotópicamente marcados que son estructuralmente idénticos a los desvelados anteriormente, pero por el hecho de que uno o más átomos están sustituidos por un átomo que tiene una masa atómica o número másico diferente de la masa atómica o número
35 másico normalmente encontrado en la naturaleza. Ejemplos de isótopos que pueden incorporarse en compuestos de la invención incluyen isótopos de hidrógeno, carbono, nitrógeno, oxígeno, fosforoso, azufre, flúor y cloro tales como2H, 3H, 13C, 14C, 15N, 18O, 17O,31P, 32P, 35S, 18F y 36Cl, respectivamente. Compuestos de la presente invención, y sales farmacéuticamente aceptables de dichos compuestos que contienen los isótopos anteriormente mencionados y/u otros isótopos de otros átomos, están dentro del alcance de la presente invención. Ciertos compuestos
40 isotópicamente marcados de la presente invención, por ejemplo, aquellos en los que se incorporan isótopos radiactivos tales como 3H y 14C, son útiles en ensayos de distribución en tejido de fármaco y/o sustrato. Isótopos tritiados, es decir, 3H, y carbono-14, es decir, 14C, son particularmente preferidos por su facilidad de preparación y detectabilidad. Además, la sustitución con isótopos más pesados tales como deuterio, es decir, 2H, puede proporcionar ciertas ventajas terapéuticas resultantes de mayor estabilidad metabólica, por ejemplo, aumento de la
45 semivida in vivo o reducción de los requisitos de dosificación y, de ahí, que puedan preferirse en algunas circunstancias. Los compuestos isotópicamente marcados de la presente invención pueden prepararse generalmente llevando a cabo procedimientos conocidos o citados y sustituyendo un reactivo isotópicamente marcado fácilmente disponible con un reactivo no isotópicamente marcado.
50 La presente invención proporciona compuestos novedosos, formulaciones farmacéuticas que incluyen los compuestos y su uso en procedimientos para tratar infecciones por bacterias Gram-negativas.
La presente divulgación proporciona compuestos de fórmula I:
55
60
imagen11
o estereoisómeros, sales farmacéuticamente aceptables, ésteres y profármacos de los mismos, en la que E está ausente o está seleccionado del grupo que consiste en
(1)
H,
(2)
alquilo C1-C6 sustituido o sin sustituir,
imagen12
imagen13
imagen14
(2)
alquilo C1-C6 sustituido o sin sustituir,
(3)
alquenilo C2-C6 sustituido o sin sustituir,
(4)
alquenilo C2-C6 sustituido o sin sustituir,
(5)
arilo sustituido o sin sustituir, 5 (6) heterociclilo sustituido o sin sustituir,
(7)
heteroarilo sustituido o sin sustituir,
(8)
alquilo C1-C6 sustituido con arilo,
(9)
alquilo C1-C6 sustituido con heterociclilo, y
(10)
alquilo C1-C6 sustituido con heteroarilo, 10
o R1 y R2, junto con el átomo de N al que están unidos, pueden formar un anillo heterocíclico sustituido o sin sustituir que tiene de 3 a 10 átomos de anillo, en el que 1-4 átomos de anillo del sistema de anillo heterocíclico están seleccionados de N, O y S, R1q, R2q, R3q, R4q y R5q están seleccionados de H o alquilo C1-C6,
15 en las que B está ausente, o E, L, G y B están ausentes, o E, L y G están ausentes, o E, L y B están ausentes, o E, L, D, G y B están ausentes.
En otro aspecto, la presente divulgación proporciona compuestos de fórmula III:
20
25
imagen15
o estereoisómeros, sales farmacéuticamente aceptables, ésteres y profármacos de los mismos, en la que D-G-Y, en 30 conjunto, está seleccionado del grupo que consiste en
imagen16
o
imagen17
o estereoisómeros, sales farmacéuticamente aceptables, ésteres y profármacos de los mismos, en la que D-G-Y, en conjunto, está seleccionado del grupo que consiste en
imagen18
30 o
35
40
45
50
55
imagen19
imagen20
imagen21
imagen22
imagen23
imagen24
imagen25
imagen26
imagen27
imagen28
imagen29
imagen30
imagen31
imagen32
imagen33
imagen34
imagen35
imagen36
imagen37
imagen38
imagen39
imagen40
imagen41
imagen42
imagen43
imagen44
imagen45
imagen46
imagen47
imagen48
imagen49
imagen50
imagen51
imagen52
imagen53
imagen54
imagen55
imagen56
imagen57
imagen58
imagen59
imagen60
imagen61
imagen62
imagen63
imagen64
imagen65
imagen66
imagen67
imagen68
imagen69
imagen70
imagen71
Tabla 3: Actividad antibacteriana frente al panel patrón de organismos (CIM, µg/ml). Tabla 4: Actividad antibacteriana frente a cepas aisladas de fibrosis quística de Pseudomonas aeruginosa (CIM, µg/ml). Las cepas tienen los siguientes fenotipos: 3198 y 3236, sensibles a la mayoría de los agentes antibacterianos; 2196, resistente a ciprofloxacina; 3224, resistente a ceftazidima; 3317, resistente a aztreonam; 1145 y 3206, resistentes a múltiples fármacos.
Clave de CIM CIM de 6,25 ug/ml o menos = A CIM superior a 6,25 ug/ml a 50 ug/ml = B CIM superior a 50 ug/ml = C
Cepa bacteriana:
P. aeruginosa 27853 E. coli 25922 S. aureus 29213 P. aerug. hiper-permeable 35151 P. aeruginosa PAO200 mexAB
Ejemplo de compuesto nº
12
A A C A A
572
A A C A A
481
A A C A A
19
A A B A A
516
A A C A A
280
A A C A A
366
A A C A A
777
A A C A A
315
A A C A A
779
A A C A A
860
A A C A A
801
A A C A A
13
A A C AA A
Clave de CIM
CIM de 6,25 ug/ml o menos = A
CIM superior a 6,25 ug/ml a 50 ug/ml = B
CIM superior a 50 ug/ml = C
Cepa número:
3198 3236 2196 3224 3232 3317 1145 3206
Fenotipo:
Sensible Sensible Cipro R Tobra R Ceftaz. R Aztr. R MDR MDR
Inhibidores de LpxC
12
A A B A A A A A
481
A A A A A A A A
19
A A A A A A A A
516
A A A A A A A A
280
A A B A A A A A
366
A A A A A A A A
777
A A A A A A A A
315
A A A A A A A A
779
A A A A A A A A
801
A A A A A A A A
13
A A A A A A A A
Agentes antibacterianos comparadores
Tobramicina
2 0,5 2 64 1 2 8-32 64
Aztreonam
1 0,5 1 1 1 64 >128 > 128
Ceftazidima
2 0,25 2 2 64 4 >128 > 128
Cefepima
4 2 2 8 2 8 >128 32
Ciprofloxacina
1 0,06 > 8 2 2 0,5 4 >8
Tabla 5: Actividad antibacteriana frente a cepas aisladas clínicas de no FQ de P. aeruginosa y frente a otros patógenos Gram-negativos. Conjunto 1: organismos no fermentantes. P. aer., P. aeruginosa; Acinet. calc., Acinetobacter calcoaceticus; Alcal. xyl., Alcaligenes xylosoxidans; B. cep., Burkholderia cepacia; S. malt., Stenotrophomonas maltophilia Tabla 6: Actividad antibacteriana frente a cepas aisladas clínicas de no FQ de P. aeruginosa y frente a otros patógenos Gram-negativos, continuación. Conjunto 2: organismos entéricos. E. aer., Enterobacter aerogenes; E. clo., Enterobacter cloacae; E. coli, Escherichia coli; K. pneu., Klebsiella pneumoniae; K. oxy., Klebsiella oxytoca; P. mir., Proteus mirabilis; S. marc., Serratia marcescens.
Clave de CIM CIM de 6,25 ug/ml o menos = A CIM superior a 6,25 ug/ml a 50 ug/ml = B CIM superior a 50 ug/ml = C
Especies:
P. aer 27853 P. aer. PAO1 P. aer 12307 P. aer psa6b Acinet. calc. Alcal. xyl. B. cepacia S. malt.
Inhibidores de LpxC
12
A A A A A A B A
481 *
A A A A C C B C
19
A A A A B B
516 *
A A A C C C C
280 *
A A A A C B B B
366 *
A A A B C A B B
777
A A B A B A C
315
A A A A C B A A
779 *
A A A C A A B
801
A A A B C B C
13 *
A A A C A A B
Agentes antibacterianos comparadores
Tobramicina
8 2 2 64 64/>128 0,5
Aztreonam
16 32 32 32 64 >128/16
Ceftazidima
4 64 16 1 8/4 1
Cefepima
2 8 8 8 32/16 8/1
Meropenem
0,5 0,25 4 0,5 4 64
Pip/Tazo
4 >128 8 1 64 16
Ciprofloxacina
0,5 2 0,5 0,5
Clave de CIM
CIM de 6,25 ug/ml o menos = A
CIM superior a 6,25 ug/ml a 50 ug/ml = B
CIM superior a 50 ug/ml = C
Especies:
E. aer. E. clo. E. coli 1619 E. coli 2788 K. pneu. K. oxy. P. mir. S. marc.
Inhibidores de LpxC
12
C A A A A A A A
481
C A A A A A A A
19
A A A A A A A A
516
C B A B C C C A
280
C A A A B C B B
366
C A A A B B A A
777
B A A A A A A A
315
C A A A C C C B
779
C A A A B B B A
801
B A A A A A A A
13
C A A A A A A A
Agentes antibacterianos
comparadores
Tobramicina
64 0,06 16/64 0,06/2 64 1 2 2
Aztreonam
<= 0,13 128/64 <= 0,13/0,25 2 0,5 <= 0,13 <= 0,13
Ceftazidima
32 0,25 > 128 0,25/<=0,13 8 0,25 <= 0,13 0,25
Cefepima
<= 0,13 4/<=0,13 <= 0,13 8 <= 0,13 <= 0,13 <= 0,13
Meropenem
2 <= 0,06 0,25/0,13 <= 0,06 0,13 <= 0,06 0,5 0,13
Pip/Tazo
2 > 128 1 > 128 2 0,25 1
Ciprofloxacina
> 8 0,015 2 0,03 0,06 0,03 0,03 0,25
Tabla 7: Resultado de estudios de combinación de fármacos (sinergia)
Concentración mínima (mg/ml) requerida para inhibir el crecimiento de E. coli 25922
Eritromicina
Inhibidor de LpxC 925 *
Inhibidor de LpxC 925 * solo
- 6,25
Eritromicina sola
128 -
Inhibidor de LpxC 925 * + eritromicina
2 0,78
Cada uno de los compuestos de ejemplo de la Tabla 1 se sintetizó y se ensayó como se ha descrito anteriormente. Muchos de los compuestos de los Ejemplos 1-1307 mostraron un valor de CI50 inferior a 10 µM con respecto a LpxC. Muchos de estos compuestos mostraron un valor de CI50 inferior a o igual a 1 µM o inferior a o igual a 0,1 µM. Muchos de estos compuestos mostraron valores de CI50 inferiores a o iguales a 0,050 µM, inferiores a o iguales a 0,030 µM, inferiores a o iguales a 0,025 µM o inferiores a o iguales a 0,010 µM.
Debe entenderse que los compuestos orgánicos según la invención pueden presentar el fenómeno de tautomería. Como las estructuras químicas dentro de esta memoria descriptiva sólo pueden representar una de las posibles formas tautómeras, debe entenderse que la invención engloba cualquier forma tautómera de la estructura dibujada.
TABLA 1
Ejemplo
Estructura Nombre MH+
30
3,4-difluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 275,2
31
imagen72 (2S,3R)-N,3-dihidroxi-2-[(4-fenilbutanoil)amino]butanamida 281,3
32
(2S,3R)-N,3-dihidroxi-2-({4-[4(metiloxi)fenil]butanoil}amino)butanamida 311.3
33
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5fenilpentanamida 295,3
34
(2E,4E)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-5-fenilpenta-2,4-dienamida 291,3
35
(2E)-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3fenilprop-2-enamida 265,3
36
ácido (2S,3R)-3-hidroxi-2-({(2E)-3-[4-(metiloxifenil]prop-2enoil}amino)butanoico 280,3
37
(3R)-3-amino-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-5-fenilpentanamida 310,4
38
(2E)-3-(4-fluorofenil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}prop-2-enamida 283,3
Ejemplo
Estructura Nombre MH+
39
imagen73 (2E)-3-(3-bromofenil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}prop-2-enamida 344,2
40
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[(2feniletil)amino]metil}benzamida 372,4
41
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[(4fenilbutil)amino]metil}benzamida 400,5
42
4-[(ciclopropilamino)metil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 308,3
43
4-[(hexilamino)metil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 352,4
44
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[(2piridin-2-iletil)amino]metil}benzamida 373,4
45
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4metilpiperazin-1-il)benzamida 337,4
46
imagen74 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(piperidin 1-ilmetil)benzamida 336,4
47
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(morfolin-4-ilmetil)benzamida 338,4
48
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({[3(2-oxopirrolidin-1-il)propil]amino}metil)benzamida 393,5
Ejemplo
Estructura Nombre MH+
49
imagen75 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[(3fenilpropil)amino]metil}benzamida 386,5
50
(2S,5R)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-5-fenilpirrolidin-2-carboxamida 308,3
51
(2R,5S)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-5-fenilpirrolidin-2-carboxamida 308,3
52
imagen76 (2S,3R)-2-{[(3S)-3-amino-4-fenilbutanoil]amino}-N,3dihidroxibutanamida 296,3
53
(2S,3R)-2-{[(2S)-2-amino-4-fenilbutanoil]amino}-N,3dihidroxibutanamida 296,3
54
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-6-(2pirrolidin-1-iletil)piridina-3-carboxamida 337,4
55
ácido 2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3-hidroxi-3metilbutanoico 342,4
56
ácido 2-{[4-(4-etilfenil)fenil]carbonilamino}-3-hidroxi-4metilpentanoico 356,4
57
ácido {[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}(tien-2-il)acético 366,5
58
N-(2-{[(1,1-dimetiletil)oxi]amino}-2-oxo-1-tien-2-iletil)-4′-etil1,1′-bifenil-4-carboxamida 437,6
Ejemplo
Estructura Nombre MH+
59
imagen77 ácido 3-(dimetilamino)-2-{[(4′-etil-1,1′-bifenil-4il)carbonil]amino}propanoico 341,4
60
4′-etil-N-{(1S)-1-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]-3-metilbutil}1,1′-bifenil-4-carboxamida 456,6
61
4′-etil-N-[(1S)-2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-2-oxo-1-(fenilmetil)etil]1,1′-bifenil-4-carboxamida 490,6
62
(2S)-1-[(4′-etil-1,1′-bifenil-4-il)carbonil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}pirrolidine-2-carboxamida 440,5
63
4′-etil-N-[(1S)-2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-1-(1H-imidazol-4-ilmetil)2-oxoetil]-1,1′-bifenil-4-carboxamida 480,5
64
(3S)-2-[(4′-etil-1,1′-bifenil-4-il)carbonil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,2,3,4-tetrahidroisoquinoline3-carboxamida 502,6
65
imagen78 (2S)-2-[(1,1′-bifenil-4-ilacetil)amino]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-4-metilpentanamida 442,5
66
(2S,3R)-2-({(2S)-2-[(1,1′-bifenil-4-ilacetil)amino]-3fenilpropanoil}amino)-N,3-dihidroxibutanamida 476,5
67
(2S,3R)-2-{[(2S)-2-[(1,1′-bifenil-4-ilacetil)amino]-3-(4hidroxifenil)propanoil]amino}-N,3-dihidroxibutanamida 492,5
68
(2S)-1-(1,1′-bifenil-4-ilacetil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}pirrolidine-2-carboxamida 426,5
69
(2S,3R)-2-{[(2S)-2-[(1,1′-bifenil-4-ilacetil)amino]-3-(1Himidazol-4-il)propanoil]amino}-N,3-dihidroxibutanamida 466,5
Ejemplo
Estructura Nombre MH+
70
(2S)-2-[(1,1′-bifenil-4-ilacetil)amino]-N~1~-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil} pentanediamida 457,5
71
ácido (3S)-3-[(1,1′-bifenil-4-ilacetil)amino]-4-({(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}amino)-4oxobutanoico 444,5
72
(2S,4R)-1-[(4′-etil-1,1′-bifenil-4-il)carbonil]-4-hidroxi-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}pirrolidina2-carboxamida 456,5
73
N-[(1S)-1-(aminometil)-2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-2-oxoetil]-4′-etil-1,1′bifenil-4-carboxamida 429,5
74
4′-etil-N-{(1S)-1-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]but-3-inil}-1,1′bifenil-4-carboxamida 438,5
75
(2S,3R)-2-({(2S)-2-[(1,1′-bifenil-4ilacetil)amino]propanoil}amino)-N,3-dihidroxibutanamida 400,4
76
(2S,4R)-1-(1,1′-bifenil-4-ilacetil)-4-hidroxi-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}pirrolidina-2carboxamida 442,5
77
4′-etil-N-{(1R,2R)-2-hidroxi-1-[(hidroxi {[(2hidroxietil)amino]carbonil}amino)metil] propil}-1,1′-bifenil-4carboxamida 416,5
78
N-((2R,3R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3hidroxibutil)-N-hidroximorfolina-4-carboxamida 442,5
79
N-((2R,3R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3hidroxibutil)-N-hidroxi-4-metilpiperazine-1-carboxamida 455,6
80
N-((1R,2R)-1-{[[(ciclopropilamino)carbonil](hidroxi) amino]metil}-2-hidroxipropil)-4′-etil-1,1′-bifenil-4-carboxamida 412,5
Ejemplo
Estructura Nombre MH+
81
4′-etil-N-{(1R,2R)-2-hidroxi-1-[(hidroxi{[(piridin-3ilmetil)amino]carbonil}amino)metil] propil}-1,1′-bifenil-4carboxamida 463,5
82
4′-etil-N-{(1R,2R)-2-hidroxi-1-[(hidroxi{[(2-piridin-2iletil)amino]carbonil}amino)metil]propil} 1,1′-bifenil-4carboxamida 477,6
83
4′-etil-N-{(1R,2R)-2-hidroxi-1-[(hidroxi{[(4-morfolin-4ilfenil)amino]carbonil}amino)metil] propil}-1,1′-bifenil-4carboxamida 533,6
84
N~1~-((2R,3R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3hidroxibutil)-N~1~-hidroxipiperidine-1,4-dicarboxamida 483,6
85
4′-etil-N-[2-hidroxiamino)etil]-1,1′-bifenil-4-carboxamida 285,4
86
N-{2-[(aminocarbonil)(hidroxi)amino]etil}-4′-etil-1,1′-bifenil-4carboxamida 328,4
87
N-{2-[(aminocarbonotioil)(hidroxi)amino]etil}-4′-etil-1,1′-bifenil4-carboxamida 344,4
88
N-{2-[({[2-(dimetilamino)etil]amino}carbonil) (hidroxi)amino]etil}-4′-etil-1,1′-bifenil-4-carboxamida 399,5
89
N-{2-[{[(2-cianoetil)amino]carbonil}(hidroxi)amino] etil}-4′-etil1,1′-bifenil-4-carboxamida 381,4
90
4′-etil-N-[2-(hidroxi{[(2-hidroxietil)amino]carbonil}amino)etil]1,1′-bifenil-4-carboxamida 372,4
91
N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-Nhidroximorfolina-4-carboxamida 398,5
Ejemplo
Estructura Nombre MH+
92
N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-N-hidroxi-4metilpiperazina-1-carboxamida 411,5
93
imagen79 N~1~-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-N~1~hidroxipiperidine-1,4-dicarboxamida 439,5
94
N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-Nhidroxipirrolidina-1-carboxamida 382,5
95
N-{2-[[(ciclopropilamino)carbonil](hidroxi) amino]etil}-4′-etil1,1′-bifenil-4-carboxamida 368,4
96
4′-etil-N-{2-[hidroxi({[2-(metiloxi)etil]amino}carboni)amino] etil}-1,1′-bifenil-4-carboxamida 386,5
97
N-{2-[({[2-(acetilamino)etil]amino}carbonil)(hidroxi) amino]etil}4′-etil-1,1′-bifenil-4-carboxamida 413,5
98
4′-etil-N-{2-[hidroxi({[3-(2-oxopirrolidin-1il)propil]amino}carbonil)amino]etil}-1,1′-bifenil-4-carboxamida 453,6
99
4′-etil-N-[2-(hidroxi{[(3hidroxipropil)amino]carbonil}amino)etil]-1,1′-bifenil-4carboxamida 386,5
100
imagen80 4′-etil-N-{2-[hidroxi({[3-(metiloxi)propil]amino}carbonil)amino] etil}-1,1′-bifenil-4-carboxamida 400,5
101
imagen81 N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-N-hidroxi-1,4′bipiperidina-1′-carboxamida 479,6
102
4′-etil-N-[2-(hidroxi{[(2-piridin-2iletil]amino]carbonil}amino)etil]-1,1′-bifenil-4-carboxamida 433,5
Ejemplo
Estructura Nombre MH+
103
4′-etil-N-[2-(hidroxi{[(piridin-3ilmetil)amino]carbonil}amino)etil]-1,1′-bifenil-4-carboxamida 419,5
104
imagen82 4′-etil-N-[2-(hidroxi{[(4-morfolin-4ilfenil)amino]carbonil}amino)etil]-1,1′-bifenil-4-carboxamida 489,6
105
imagen83 N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-N,3dihidroxipiperidina-1-carboxamida 412,5
106
N-{2-[{[(3-aminociclohexil)amino]carbonil}(hidroxi) amino]etil}4′-etil-1,1′-bifenil-4-carboxamida 425,5
107
N-{2-[{[(2-aminoetil)amino]carbonil}(hidroxi)amino] etil}-4′-etil1,1′-bifenil-4-carboxamida 371,4
108
N-{2-[{[(3-aminopropil)amino]carbonil}(hidroxi)amino] etil}-4′etil-1,1′-bifenil-4-carboxamida 385,5
109
1,1-dimetiletil 3-({[(2-{[(4′-etil-1,1′-bifenil-4il)carbonil]amino}etil)(hidroxi)amino] carbonil}amino)propilcarbamato 485,6
110
4′-etil-N-{2-[({[(4-fluorofenil)metil]amino}carbonil)(hidroxi) amino]etil}-1,1′-bifenil-4-carboxamida 436,5
111
N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-N-hidroxi-3[(trifluoroacetil)amino]pirrolidina-1-carboxamida 493,5
112
N-{2-[{[(4-aminotien-3-il)amino]carbonil}(hidroxi)amino]etil}-4′etil-1,1′-bifenil-4-carboxamida 425,5
113
imagen84 4′-etil-N-(2-{hidroxi[(piperidin-3-ilamino)carbonil]amino}etil)1,1′-bifenil-4-carboxamida 411,5
Ejemplo
Estructura Nombre MH+
114
4′-etil-N-(2-{hidroxi[(piperidin-4-ilamino)carbonil]amino}etil)1,1′-bifenil-4-carboxamida 411,5
115
4′-etil-N-[2-(hidroxi{[(piperidin-2ilmetil)amino]carbonil}amino)etil]-1,1′-bifenil-4-carboxamida 425,5
116
4′-etil-N-[2-(hidroxi{[(piperidin-3ilmetil)amino]carbonil}amino)etil]-1,1′-bifenil-4-carboxamida 425,5
117
imagen85 3-amino-N-(2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}etil)-Nhidroxipirrolidina-1-carboxamida 397,5
118
1,1-dimetiletil 3-[({[(2-{[(4′-etil-1,1′-bifenil-4il)carbonil]amino}etil)(hidroxi)amino] carbonil}amino)metil]piperidina-1-carboxilate 525,7
119
1,1-dimetiletil 1-{[(2-{[(4′-etil-1,1′-bifenil-4il)carbonil]amino}etil)(hidroxi)amino] carbonil}pirrolidin-3ilcarbamato 497,6
120
4′-etil-N-[(1S,2R)-2-hidroxi-1-({[2(hidroxiamino)etil]amino}carbonil)propil]-1,1′-bifenil-4carboxamida 386,5
121
N-{(1S,2R)-1-[({2-[(aminocarbonil)(hidroxi)amino]etil}amino) carbonil]-2-hidroxipropil}-4′-etil-1,1′-bifenil-4-carboxamida 429,5
122
N-{(1S,2R)-1-[({2-[(aminocarbonotioil)(hidroxi)amino]etil} amino)carbonil]-2-hidroxipropil}-4′-etil-1,1′-bifenil-4carboxamida 445,6
123
4′-etil-N-[(1S,2R)-2-hidroxi-1-({[2-(hidroxi{[(2-hidroxietil) amino]carbonil}amino)etil]amino} carbonil)propil]-1,1′-bifenil-4carboxamida 473,5
124
4′-etil-N-{(1S)-6-hidroxi-1-[(1R)-1-hidroxietil]-2,7-dioxo-11-oxa3,6,8-triazadodec-1-il}-1,1′-bifenil-4-carboxamida 487,6
Ejemplo
Estructura Nombre MH+
125
4′-etil-N-{(1S)-6-hidroxi-1-[(1R)-1-hidroxietil]-11-metil-2,7dioxo-3,6,8,11-tetraazadodec-1-il}-1,1′-bifenil-4-carboxamida 500,6
126
4′-etil-N-{(1S)-6-hidroxi-1-[(1R)-1-hidroxietil]-2,7,12-trioxo3,6,8,11-tetraazatridec-1-il}-1,1′-bifenil-4-carboxamida 514,6
127
4′-etil-N-{(1S,2R)-2-hidroxi-1-[({2-[hidroxi({[3-(2-oxopirrolidin1-il)propil]amino}carbonil)amino]etil} amino)carbonil]propil}1,1′-bifenil-4-carboxamida 554,7
128
N-{(1S,2R)-1-[({2-[{[(2-cianoetil)amino]carbonil}(hidroxi)amino] etil}amino)carbonil]-2-hidroxipropil}-4′-etil-1,1′-bifenil-4carboxamida 482,6
129
N-{(1S,2R)-1-[({2-[[(ciclopropilamino)carbonil](hidroxi) amino]etil}amino)carbonil]-2-hidroxipropil}-4′-etil-1,1′-bifenil-4carboxamida 469,6
130
imagen86 N-{2-[((2S,3R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3hidroxibutanoil)amino]etil}-N-hidroxipirrolidina-1-carboxamida 483,6
131
N-{2-[((2S,3R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3hidroxibutanoil)amino]etil}-N-hidroximorfolina-4-carboxamida 499,6
132
N-{2-[((2S,3R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3hidroxibutanoil)amino]etil}-N-hidroxi-4-metilpiperazina-1carboxamida 512,6
133
4′-etil-N-[(1S,2R)-2-hidroxi-1-({[2-(hidroxi{[(piridin-3ilmetil)amino]carbonil}amino)etil]amino} carbonil)propil]-1,1′bifenil-4-carboxamida 520,6
134
4′-etil-N-[(1S,2R)-2-hidroxi-1-({[2-(hidroxi{[(2-piridin-2iletil)amino]carbonil}amino)etil]amino} carbonil)propil]-1,1′bifenil-4-carboxamida 534,6
135
3-cloro-N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}4-[(trifluorometil)oxi]benzamida 357,7
Ejemplo
Estructura Nombre MH+
136
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[(3nitrofenil)metil]oxi}benzamida 390,4
137
(4R)-2-(4-fluoro-3-prop-2-enilfenil)-N-hidroxi-4,5-dihidro-1,3oxazol-4-carboxamida 265,3
138
imagen87 3-fluoro-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}4-(metiloxi)benzamida 287,3
139
4-(but-3-eniloxi)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 309,3
140
3-bromo-5-fluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}4-(prop-2-eniloxi)benzamida 392,2
141
4-fluoro-N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}3-prop-2-enilbenzamida 297,3
142
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(prop2-eniloxi)-3-(trifluorometil)benzamida 363,3
143
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(metiloxi)benzamida 269,3
144
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3(feniloxi)benzamida 331,3
145
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(metiloxi)-3-[(trifluorometil)oxi]benzamida 353,3
Ejemplo
Estructura Nombre MH+
146
N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[(trifluorometil)oxi]benzamida 323,2
147
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[(trifluorometil)oxi]benzamida 323,2
148
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(trifluorometil)benzamida 307,2
149
imagen88 3,4-difluoro-N-{(2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 275,2
150
N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(metiloxi)benzamida 269,3
151
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4′propil-1,1′-bifenil-4-carboxamida 357,4
152
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4′propil-1,1′-bifenil-4-carboxamida 357,4
153
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[trifluoro(metilidene)-lambda~6~-sulfanil]benzamida 341,3
154
N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 239,2
155
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-1,1'bifenil-4-carboxamida 315,3
Ejemplo
Estructura Nombre MH+
156
3-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-4-(metiloxi)benzamida 348,2
157
4-fluoro-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}3-(prop-2-eniloxi)benzamida 313,3
158
2,3,5,6-tetrafluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-4-prop-2-enilbenzamida 351,3
159
3-fluoro-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}5-(trifluorometil)benzamida 325,2
160
4-bromo-2-fluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 336,1
161
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(feniloxi)benzamida 331,3
162
4-(dimetilamino)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 282,3
163
imagen89 2-[3-fluoro-4-(metiloxi)-5-prop-2-enilfenil]-N-hidroxi-4,5dihidro-1,3-oxazol-4-carboxamida 295,3
164
imagen90 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5-[3(trifluorometil)fenil]furan-2-carboxamida 373,3
Ejemplo
Estructura Nombre MH+
165
4-{[(1E)-1,2-difluorobuta-1,3-dienil]oxi}-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 343,3
166
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}quinolin2-carboxamida 290,3
167
N-[2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-1,1′-bifenil-4carboxamida 301,3
168
N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-1,1'bifenil-4-carboxamida 315,3
169
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-2'-metil1,1'-bifenil-4-carboxamida 329,4
170
N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(trifluorometil)benzamida 307,2
171
4-fluoro-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}3-(trifluorometil)benzamida 325,2
172
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[(3nitrofenil)oxi]metil}benzamida 390,4
173
imagen91 N-[(1R)-2-(hidroxiamino)-1-(mercaptometil)-2-oxoetil]-4[(trifluorometil)oxi]benzamida 325,3
174
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-1,3benzodioxol-5-carboxamida 283,3
Ejemplo
Estructura Nombre MH+
175
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-6(bifluorometil)piridina-3-carboxamida 308,2
176
N-{3-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[(trifluorometil)oxi]benzamida 323,2
177
N-{3-hidroxi-1-[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4carboxamida 315,3
178
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[hidroxi(fenil)metil]benzamida 345,4
179
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-[({4[(trifluorometil)oxi]fenil}oxi) metil]benzamida 429,4
180
imagen92 4-[({4-bromo-2-[(trifluorometil)oxi]fenil}oxi)metil]-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 508,3
181
imagen93 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3′-nitro1,1′-bifenil-4-carboxamida 360,3
182
imagen94 4-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 318,1
183
imagen95 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4'(metiloxi)-1,1'-bifenil-4-carboxamida 345,4
Ejemplo
Estructura Nombre MH+
184
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4'[(trifluorometil)oxi)-1,1'-bifenil-4-carboxamida 399,3
185
4'-(etiloxi)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1'-bifenil-4-carboxamida 359,4
186
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{5[(Z)-(hidroxiimino)metil]tien-2-il}benzamida 364,4
187
3′-(etiloxi)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4-carboxamida 359,4
188
imagen96 (2R,3R)-N,3-dihidroxi-1-({4-[(trifluorometil)oxi]fenil}carbonil) pirrolidina-2-carboxamida 335,2
189
imagen97 N-[2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-3-(1-metiletil)-4(metiloxi)benzamida 297,3
190
N-[2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-3-(1-metiletil)-4(prop-2-eniloxi)benzamida 323,4
191
N-[2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-4-(metiloxi)-3propilbenzamida 297,3
192
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4′(metiltio)-1,1′-bifenil-4-carboxamida 361,4
Ejemplo
Estructura Nombre MH+
193
5-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}tiofeno-2-carboxamida 324,2
194
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5-{4[(trifluorometil)oxi]fenil}tiofeno-2-carboxamida 405,4
195
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-1benzofurano-2-carboxamida 279,3
196
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5feniltiofeno-2-carboxamida 321,4
197
4'-(dimetilamino)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1'-bifenil-4-carboxamida 358,4
198
(2S,3R)-N,3-dihidroxi-2-[({2[(trifluorometil)oxi]fenil}acetil)amino] butanamida 337,3
199
imagen98 5-[4-(etiloxi)fenil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}tiofeno-2-carboxamida 365,4
200
5-[3-(etiloxi)fenil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}tiofeno-2-carboxamida 365,4
201
(4R)-N-hidroxi-2-{2′-[(trifluorometil)oxi]-1,1′-bifenil-4-il}-4,5dihidro-1,3-oxazol-4-carboxamida 367,3
Ejemplo
Estructura Nombre MH+
202
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4'(hidroximetil)-1,1'-bifenil-4-carboxamida 345,4
203
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{5-[(4metilpiperazin-1-il)metil]tien-2-il}benzamida 433,5
204
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(metiloxi)fenil]carbonil}benzamida 373,4
205
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(E)fenildiazenil]benzamida 343,4
206
(4R)-N-hidroxi-2-{4-(metiloxi)-3-[(trifluorometil)oxi]fenil}-4,5dihidro-1,3-oxazol-4-carboxamida 321,2
207
4'-etil-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}1,1'-bifenil-4-carboxamida 343,4
208
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4'(trifluorometil)-1,1'-bifenil-4-carboxamida 383,3
209
5-(4-etilfenil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}tiofeno-2-carboxamida 349,4
210
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5-[4(metiloxi)fenil]tiofeno-2-carboxamida 351,4
211
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5-[4(metiltio)fenil]tiofeno-2-carboxamida 367,5
Ejemplo
Estructura Nombre MH+
212
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5-(3nitrofenil)tiofeno-2-carboxamida 366,4
213
imagen99 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-oxo4H-cromeno-2-carboxamida 307,3
214
imagen100 N-[1-[(hidroxiamino)carbonil]-1-(hidroximetil)-2-metilpropil]-4[(trifluorometil)oxi]benzamida 351,3
215
N-[2-hidroxi-3-(hidroxiamino)-3-oxopropil]-1,1′-bifenil-4carboxamida 301,3
216
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(E)-2feniletenil]benzamida 341,4
217
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-9Hfluoreno-2-carboxamida 327,4
218
ácido 4'-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]-1,1'-bifenil-4carboxílico 359,3
219
imagen101 N-[2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-4-(prop-2eniloxi)-3-propilbenzamida 323,4
220
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4iodobenzamida 365,1
221
imagen102 4'-hidroxi-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1'-bifenil-4-carboxamida 331,3
Ejemplo
Estructura Nombre MH+
222
6-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}piridina-2-carboxamida 319,1
223
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-6fenilpiridina-2-carboxamida 316,3
224
4′-butil-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}1,1′-bifenil-4-carboxamida 371,4
225
4′-(1,1-dimetiletil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4-carboxamida 371,4
226
imagen103 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-5-[3(metiloxi)fenil]tiofeno-2-carboxamida 351,4
227
4′-[({(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}amino) carbonil]-1,1′-bifenil-4-il dihidrogen phosphate 411,3
228
N-etil-N′-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}1,1′-bifenil-4,4′-dicarboxamida 386,4
229
N-[(1S,2R)-1-(hidrazinocarbonil)-2-hidroxipropil]-4′-propil-1,1′bifenil-4-carboxamida 356,4
230
N-{(1S,2R)-2-hidroxi-1-[(metilamino)carbonil]propil}-4′-propil1,1′ bifenil-4-carboxamida 355,4
Ejemplo
Estructura Nombre MH+
231
N-[(1S,2R)-1-(hidrazinocarbonil)-2-hidroxipropil]-4(metiloxi)benzamida 268,3
232
(2S,3R)-2-[(1,1′-bifenil-4-ilsulfonil)amino]-N,3dihidroxibutanamida 351,4
233
4-hidroxi-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 255,2
234
3′-ciano-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4-carboxamida 340,3
235
1,1-dimetiletil ({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}oxi)acetato 369,4
236
(2S,3R)-2-[(1,1′-bifenil-4-ilsulfonil)(metil)amino]-N,3dihidroxibutanamida 365,4
237
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3′-[(Z)(hidroxiimino)metil]-4′-(metiloxi)-1,1′-bifenil-4-carboxamida 388,4
238
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[(fenilcarbonil)amino]benzamida 358,4
239
N-hidroxi-2-[3-(1-metiletil)-4-(prop-2-eniloxi)fenil]-4,5-dihidro1,3-oxazol-4-carboxamida 305,3
240
4′-butil-N-{(1S,2R)-2-hidroxi-1-[(metilamino)carbonil]propil}1,1′-bifenil-4-carboxamida 369,5
Ejemplo
Estructura Nombre MH+
241
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(5metilpiridin-2-il)benzamida 330,4
242
5-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}piridina-3-carboxamida 319,1
243
imagen104 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4piridin-3-ilbenzamida 316,3
244
N-{(1R,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-N′{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-1,1′bifenil-4,4′-dicarboxamida 475,5
245
(2S,3R)-N,3-dihidroxi-2-[({4-[(E)-2-feniletenil]fenil}metil)amino] butanamida 327,4
246
4-{[(4-bromofenil)sulfonil]amino}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 473,3
247
1,1-dimetiletil 4-({4-[({(1S,2R)-2-hidroxi-1-[(hidroxiamino) carbonil]propil}amino)carbonil] fenil}amino)-4oxobutilcarbamato 439,5
248
4-[(4-aminobutanoil)amino]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 339,4
249
1,1-dimetiletil {4′-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) metil]-1,1′-bifenil-4il}metilcarbamato 430,5
250
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4pyrimidin 5-ilbenzamida 317,3
251
1,1-dimetiletil 5-{4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}piridina-3carboxilate 416,4
Ejemplo
Estructura Nombre MH+
252
ácido 5-{4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}piridina-3carboxilico 360,3
253
(4S)-N-hidroxi-2-{4-(metiloxi)-3-[(trifluorometil)oxi]fenil}-4,5dihidro-1,3-oxazol-4-carboxamida 321,2
254
(2S,3R)-2-({[4′-(aminometil)-1,1′-bifenil-4-il]metil}amino)-N,3dihidroxibutanamida 330,4
255
(3S)-1-hidroxi-3-[(1R)-1-hidroxietil]-4-({4-[(E)-2feniletenil]fenil}metil)piperazina-2,6-diona 367,4
256
(2S,3R)-N,3-dihidroxi-2-({[4-(feniletinil)fenil]metil}amino) butanamida 325,4
257
N-(3-aminopropil)-N′-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzene-1,4-dicarboxamida 339,4
258
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(propanoilamino)benzamida 310,3
259
1,1-dimetiletil 3-[({4-[({(1S,2R)-2-hidroxi-1-[(hidroxiamino) carbonil]propil}amino)carbonil] fenil}carbonil)amino]propilcarbamato 439,5
260
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4′(feniloxi)-1,1′-bifenil-4-carboxamida 407,4
Ejemplo
Estructura Nombre MH+
261
N-[(1S,2R)-1-({[ciano(fenil)metil]amino}carbonil)-2hidroxipropil]-4′-hidroxi-1,1′-bifenil-4-carboxamida 430,5
262
4′-{[2-(hidroxiamino)-2-oxoetil]oxi}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4-carboxamida 404,4
263
imagen105 4′-({[(1S,2R)-1-{[(cianometil)amino]carbonil}-2(propanoiloxi)propil]amino}carbonil)-1,1′-bifenil-4-il propanoato 466,5
264
4′-({[(1S,2R)-1-{[(cianometil)(propanoil)amino]carbonil}-2(propanoiloxi)propil]amino}carbonil)-1,1′-bifenil-4-il propanoato 522,6
265
N-((1S,2R)-1-{[(cianometil)amino]carbonil}-2-hidroxipropil)-4′hidroxi-1,1′-bifenil-4-carboxamida 354,4
266
(2S,3S)-2-[(1,1′-bifenil-4-ilmetil) amino]-N,3dihidroxibutanamida 301,4
267
N-{2-hidroxi-1-[(hidroxiamino)carbonil]-2-feniletil}-1,1′-bifenil4-carboxamida 377,4
268
(2S,3R)-2-[(difenilacetil)amino]-N,3-dihidroxibutanamida 329,4
269
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-6[(fenilmetil)tio]piridina-3-carboxamida 362,4
Ejemplo
Estructura Nombre MH+
270
N,3-dihidroxi-2-({[4-(feniloxi)fenil]metil}amino)butanamida 317,4
271
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)-2′[(trifluorometil)oxi]-1,1′-bifenil-4-carboxamida 399,3
272
(2R,3S)-2-[(1,1′-bifenil-4-ilmetil)amino]-N,3dihidroxibutanamida 301,4
273
imagen106 ácido 4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]benzoico 283,3
274
1,1-dimetiletil 4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]benzoato 339,4
275
ácido (4R)-4-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-5(hidroxiamino)-5-oxopentanoico 371,4
276
4′-etil-N-[(1R)-2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-1,1′bifenil-4-carboxamida 329,4
277
4′-etil-N-[(1S)-2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-1,1′bifenil-4-carboxamida 329,4
278
(2S)-1-[(4′-etil-1,1′-bifenil-4-il)carbonil]-N,4-dihidroxipirrolidina2-carboxamida 355,4
279
4′-etil-N-{(1S)-1-[(hidroxiamino)carbonil]but-3-inil}-1,1′-bifenil4-carboxamida 337,4
Ejemplo
Estructura Nombre MH+
280
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4'-etil-1,1'bifenil-4-carboxamida 328,4
281
N-{(1S)-1-[(hidroxiamino)carbonil]-2-metilpropil)-1,1′-bifenil-4carboxamida 313,4
282
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-N-metil1,1′-bifenil-4-carboxamida 329,4
283
imagen107 4-etinil-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 263,3
284
4-(1,3-benzodioxol-5-il)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 359,3
285
N-{(1R,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4′propil-1,1′-bifenil-4-carboxamida 357,4
286
2-({[3′-(etiloxi)-1,1′-bifenil-4-il]metil}amino)-N,3dihidroxibutanamida 345,4
287
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3′,4′bis(metiloxi)-1,1′-bifenil-4-carboxamida 375,4
288
3′-formil-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil)-4′-(metiloxi)-1,1′-bifenil-4carboxamida 373,4
289
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}buta-1,3-diinil)benzamida 523,5
290
(2S,3R)-2-({[4′-(etiloxi)-1,1′-bifenil-4-il]metil}amino)-N,3dihidroxibutanamida 345,4
Ejemplo
Estructura Nombre MH+
291
3′-cloro-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}4′-(metiloxi)-1,1′-bifenil-4-carboxamida 379,8
292
imagen108 (1R,2R)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-2fenilciclopropanecarboxamida 279,3
293
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(1Hpyrrol-1-il)benzamida 304,3
294
imagen109 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4propilbenzamida 281,3
295
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4pentilbenzamida 309,4
296
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4octilbenzamida 351,5
297
(2E)-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3(4-metilfenil)prop-2-enamida 279,3
298
(2E)-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3[4-(trifluorometil)fenil]prop-2-enamida 333,3
299
(2E)-3-(1,1'-bifenil-4-il)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}prop-2-enamida 341,4
300
(2S,3R)-2-[(1,1'-bifenil-4-ilacetil)amino]-N,3dihidroxibutanamida 329,4
Ejemplo
Estructura Nombre MH+
301
(2S,3R)-2-{[(2S)-2-amino-3-(1,1′-bifenil-4-il)propanoil]amino}N,3-dihidroxibutanamida 358,4
302
(2S,3R)-2-{[(2R)-2-amino-3-(1,1′-bifenil-4-il)propanoil]amino}N,3-dihidroxibutanamida 358,4
303
(3S)-3-amino-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-5-fenilpentanamida 310,4
304
imagen110 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4[(fenilamino)metil]benzamida 344,4
305
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4{[(fenilmetil)amino]metil}benzamida 358,4
306
4′-etil-N-{(1S,2R)-2-hidroxi-1-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]propil}-1,1′bifenil-4-carboxamida 444,5
307
imagen111 (2S,3R)-2-[(1,1′-bifenil-4-ilacetil)amino]-3-hidroxi-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}butanamida 430,5
308
4-(4-clorofenil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}ciclohexanocarboxamida 355,8
309
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(1Hpirazol-1-il)benzamida 305,3
310
N-(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4morfolin-4-ilbenzamida 324,3
311
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(1,2,3-tiadiazol-4-il)benzamida 323,3
312
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4metilpiperazin-1-il)metil]benzamida 351,4
Ejemplo
Estructura Nombre MH+
313
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(1Himidazol-1-ilmetil)benzamida 319,3
314
(2S,4S)-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}4-fenilpirrolidina-2-carboxamida 308,3
315
imagen112 4'-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1'-bifenil-4-carboxamida 394,2
316
4'-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1'-bifenil-4-carboxamida 394,2
317
4'-bromo-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1'-bifenil-4-carboxamida 394,2
318
imagen113 (2R)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-N~1~hidroxipentanediamida 370,4
319
ácido (2S,3S)-1-[(4′-etil-1,1′-bifenil-4-il)carbonil]-3hidroxipirrolidina-2-carboxilico 340,4
320
(2S,3S)-N-[(1,1-dimetiletil)oxi]-1-[(4′-etil-1,1′-bifenil-4il)carbonil]-3-hidroxipirrolidina-2-carboxamida 411,5
321
(2S,3S)-1-[(4′-etil-1,1′-bifenil-4-il)carbonil]-N,3dihidroxipirrolidina-2-carboxamida 355,4
322
imagen114 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4nitrofenil)etinil]benzamida 384,4
323
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(1H-pirrol-1-il)fenil]etinil}benzamida 404,4
Ejemplo
Estructura Nombre MH+
324
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4′-nitro1,1′-bifenil-4-carboxamida 360,3
325
(2S,3R)-N,3-dihidroxi-2-({[4′-(metiloxi)-3′-propil-1,1′-bifenil-4il]metil}amino)butanamida 373,5
326
imagen115 4'-ciano-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}1,1'-bifenil-4-carboxamida 340,3
327
(2S,3R)-2-({[4′-(etiloxi)-4-(metiloxi)-1,1′-bifenil-3il]metil}amino)-N,3-dihidroxibutanamida 375,4
328
2,5′-difluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4-carboxamida 351,3
329
imagen116 N-[(1S)-1-[(acetilamino)metil]-2-(hidroxiamino)-2-oxoetil]-4′etil-1,1′-bifenil-4-carboxamida 370,4
330
N-{(1S)-4-amino-1-[(hidroxiamino)carbonil]butil}-4′-etil-1,1′bifenil-4-carboxamida 356,4
331
4′-etil-N-[(1S)-2-(hidroxiamino)-1-(1H-imidazol-5-ilmetil)-2oxoetil]-1,1′-bifenil-4-carboxamida 379,4
332
(2S,3R)-2-{[1-(1,1′-bifenil-4-il)etil]amino}-N,3dihidroxibutanamida 315,4
333
(2S,3R)-2-{[1-(1,1′-bifenil-4-il)propil]amino}-N,3dihidroxibutanamida 329,4
Ejemplo
Estructura Nombre MH+
334
(2S,3R)-2-{[1-{4′-bromo-1,1′-bifenil-4-il)etil]amino}-N,3dihidroxibutanamida 394,3
335
(2S,3R)-N,3-dihidroxi-2-{[1-(4′-metil-1,1′-bifenil-4il)etil]amino}butanamida 329,4
336
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-1,1′-bifenil4-carboxamida 300,3
337
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(1Hpirrol-1-il)benzamida 289,3
338
imagen117 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4clorofenil)ciclohexanecarboxamida 340,8
339
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4pentilbenzamida 294,4
340
(2E)-N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-3(1,1′-bifenil-4-il)prop-2-enamida 326,4
341
(2S)-3-amino-2-{[(4′-etil-1,1′-bifenil-4-il)metil]amino}-Nhidroxipropanamida 314,4
342
(2S)-3-amino-2-[(1,1′-bifenil-4-ilmetil)amino]-Nhidroxipropanamida 286,3
343
(2S)-3-amino-2-{[1-(4′-bromo-1,1′-bifenil-4-il)etil]amino}-Nhidroxipropanamida 379,3
Ejemplo
Estructura Nombre MH+
344
(2S)-3-amino-N-hidroxi-2-{[1-(4′-metil-1,1′-bifenil-4il)etil]amino}propanamida 314,4
345
4′-etil-N-[(1S)-2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-1-(hidroximetil)-2oxoetil]-1,1′-bifenil-4-carboxamida 430,5
346
4′-etil-N-{(1S)-2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-1-[(4-hidroxifenil)metil]2-oxoetil}-1,1′-bifenil-4-carboxamida 506,6
347
(2S)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-N~1~-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil} pentanediamida 471,5
348
ácido (4S)-4-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-5({(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}amino)-5oxopentanoico 472,5
349
ácido (3S)-3-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-4({(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}amino)-4oxobutanoico 458,5
350
(3S)-2-(1,1′-bifenil-4-ilacetil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,2,3,4-tetrahidroisoquinoline3-carboxamida 488,6
351
4′-etil-N-[(1S)-2-({(1S,2R)-2-hidroxi-1(hidroxiamino)carbonil]propil}amino)-1-metil-2-oxoetil]-1,1′bifenil-4-carboxamida 414,5
352
(2S,3R)-2-({(2S)-3-amino-2-[(1,1′-bifenil-4ilacetil)amino]propanoil}amino)-N,3-dihidroxibutanamida 415,5
353
(2S)-2-[(1,1′-bifenil-4-ilacetil)amino]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}pent-4-inamida 424,5
354
imagen118 (2S,3R)-2-{[(2S)-2-amino-2-(1,1′-bifenil-4-il)etanoil]amino}N,3-dihidroxibutanamida 344,4
Ejemplo
Estructura Nombre MH+
355
(2S,3R)-2-{[(2R)-2-amino-2-(1,1′-bifenil-4-il)etanoil]amino}N,3-dihidroxibutanamida 344,4
356
N-(3-aminopropil)-4′-etil-N-[2-(hidroxiamino)-2-oxoetil]-1,1′bifenil-4-carboxamida 356,4
357
N-(2-cianoetil)-4′-etil-[2-(hidroxiamino)-2-oxoetil]-1,1′-bifenil-4carboxamida 352,4
358
N-[2-(acetilamino)etil]-4′-etil-N[2-(hidroxiamino)-2-oxoetil]-1,1′bifenil-4-carboxamida 384,4
359
4′-etil-N-[2-(hidroxiamino)-2-oxoetil]-N-prop-2-inil-1,1′-bifenil4-carboxamida 337,4
360
4-ciano-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 264,3
361
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4cianobenzamida 249,2
362
1,1-dimetiletil (2S)-2-{[(4-etinilfenil)carbonil]amino}-3(hidroxiamino)-3-oxopropilcarbamato 348,4
363
imagen119 1,1-dimetiletil (2S)-3-(hidroxiamino)-3-oxo-2-[({4-[(E)-2feniletenil]fenil}metil)amino] propilcarbamato 412,5
364
N-{(1R,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3′(trifluorometil)-1,1′-bifenil-4-carboxamida 383,3
Ejemplo
Estructura Nombre MH+
365
ácido (2S,3R)-2-[(1,1′-bifenil-4-ilmetil)amino]-3hidroxibutanoico 286,3
366
imagen120 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4(feniletinil)benzamida 324,4
367
1,1-dimetiletil (2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino)propil carbamato 424,5
368
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4etinilbenzamida 248,3
369
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4etinilbenzamida 248,3
370
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{(4(metiloxi)fenil]etinil}benzamida 369,4
371
imagen121 (2S)-3-amino-N-hidroxi-2-[({4-[(E)-2feniletenil]fenil}metil)amino] propanamida 312,4
372
1,1-dimetiletil 2-{4′-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]-1,1′-bifenil-4il}etilcarbamato 458,5
373
(2S,3R)-N,3-dihidroxi-2-[({4′-[(2-pirrolidin-1-iletil)oxi]-1,1′bifenil-4-il}metil)amino]butanamida 414,5
374
(1S)-4-({[(1,1-dimetiletil)oxi]carbonil}amino)-1-({[4-({4[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}etinil) fenil]amino}carbonil)butilcarbamato de 1,1-dimetiletilo 668,8
375
imagen122 4-(4-clorofenil)-N-[(1S)-2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-1-metil-2oxoetil]ciclohexanecarboxamida 426,9
Ejemplo
Estructura Nombre MH+
376
4′-etil-N-[2-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-2-oxoetil]-1,1′-bifenil-4carboxamida 400,4
377
4′-etil-N-[3-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-3-oxopropil)-1,1′-bifenil4-carboxamida 414,5
378
4′-etil-N-[4-({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)-4-oxobutil]-1,1′-bifenil-4carboxamida 428,5
379
N-((1S)-2-{[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}-1-metil-2-oxoetil)-4′-etil-1,1′-bifenil-4carboxamida 399,5
380
N-(2-{[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]amino}2-oxoetil)-4′-etil-1,1′-bifenil-4-carboxamida 385,4
381
imagen123 N-(3-{[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]amino}3-oxopropil)-4′-etil-1,1′-bifenil-4-carboxamida 399,5
382
N-(4-{[(1S)-1-(aminometil)-2-(hidroxianino)-2-oxoetil]amino}-4 -oxobutil)-4′-etil-1,1′-bifenil-4-carboxamida 413,5
383
4′-etil-N-[1-[(hidroxiamino)carbonil]-2-(metiloxi)propil]-1,1′bifenil-4-carboxamida 357,4
384
imagen124 4′-etil-N-[(1S,2R)-1-[(hidroxiamino)carbonil]-2(metiloxi)propil]-1,1′-bifenil-4-carboxamida 357,4
385
N-[1-[(dimetilamino)metil]-2-(hidroxiamino)-2-oxoetil]-4′-etil1,1′-bifenil-4-carboxamida 356,4
386
N-{(1S)-3-ciano-1-[(hidroxiamino)carbonil]propil}-4′-etil-1,1′bifenil-4-carboxamida 352,4
387
N-{(1S)-5-amino-1-[(hidroxiamino)carbonil]pentil}-4′-etil-1,1′bifenil-4-carboxamida 370,5
Ejemplo
Estructura Nombre MH+
388
N-{(1S)-3-amino-1-[(hidroxiamino)carbonil]propil}-4′-etil-1,1′bifenil-4-carboxamida 342,4
389
4′-etil-N-hidroxi-1,1′-bifenil-4-carboxamida 242,3
390
4′-etil-N-{2-hidroxi-1-[(hidroxiamino)carbonil]-2-metilpropil}1,1′-bifenil-4-carboxamida 357,4
391
N-[(2S)-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-3(hidroxiamino)-3-oxopropil]morfolina-4-carboxamida 441,5
392
N-[(1S)-1-{[(aminocarbonil)amino]metil}-2-(hidroxiamino)-2oxoetil)-4′-etil-1,1′-bifenil-4-carboxamida 371,4
393
N-[(1S)-1-({[amino(imino)metil]amino}metil)-2-(hidroxiamino)2-oxoetil]-4′-etil-1,1′-bifenil-4-carboxamida 370,4
394
N-[(2S)-2-amino-3-(hidroxiamino)-3-oxopropil]-4′-etil-1,1′bifenil-4-carboxamida 328,4
395
1-[(4′-etil-1,1′-bifenil-4-il)carbonil]-N-hidroxipiperazina-2carboxamida 354,4
396
N-[(2S)-2-amino-3-(hidroxiamino)-3-oxopropil]-4(feniletinil)benzamida 324,4
397
N-hidroxi-1-{[4-(feniletinil)fenil]carbonil}piperazina-2carboxamida 350,4
398
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4pentilfenil)etinil]benzamida 409,5
399
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[3(metiloxi)fenil]etinil}benzamida 369,4
Ejemplo
Estructura Nombre MH+
400
4-[(3-fluoro-4-metilpheny)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 371,4
401
imagen125 4-[(2,4-difluorofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 375,3
402
metil (2E)-3-(etilamino)-2-({[4-(feniletinil)fenil]carbonil}amino) but-2-enoato 363,4
403
1,1-dimetiletil 4-{[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]amino}-4oxobutilcarbamato 509,6
404
imagen126 N-(1-(N-hidroxicarbamoil)-2-hidroxi-3-metilbutil)[4-(4etilfenil)fenil]carboxamida 371,4
405
N-((1R,2R)-1-{[(aminocarbonil)(hidroxi)amino]metil}-2hidroxipropil)-4′-etil-1,1′-bifenil-4-carboxamida 372,4
406
4′-etil-N-((1R,2R)-1-{[formil(hidroxi)amino]metil}-2hidroxipropil)-1,1′-bifenil-4-carboxamida 357,4
407
imagen127 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(trifluorometil)fenil]etinil}benzamida 407,4
408
1,1-dimetiletil 2-{[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]amino}-2oxoetilcarbamato 481,5
Ejemplo
Estructura Nombre MH+
409
N-[(1S)-1-{[(aminoacetil)amino]metil}-2-(hidroxiamino)-2oxoetil]-4-(feniletinil)benzamida 381,4
410
imagen128 N-[(1S)-1-{[(4-aminobutanoil)amino]metil}-2-(hidroxiamino)-2oxoetil]-4-(feniletinil)benzamida 409,5
411
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-pent1-inilbenzamida 305,3
412
N-{(1S,2R)-2-[(1,1-dimetiletil)oxi]-1[(hidroxiamino)carbonil]propil}-4′-propil-1,1′-bifenil-4carboxamida 413,5
413
1,1-dimetiletil (1S)-4-({[(1,1-dimetiletil)oxi]carbonil}amino)-1{[(2-{4′-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]-1,1′-bifenil-4il}etil)amino]carbonil}butilcarbamato 672,8
414
4′-(2-aminoetil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil)-1,1′-bifenil-4-carboxamida 358,4
415
4′-(2-{[(2S)-2,5-diaminopentanoil]amino}etil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4carboxamida 472,6
416
4-(ciclohex-1-en-1-iletinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 343,4
417
4-(3,3-dimetilbut-1-inil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 319,4
Ejemplo
Estructura Nombre MH+
418
N-{(1S)-1-[(aminoacetil)amino]metil}-2-[(2-{[(2S)-3(hidroxiamino)-3-oxo-2-({[4-(feniletinil)fenil]carbonil}amino) propil]amino}-2-oxoetil)amino]-2-oxoetil}-4(feniletinil)benzamida 728,8
419
4-[(4-{[(2S)-2,5-diaminopentanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 468,5
420
4′-(2-aminoetil)-N-{(1E)-1-[(hidroxiamino)carbonil]prop-1-enil}1,1′-bifenil-4-carboxamida 340,4
421
2′,4′-difluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-1,1′-bifenil-4-carboxamida 351,3
422
N-[(1E)-1-formilprop-1-enil]-4′-propil-1,1′-bifenil-4carboxamida 308,4
423
N-hidroxi-4-(piridin-3-iletinil)benzamida 239,2
424
4-(3-hidroxi-3,5-dimetilhex-1-inil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 363,4
425
4′-etil-N-{(1R,2R)-2-hidroxi-1-[(hidroxiamino)metil]propil}-1,1′bifenil-4-carboxamida 329,4
426
imagen129 4′-etil-N-{(1R,2R)-1-[(hidroxiamino)metil]-2[(fenilmetil)oxi]propil}-1,1′-bifenil-4-carboxamida 419,5
427
4′-etil-N-[(5R,6R)-3-hidroxi-6-metil-2-oxo-1,3-oxazinan-5-il]1,1′-bifenil-4-carboxamida 355,4
Ejemplo
Estructura Nombre MH+
428
N-((1R,2R)-1-{[({[2-(dimetilamino)etil]amino}carbonil) (hidroxi)amino]metil}-2-hidroxipropil)-4′-etil-1,1′-bifenil-4carboxamida 443,6
429
N-((1R,2R)-1-{[{[(2-cianoetil)amino]carbonil}(hidroxi)amino] metil}-2-hidroxipropil)-4′-etil-1,1′-bifenil-4-carboxamida 425,5
430
4′-etil-N-((1R,2R)-2-hidroxi-1-{[hidroxi({[3-(2-oxopirrolidin-1-il) propil]amino}carbonil)amino]metil} propil)-1,1′-bifenil-4carboxamida 497,6
431
(1R,2R)-3-[({[2-(dimetilamino)etil]amino}carbonil) (hidroxi)amino]-2-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-1metilpropil 2-(dimetilamino)etilcarbamato 557,7
432
(1R,2R)-3-[{[(2-cianoetil)amino]carbonil}(hidroxi)amino]-2{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-1-metilpropil 2cianoetilcarbamato 521,6
433
N-{(1E)-1-[(E)-(hidroxiimino)metil]prop-1-enil}-4′-propil-1,1′bifenil-4-carboxamida 323,4
434
imagen130 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(piridin-3-iletinil)benzamida 340,3
435
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[3(metilamino)prop-1-inil]benzamida 306,3
436
N-[(1S)-1-[(dimetilamino)metil]-2-(hidroxiamino)-2-oxoetil]-4′etil-1,1′-bifenil-4-carboxamida 356,4
437
N-[1-(N-hidroxicarbamoilmetil)(1R,2R)-2-hidroxipropil][4-(4etilfenil)fenil]carboxamida 357,4
438
N-[(1S)-1-[(dietilamino)metil]-2-(hidroxiamino)-2-oxoetil]-4′etil-1,1′-bifenil-4-carboxamida 384,5
Ejemplo
Estructura Nombre MH+
439
4-[(3-aminofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 354,4
440
4-[3-(dimetilamino)prop-1-inil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 320,4
441
4-[3-(dimetilamino)prop-1-inil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 320,4
442
4-({4-[(aminoacetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 411,4
443
3′-fluoro-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-4′-metil-1,1′-bifenil-4carboxamida 347,4
444
N-[(1S)-1-formil-2-metilpropil]-1,1′-bifenil-4-carboxamida 282,4
445
N-{(1S)-1-[(E)-(hidroxiimino)metil]-2-metilpropil}-1,1′-bifenil-4carboxamida 297,4
446
N-((1E)-1-{(E)-[(aminocarbonil)hidrazono]metil}prop-1-enil)4′-propil-1,1′-bifenil-4-carboxamida 365,4
447
4-[(4-aminofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 354,4
448
4-{[3-(aminometil)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 368,4
Ejemplo
Estructura Nombre MH+
449
N-(2-aminoetil)-3-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)benzamida 425,5
450
imagen131 N-((1S)-1-{(E)-[(aminocarbonil)hidrazono]metil}-2-metilpropil)1,1′-bifenil-4-carboxamida 339,4
451
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[3(propanoilamino)fenil]etinil}benzamida 410,4
452
imagen132 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[3(morfolin-4-ilmetil)fenil]etinil}benzamida 438,5
453
4-[(3-{[(2-aminoetil)amino]metil}pheny)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 411,5
454
N-[(1R)-2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-4′-propil1,1′-bifenil-4-carboxamida 343,4
455
N-[1-(N-hidroxicarbamoil)metil)(1R,2R)-2-hidroxipropil][4-(2feniletinil)fenil]carboxamida 353,4
456
4′-etil-N-[(1R,2R)-1-[(hidroxiamino)carbonil]-2(metiloxi)propil]-1,1′-bifenil-4-carboxamida 357,4
457
4′-etil-N-[(1S)-1-[(etilamino)metil]-2-(hidroxiamino)-2-oxoetil]1,1′-bifenil-4-carboxamida 356,4
458
4′-etil-N-[(1S)-2-(hidroxiamino)-2-oxo-1-({[(2S)-pirrolidin-2ilmetil]amino}metil)etil]-1,1′-bifenil-4-carboxamida 411,5
459
N-[(1S)-1-[(etilamino)metil]-2-(hidroxiamino)-2-oxoetil]-4(feniletinil)benzamida 352,4
Ejemplo
Estructura Nombre MH+
460
N-[(1S)-2-(hidroxiamino)-2-oxo-1-({[(2S)-pirrolidin-2ilmetil]amino}metil)etil]-4-(feniletinil)benzamida 407,5
461
4′-etil-N-((1S)-2-(hidroxiamino)-1-{[(1-metiletil)amino]metil}-2oxoetil)-1,1′-bifenil-4-carboxamida 370,5
462
4′-etil-N-[(1S)-2-(hidroxiamino)-1-({[2(metilamino)etil]amino}metil)-2-oxoetil]-1,1′-bifenil-4carboxamida 385,5
463
4′-etil-N-((1S)-2-(hidroxiamino)-1-{[(1-metilpiperidin-4il)amino]metil}-2-oxoetil)-1,1′-bifenil-4-carboxamida 425,5
464
N-((1S)-2-(hidroxiamino)-1-{[(1-metiletil)amino]metil}-2oxoetil)-4-(feniletinil)benzamida 366,4
465
N-[(1S)-2-(hidroxiamino)-1-({[2-(metilamino)etil]amino}metil)2-oxoetil]-4-(feniletinil)benzamida 381,4
466
N-((1S)-2-(hidroxiamino)-1-{[(1-metilpiperidin-4il)amino]metil}-2-oxoetil)-4-(feniletinil)benzamida 421,5
467
N-[(1S)-1-{[(2-aminoetil)amino]metil}-2-(hidroxiamino)-2oxoetil]-4-(feniletinil)benzamida 367,4
468
N-[(1S)-1-{[bis(2-aminoetil)amino]metil}-2-(hidroxiamino)-2oxoetil]-4-(feniletinil)benzamida 410,5
469
imagen133 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(morfolin-4-ilacetil)amino]fenil}etinil)benzamida 481,5
470
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(propanoilamino)fenil]etinil}benzamida 410,4
Ejemplo
Estructura Nombre MH+
471
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(triffuorometil)oxi]fenil}etinil)benzamida 423,4
472
imagen134 1,1-dimetiletil (2S)-3-(hidroxiamino)-3-oxo-2-{[(4-{[3(propanoilamino)fenil]etinil}fenil) carbonil]amino}propilcarbamato 495,5
473
imagen135 1,1-dimetiletil (2S)-3-(hidroxiamino)-3-oxo-2-{[(4-pent-1inilfenil)carbonil]amino}propilcarbamato 390,4
474
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[3(propanoilamino)fenil]etinil}benzamida 395,4
475
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-pent-1inilbenzamida 290,3
476
4-(feniloxi)benzaldehido tiosemicarbazona 272,3
477
4-(feniloxi)benzaldehido semicarbazona 256,3
478
imagen136 4-{[3-(trifluorometil)fenil]oxi}benzaldehido tiosemicarbazona 340,3
479
4-[(3,4-difluorofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 375,3
480
4-[(2,4-dioxo-1,2,3,4-tetrahidropyrimidin-5-il)etinil]-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 373,3
Ejemplo
Estructura Nombre MH+
481
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4fenilbuta-1,3-diinil)benzamida 348,4
482
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4′-propil1,1′-bifenil-4-carboxamida 342,4
483
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-1,1′:4′,1″terfenil-4-carboxamida 376,4
484
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}1,1′:4′,1″-terfenil-4-carboxamida 391,4
485
1,1-dimetiletil (2S)-2-[({4-[(4-{[({[(1,1dimetiletil)oxi]carbonil}amino)acetil] amino}fenil)etinil]fenil}carbonil) amino]-3-(hidroxiamino)-3oxopropilcarbamato 596,6
486
imagen137 N-[(1S,2R)-1-(hidrazinocarbonil)-2-hidroxipropil]-4(feniletinil)benzamida 338,4
487
imagen138 2-[(2S,3R)-3-hidroxi-2-({[4-(feniletinil)fenil]carbonil}amino) butanoil]hidrazinecarboxamida 381,4
488
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(2metilfenil)etinil]benzamida 353,4
489
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(3hidroxifenil)etinil]benzamida 355,4
490
4-({3-[(aminoacetil)amino]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 411,4
Ejemplo
Estructura Nombre MH+
491
4-{[4-({[(cianometil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 450,5
492
4′-etil-N-{(1S)-2-(hidroxiamino)-2-oxo-1-[(tetrahidro-2H-pyran4-ilamino)metil]etil}-1,1′-bifenil-4-carboxamida 412,5
493
N-{(1S)-2-(hidroxiamino)-2-oxo-1-[(tetrahidro-2H-pyran-4ilamino)metil]etil}-4-(feniletinil)benzamida 408,5
494
imagen139 4-[(4-clorofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 373,8
495
imagen140 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4metilfenil)etinil]benzamida 353,4
496
4-[(2-fluorofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 357,4
497
4-[(3-fluorofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 357,4
498
imagen141 4-[(4-fluorofenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 357,4
499
4-[(4-{[(ciclopropilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 451,5
500
4-({4-[({[2-(dimetilamino)etil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 482,6
501
4-({4-[({[2-(acetilamino)etil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 496,5
502
imagen142 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)-4-({4[({[3-(2-oxopirrolidin-1il)propil]amino}acetil)amino]fenil}etinil)benzamida 536,6
503
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(piridin-3-ilmetil)amino]acetil}amino)fenil]etinil}benzamida 502,5
Ejemplo
Estructura Nombre MH+
504
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2-piridin-2-iletil)amino]acetil}amino)fenil]etinil}benzamida 516,6
505
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(4-metilpiperazin-1-il)acetil]amino}fenil)etinil]benzamida 494,6
506
4-({4-[(1,4'-bipiperidin-1'-ilacetil)amino]fenil}etinil)-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 562,7
507
1-(2-{[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}etinil) fenil]amino}-2-oxoetil)piperidina-4-carboxamida 522,6
508
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piperidin-3-ilamino)acetil]amino}fenil)etinil]benzamida 494,6
509
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piperidin-4-ilamino)acetil]amino}fenil)etinil]benzamida 494,6
510
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(piperidin-2-ilmetil)amino]acetil})amino)fenil]etinil}benzamida 508,6
511
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(piperidin-3-ilmetil)amino]acetil}amino)fenil]etinil}benzamida 508,6
512
4-[(4-{[(3-aminopirrolidin-1-il)acetil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 480,5
513
4-({4-[(azepan-1-ilacetil)amino]fenil}etinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}beazamida 493,6
514
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(4-morfolin-4-ilfenil)amino]acetil}amino)fenil]etinil}benzamida 572,6
515
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2hidroxietil)amino]acetil}amino)fenil] etinil}benzamida 440,5
516
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(ciclopropilamino)acetil]amino}fenil)etinil]benzamida 436,5
517
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[3(2-oxopirrolidin-1-il)propil]amino}acetil)amino]fenil} etinil)benzamida 521,6
518
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(4metilpiperazin-1-il)acetil]amino}fenil)etinil]benzamida 479,6
Ejemplo
Estructura Nombre MH+
519
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(piridin-3-ilmetil)amino]acetil}amino)fenil] etinil}benzamida 487,5
520
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(piperidin-1-ilacetil)amino]fenil}etinil)benzamida 464,5
521
4-{[4-({[(2-hidroxietil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 455,5
522
imagen143 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[2-(metiloxi)etil]amino}acetil)amino]fenil}etinil)benzamida 469,5
523
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({metil[2(metiloxi)etil]amino}acetil)amino]fenil}etinil)benzamida 483,5
524
4-{[4-({[[2(dimetilamino)etil](metil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 496,6
525
4-{[4-({[(3R)-3-(dimetilamino)pirrolidin-1il]acetil}amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 508,6
526
4-{[4-({[(3S)-3-(dimetilamino)pirrolidin-1il]acetil)amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 508,6
527
4-{[4-({[(3R)-3-(acetilamino)pirrolidin-1il]acetil)amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 522,6
528
4-{[4-({[(3S)-3-(acetilamino)pirrolidin-1il]acetil}amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 522,6
529
4-{[4-({[(3R)-1-azabiciclo[2.2.2]oct-3ilamino]acetil}amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 520,6
530
imagen144 4-{[4-({[(3S)-1-azabiciclo[2.2.2]oct-3ilamino]acetil}amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 520,6
531
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(2R)-pirrolidin-2ilmetil]amino)acetil)amino]fenil}etinil)benzamida 494,6
532
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4({4[({[(2S)-pirrolidin-2ilmetil]amino)acetil)amino]fenil}etinil)benzamida 494,6
Ejemplo
Estructura Nombre MH+
533
4-{[4-({[(3-aminociclohexil)amino]acetil}amino)fenil]etinil}N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)benzamida 508,6
534
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(3-hidroxipiperidin-1-il)acetil]amino}fenil)etinil]benzamida 495,5
535
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(3-morfolin-4ilpropil)amino]acetil}amino)fenil]etinil}benzamida 538,6
536
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2-metilpropil)amino]acetil}amino)fenil]etinil}benzamida 467,5
537
imagen145 4-[(4-{[(etilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 439,5
538
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(piperidin-1-ilacetil)amino]fenil}etinil)benzamida 479,5
539
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-1-{[4({[(3-hidroxipropil)amino]acetil}amino)fenil]etinil}benzamida 469,5
540
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[3-(metiloxi)propil]amino}acetil)amino]fenill}etinil)benzamida 483,5
541
4-{[4-({[(2-cianoetil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 464,5
542
imagen146 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2-pirrolidin-1-iletil)amino]acetil}amino)fenil]etinil}benzamida 508,6
543
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(2-metil-1H-imidazol-1-il)acetil]amino}fenil)etinil]benzamida 476,5
544
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(metilamino)acetil]amino}fenil) etinil]benzamida 410,4
545
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2metilpropil)amino]acetil}amino)fenil] etinil}benzamida 452,5
546
imagen147 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[2(metiloxi)etil]amino}acetil)amino]fenil} etinil)benzamida 454,5
547
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({metil[2-(metiloxi)etil]amino}acetil)amino] fenil}etinil)benzamida 468,5
Ejemplo
Estructura Nombre MH+
551
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[[2(dimetilamino)etil](metil)amino]acetil} amino)fenil]etinil}benzamida 481,6
552
4-({4-[({[2-(acetilamino)etil]amino}acetil)amino] fenil}etinil)-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 481,5
553
imagen148 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2cianoetil)amino]acetil}amino)fenil] etinil}benzamida 449,5
554
imagen149 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2pirrolidin-1-iletil)amino]acetil}amino)fenil]etinil} benzamida 493,6
555
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[4(dimetilamino)butil]amino}acetil)amino] fenil}etinil)benzamida 495,6
556
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(morfolin-4-ilacetil)amino]fenil}etinil)benzamida 466,5
557
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(azepan-1-ilacetil)amino]fenil}etinil)benzamida 478,6
558
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(pirrolidin-1-ilacetil)amino]fenil}etinil)benzamida 450,5
559
1-{2-[(4-{[4-({[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}carbonil)fenil]etinil} fenil)amino]-2oxoetil}piperidina-4-carboxamida 507,6
560
imagen150 4-{[4-({[(3R)-3-(acetilamino)pirrolidin-1il]acetil}amino)fenil]etinil}-N-[(1S)-1-(aminometil)-2(hidroxiamino)-2-oxoetil]benzamida 507,6
561
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(3R)-3-(dimetilamino)pirrolidin-1il]acetil}amino)fenil]etinil}benzamida 493,6
562
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(3aminopirrolidin-1-il)acetil]amino}fenil)etinil]benzamida 465,5
Ejemplo
Estructura Nombre MH+
563
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piperidin-3-ilamino)acetil]amino}fenil)etinil] benzamida 479,6
564
imagen151 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piperidin-4-ilamino)acetil]amino}fenil)etinil] benzamida 479,6
565
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(piperidin-2-ilmetil)amino]acetil}amino)fenil]etinil} benzamida 493,6
566
imagen152 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(piperidin-3-ilmetil)amino]acetil}amino)fenil]etinil} benzamida 493,6
567
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(piridin-2-ilmetil)amino]acetil}amino)fenil]etinil} benzamida 487,5
568
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(piridin-4-ilmetil)amino]acetil}amino)fenil]etinil} benzamida 487,5
569
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2piridin-2-iletil)amino]acetil}amino)fenil]etinil} benzamida 501,6
570
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2piridin-3-iletil)amino]acetil}amino)fenil]etinil} benzamida 501,6
571
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2piridin-4-iletil)amino]acetil}amino)fenil]etinil} benzamida 501,6
572
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(fenilamino)acetil]amino}fenil)etinil]benzamida 472,5
573
imagen153 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(fenilmetil)amino]acetil}amino)fenil] etinil}benzamida 486,5
574
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2feniletil)amino]acetil}amino)fenil] etinil}benzamida 500,6
Ejemplo
Estructura Nombre MH+
575
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[(1Himidazol-1-ilacetil)amino]fenil}etinil)benzamida 447,5
576
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(1H-imidazol-1-ilacetil)amino]fenil}etinil)benzamida 462,5
577
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4([(fenilamino)acetil]amino}fenil)etinil]benzamida 487,5
578
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{(4({[(2-feniletil)aminolacetil}amino)fenil]etinil}benzamida 515,6
579
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(3-fenilpropil)amino]acetil}amino)fenil]etinil}benzamida 529,6
580
4-[(3-{[(aminoacetil)amino]metil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 425,5
581
4-[(2-aminopyrimidin-5-il)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 356,4
582
4-[(4-acetilfenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 381,4
583
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)caibonil]propil}-4-[(4{[({2-[4-(fenilmetil)piperazin-1il]etil}amino)acetil]amino}fenil)etinil]benzamida 613,7
584
4-{[4-({[(aminoacetil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 468,5
585
4-{[4-({[4-(2-hidroxietil)piperazin-1-il]acetil)amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 524,6
586
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({(3R}-3-[(trifluoroacetil)amino]pirrolidin-1il)acetil)amino]fenil}etinil)benzamida 576,5
587
imagen154 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(metilamino)acetil]amino}fenil)etinil]benzamida 425,5
Ejemplo
Estructura Nombre MH+
589
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(piridin-2-ilmetil)amino]acetil}amino)fenil]etinil}benzamida 502,5
590
imagen155 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{(4({[(piridin-4-ilmetil)amino]acetil}amino)fenil]etinil}benzamida 502,5
591
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)-4-{[4({[(2-piridin-3-iletil)amino]acetil}amino)fenil]etinil}benzamida 516,6
592
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2-piridin-4-iletil)amino]acetil}amino)fenil]etinil}benzamida 516,6
593
4-({4-[({[(2-fluorofenil)metil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 519,5
594
imagen156 4-({4-[({[(2-clorofenil)metil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 536,0
595
imagen157 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)-4-[(4{[({[2(metiloxi)fenil]metil}amino)acetil]amino}fenil)etinil]benzami da 531,6
596
imagen158 4-({4-[({[(3-fluorofenil)metil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 519,5
597
4-({4-[({[(3-clorofenil)metil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 536,0
598
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[({[3(metiloxi)fenil]metil}amino)acetil]amino}fenil)etinil]benzami da 531,6
599
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(3(metilfenil)metil]amino}acetil)amino]fenil}etinil)benzamida 515,6
600
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[({[3(trifluorometil)fenil]metil}amino)acetil]amino}fenil) etinil]benzamida 569,5
601
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[({3-[(trifluorometil)oxi]fenil}metil)amino]acetil}amino)fenil] etinil}benzamida 585,5
602
4-({4-[({[(4-fluorofenil)metil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 519,5
Ejemplo
Estructura Nombre MH+
603
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(4-etilfenil)metil]amino}acetil)amino]fenil}etinil)benzamida 515,6
604
4-[(4-{[({[4(dimetilamino)fenil]metil}amino)acetil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 544,6
605
imagen159 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[({[4(trifluorometil)fenil]metil}amino)acetil]amino}fenil)etinil]benzami da 569,5
606
4-[(4-{[({[4-fluoro-2(trifluorometil)fenil]metil}amino)acetil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 587,5
607
4-({4-[({[(2,4-difluorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 537,5
608
4-({4-[({[(2,4-diclorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 570,4
609
4-{[4-({[(2-fluorofenil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 505,5
610
4-{[4-({[(4-fluorofenil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 505,5
611
4-({4-[({[(3,5-difluorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 537,5
612
4-{[4-({[(4-bromofenil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 566,4
613
4-({4-[({[4-(dimetilamino)fenil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 530,6
614
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2S)2-aminopropanoil]amino}fenil)etinil] benzamida 410,4
615
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2R)2-aminopropanoil]amino}fenil)etinil] benzamida 410,4
616
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2S)2-amino-4-metilpentanoil]amino}fenil)etinil] benzamida 452,5
Ejemplo
Estructura Nombre MH+
617
4-[(4-{[(2S,3R)-2-amino-3-hidroxibutanoil]amino}fenil)etinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 440,5
618
4-[(4-{[(2S)-2-amino-4-cianobutanoil]amino}fenil)etinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 449,5
619
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2S)2,3-diaminopropanoil]amino}fenil)etinil] benzamida 425,5
620
(2S)-N-(4-{[4-({[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}carbonil)fenil]etinil} fenil)pirrolidina-2carboxamida 436,5
621
(2S)-N-(4-{[4-({[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}carbonil)fenil]etinil} fenil)piperidina-2carboxamida 450,5
622
N-(4-{[4-({[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}carbonil)fenil]etinil} fenil)piperidina-3carboxamida 450,5
623
4-[(4-{[(2S)-2-amino-3-(1H-imidazol-4il)propanoil]amino}fenil)etinil]-N-[(1S)-1-(aminometil)-2(hidroxiamino)-2-oxoetil]benzamida 476,5
624
imagen160 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4metilfenil)etinil]benzamida 338,4
625
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(2fluorofenil)etinil]benzamida 342,3
626
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(3fluorofenil)etinil]benzamida 342,3
627
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4fluorofenil)etinil]benzamida 342,3
Ejemplo
Estructura Nombre MH+
628
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4clorofenil)etinil]benzamida 358,8
629
4-[(4-{[(2S)-2-amino-4-metilpentanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 467,5
630
4-[(4-{[(2S)-2-amino-4-cianobutanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 464,5
631
4-[(4-{[(2S)-2,3-diaminopropanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 440,5
632
N-[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)fenil]piperidina-3-carboxamida 465,5
633
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({3[(morfolin-4-ilacetil)amino]fenil}etinil)benzamida 481,5
634
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4(pirazin-2-iletinil)benzamida 341,3
635
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[3-(1H-imidazol-1il)propil]amino}acetil)amino]fenil}etinil)benzamida 519,6
637
imagen161 ácido 4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}etinil)benzoi co 383,4
638
N-(2-{[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiaminocarbonil]propil}amino}carbonil]fenil}etinil) fenil]amino}-2-oxoetil)-1,3-benzodioxol-4-carboxamida 559,5
639
4-({4-[((2R)-2-{[(2R)-2,5-diaminopentanoil]amino}-4fenilbutanoil)amino]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 629,7
Ejemplo
Estructura Nombre MH+
640
4-[(4-{[(2R)-2-amino-4-fenilbutanoil}amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 515,6
641
4-[(4-{[(2S)-2-amino-3-fenilpropanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 501,6
642
4-{[4-({[(2-aminoetil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 454,5
643
N-{(1S)-2-(hidroxiamino)-1-[({[metil(1-metilpiperidin-4il)amino]acetil}amino)metil]-2-oxoetil)-4-(feniletinil)benzamida 492,6
644
4-[(4-{[(ciclobutilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 465,5
645
4-[(4-{[(ciclopentilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 479,5
646
4-[(4-{[(ciclohexilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 493,6
647
4-[(4-{[(cicloheptilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 507,6
648
4-[(4-{[(ciclooctilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 521,6
649
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(propilamino)acetil]amino}fenil)etinil]benzamida 453,5
650
4-[(4-{[(hexilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 495,6
651
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(1-metiletil)amino]acetil}amino)fenil]etinil}benzamida 453,5
652
4-{[4-({[(1,1-dimetiletil)amino]acetil}amino)fenil]etinil}-N{(1S,2R}-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 467,5
Ejemplo
Estructura Nombre MH+
653
4-{[4-({[etil(metil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonillpropil}benzamida 453,5
654
4-[(4-{[(dietilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 467,5
655
4-{[4-({[(1,1-dimetiletil)(metil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 481,6
656
4-{[4-({[ciclohexil(metil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 507,6
657
4-{[4-({[bis(1-metiletil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 495,6
658
4-{[4-({[(ciclohexilmetil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 507,6
659
4-{[4-({[(2,3-dimetilciclohexil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 521,6
660
4-{[4-({[(1R,2R,4S)-biciclo[2.2.1]hept-2ilamino]acetil}amino)fenil]etinil-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 505,6
661
4-[(4-{[({[(1S,2R,5S)-6,6-dimetilbiciclo[3.1.1]hept-2il]metil}amino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 547,7
662
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[4-(trifluorometil)piperidin-1il]acetil}amino)fenil]etinil}benzamida 547,5
663
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(2fluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 504,5
664
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(2clorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 521,0
665
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(2metilfenil)metil]amino}acetil)amino] fenil}etinil)benzamida 500,6
666
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[2(metiloxi)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 516,6
Ejemplo
Estructura Nombre MH+
667
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[2(trifluorometil)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 554,5
668
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[({2[(fluorometil)oxi]fenil}metil)amino] acetil}amino)fenil]etinil}benzamida 570,5
669
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(3fluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 504,5
670
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(3clorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 521,0
671
imagen162 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(3metilfenil)metil]amino}acetil)amino] fenil}etinil)benzamida 500,6
672
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[3(metiloxi)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 516,6
673
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[3(trifluorometil)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 554,5
674
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[({3[(fluorometil)oxi]fenil}metil)amino] acetil}amino)fenil]etinil}benzamida 570,5
675
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(4fluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 504,5
676
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(4clorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 521,0
677
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(4metilfenil)metil]amino}acetil)amino] fenil}etinil)benzamida 500,6
678
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[4(metiloxi)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 516,6
679
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[4(trifluorometil)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 554,5
Ejemplo
Estructura Nombre MH+
680
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[4(1,1-dimetiletil)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 542,6
681
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(1R)-1-feniletil]amino}acetil)amino]fenil} etinil)benzamida 500,6
682
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(1S)-1-feniletil]amino}acetil)amino]fenil} etinil)benzamida 500,6
683
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(ciclohexilmetil)amino]acetil}amino) fenil]etinil}benzamida 492,6
684
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(ciclobutilamino)acetil]amino}fenil) etinil]benzamida 450,5
685
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(ciclopentilamino)acetil]amino}fenil) etinil]benzamida 464,5
686
imagen163 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(ciclohexilamino)acetil]amino}fenil) etinil]benzamida 478,6
687
imagen164 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(cicloheptilamino)acetil]amino}fenil) etinil]benzamida 492,6
688
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(ciclooctilamino)acetil]amino}fenil) etinil]benzamida 506,6
689
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(etilamino)acetil]amino}fenil)etinil] benzamida 424,5
690
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(propilamino)acetil]amino}fenil)etinil] benzamida 438,5
691
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(butilamino)acetil]amino}fenil)etinil] benzamida 452,5
Ejemplo
Estructura Nombre MH+
692
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(hexilamino)acetil]amino}fenil)etinil] benzamida 480,6
693
imagen165 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(1metiletil)amino]acetil}amino)fenil] etinil}benzamida 438,5
694
imagen166 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1,1-dimetiletil)amino]acetil}amino)fenil] etinil}benzamida 452,5
695
imagen167 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{(4({[etil(metil)amino]acetil}amino)fenil] etinil}benzamida 438,5
696
imagen168 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(dietilamino)acetil]amino}fenil) etinil]benzamida 452,5
697
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1,1-dimetiletil)(metil)amino]acetil}amino) fenil]etinil}benzamida 466,6
698
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[ciclohexil(metil)amino]acetil}amino) fenil]etinil}benzamida 492,6
699
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[2(2-fluorofenil)etil]amino}acetil)amino] fenil}etinil)benzamida 518,6
700
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[2(3-fluorofenil)etil]amino}acetil)amino] fenil}etinil)benzamida 518,6
701
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[2(4-fluorofenil)etil]amino}acetil)amino] fenil}etinil)benzamida 518,6
702
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(1S,2R)-2-fenilciclopropil]amino}acetil)amino] fenil}etinil)benzamida 512,6
703
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(2,4-difluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 522,5
Ejemplo
Estructura Nombre MH+
704
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(2,4-diclorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 555,4
705
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[4fluoro-2-(trifluorometil)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 572,5
706
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(2,5-difluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 522,5
707
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(3,4-difluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 522,5
708
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(3,4-diclorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 555,4
709
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(3,4-dimetilfenil)metil]amino}acetil)amino] fenil}etinil)benzamida 514,6
710
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(3,5-difluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 522,5
711
imagen169 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(3,5-diclorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 555,4
712
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[({[3,5-bis(trifluorometil)fenil]metil}amino)acetil]amino} fenil)etinil]benzamida 622,5
713
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[(4nitrofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 531,5
714
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piridin-2-ilamino)acetil]amino}fenil)etinil] benzamida 473,5
715
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piridin-3-ilamino)acetil]amino}fenil)etinil] benzamida 473,5
716
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2fluorofenil)amino]acetil}amino)fenil] etinil}benzamida 490,5
Ejemplo
Estructura Nombre MH+
717
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(3fluorofenil)amino]acetil}amino)fenil] etinil}benzamida 490,5
718
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(4fluorofenil)amino]acetil}amino)fenil] etinil}benzamida 490,5
719
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piridin-4-ilamino)acetil]amino}fenil)etinil] benzamida 473,5
720
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(2,2,2-trifluoroetil)amino]acetil}amino)fenil] etinil}benzamida 478,4
721
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piridin-2-ilamino)acetil]amino}fenil)etinil]benzamida 488,5
722
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piridin-3-ilamino)acetil]amino}fenil)etinil]benzamida 488,5
723
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piridin-4-ilamino)acetil]amino}fenil)etinil]benzamida 488,5
724
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(4-fenilpiperazin-1-il)acetil]amino}fenil)etinil]benzamida 556,6
725
4-{[4-({[4-(4-fluorofenil)piperazin-1-il]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 574,6
726
4-{[4-({[(1-acetilpiperidin-4il)(ciclopropil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 576,7
727
4-[(4-{[(butilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 467,5
728
imagen170 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(1R)-1-feniletil]amino}acetil)amino]fenil}etinil)benzamida 515,6
729
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(1S)-1-feniletil]amino}acetil)amino]fenil}etinil)benzamida 515,6
730
4-{[4-({[ciclopropil(metil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 465,5
Ejemplo
Estructura Nombre MH+
731
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[metil(fenilmetil)amino]acetil}amino)fenil]etinil}benzamida 515,6
732
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[ciclopropil(metil)amino]acetil}amino) fenil]etinil}benzamida 450,5
733
4-[(4-{[(2S)-2-aminopropanoil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 425,5
734
4-[(4-{[(2R)-2-aminopropanoil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 425,5
735
4-[(4-{[(2S)-2-amino-3-metilbutanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 453,5
736
imagen171 4-[(4-{[(2S,3R)-2-amino-3-hidroxibutanoil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 455,5
737
(2S)-N-[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}etinil)fenil] pirrolidin-2-carboxamida 451,5
738
4-[(4-{[(2S)-2-amino-3-(1H-imidazol-4il)propanoil]amino}fenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 491,5
739
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(metiloxi)acetil]amino}fenil)etinil] benzamida 426,4
740
4-[(4-{[(2S)-2-amino-3-metilbutanoil]amino}fenil)etinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 438,5
741
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(3fenilpropil)amino]acetil}amino)fenil] etinil}benzamida 514,6
742
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(tien2-iletinil)benzamida 345,4
743
4-({4-[((2S)-2-{[(2S)-2,5-diaminopentanoil]amino}-3-fenilpropanoil)amino]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 615,7
Ejemplo
Estructura Nombre MH+
744
3,4-dihidroxi-N-[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]benzamida 460,5
745
1,1-dimetiletil 3-[(2-{[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino)propil] amino}-2oxoetil)amino]propilcarbamato 538,6
746
N-[(1S)-2-(hidroxiamino)-1-({[(4-metilpiperazin-1il)acetil]amino}metil)-2-oxoetil]-4-(feniletinil)benzamida 464,5
747
4-{[4-({2-[(2-aminoetil)amino]-2-oxoetil}oxi)fenil]etinil}-N{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 455,5
748
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[3(aminometil)fenil]etinil}benzamida 353,4
749
1,1-dimetiletil (2S)-3-(hidroxiamino)-2-[({4-[(4-{[2(hidroxiamino)-2-oxoetil]oxi}fenil)etinil]fenil} carbonil)amino]-3oxopropilcarbamato 513,5
750
imagen172 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[2(hidroxiamino)-2-oxoetil]oxi}fenil)etinil]benzamida 413,4
751
3,4-dihidroxi-N-(2-{[4-({4-[({(1S,2R)-2-hidroxil-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}etinil)fenil] amino}-2-oxoetil)benzamida 547,5
752
4-({4-[({[(2S)-2,5diaminopentanoil]amino}acetil)amino]fenil}etinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 525,6
753
imagen173 4-[(4-{[(2-aminoetil)amino]carbonil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 425,5
Ejemplo
Estructura Nombre MH+
754
N-[(1S)-1-[({[(3-aminopropil)amino]acetil}amino)metil]-2(hidroxiamino)-2-oxoetil]-4-(feniletinil)benzamida 438,5
755
ácido 3-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}etinil)benzoi co 383,4
756
4-{[4-({[(3-aminopropil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 468,5
757
imagen174 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(pyrazin2-iletinil)benzamida 326,3
758
4-({3-[(4-aminobutanoil)amino]fenil}etinil)-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 424,5
759
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2S)2,5-diaminopentanoil]amino}fenil)etinil] benzamida 453,5
760
4-({2-[(aminoacetil)amino]fenil}etinil)-N-[(1S)-1-(aminometil)-2(hidroxiamino)-2-oxoetil]benzamida 396,4
761
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[2(etilamino)-2-oxoetil]fenil}etinil)benzamida 409,5
762
4-({4-[(aminoacetil)amino]-3-metilfenil}etinil)-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 410,4
763
4-({4-[(aminoacetil)amino]fenil}etinil)-N-[(1S)-1-(aminometil)-2(hidroxiamino)-2-oxoetil]-3-fluorobenzamida 414,4
764
imagen175 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(cianometil)amino]acetil}amino) fenil]etinil}benzamida 435,5
Ejemplo
Estructura Nombre MH+
765
ácido [4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)fenil]acético 397,4
766
ácido 4-amino-2-({[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)fenil]carbonil} amino)-4-oxobutanoico 497,5
767
imagen176 ácido 4-amino-2-[({[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)fenil]oxi}acetil) amino]-4-oxobutanoico 527,5
768
N-((1S)-2-(hidroxiamino)-1-{[(morfolin-4-ilacetil)amino]metil}2-oxoetil)-4-(feniletinil)benzamida 451,5
769
N-[(1S)-1-[({[(2,3-dihidroxipropil)tio]acetil}amino)metil]-2(hidroxiamino)-2-oxoetil)-4-(feniletinil)benzamida 472,5
770
metil (2S)-3-amino-2-({[4-(feniletinil)fenil]carbonil}amino) propanoato 323,4
771
N-{(1S)-2-(hidroxiamino)-2-oxo-1-[({[(2feniletil)amino]acetil}amino)metil] etil}-4-(feniletinil)benzamida 485,6
772
4-[(4-{2-[(2-aminoetil)amino]-2-oxoetil}fenil)etinil]-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 439,5
773
4-[(4-{[(6-aminohexil)amino]carbonil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 481,6
774
4-[4-(4-{[(etilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 463,5
Ejemplo
Estructura Nombre MH+
775
4-[4-(4-{[(ciclopropilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 475,5
776
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[(piperidin-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 503,6
777
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[(fenilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 511,5
778
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(fenilmetil)amino]acetil}amino)fenil]buta-1,3-diinil}benzamida 525,6
779
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4'-etil1,1'-bifenil-4-carboxamida 342,4
780
4-[(4-{[(dimetilamino)acetil]amino}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 439,5
781
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(pirrolidin-1-ilacetil)amino]fenil}etinil)benzamida 465,5
782
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{(4{[(pentilamino)acetil]amino}fenil)etinil]benzamida 481,6
783
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(tien-2-ilmetil)amino]acetil}amino)fenil]etinil}benzamida 507,6
784
4-{[4-({[(1H-bencimidazol-2ilmetil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 541,6
785
4-{[4-({[(1-benzotien-3-ilmetil)amino]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 557,6
786
4-(4-{4-[({[(2-fluorofenil)metil]amino}acetil)amino]fenil}buta-1,3diinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 543,6
787
4-(4-{4-[({[(3-fluorofenil)metil]amino}acetil)amino]fenil}buta-1,3diinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 543,6
788
4-(4-{4-[({[(4-fluorofenil)metil]amino}acetil)amino]fenil}buta-1,3diinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 543,6
789
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[(2-metilfenil)metil]amino}acetil)amino]fenil}buta-1,3diinil)benzamida 539,6
Ejemplo
Estructura Nombre MH+
790
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[(3-metilfenil)metil]amino}acetil)amino]fenil}buta-1,3diinil)benzamida 539,6
791
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[(4-metilfenil)metil]amino}acetil)amino]fenil}buta-1,3diinil)benzamida 539,6
792
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(piridin-2-ilmetil)amino]acetil}atnino)fenil]buta-1,3diinil}benzamida 526,6
793
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(piridin-3-ilmetil)amino]acetil}amino)fenil]buta-1,3diinil}benzamida 526,6
794
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(piridin-4-ilmetil)amino]acetil}amino)fenil]buta-1,3diinil}benzamida 526,6
795
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[({[2-(metiloxi)fenil]metil}amino)acetil]amino}fenil)buta-1,3diinil]benzamida 555,6
796
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[({[3-(metiloxi)fenil]metil]amino)acetil]amino}fenil)buta-1,3diinil]benzamida 555,6
797
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[({[4-(metiloxi)fenil]metil]amino)acetil]amino}fenil)buta-1,3diinil]benzamida 555,6
798
imagen177 4-{4-[4-({[(2-fluorofenil)amino]acetil}amino)fenil]buta-1,3-diinil}N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 529,5
799
4-{4-[4-({[(3-fluorofenil)amino]acetil}amino)fenil]buta-1,3-diinil}N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 529,5
800
imagen178 4-{4-[4-({[(4-fluorofenil)amino]acetil]amino}fenillbuta-1,3-diinil}N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 529,5
801
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[(piridin-2-ilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 512,5
802
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[(piridin-3-ilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 512,5
803
N-{(1S,2R)-2-hidroxi-1-[(hidroxiaminocarbonil]propil}-4-[4-(4{[(piridin-4-ilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 512,5
Ejemplo
Estructura Nombre MH+
804
4-[4-(4-{[(ciclobutilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 489,5
805
4-[4-(4-{[(ciclopentilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 503,6
806
4-[4-(4-{[(ciclohexilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 517,6
807
4-[4-(4-{[(cicloheptilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 531,6
808
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[(metilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 449,5
809
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[(propilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 477,5
810
4-[4-(4-{[(butilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 491,6
811
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(4{[(pentilamino)acetil]amino}fenil)buta-1,3-diinil]benzamida 505,6
812
imagen179 4-[4-(4-{[(hexilamino)acetil]amino}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 519,6
813
4-{4-[4-({[etil](metil)amino]acetil}amino)fenil]buta-1,3-diinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 477,5
814
imagen180 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(1-metiletil)amino]acetil}amino)fenil]buta-1,3diinil}benzamida 477,5
815
imagen181 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(2-metilpropil)amino]acetil}amino)fenil]buta-1,3diinil}benzamida 491,6
816
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(2,2,2-trifluoroetil)amino]acetil}amino)fenil]buta-1,3diinil}benzamida 517,5
817
4-{4-[4-({[(2-hidroxietil)amino]acetil}amino)fenil]buta-1,3-diinil}N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 479,5
818
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[2-(metiloxi)etil]amino}acetil)amino]fenil}buta-1,3diinil)benzamida 493,5
Ejemplo
Estructura Nombre MH+
819
4-(4-{4-[({[2-(dimetilamino)etil]amino}acetil)amino]fenil}buta1,3-diinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 506,6
820
4-{4-[4-({[(2-cianoetil)amino]acetil}amino)fenil]buta-1,3-diinil}N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 488,5
821
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[(pirrolidin-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 489,5
822
4-(4-{4-[(azepan-1-ilacetil)amino]fenil}buta-1,3-diinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 517,6
823
imagen182 N-{(1S,2R)-2-hidroxi-1-(hidroxiamino)carbonil]propil}-4-[4-(4{[(4-metilpiperazin-1-il)acetil]amino}fenil)buta-1,3diinil]benzamida 518,6
824
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[(morfolin-4-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 505,5
825
4-{4-[4-({[ciclohexil(metil)amino]acetil}amino)fenil]buta-1,3diinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 531,6
826
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[(1R)-1-feniletil]amino}acetil)amino]fenil)buta-1,3diinil)benzamida 539,6
827
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[(1S)-1-feniletil]amino}acetil)amino]fenil}buta-1,3diinil)benzamida 539,6
828
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[4({[(2-feniletil)amino]acetil}amino)fenil]buta-1,3-diinil}benzamida 539,6
829
imagen183 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[(1H-imidazol-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 486,5
830
4-{4-[4-({[(1R,2R,4S}-biciclo[2.2.1]hept-2ilamino]acetil}amino)fenil]buta-1,3-diinil}-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 529,6
831
4-{4-[4-({[(ciclohexilmetil)amino]acetil}amino)fenil]buta-1,3diinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 531,6
832
imagen184 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4′-etil-2fluoro-1,1′-bifenil-4-carboxamida 346,4
Ejemplo
Estructura Nombre MH+
833
4-({4-[(aminoacetil)amino]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}-3-(metiloxi)benzamida 441,5
834
4′-etil-N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-2(metiloxi)-1,1′-bifenil-4-carboxamida 373,4
835
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-3(metiloxi)-4-(feniletinil)benzamida 369,4
836
4-[(4-etilfenil)etinil]-N-{(1S,2R}-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 367,4
837
imagen185 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4hidroxifenil)etinil]benzamida 355,4
838
ácido 2-[(2-{[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]amino}-2oxoetil)tio]propanoico 470,5
839
ácido 4-amino-2-[(2-{[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]amino}-2-oxoetil)amino]4-oxobutanoico 496,5
840
1,1-dimetiletil 4-amino-2-[(2-{[(2S)-3-(hidroxiamino)-3-oxo-2({[4-(feniletinil)fenil]carbonil}amino) propil]amino}-2oxoetil)amino]-4-oxobutanoato 552,6
841
2,6-dihidroxi-N-[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]piridina-4-carboxamida 461,4
842
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4aminofenil)etinil]benzamida 339,4
Ejemplo
Estructura Nombre MH+
843
imagen186 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4etilfenil)etinil]benzamida 352,4
844
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4etilfenil)etinil]-3-fluorobenzamida 370,4
845
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[(3aminopropanoil)amino]fenil}etinil) benzamida 410,4
846
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(dimetilamino)acetil]amino}fenil) etinil]benzamida 424,5
847
4-({4-[(4-aminobutanoil)amino]fenil}etinil)-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 424,5
848
N-{(1S)-2-(hidroxiamino)-1-[({[2(metiloxi)fenil]metil}amino)metil]-2-oxoetil}-4(feniletinil)benzamida 444,5
849
N-[(1S)-1-[diprop-2-enilamino)metil]-2-(hidroxiamino)-2oxoetil]-4-(feniletinil)benzamida 404,5
850
N-[(1S)-2-(hidroxiamino)-1-({[({[2(metiloxi)fenil]metil}amino)acetil] amino}metil)-2-oxoetil]-4(feniletinil)benzamida 501,6
851
N-((1S)-2-(hidroxiamino)-1-{[({[2(metiloxi)fenil]tio}acetil)amino]metil}-2-oxoetil)-4(feniletinil)benzamida 504,6
Ejemplo
Estructura Nombre MH+
852
ácido (2S,3R)-3-amino-2-({[4-(feniletinil)fenil]carbonil}amino) butanoico 323,4
853
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(dimetilanino)aceil]amino}fenil) buta-1,3-diinil]benzamida 448,5
854
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(etilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 448,5
855
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(ciclopropilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 460,5
856
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(piperidin-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 488,6
857
imagen187 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(fenilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 496,5
858
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(fenilmetil)amino]acetil}amino) fenil]buta-1,3diinil}benzamida 510,6
859
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4aminofenil)buta-1,3-diinil]benzamida 363,4
860
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(pirazin-2-ilamino)acetil]amino}fenil)etinil]benzamida 489,5
861
N-{(1S,2R}-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(4-fenilpiperidin-1-il)acetil]amino}fenil)etinil]benzamida 555,6
862
imagen188 4-{[4-({[4-(2-fluorofenil)piperazin-1-il]acetil}amino)fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 574,6
863
4-{[4-({[(1S,4R)-biciclo[2.2.1]hept-2ilamino]acetil)amino)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 505,6
864
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(1S,2S,3S,5R)-2,6,6-trimetilbiciclo[3.1.1]hept-3il]amino}acetil)amino]fenil}etinil)benzamida 547,7
Ejemplo
Estructura Nombre MH+
865
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(triciclo[3,3,1,1~3,7~]dec-1ilmetil)amino]acetil}amino)fenil]etinil}benzamida 559,7
866
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(4-metilciclohexil)amino]acetil}amino)fenil]etinil}benzamida 507,6
867
imagen189 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2,2,2-trifluoroetil)amino]acetil}amino)fenil]etinil}benzamida 493,5
868
4-({4-[({[2-(2-fluorofenil)etil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 533,6
869
4-({4-[({[2-(3-fluorofenil)etil]amino}acetil}amino]fenil}etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 533,6
870
4-({4-[({[2-(4-fluorofenil)etil]amino}acetil]amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 533,6
871
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(1S,2R)-2fenilciclopropil]aminolacetil)amino]fenil}etinil)benzamida 527,6
872
N-{1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(2-metilfenil)metil]amino}acetil)amino]fenil}etinil)benzamida 515,6
873
imagen190 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[({[2(trifluorometil)fenil]metil}amino)acetil]amino}fenil)etinil]benzami da 569,5
874
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[({2-[(trifluorometil)oxi]fenil}metil)amino]acetil}amino)fenil] etinil}benzamida 585,5
875
imagen191 4-({4-[({[(4-clorofenil)metil]amino}acetil)amino]fenil}etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 536,0
876
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{({(4(metiloxi)fenil]metil}amino)acetil]amino}fenil)etinil]benzamida 531,6
877
imagen192 4-[(4-{[({[4-(1,1dimetiletil)fenil]metil}amino)acetil]amino}fenil)etinil]-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 557,7
878
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(4-nitrofenil)metil]amino}acetil)amino]fenil}etinil)benzamida 546,5
Ejemplo
Estructura Nombre MH+
879
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[({4-[(trifluorometil)oxi)fenil]metil)amino]acetil}amino)fenil] etinil}benzamida 585,5
880
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[({[4(metiltio)fenil]metil]amino)acetil]amino}fenil)etinil]benzamida 547,6
881
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[({4-[(trifluorometil)tio]fenil}metil)amino]acetil}amino)fenil] etinil}benzamida 601,6
882
imagen193 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[({[4(metilsulfonil)fenil]metil}amino)acetil]amino}fenil)etinil]benzami da 579,6
883
4-({4-[({[(2,5-difluorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 537,5
884
4-1({4-[({[2,6-difluorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 537,5
885
imagen194 4-({4-({[(3,4-difluorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil)carpropil}benzamida 537,5
886
4-({4-[({[(3,4-diclorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 570,4
887
4-({4-[({[(3,4-dimetilfenil)metil)amino}acetil]amino]fenil}etinil)N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil}propil}benzamida 529,6
888
4-({4-[({[(3,5-diclorofenil)metil]amino}acetil)amino]fenil}etinil)N-{(1S,2R}-2-hidroxi-1[(hidroxiamino)carbonil)propil}benzamida 570,4
889
imagen195 4-L(4-{[({[3,5bis(trifluorometil)fenil]metil}amino)acetil]amino}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 637,5
890
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(2,3,4trifluorofenil)metil]amino}acetil)amino]fenil}etinil)benzamida 555,5
891
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbopil]propil}-4-({4[({[(2,4,5trifluorofenil)metil]amino)acetil)amino]fenil}etinil)benzamida 555,5
892
imagen196 N-{(1S,2R]-2-hidroxi-1-[(hidroxiamino)carbonil}propil}-4-({4[({[(3,4,5trifluorofenil)metil]amino)acetil)amino]fenil}etinil)benzamida 555,5
Ejemplo
Estructura Nombre MH+
893
imagen197 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(pentilamino)acetil]amino}fenil) etinil]benzamida 466,6
894
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(tien-2-ilmetil)amino]acetil}amino)fenil] etinil}benzamida 492,6
895
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(4fenilpiperidin-1-il)acetil]amino}fenil)etinil]benzamida 540,6
896
imagen198 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(4fenilpiperazin-1-il)acetil]amino}fenil)etinil]benzamida 541,6
897
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[4(2-fluorofenil)piperazin-1-il]acetil}amino)fenil]etinil}benzamida 559,6
898
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[4(4-fluorofenil)piperazin-1-il]acetil}amino)fenil]etinil}benzamida 559,6
899
4-{[4-({[(1-acetilpiperidin-4il)(ciclopropil)amino]acetil}amino)fenil] etinil}-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 561,7
900
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2,3dimetilciclohexil)amino]acetil}amino) fenil]etinil}benzamida 506,6
901
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1R,2R,4S)-biciclo[2,2,1]hept-2ilamino]acetil}amino)fenil]etinil} benzamida 490,6
902
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[({[(1S,2R,5S)-6,6-dimetilbiciclo[3,1,1]hept-2il]metil}amino)acetil]amino}fenil) etinil]benzamida 532,7
903
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1S,4R)-biciclo[2,2,1] hept-2-ilamino]acetil}amino)fenil]etinil} benzamida 490,6
904
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(1S,2S,3S,5R)-2,6,6-trimetilbiciclo[3,1,1]hept-3il]amino}acetil)amino]fenil}etinil) benzamida 532,7
Ejemplo
Estructura Nombre MH+
905
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(triciclo[3,3,1,1~3,7~] dec-1ilmetil)amino]acetil}amino)fenil]etinil} benzamida 544,7
906
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(2,6-difluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 522,5
907
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[4(metiltio)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 532,6
908
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[({[4(metilsulfonil)fenil]metil}amino)acetil] amino}fenil)etinil]benzamida 564,6
909
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[({4[(trifluorometil)tio]fenil}metil)amino] acetil}amino)fenil]etinil}benzamida 586,6
910
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[({4[(trifluorometil)oxi]fenil}metil)amino] acetil}amino)fenil]etinil}benzamida 570,5
911
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(2,4,5-trifluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 540,5
912
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(2,3,4-trifluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 540,5
913
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(3,4,5-trifluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 540,5
914
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(pirrolidin-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 474,5
915
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(azepan-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 502,6
916
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(piperazin-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 489,5
Ejemplo
Estructura Nombre MH+
917
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4-{[(4metilpiperazin-1-il)acetil]amino}fenil)buta-1,3-diinil]benzamida 503,6
918
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(morfolin-4-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 490,5
919
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[ciclohexil(metil)amino]acetil}amino) fenil]buta-1,3diinil}benzamida 516,6
920
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(2-fluorofenil)metil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 528,6
921
imagen199 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(3-fluorofenil)metil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 528,6
922
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(4-fluorofenil)metil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 528,6
923
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(2-metilfenil)metil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 524,6
924
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(3-metilfenil)metil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 524,6
925
imagen200 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(4-metilfenil)metil]amino)acetil)amino]fenil}buta-1,3diinil)benzamida 524,6
926
imagen201 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(piridin-2-ilmetil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 511,6
927
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(piridin-3-ilmetil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 511,6
928
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(piridin-4-ilmetil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 511,6
Ejemplo
Estructura Nombre MH+
929
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[({[2-(metiloxi)fenil]metil}amino)acetil] amino}fenil)buta-1,3diinil]benzamida 540,6
930
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[({[3-(metiloxi)fenil]metil}amino)acetil] amino}fenil)buta-1,3diinil]benzamida 540,6
931
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[({[4-(metiloxi)fenil]metil}amino)acetil] amino}fenil)buta-1,3diinil]benzamida 540,6
932
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(2-fluorofenil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 514,5
933
imagen202 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(3-fluorofenil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 514,5
934
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(4-fluorofenil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 514,5
935
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(piridin-2-ilamino)acetil]amino}fenil) buta-1,3diinil]benzamida 497,5
936
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(piridin-3-ilamino)acetil]amino}fenil) buta-1,3diinil]benzamida 497,5
937
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(piridin-4-ilamino)acetil]amino}fenil) buta-1,3diinil]benzamida 497,5
938
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(ciclobutilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 474,5
939
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(ciclopentilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 488,6
Ejemplo
Estructura Nombre MH+
940
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(ciclohexilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 502,6
941
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(cicloheptilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 516,6
942
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(metilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 434,5
943
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(propilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 462,5
944
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(butilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 476,5
945
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(pentilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 490,6
946
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4{[(hexilamino)acetil]amino}fenil) buta-1,3-diinil]benzamida 504,6
947
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[etil(metil)amino]acetil}amino)fenil] buta-1,3-diinil}benzamida 462,5
948
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(1-metiletil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 462,5
949
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(2-metilpropil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 476,5
950
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(2-hidroxietil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 464,5
951
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[2-(metiloxi)etil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 478,5
952
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[2-(dimetilamino)etil]amino}acetil)amino] fenil}buta-1,3diinil)benzamida 491,6
Ejemplo
Estructura Nombre MH+
953
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(2-cianoetil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 473,5
954
imagen203 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(tien-2-ilmetil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 516,6
955
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(1R)-1-feniletil]amino}acetil)amino]fenil} buta-1,3diinil)benzamida 524,6
956
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[({[(1S)-1-feniletil]amino}acetil)amino]fenil} buta-1,3diinil)benzamida 524,6
957
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(2-feniletil)amino]acetil}amino)fenil] buta-1,3diinil}benzamida 524,6
958
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(1H-imidazol-1-ilacetil)amino]fenil}buta-1,3-diinil)benzamida 471,5
959
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(1R,2R,4S)-biciclo[2,2,1]hept-2-ilamino]acetil}amino)fenil] buta-1,3-diinil}benzamida 514,6
960
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(ciclohexilmetil)amino]acetil}amino) fenil]buta-1,3diinil}benzamida 516,6
961
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(6piperidin-1-ilpiridin-3-il)etinil]henzamida 423,5
962
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[6-(4metilpiperazin-1-il)piridin-3-il]etinil}benzamida 438,5
963
imagen204 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(6piperazin-1-ilpiridin-3-il)etinil]benzamida 424,5
964
imagen205 4-[(6-azepan-1-ilpiridin-3-il)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 437,5
965
4-{[6-(ciclobutilamino)piridin-3-il]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 409,5
Ejemplo
Estructura Nombre MH+
966
4-{[6-(ciclohexilamino)piridin-3-il]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 437,5
967
4-{[6-(butilamino)piridin-3-il]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 411,5
968
4-({6-[(2-hidroxietil)amino]piridin-3-il}etinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 399,4
969
4-[(6-{[2-(dimetilamino)etil]amino}piridin-3-il)etinil)-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 426,5
970
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({6[(fenilmetil)amino]piridin-3-il}etinil)benzamida 445,5
971
imagen206 4-[(6-{[(4-fluorofenil)metil]amino}piridin-3-il)etinil]-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 463,5
972
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[6(piridin-4-ilamino)piridin-3-il]etinil}benzamida 432,4
973
4-[(6-cloropiridin-3-il)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 374,8
974
1,1-dimetiletil (2S)-2-[({4-[(4etilfenil)etinil]fenil}carbonil)amino]-3-(hidroxiamino)-3oxopropilcarbamato 452,5
975
imagen207 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4({[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}carbonil)fenil] buta-1,3-diinil}benzamida 493,5
976
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(morfolin-4-ilmetil)fenil]etinil}benzamida 438,5
Ejemplo
Estructura Nombre MH+
977
4-[(4-{[(2-aminoetil)amino]metil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 411,5
978
4-({4-[((2S)-2-amino-5-{[amino(imino)metil]amino}pentanoil) amino]fenil}etinil)-N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil] benzamida 495,6
979
ácido (2S)-6-amino-2-({[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)fenil]carbonil} amino)hexanoico 511,5
980
ácido (2S)-6-amino-2-({[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}etinil)fenil]acetil} amino)hexanoico 525,6
981
ácido 5-{[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]amino}-5-oxopentanoico 438,4
982
N-(2-aminoetil)-N′-[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]pentanediamida 480,5
983
N-[(1S)-1-[(2,6-dioxopiperidin-1-il)metil]-2-(hidroxiamino)-2oxoetil]-4-(feniletinil)benzamida 420,4
984
imagen208 N,N′-bis[(2S)-3-(hidroxiamino)-3-oxo-2-({[4(feniletinil)fenil]carbonil}amino) propil]pentanediamida 743,8
985
N-((1S)-2-(hidroxiamino)-2-oxo-1-{[({[(1S)-1feniletil]amino}acetil)amino]metil} etil)-4-(feniletinil)benzamida 485,6
986
N-{(1S)-2-hidroxi-1-[(hidroxiamino)carbonil]-2-metilpropil}-4(feniletinil)benzamida 353,4
Ejemplo
Estructura Nombre MH+
987
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(6piperidin-1-ilpiridin-3-il)etinil]benzamida 408,5
988
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(6morfolin-4-ilpiridin-3-il)etinil]benzamida 410,4
989
imagen209 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[6-(4metilpiperazin-1-il)piridin-3-il]etinil}benzamida 423,5
990
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(6piperazin-1-ilpiridin-3-il)etinil]benzamida 409,5
991
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(6azepan-1-ilpiridin-3-il)etinil]benzamida 422,5
992
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[6(ciclobutilamino)piridin-3-il]etinil}benzamida 394,4
993
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[6(ciclohexilamino)piridin-3-il]etinil}benzamida 422,5
994
imagen210 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[6(butilamino)piridin-3-il]etinil}benzamida 396,5
995
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(6-{[2(metiloxi)etil]amino}piridin-3-il)etinil]benzamida 398,4
996
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(piperidin-1-ilmetil)fenil]etinil}benzamida 436,5
997
imagen211 4-[(4-{[(2S)-2-amino-3-(4aminofenil)propanoil]amino)fenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil)propil}benzamida 516,6
Ejemplo
Estructura Nombre MH+
998
ácido 4-((2S)-2-amino-3-{[4-({4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil)amino)carbonil]fenil}etinil)fenil] amino}-3-oxopropil)benzoico 545,6
999
1000
imagen212 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[1-(hidroximetil)-2metilpropil]aminol]acetil)amino)fenil}etinil)benzamida 497,6
1001
4-[4-(3-aminofenil)buta-1,3-diinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 378,4
1002
imagen213 4-[4-(3-{[(2-aminoetil)amino]metil}fenil) buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 435,5
1003
imagen214 ácido 5-[(4-{[4-({[(1S)-1-(aminometil)-2-(hidroxiamino)-2oxoetil]amino}carbonil)fenil]etinil} fenil)amino]-5-oxopentanoico 453,5
1004
imagen215 N-(2-aminoetil)-3-{4-[4-({[(1S)-1-(aminometil)-2(hidroxiamino)-2-oxoetil]amino}carbonil)fenil] buta-1,3diinil}benzamida 434,5
1005
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[3(aminometil)fenil] buta-1,3-diinil}benzamida 377,4
1006
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[3(trifluorometil)fenil]buta-1,3-diinil}benzamida 416,4
1007
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-buta-1,3diinilbenzamida 272,3
Ejemplo
Estructura Nombre MH+
1008
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(2metilfenil)buta-1,3-diinil]benzamida 362,4
1009
imagen216 4-(4-{4-[(3-aminopropanoil)amino]fenil}buta-1,3-diinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 449,5
1010
4-[4-(3-{[(aminoacetil)amino]metil}fenil) buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 449,5
1011
4-(4-{3-[(aminoacetil)amino]fenil}buta-1,3-diinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 435,4
1012
imagen217 4-[4-(4-{[(2S)-2-aminopropanoil]animo}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 449,5
1013
4-(4-{4-[(aminoacetil)amino]fenil}buta-1,3-diinil)-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 420,4
1014
imagen218 4-[4-(3-{[(aminoacetil)amino]metil}fenil) buta-1,3-diinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 434,5
1015
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4-[(3aminopropanoil)amino]fenil}buta-1,3-diinil)benzamida 434,5
1016
imagen219 4-(4-{3-[(aminoacetil)amino]fenil} buta-1,3-diinil)-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 420,4
1017
4-[(4-{[(2S)-2-amino-3-(4hidroxifenil)propanoil]amino}fenil)etinill-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 517,6
Ejemplo
Estructura Nombre MH+
1018
4-(4-{4-[(aminoacetil)amino]fenil}buta-1,3-diinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 435,4
1019
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(butilamino)metil]fenil}etinil) benzamida 409,5
1020
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(piperidin-1-ilmetil)fenil]etinil}benzamida 421,5
1021
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4formilfenil)etinil]benzamida 352,4
1022
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(metilsulfonil)amino]fenil}etinil)benzamida 432,5
1023
imagen220 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(metilsulfonil)amino]fenil}etinil) benzamida 417,5
1024
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(fenilsulfonil)amino]fenil}etinil) benzamida 479,5
1025
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-{4[(fenilsulfonil)amino]fenil} buta-1,3-diinil)benzamida 503,5
1026
imagen221 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(morfolin-4-ilmetil)fenil]etinil}benzamida 423,5
1027
imagen222 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[(4metilpiperazin-1-il)metil]fenil}etinil)benzamida 436,5
1028
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2hidroxietil)amino]metil}fenil)etinil] benzamida 397,4
Ejemplo
Estructura Nombre MH+
1029
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[2(metiloxi)etil]amino}metil)fenil] etinil}benzamida 411,5
1030
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(ciclohexilamino)metil]fenil}etinil) benzamida 435,5
1031
imagen223 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(fenilmetil)amino]metil}fenil) etinil]benzamida 443,5
1032
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(6cloropiridin-3-il)etinil]benzamida 359,8
1033
imagen224 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[6-(metiloxi)piridin-3-il]amino}acetil)amino]fenil}buta-1,3diinil)benzamida 542,6
1034
4-{4-[4-({[(6-cloropiridin-3-il)amino]acetil}amino)fenil]buta-1,3diinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 547,0
1035
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(pirrolidin-1-ilmetil)fenil]etinil}benzamida 422,5
1036
4-({4-[(etilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 396,5
1037
4-({4-[(dimetilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 396,5
1038
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(4-metilpiperazin-1-il)metil]fenil}etinil)benzamida 451,5
1039
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[3-(1H-imidazol-1-il)propil]amino}metil)fenil]etinil} benzamida 476,5
1040
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4-tien-2ilbuta-1,3-diinil)benzamida 354,4
Ejemplo
Estructura Nombre MH+
1041
1042
4-[4-(2-aminofenil)buta-1,3-diinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 378,4
1043
4-[4-(3-{[(2-aminoetil)amino]metil}fenil)buta-1,3-diinil]-N-[(1S)1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 420,5
1044
4-buta-1,3-diinil-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 287,3
1045
4-[4-(4-{[(2S)-2-amino-4-metilpentanoil]amino}fenil)buta-1,3diinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 491,6
1046
(2S)N-[4-(4-{4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil)amino)carbonil]fenil}buta-1,3diinil)fenil]pirrolidin-2-carboxamida 475,5
1047
(2S)-N-[4-(4-{4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino)carbonil]fenil}buta-1,3diinil)fenil]piperidin-2-carboxamida 489,5
1048
4-[4-(4-{[(2S)-2,3-diaminopropanoil]amino}fenil)buta-1,3-diinil]N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 464,5
1049
4-[4-(4-{[(2S)-2-amino-3-(1H-imidazol-4il)propanoil]amino}fenil)buta-1,3-diinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}beazamida 515,5
1050
imagen225 N-[1-[(hidroxiamino)carbonil]-2-(propilamino)propil]-4-[(4{[(propilamino)acetil]amino}fenil) etinil]benzamida 494,6
1051
4-[(4-{[(ciclobutilamino)acetil]amino}fenil) etinil]-N-{2(ciclobutilamino)-1-[(hidroxiamino)carbonil]propil}benzamida 518,6
Ejemplo
Estructura Nombre MH+
1052
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(ciclopropilamino)acetil]amino}fenil) etinil]benzamida 450,5
1053
imagen226 1-[(1R,2S)-2-[({4-[(4-{[(ciclopropilamino)acetil]amino}fenil) etinil]fenil}carbonil)amino]-3-(hidroxiamino)-1-metil-3oxopropil] triaza-1,2-dien-2-ium 477,5
1054
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(4-fluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 518,6
1055
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-({4[({[(3-fluorofenil)metil]amino}acetil)amino] fenil}etinil)benzamida 518,6
1056
imagen227 N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(propilamino)acetil]amino}fenil) etinil]benzamida 452,5
1057
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(fenilmetil)amino]acetil}amino) fenil]etinil}benzamida 500,6
1058
1-((1R,2S)-3-(hidroxiamino)-1-metil-3-oxo-2-{[(4-{[4({[(fenilmetil)amino]acetil}amino) fenil]etinil}fenil)carbonil]amino} propil)triaza-1,2-dien-2-ium 527,6
1059
imagen228 N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(ciclobutilamino)acetil]amino}fenil) etinil]benzamida 464,5
1060
1-[(1R,2S)-2-[({4-[(4-{[(ciclobutilamino)acetil]amino}fenil) etinil]fenil}carbonil)amino]-3-(hidroxiamino)-1-metil-3oxopropil] triaza-1,2-dien-2-ium 491,5
1061
4-[(4-etilfenil)etinil]-N-{(1S)-1-[(hidroxiamino)carbonil]-2metilpropil}benzamida 365,4
1062
4-(4-{4-[(etilamino)metil]fenil}buta-1,3-diinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 420,5
Ejemplo
Estructura Nombre MH+
1063
imagen229 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(3aminofenil)buta-1,3-diinil]benzamida 363,4
1064
4-(4-{3-[(4-aminobutanoil)amino]fenil} buta-1,3-diinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 463,5
1065
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(3hidroxifenil)buta-1,3-diinil]benzamida 379,4
1066
4-(4-{2-[(aminoacetil)amino]fenil}buta-1,3-diinil)-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 435,4
1067
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[2,4bis(metiloxi)pyrimidin-5-il]buta-1,3-diinil}benzamida 410,4
1068
ácido (2S)-6-amino-2-{[(4-{4-[4-({[(1S)-1-(aminometil)-2(hidroxiamino)-2-oxoetil]amino}carbonil)fenil]buta-1,3diinil}fenil)carbonil]amino}hexanoico 520,6
1069
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(2aminofenil)buta-1,3-diinil]benzamida 363,4
1070
imagen230 4-[4-(4-{2-[(2-aminoetil)amino]-2-oxoetil}fenil)buta-1,3-diinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 448,5
1071
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(2aminopyrimidin-5-il)buta-1,3-diinil]benzamida 365,4
1072
4-(4-{3-[(4-aminobutanoil)amino]fenil} buta-1,3-diinil)-N-[(1S)1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 448,5
Ejemplo
Estructura Nombre MH+
1073
4-(4-{2-[(aminoacetil)amino]fenil}buta-1,3-diinil)-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 420,4
1074
imagen231 4-[4-(4-{2-[(2-aminoetil)amino]-2-oxoetil}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 463,5
1075
4-[4-(4-{[(2,3-dihidroxipropil)amino]metil}fenil)buta-1,3-diinil]N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 466,5
1076
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[({[2-(metiloxi)fenil]metil}amino)metil] fenil}buta-1,3diinil)benzamida 512,6
1077
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[(piridin-2-ilamino)metil]fenil}buta-1,3-diinil)benzamida 469,5
1078
4-[4-(4-{[(2-aminoetil)amino]metil}fenil)buta-1,3-diinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 435,5
1079
4-[(4-etilfenil)etinil]-N-[(1R)-1-[(etiltio)metil]-2-(hidroxiamino)-2oxoetil]benzamida 397,5
1080
imagen232 4-[(4-{[(2S)-2-aminopropanoil]amino}fenil)etinil]-N-[(1R)-1[(etiltio)metil]-2-(hidroxiamino)-2-oxoetil]benzamida 455,5
1081
imagen233 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(3clorofenil)buta-1,3-diinil]benzamida 382,8
1082
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[3(metiloxi)fenil]buta-1,3-diinil}benzamida 378,4
Ejemplo
Estructura Nombre MH+
1083
imagen234 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-0-(4-{4[(metilsulfonil)amino]fenil}buta-1,3-diinil)benzamida 456,5
1084
N-{(1S,2R,2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{3[(metilsulfonil)amino]fenil}buta-1,3-diinil)benzamida 456,5.
1085
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-(4pyrazin-2-ilbuta-1,3-diinil)benzamida 350,3
1086
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[4-(3ntrofenil)buta-1,3-diinil]benzamida 408,4
1087
imagen235 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(3{[(metilsulfonil)amino]metil}fenil) etinil]benzamida 446,5
1088
4-[(2-formilfenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 367,4
1089
N-{(1R,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(3{[(metilsulfonil)amino]metil}fenil) etinil]benzamida 446,5
1090
4-({2-[(aminoacetil)amino]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 411,4
1091
imagen236 N-{(1S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{4-[3(morfolin-4-ilmetil)fenil]buta-1,3-diinil}benzamida 462,5
1092
imagen237 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(metilamino)metil]fenil}etinil) benzamida 367,4
Ejemplo
Estructura Nombre MH+
1093
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(etilamino)metil]fenil}etinil) benzamida 381,4
1094
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(propilamino)metil]fenil}etinil) benzamida 395,5
1095
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(pentilamino)metil]fenil}etinil) benzamida 423,5
1096
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(hexilamino)metil]fenil}etinil) benzamida 437,6
1097
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(1metiletil)amino]metil}fenil)etinil] benzamida 395,5
1098
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2metilpropil)amino]metil}fenil)etinil] benzamida 409,5
1099
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(1,1dimetiletil)amino]metil}fenil)etinil] benzamida 409,5
1100
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(dimetilamino)metil]fenil}etinil) benzamida 381,4
1101
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[etil(metil)amino]metil}fenil) etinil]benzamida 395,5
1102
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[2(dimetilamino)etil]amino}metil)fenil] etinil}benzamida 424,5
1103
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[4(dimetilamino)butil]amino}metil)fenil] etinil}benzamida 452,6
1104
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2cianoetil)amino]metil}fenil)etinil] benzamida 406,5
Ejemplo
Estructura Nombre MH+
1105
4-{[4-({[2-(acetilamino)etil]amino}metil)fenil] etinil}-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 438,5
1106
4-[(4-{[(2-aminoetil)amino]metil}fenil)etinil]-N-[(1S)-1(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 396,5
1107
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(3hidroxipropil)amino]metil}fenil) etinil]benzamida 411,5
1108
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[3(metiloxi)propil]amino}metil)fenil] etinil}benzamida 425,5
1109
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({metil[2-(metiloxi)etil]amino}metil)fenil] etinil}benzamida 425,5
1110
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[3(2-oxopirrolidin-1-il)propil]amino}metil)fenil] etinil}benzamida 478,6
1111
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(3morfolin-4-ilpropil)amino]metil}fenil) etinil]benzamida 480,6
1112
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(ciclopropilamino)metil]fenil} etinil)benzamida 393,5
1113
imagen238 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(ciclobutilamino)metil]fenil} etinil)benzamida 407,5
1114
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(ciclopentilamino)metil]fenil} etinil)benzamida 421,5
1115
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(cicloheptilamino)metil]fenil} etinil)benzamida 449,6
Ejemplo
Estructura Nombre MH+
1116
imagen239 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(ciclooctilamino)metil]fenil} etinil)benzamida 463,6
1117
imagen240 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(pirrolidin-1-ilmetil)fenil]etinil}benzamida 407,5
1118
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(azepan-1-ilmetil)fenil]etinil}benzamida 435,5
1119
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(3R)3-(dimetilamino)pirrolidin-1-il]metil}fenil)etinil]benzamida 450,6
1120
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(3S)3-(dimetilamino)pirrolidin-1-il]metil}fenil)etinil]benzamida 450,6
1121
4-[(4-{[(3R)-3-(acetilamino)pirrolidin-1-il]metil}fenil)etinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 464,5
1122
4-[(4-{[(3S)-3-(acetilamino)pirrolidin-1-il]metil}fenil)etinil]-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 464,5
1123
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-(1,4′bipiperidin-1′-ilmetil)fenil]etinil}benzamida 504,6
1124
imagen241 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(ciclohexilmetil)amino]metil}fenil) etinil]benzamida 449,6
1125
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[ciclohexil(metil)amino]metil}fenil) etinil]benzamida 449,6
1126
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1R)-1-feniletil]amino}metil)fenil]etinil} benzamida 457,5
1127
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1S)-1-feniletil]amino}metil)fenil]etinil} benzamida 457,5
Ejemplo
Estructura Nombre MH+
1128
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(tien2-ilmetil)amino]metil}fenil)etinil] benzamida 449,5
1129
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2feniletil)amino]metil}fenil)etinil] benzamida 457,5
1130
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(piperidin-3-ilamino)metil]fenil}etinil)benzamida 436,5
1131
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(piperidin-4-ilamino)metil]fenil}etinil)benzamida 436,5
1132
imagen242 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piperidin-2-ilmetil)amino]metil}fenil)etinil] benzamida 450,6
1133
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piperidin-3-ilmetil)amino]metil}fenil)etinil] benzamida 450,6
1134
imagen243 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(2R)-pirrolidin-2-ilmetil]amino}metil)fenil]etinil} benzamida 436,5
1135
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(2S)-pirrolidin-2-ilmetil]amino}metil)fenil]etinil} benzamida 436,5
1136
imagen244 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(pirrolidin-3-ilamino)metil]fenil}etinil)benzamida 422,5
1137
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2fluorofenil)metil]amino}metil)fenil] etinil}benzamida 461,5
1138
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(3fluorofenil)metil]amino}metil)fenil] etinil}benzamida 461,5
1139
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(4fluorofenil)metil]amino}metil)fenil] etinil}benzamida 461,5
Ejemplo
Estructura Nombre MH+
1140
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(2metilfenil)metil]amino}metil)fenil] etinil}benzamida 457,5
1141
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(3metilfenil)metil]amino}metil)fenil] etinil}benzamida 457,5
1142
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[(4metilfenil)metil]amino}metil)fenil] etinil}benzamida 457,5
1143
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[2(metiloxi)fenil]metil}amino)metil] fenil}etinil)benzamida 473,5
1144
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[3(metiloxi)fenil]metil}amino)metil] fenil}etinil)benzamida 473,5
1145
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[({[4(metiloxi)fenil]metil}amino)metil] fenil}etinil)benzamida 473,5
1146
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(fenilamino)metil]fenil}etinil) benzamida 429,5
1147
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(piridin-3-ilmetil)amino]metil}fenil)etinil] benzamida 444,5
1148
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[(4fenilpiperidin-1-il)metil]fenil}etinil)benzamida 497,6
1149
imagen245 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4-[(4fenilpiperazin-1-il)metil]fenil}etinil)benzamida 498,6
1150
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(1R,2R,4S)-biciclo[2,2,1]hept-2ilamino]metil}fenil)etinil]benzamida 447,5
1151
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({[(1S,2R,5S)-6,6-dimetilbiciclo[3,1,1]hept-2il]metil}amino)metil]fenil} etinil)benzamida 489,6
Ejemplo
Estructura Nombre MH+
1152
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4{[(1S,4R)-biciclo[2,2,1]hept-2ilamino]metil}fenil)etinil]benzamida 447,5
1153
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[(1S,2S,3S,5R)-2,6,6-trimetilbiciclo[3,1,1]hept-3il]amino}metil)fenil]etinil}benzamida 489,6
1154
1-((1R,2S)-3-(hidroxiamino)-1-metil-3-oxo-2-{[(4-{[4-({[(piridin4-ilmetil)amino]acetil}amino)fenil]etinil} fenil)carbonil]amino}propil)triaza-1,2-dien-2-ium 528,6
1155
1-((1R,2S)-3-(hidroxiamino)-1-metil-3-oxo-2-{[(4-{[4-({[(piridin3-ilmetil)amino]acetil}amino)fenil]etinil} fenil)carbonil]amino}propil)triaza-1,2-dien-2-ium 528,6
1156
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(piridin-4-ilmetil)amino]acetil}amino)fenil]etinil} benzamida 501,6
1157
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(piridin-3-ilmetil)amino]acetil}amino)fenil]etinil} benzamida 501,6
1158
N-[1-[(hidroxiamino)carbonil]-2-(metilamino)propil]-4-{[4({[(fenilmetil)amino]acetil}amino) fenil]etinil}benzamida 514,6
1159
4-[(4-{[(ciclobutilamino)acetil]amino}pheny) etinil]-N-[1[(hidroxiamino)carbonil]-2-(metilamino)propil]benzamida 478,6
1160
4-[(4-{[(2S)-2-aminopropanoil]amino}fenil)etinil]-N-[(1R)-1{[etil(hidroxi)-lambda~4~-sulfanil]metil}-2-(hidroxiamino)-2oxoetil]benzamida 473,6
1161
4-[(4-etilfenil)etinil]-N-hidroxibenzamida 266,3
Ejemplo
Estructura Nombre MH+
1162
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(2,4difluorofenil)buta-1,3-diinil]benzamida 384,4
1163
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(2aminofenil)etinil]benzamida 339,4
1164
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(3{[(metilsulfonil)amino]metil}fenil) buta-1,3-diinil]benzamida 455,5
1165
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(3{[(metilsulfonil)amino]metil}fenil) buta-1,3-diinil]benzamida 455,5
1166
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({3[(metilsulfonil)amino]fenil}etinil) benzamida 417,5
1167
4-[(4-{[(2S)-2-aminopropanoil]amino}fenil)etinil]-Nhidroxibenzamida 324,4
1168
imagen246 4-[(2-{[(2-aminoetil)amino]metil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 411,5
1169
N-{(1R,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4(feniletinil)benzamida 338,4
1170
N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-[4-(4aminofenil)buta-1,3-diinil]benzamida 377,4
1171
imagen247 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(3hidroxifenil)buta-1,3-diinil]benzamida 364,4
Ejemplo
Estructura Nombre MH+
1172
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[3(morfolin-4-ilmetil)fenil]buta-1,3-diinil}benzamida 447,5
1173
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[({[2-(metiloxi)fenil]metil}amino)metil] fenil}etinil)benzamida 488,6
1174
4-[(4-{[(2,3-dihidroxipropil)amino]metil}fenil) etinil]-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 442,5
1175
4-({2-[(dimetilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 396,5
1176
imagen248 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(metilamino)metil]fenil}etinil) benzamida 382,4
1177
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(propilamino)metil]fenil}etinil) benzamida 410,5
1178
4-({4-[(butilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 424,5
1179
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(pentilamino)metil]fenil}etinil) benzamida 438,5
1180
4-({4-[(hexilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 452,6
1181
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(1-metiletil)amino]metil}fenil)etinil] benzamida 410,5
1182
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(2-metilpropil)amino]metil}fenil)etinil] benzamida 424,5
1183
4-[(4-{[(1,1-dimetiletil)amino]metil}fenil) etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 424,5
1184
imagen249 4-[(4-{[etil(metil)amino]metil}fenil) etinil]-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 410,5
Ejemplo
Estructura Nombre MH+
1185
imagen250 4-{[4-({[2-(dimetilamino)etil]amino}metil)fenil] etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 439,5
1186
4-{[4-({[4-(dimetilamino)butil]amino}metil)fenil] etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 467,6
1187
4-[(4-{[(2-hidroxietil)amino]metil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 412,5
1188
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(3-hidroxipropil)amino]metil}fenil)etinil] benzamida 426,5
1189
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({metil[2-(metiloxi)etil]amino}metil)fenil] etinil}benzamida 440,5
1190
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[2-(metiloxi)etil]amino}metil)fenil] etinil}benzamida 426,5
1191
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[3-(metiloxi)propil]amino}metil)fenil] etinil}benzamida 440,5
1192
4-[(4-{[(2-cianoetil)amino]metil}fenil)etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 421,5
1193
4-{[4-({[2-(acetilamino)etil]amino}metil)fenil] etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 453,5
1194
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[3-(2-oxopirrolidin-1-il)propil]amino}metil)fenil]etinil} benzamida 493,6
1195
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(3-morfolin-4-ilpropil)amino]metil}fenil)etinil] benzamida 495,6
1196
4-({4-[(ciclopropilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 408,5
1197
4-({4-[(ciclobutilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 422,5
Ejemplo
Estructura Nombre MH+
1198
4-({4-[(ciclopentilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 436,5
1199
4-({4-[(ciclohexilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 450,5
1200
4-({4-[(cicloheptilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 464,6
1201
4-({4-[(ciclooctilamino)metil]fenil}etinil)-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 478,6
1202
4-{[4-(azepan-1-ilmetil)fenil]etinil}-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 450,5
1203
4-[(4-{[(3R)-3-(dimetilamino)pirrolidin-1-il]metil}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 465,6
1204
4-[(4-{[(3S)-3-(dimetilamino)pirrolidin-1-il]metil}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 465,6
1205
4-[(4-{[(3R)-3-(acetilamino)pirrolidin-1-il]metil}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 479,5
1206
4-[(4-{[(3S)-3-(acetilamino)pirrolidin-1-il]metil}fenil)etinil]-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 479,5
1207
4-{[4-(1,4′-bipiperidin-1′-ilmetil)fenil]etinil}-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 519,7
1208
4-[(4-{[(ciclohexilmetil)amino]metil}fenil) etinil]-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 464,6
1209
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(4-fenilpiperazin-1-il)metil]fenil}etinil)benzamida 513,6
1210
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(2-feniletil)amino]metil}fenil)etinil] benzamida 472,6
Ejemplo
Estructura Nombre MH+
1211
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(1R)-1-feniletil]amino}metil)fenil] etinil}benzamida 472,6
1212
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(1S)-1-feniletil]amino}metil)fenil] etinil}benzamida 472,6
1213
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(tien-2-ilmetil)amino]metil}fenil)etinil] benzamida 464,6
1214
imagen251 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(piperidin-3-ilamino)metil]fenil}etinil)benzamida 451,5
1215
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(piperidin-4-ilamino)metil]fenil}etinil)benzamida 451,5
1216
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piperidin-2-ilmetil)amino]metil}fenil) etinil]benzamida 465,6
1217
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piperidin-3-ilmetil)amino]metil}fenil) etinil]benzamida 465,6
1218
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2R)-pirrolidin-2-ilmetil]amino}metil)fenil] etinil}benzamida 451,5
1219
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2S)-pirrolidin-2-ilmetil]amino}metil)fenil] etinil}benzamida 451,5
1220
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(pirrolidin-3-ilamino)metil]fenil}etinil)benzamida 437,5
1221
4-{[4-({[(2-fluorofenil)metil]amino}metil)fenil] etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 476,5
Ejemplo
Estructura Nombre MH+
1222
4-{[4-({[(3-fluorofenil)metil]amino}metil)fenil] etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 476,5
1223
4-{[4-({[(4-fluorofenil)metil]amino}metil)fenil] etinil}-N-{(1S,2R)2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 476,5
1224
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(2-metilfenil)metil]amino}metil)fenil] etinil}benzamida 472,6
1225
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(3-metilfenil)metil]amino}metil)fenil] etinil}benzamida 472,6
1226
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[(4-metilfenil)metil]amino}metil)fenil] etinil}benzamida 472,6
1227
imagen252 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(fenilmetil)amino]metil}fenil) etinil]benzamida 458,5
1228
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-({4[(fenilamino)metil]fenil} etinil)benzamida 444,5
1229
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-[(4{[(piridin-3-ilmetil)amino]metil}fenil) etinil]benzamida 459,5
1230
4-[(4-{[(1R,2R,4S)-biciclo[2,2,1]hept-2ilamino]metil}fenil)etinil]-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 462,6
1231
(3R)-N-hidroxi-3-({[4-(feniletinil)fenil]carbonil}amino) piperidina-3-carboxamida 364,4
1232
ácido 4-({[4-(feniletinil)fenil]carbonil}amino) piperidina-4carboxilico 349,4
1233
N-{(1S)-2-(hidroxiamino)-2-oxo-1-[(2S)-pirrolidin-2-ilmetil]etil}4-(feniletinil)benzamida 378,4
Ejemplo
Estructura Nombre MH+
1234
(3R)-3-{[(4′-etil-1,1′-bifenil-4-il)carbonil]amino}-Nhidroxipiperidina-3-carboxamida 368,4
1235
1,1-dimetiletil 3-(4-{4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}buta-1,3diinil) fenilcarbamato 478,5
1236
4-[4-(3-amino-4-metilfenil)buta-1,3-diinil]-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 392,4
1237
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(3amino-4-metilfenil) buta-1,3-diinil]benzamida 377,4
1238
4-(4-{4-[(aminoacetil)amino]-3-metilfenil}buta-1,3-diinil)-N[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]benzamida 434,5
1239
imagen253 N-{(1S,2R)-2-amino-1-[(hidroxiamino)carbonil]propil}-4-(2feniletenil)benzamida 340,4
1240
imagen254 N-[(2R)-2-amino-3-(hidroxiamino)-3-oxopropil]-4′-etil-1,1′bifenil-4-carboxamida 328,4
1241
imagen255 N-[(2R)-2-amino-3-(hidroxiamino)-3-oxopropil]-4(feniletinil)benzamida 324,4
1242
N-[(2R)-2-amino-3-(hidroxiamino)-3-oxopropil]-4-(4clorofenil)ciclohexanecarboxamida 340,8
1243
N-[(2S)-2-amino-3-(hidroxiamino)-3-oxopropil]-4-(4clorofenil)ciclohexanecarboxamida 340,8
1244
imagen256 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[2-(4metilfenil)etil]benzamida 342,4
1245
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4aminofenil)butil]benzamida 371,4
Ejemplo
Estructura Nombre MH+
1246
N-(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[metil(piridin-2ilmetil)amino]acetil}amino)fenil]etinil}benzamida 516,6
1247
4-{(4-({[(2fluorofenil)metil](metil)amino]acetil}amino)fenil]etinil)-N((1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 533,6
1248
4-{[4-({[[(3fluorofenil)metil](metil]amino]acetil)amino)fenil]etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 533,6
1249
4-{[4-({[[(4fluorofenil)metil](metil)amino]acetil}amino)fenil]etinil)-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 533,6
1250
imagen257 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[[(2fluorofenil)metil](metil)amino]acetil} amino)fenil]etinil}benzamida 518,6
1251
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[[(3fluorofenil)metil](metil)amino]acetil} amino)fenil]etinil}benzamida 518,6
1252
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[[(4fluorofenil)metil](metil)amino]acetil} amino)fenil]etinil}benzamida 518,6
1253
imagen258 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({metil[(2-metilfenil)metil]amino}acetil)amino] fenil}etinil)benzamida 514,6
1254
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[({metil[(4-metilfenil)metil]amino}acetil)amino] fenil}etinil)benzamida 514,6
1255
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[metil(fenilmetil)amino]acetil} amino)fenil]etinil}benzamida 500,6
1256
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)-4-{[4({(metil(propil)amino)acetil}amino)fenil]etinil}benzamida 467,5
1257
4-{[4-({[butil(metil)amino]acetil}fenil]etinil}-N-{(1S,2R)-2-hidroxi1-[(hidroxiamino)carbonil]propil}benzamida 481,6
1258
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[metil(pentil)amino]acetil}amino)fenil]etinil}benzamida 495,6
Ejemplo
Estructura Nombre MH+
1259
4-{[4-({[hexil(metil)amino]acetil}amino)fenil]etinil}-N-{(1S,2R)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 509,6
1260
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)-4-([4({[metil(1-metiletil)amino]acetil]amino)fenil]etinil}benzamida 467,5
1261
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4({[metil(2-metilpropil)amino]acetil]amino)fenil]etinil}benzamida 481,6
1262
imagen259 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil)4-({4[({metil[(2metilfenil)metil]amino)acetil)amino]fenil}etinil)benzamida 529,6
1263
imagen260 N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-0-({4[({metil[(4metilfenil)metil]amino}acetil)amino]fenil}etinil)benzamida 529,6
1264
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[metil(propil)amino]acetil}amino) fenil]etinil}benzamida 452,5
1265
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[butil(metil)amino]acetil}amino) fenil]etinil}benzamida 466,6
1266
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[metil(pentil)amino]acetil}amino) fenil]etinil}benzamida 480,6
1267
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[hexil(metil)amino]acetil}amino) fenil]etinil}benzamida 494,6
1268
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[metil(1-metiletil)amino]acetil}amino) fenil]etinil}benzamida 452,5
1269
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[metil(2-metilpropil)amino]acetil}amino) fenil]etinil}benzamida 466,6
1270
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4({[metil(piridin-2-ilmetil)amino]acetil}amino) fenil]etinil}benzamida 501,6
Ejemplo
Estructura Nombre MH+
1271
4-{[4-({[(3,4-dihidroxifenil)metil]amino}metil) fenil]etinil}-N{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 490,5
1272
4-({2-[(aminoacetil)amino]fenil}etinil)-N-{(1S,2S)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 411,4
1273
4-[(4-{[(2S)-2-aminopropanoil]amino}fenil)etinil]-N-{(1S,2S)-2hidroxi-1-[(hidroxiamino)carbonil]propil}benzamida 425,5
1274
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(dietilamino)fenil]etinil}benzamida 395,5
1275
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4(etilamino)fenil] buta-1,3-diinil}benzamida 391,4
1276
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[(4-{[(2amino-2-oxoetil)amino]metil}fenil)etinil] benzamida 410,4
1277
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4-({[1(hidroximetil)-2-metilpropil]amino}metil)fenil] etinil}benzamida 439,5
1278
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-({4[(piridin-2-ilamino)metil]fenil}etinil)benzamida 430,5
1279
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[3(etilamino)fenil] buta-1,3-diinil}benzamida 391,4
1280
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[3(etilamino)fenil]etinil}benzamida 367,4
Ejemplo
Estructura Nombre MH+
1281
imagen261 N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(hidroximetil)fenil]etinil}benzamida 354,4
1282
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[3(dietilamino)fenil]etinil}benzamida 395,5
1283
imagen262 N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-{[4(morfolin-4-ilmetil)fenil]etinil}benzamida 438,5
1284
4-({4-[(dimetilamino)metil]fenil}etinil)-N-{(1S,2S)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 396,5
1285
4-[(4-aminofenil)etinil]-N-I(1S,2S)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 354,4
1286
4-[4-(4-aminofenil)buta-1,3-diinil]-N-{(1S,2S)-2-hidroxi-1[(hidroxiamino)carbonil)propil}benzamida 378,4
1287
imagen263 1,1-dimetiletil 4-(4-{4-[({(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}amino) carbonil]fenil}buta-1,3diinil) fenilcarbamato 478,5
1288
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4-({[1(hidroximetil)-2-metilpropil]amino}metil)fenil] buta-1,3diinil}benzamida 463,5
1289
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-[4-(4hidroxifenil)buta-1,3-diinil]benzamida 364,4
1290
4-[(2,4-difluorofenil)etinil]-N-{(1S,2S)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 375,3
Ejemplo
Estructura Nombre MH+
1291
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4(morfolin-4-ilmetil)fenil]buta-1,3-diinil}benzamida 447,5
1292
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{4-[4(hidroximetil)fenil]buta-1,3-diinil}benzamida 378,4
1293
4-({3-[(2-aminoetil)amino]fenil}etinil)-N-{(1S,2R)-2-hidroxi-1[(hidroxiamino)carbonil]propil}benzamida 397,4
1294
N-[(1S)-1-(aminometil)-2-(hidroxiamino)-2-oxoetil]-4-{[4(trifluorometil)fenil]etinil}benzamida 392,3
1295
ácido (2S,3R)-3-hidroxi-2-({[4-(feniletinil)fenil]carbonil}amino) butanoico 324,3
1296
N-((1S,2R)-1-{[(2-aminoetil)amino]carbonil}-2-hidroxipropil)-4(feniletinil)benzamida 366,4
1297
1,1-dimetiletil (2S)-3-(hidroxiamino)-3-oxo-2-({[4-(4-fenilbuta1,3-diinil)fenil]carbonil}amino) propilcarbamato 448,5
1298
N-{(1S,2R)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4-{4[(3-morfolin-4-ilpropil)amino]fenil}buta-1,3-diinil)benzamida 505,6
1299
imagen264 N-[(1S,2R)-2-hidroxi-1-({[2(metiltio)fenil]amino}carbonil)propil]-4-(feniletinil)benzamida 445,6
Ejemplo
Estructura Nombre MH+
1300
N-((1S)-1-(aminometil)-2-{[(1,1-dimetiletil)oxi]amino}-2oxoetil)-4-(4-fenilbuta-1,3-diinil)benzamida 404,5
1301
N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4fenilbuta-1,3-diinil)benzamida 363,4
1302
N-{(1S,2S)-2-hidroxi-1-[(hidroxiamino)carbonil]propil}-4-(4fenilbuta-1,3-diinil)benzamida 363,4
1303
(2S,3R)-N,3-dihidroxi-2-({[4-(4-fenilbuta-1,3diinil)fenil]metil}amino)butanamida 349,4
1304
imagen265 1,1-dimetiletil (2S)-3-(hidroxiamino)-3-oxo-2-({[4-(4-fenilbuta1,3-diinil)fenil]metil}amino)propilcarbamato 434,5
1305
(2S)-3-amino-N-hidroxi-2-({[4-(4-fenilbuta-1,3diinil)fenil]metil}amino)propanamida 334,4
1306
N-[(1S)-2-(hidroxiamino)-1-(hidroximetil)-2-oxoetil]-4[(trifluorometil)oxi]benzamida 309,2
1307
N-{2-hidroxi-1-[(hidroxiamino)carbonil]-2-feniletil}-4[(trifluorometil)oxi]benzamida 385,3

Claims (4)

  1. imagen1
    imagen2
    imagen3
    imagen4
    imagen5
    X está seleccionado de los grupos que consisten en
    (1)
    -(C=O)-,
    (2)
    -alquilo C1-C6-(C=O)-, y
    (3)
    -alquenilo C2-C6-(C=O)
  2. 4. Un compuesto de la reivindicación 1 de acuerdo con la fórmula VII:
    imagen6
    o un estereoisómero, sal farmacéuticamente aceptable o éster del mismo, en la que E está ausente o está seleccionado del grupo que consiste en
    (1)
    H,
    (2)
    alquilo C1-C6 sustituido o sin sustituir,
    (3)
    arilo sustituido o sin sustituir,
    (4)
    heterociclilo sustituido o sin sustituir, y
    (5)
    heteroarilo sustituido o sin sustituir,
    o E y R3L, junto con los átomos a los que están unidos, pueden formar un anillo heterocíclico sustituido o sin sustituir que tiene de 3 a 10 átomos de anillo, en el que 1-4 átomos de anillo del sistema de anillo heterocíclico están seleccionados de N, O y S;
    R1L, R3L están seleccionados independientemente del grupo que consiste en
    (1)
    H,
    (2)
    alquilo C1-C6 sustituido o sin sustituir,
    (3)
    alquilo C1-C6 sustituido con arilo,
    (4)
    alquilo C1-C6 sustituido con heterociclilo, y
    (5)
    alquilo C1-C6 sustituido con heteroarilo,
    o R1L y R3L, junto con los átomos a los que están unidos, pueden formar un anillo heterocíclico sustituido o sin sustituir que tiene de 3 a 8 átomos de anillo, en el que 1-2 átomos de anillo del sistema de anillo heterocíclico están seleccionados de N, O y S.
  3. 5. Un compuesto de la reivindicación 1 de acuerdo con la fórmula IX:
    imagen7
    o un estereoisómero, sal farmacéuticamente aceptable o éster del mismo, en la que E está ausente o está seleccionado del grupo que consiste en
    (1)
    H,
    (2)
    alquilo C1-C6 sustituido o sin sustituir,
    (3)
    arilo sustituido o sin sustituir,
    194
    imagen8
  4. 9. Un compuesto de cualquiera de las reivindicaciones 1-6 para su uso en el tratamiento de una infección bacteriana.
    196
ES10179798.3T 2003-01-08 2004-01-08 Agentes antibacterianos Expired - Lifetime ES2552247T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US43852303P 2003-01-08 2003-01-08
US438523P 2003-01-08
US46697403P 2003-04-30 2003-04-30
US466974P 2003-04-30
US52021103P 2003-11-13 2003-11-13
US520211P 2003-11-13

Publications (1)

Publication Number Publication Date
ES2552247T3 true ES2552247T3 (es) 2015-11-26

Family

ID=32719190

Family Applications (2)

Application Number Title Priority Date Filing Date
ES04700887T Expired - Lifetime ES2387803T3 (es) 2003-01-08 2004-01-08 Agentes antibacterianos
ES10179798.3T Expired - Lifetime ES2552247T3 (es) 2003-01-08 2004-01-08 Agentes antibacterianos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES04700887T Expired - Lifetime ES2387803T3 (es) 2003-01-08 2004-01-08 Agentes antibacterianos

Country Status (14)

Country Link
US (8) US20040229955A1 (es)
EP (2) EP1618087B1 (es)
JP (2) JP5086635B2 (es)
KR (2) KR101145252B1 (es)
CN (2) CN1777577B (es)
AU (2) AU2004204760C1 (es)
CA (2) CA2851462A1 (es)
EA (1) EA011808B1 (es)
ES (2) ES2387803T3 (es)
HK (1) HK1155718A1 (es)
IL (2) IL169475A (es)
MX (1) MXPA05007394A (es)
SG (2) SG159388A1 (es)
WO (1) WO2004062601A2 (es)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
JP4617449B2 (ja) * 2002-07-11 2011-01-26 ヴィキュロン ファーマシューティカルズ インコーポレイテッド 抗菌活性を有するｎ−ヒドロキシアミド誘導体
KR101145252B1 (ko) 2003-01-08 2012-05-24 유니버시티 오브 워싱톤 항균제
CA2532965C (en) 2003-07-22 2013-05-14 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
EP1680109A4 (en) * 2003-10-07 2009-05-06 Renovis Inc AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE DERIVATIVES
CN1894202A (zh) * 2003-12-19 2007-01-10 巴斯福股份公司 苯甲酰基取代的苯基丙氨酸酰胺
US7638513B2 (en) 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
WO2006022442A1 (ja) * 2004-08-24 2006-03-02 Santen Pharmaceutical Co., Ltd. ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
US7776869B2 (en) 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
JP5042040B2 (ja) 2005-01-26 2012-10-03 アラーガン、インコーポレイテッド 鎮痛活性および／または免疫賦活活性を有する１−アリール−１−ヒドロキシ−２，３−ジアミノ−プロピルアミン、１−ヘテロアリール−１−ヒドロキシ−２，３−ジアミノ−プロピルアミンおよび関連化合物
BRPI0606365A2 (pt) * 2005-02-28 2017-06-27 Renovis Inc composto ou um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo e estereoisômeros e tautômeros do mesmo, composição farmacêutica, métodos para prevenir, tratar, melhorar ou controlar uma doença ou condição e para preparar um composto, uso de um composto ou um sal, solvato ou composição farmaceuticamente aceitável do mesmo, método de tratamento de um mamífero, e, combinação
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP2491926B1 (en) 2005-03-22 2018-05-09 President and Fellows of Harvard College Treatment of protein degradation disorders
TW200800209A (en) * 2005-07-11 2008-01-01 Wyeth Corp Glutamate aggrecanase inhibitors
JP4961773B2 (ja) * 2005-07-29 2012-06-27 住友ベークライト株式会社 芳香族カルボン酸及びその酸ハロゲン化物
EP2338878A3 (en) * 2005-12-15 2011-11-16 Vicuron Pharmaceuticals, Inc. N-hydroxyamide derivatives possessing antibacterial activity
WO2008091349A1 (en) * 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
CA2654540C (en) 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
WO2007138304A1 (en) 2006-05-30 2007-12-06 Astrazeneca Ab 1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors
DE102006033321A1 (de) * 2006-07-17 2008-01-24 Westfälische Wilhelms-Universität Münster Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen
JP2009544611A (ja) 2006-07-20 2009-12-17 メルク エンド カムパニー インコーポレーテッド ヒストン脱アセチル化酵素阻害剤としてのリン誘導体
EP2046122A4 (en) * 2006-07-24 2009-12-23 Univ Maryland HEMOXYGENASE INHIBITORS AND METHOD FOR THEIR THERAPEUTIC APPLICATION
TW200821276A (en) * 2006-08-18 2008-05-16 Leo Pharma As Substituted acetylenic compounds useful for the treatment of diseases
CN101528711A (zh) 2006-08-31 2009-09-09 先灵公司 可用作抗细菌剂的乙内酰脲衍生物
CA2680507A1 (en) * 2006-10-13 2008-04-24 Xtl Biopharmaceuticals Ltd. Compounds and methods for treatment of hcv
CA2668070A1 (en) 2006-10-30 2008-05-08 Chroma Therapeutics Ltd. Hydroxamates as inhibitors of histone deacetylase
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5227304B2 (ja) * 2007-02-28 2013-07-03 大正製薬株式会社 新規なヒドロキサム酸誘導体
ES2576643T3 (es) 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
TWI519508B (zh) * 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
CN101417937B (zh) * 2007-10-23 2013-05-29 中山大学 β-醛酮类抗菌化合物及其应用
WO2009105140A2 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
ES2535083T3 (es) 2007-12-20 2015-05-05 Astrazeneca Ab Compuestos de carbamoilo como inhibidores 190 de DGAT1
JP2011525927A (ja) 2008-06-25 2011-09-29 シェーリング コーポレイション 複素環式抗菌剤の合成および使用
WO2010011296A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
CN102171185A (zh) * 2008-08-01 2011-08-31 拜奥西尼斯医药股份有限公司 甲硫氨酸类似物及其使用方法
AU2009279949A1 (en) * 2008-08-04 2010-02-11 Merck Sharp & Dohme Corp. Urea derivatives as antibacterial agents
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
US8372885B2 (en) * 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
JP5524215B2 (ja) * 2008-09-19 2014-06-18 ファイザー・インク 抗菌剤として有用なヒドロキサム酸誘導体
EP2177502A1 (en) * 2008-10-17 2010-04-21 Oryzon Genomics, S.A. Compounds and their use
EP2361242B1 (en) 2008-10-17 2018-08-01 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
WO2011005355A1 (en) 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
EP2435081B1 (en) * 2009-05-25 2013-04-17 Chiesi Farmaceutici S.p.A. A therapeutic combination comprising a pulmonary surfactant and a steroid
EP2443096A1 (en) 2009-06-19 2012-04-25 AstraZeneca AB Pyrazine carboxamides as inhibitors of dgat1
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
FR2950057B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950056B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
MX338041B (es) 2009-09-25 2016-03-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especificos de lisina y su uso.
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
PL2512474T3 (pl) * 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX2012012111A (es) 2010-04-19 2013-05-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especifica de lisina y su uso.
US9073821B2 (en) * 2010-04-20 2015-07-07 Taisho Pharmaceutical Co., Ltd Hydroxamic acid derivative
KR101984225B1 (ko) 2010-04-22 2019-05-30 버텍스 파마슈티칼스 인코포레이티드 시클로알킬카르복스아미도-인돌 화합물의 제조 방법
RS57331B1 (sr) 2010-07-29 2018-08-31 Oryzon Genomics Sa Inhibitori demetilaze za lsd1 zasnovani na arilciklopropilaminu i njihova medicinska upotreba
US9006449B2 (en) 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
US9738604B2 (en) 2010-09-03 2017-08-22 Duke University Ethynylbenzene derivatives
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
EP2638006A1 (en) 2010-11-10 2013-09-18 Achaogen, Inc. Hydroxamic acid derivatives and their use in the treatment of bacterial infections
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
BR112013017316A2 (pt) 2011-01-04 2019-09-24 Novartis Ag compostos de indol ou análogos dos mesmos para o tratamento de degeneração macular relacionada à idade (amd)
EP3981395A1 (en) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
US8877940B2 (en) 2011-02-22 2014-11-04 Institut National De La Recherche Scientifique Antibiotic tolerance inhibitors
UA107423C2 (en) 2011-03-07 2014-12-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
DK2694488T3 (en) 2011-04-08 2014-12-15 Pfizer Isoxazole derivatives useful as antibacterial SUBSTANCES
JP2014514299A (ja) 2011-04-08 2014-06-19 ファイザー・インク 抗菌剤として有用なイミダゾール、ピラゾールおよびトリアゾール誘導体
WO2013039947A1 (en) 2011-09-12 2013-03-21 Achaogen, Inc. Polymorphs of n-((s)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1r,2r)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide
JP6006609B2 (ja) * 2011-10-19 2016-10-12 大正製薬株式会社 新規なヒドロキサム酸誘導体を含有する医薬
PE20141692A1 (es) 2011-10-20 2014-11-08 Oryzon Genomics Sa Compuestos de (hetero) aril ciclopropilamina como inhibidores de lsd1
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
US8999922B2 (en) * 2012-02-16 2015-04-07 Rqx Pharmaceuticals, Inc. Linear peptide antibiotics
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2014002052A1 (en) 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
CN104603126B (zh) 2012-06-28 2017-05-31 诺华股份有限公司 吡咯烷衍生物及其作为补体途径调节剂的用途
ES2710491T3 (es) 2012-06-28 2019-04-25 Novartis Ag Moduladores de la vía del complemento y sus usos
JP6155332B2 (ja) 2012-06-28 2017-06-28 ノバルティス アーゲー ピロリジン誘導体、および補体経路調節因子としてのその使用
WO2014002058A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
JP6238980B2 (ja) 2012-07-12 2017-11-29 ノバルティス アーゲー 補体経路モジュレーターおよびその使用
CN103012207B (zh) * 2012-12-29 2015-05-27 吉首大学 二芳基丙酰-n-甲基氧肟酸类尿素酶抑制剂及其合成和用途
WO2014165075A1 (en) * 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
LT2975022T (lt) 2013-03-15 2019-07-25 Fujifilm Toyama Chemical Co., Ltd. Naujas hidroksamo rūgšties darinys arba jo druska
WO2014160649A1 (en) * 2013-03-29 2014-10-02 Novartis Ag Hydroxamic acid derivatives as lpxc inhibitors for the treatment of bacterial infections
WO2015024021A2 (en) 2013-08-16 2015-02-19 Duke University Antibacterial compounds
WO2015024010A2 (en) * 2013-08-16 2015-02-19 Duke University Substituted hydroxamic acid compounds
WO2015024016A2 (en) 2013-08-16 2015-02-19 Duke University 2-piperidinyl substituted n,3-dihydroxybutanamides
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
PT3925607T (pt) 2014-04-15 2023-09-26 Vertex Pharma Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística
JP6514716B2 (ja) 2014-04-22 2019-05-15 ノバルティス アーゲー ＬｐｘＣ阻害剤としてのイソオキサゾリンヒドロキサム酸誘導体
BR112017004796A2 (pt) 2014-09-12 2017-12-12 Toyama Chemical Co Ltd método para utilizar derivados de ácido hidroxâmico e substância antibacterial em combinação
MX2017002967A (es) 2014-09-12 2017-05-30 Toyama Chemical Co Ltd Composicion farmaceutica novedosa que contiene derivado de acido hidroxamico o sal del mismo.
CN104262433B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-腺苷型化合物作为TyrRS抑制剂及其制法和用途
CN104231024B (zh) * 2014-10-11 2016-06-15 吉首大学 噁二唑-肌苷型化合物作为TyrRS抑制剂及其制法和用途
CN104327140B (zh) * 2014-10-11 2016-06-15 吉首大学 噁唑烷酮-腺苷型多靶点抗菌化合物及其制法和用途
CN104341476A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-肌苷型多靶点抗菌化合物及其制法和用途
CN104341475A (zh) * 2014-10-11 2015-02-11 吉首大学 利奈唑胺-腺苷型多靶点抗菌化合物及其制法和用途
US9549916B2 (en) 2014-12-16 2017-01-24 Novartis Ag Isoxazole hydroxamic acid compounds as LpxC inhibitors
CN105777464B (zh) * 2014-12-26 2020-09-29 中国科学院上海药物研究所 异羟肟酸衍生物及其制备方法和应用
AU2016275764B8 (en) 2015-06-11 2021-03-04 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
WO2017042099A1 (en) * 2015-09-09 2017-03-16 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof
WO2017083434A1 (en) 2015-11-09 2017-05-18 Forge Therapeutics, Inc. Pyrone based compounds for treating bacterial infections
WO2017083431A2 (en) 2015-11-09 2017-05-18 Forge Therapeutics, Inc. Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections
JP2019501896A (ja) * 2015-12-08 2019-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 抗菌化合物としての置換ベンザジノン
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
KR102410199B1 (ko) * 2016-04-18 2022-06-17 프라운호퍼-게젤샤프트 츄어 푀르더룽 데어 안게반텐 포르슝에.파우. 새로운 메프린 알파 및 베타 저해제
CA3022102A1 (en) * 2016-04-25 2017-11-02 Duke University Benzoylglycine derivatives and methods of making and using same
SI3468957T1 (sl) 2016-06-14 2020-11-30 Novartis Ag Kristalna oblika (R)-4-(5-(ciklopropiletinil) izoksazol-3-IL)-N- hidroksi-2-metil-2-(metilsul fonil) butanamida kot antibakterijsko sredstvo
CN109563033B (zh) 2016-06-21 2023-04-04 奥瑞恩眼科有限责任公司 脂族脯氨酰胺衍生物
DK3472149T3 (da) 2016-06-21 2023-11-27 Orion Ophthalmology LLC Heterocykliske prolinamidderivater
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
CA3038331A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
US11406617B2 (en) 2016-12-23 2022-08-09 Intervet Inc. Compounds for the treatment of bovine or swine respiratory disease
WO2018115421A1 (en) * 2016-12-23 2018-06-28 Intervet International B.V. Compounds useful for treating a mannheimia haemolytica or histophilus somni infection
US11021471B2 (en) 2017-05-10 2021-06-01 Forge Therapeutics, Inc. Antibacterial compounds
WO2018213185A1 (en) * 2017-05-17 2018-11-22 Drexel University Rela inhibitors for biofilm disruption
TW201920081A (zh) 2017-07-11 2019-06-01 美商維泰克斯製藥公司 作為鈉通道調節劑的羧醯胺
IL272188B (en) * 2017-07-27 2022-08-01 Biomendics Llc Claws replaced for bacterial colony regulation
JP7412004B2 (ja) * 2018-02-10 2024-01-12 山東亨利醫藥科技有限責任公司 抗菌剤化合物
CA3113226A1 (en) 2018-09-20 2020-03-26 Forge Therapeutics, Inc. Antibacterial compounds
CA3114240C (en) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
CA3131712A1 (en) * 2019-02-22 2020-08-27 Cila Therapeutic Inc. Inhalable therapeutic agent
CA3148613A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin
CN110563611B (zh) 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
CR20220316A (es) 2019-12-06 2022-10-07 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio
CN111254091B (zh) * 2020-01-20 2022-04-19 浙江工业大学 一种嗜麦芽窄食单胞菌gyh及其在降解氯代烃类污染物中的应用
WO2021195260A1 (en) 2020-03-25 2021-09-30 Forge Therapeutics, Inc. Lpxc inhibitor and methods of making
EP4165037A4 (en) 2020-06-10 2024-07-03 Aligos Therapeutics Inc ANTIVIRAL COMPOUNDS FOR THE TREATMENT OF CORONAVIRUS, PICORNAVIRUS AND NOROVIRUS INFECTIONS
CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂
IL309732A (en) 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds
WO2023128033A1 (ko) * 2021-12-31 2023-07-06 (주)앰틱스바이오 감염성 진균의 바이오필름 생성을 억제하는 신규한 항진균용 조성물
CN116730870B (zh) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US628988A (en) * 1898-11-21 1899-07-18 F B Fargo & Company Combined churn and butter-worker.
US2772281A (en) * 1954-12-23 1956-11-27 Merck & Co Inc Synthesis of 4-amino-3-isoxazolidone and its derivatives
GB9503749D0 (en) 1995-02-24 1995-04-12 British Biotech Pharm Synthesis of hydroxamic acid derivatives
AU711755B2 (en) * 1995-07-26 1999-10-21 Pfizer Inc. N-(aroyl)glycine hydroxamic acid derivatives and related compounds
US5925659A (en) * 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
EP0915086A4 (en) * 1996-05-24 2001-01-17 Ono Pharmaceutical Co PHENYLSULFONAMIDE DERIVATIVES
WO1998015525A1 (fr) * 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Acides hydroxamiques
US6281245B1 (en) * 1996-10-28 2001-08-28 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
AR016751A1 (es) * 1996-11-22 2001-08-01 Athena Neurosciences Inc Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo
GB9715030D0 (en) * 1997-07-18 1997-09-24 British Biotech Pharm Metalloproteinase inhibitors
BR9810841A (pt) * 1997-07-31 2001-07-10 Procter & Gamble Inibidores de metaloprotease alicìclicos
CA2320476A1 (en) 1998-02-07 1999-08-12 British Biotech Pharmaceuticals Limited Antibacterial agents
AU5034699A (en) * 1998-07-08 2000-02-01 Dirk Krumme Matrix metalloproteinase inhibitors containing aminomalonic acid derivatives andpeptide backbone modified derivatives thereof
GB9901863D0 (en) 1999-01-29 1999-03-17 British Biotech Pharm Antibacterial agents
WO2000059874A1 (en) * 1999-04-02 2000-10-12 Du Pont Pharmaceuticals Company NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE
JP2002541197A (ja) 1999-04-09 2002-12-03 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 抗菌剤
WO2002030873A1 (fr) * 2000-10-10 2002-04-18 Fujisawa Pharmaceutical Co., Ltd. Inhibiteur des mmp
EP1343753A2 (en) * 2000-12-21 2003-09-17 De Novo Pharmaceuticals Ltd. Antimicrobial agents
GB0115195D0 (en) 2001-06-21 2001-08-15 Bae Systems Plc Split-pin drill jig
WO2003004488A1 (en) * 2001-07-03 2003-01-16 Chiron Corporation Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors
JP4617449B2 (ja) 2002-07-11 2011-01-26 ヴィキュロン ファーマシューティカルズ インコーポレイテッド 抗菌活性を有するｎ−ヒドロキシアミド誘導体
KR101145252B1 (ko) * 2003-01-08 2012-05-24 유니버시티 오브 워싱톤 항균제

Also Published As

Publication number Publication date
EP2295402A3 (en) 2011-08-03
US8084615B2 (en) 2011-12-27
EP1618087A4 (en) 2007-01-31
SG2012000667A (en) 2015-03-30
CN1777577B (zh) 2011-07-06
AU2009212909B2 (en) 2011-06-16
US8153843B2 (en) 2012-04-10
JP2010280684A (ja) 2010-12-16
US20090247506A1 (en) 2009-10-01
WO2004062601A3 (en) 2005-04-21
EP1618087A2 (en) 2006-01-25
JP5086635B2 (ja) 2012-11-28
US20040229955A1 (en) 2004-11-18
IL213597A0 (en) 2011-07-31
CA2512582C (en) 2014-07-08
EA200501098A1 (ru) 2006-02-24
KR101145252B1 (ko) 2012-05-24
ES2387803T3 (es) 2012-10-02
CN1777577A (zh) 2006-05-24
AU2009212909A1 (en) 2009-10-01
EP2295402B1 (en) 2015-08-12
CA2851462A1 (en) 2004-07-29
US20070244197A1 (en) 2007-10-18
SG159388A1 (en) 2010-03-30
WO2004062601A2 (en) 2004-07-29
KR20050098865A (ko) 2005-10-12
US8101640B2 (en) 2012-01-24
CA2512582A1 (en) 2004-07-29
MXPA05007394A (es) 2005-09-12
HK1155718A1 (zh) 2012-05-25
JP5277213B2 (ja) 2013-08-28
US20060154988A1 (en) 2006-07-13
EP2295402A2 (en) 2011-03-16
US20090163496A1 (en) 2009-06-25
EP1618087B1 (en) 2012-06-13
US7358359B2 (en) 2008-04-15
US20080269221A1 (en) 2008-10-30
US20110172174A1 (en) 2011-07-14
US7989660B2 (en) 2011-08-02
AU2004204760C1 (en) 2010-08-19
IL169475A0 (en) 2007-07-04
CN102267924A (zh) 2011-12-07
AU2004204760A1 (en) 2004-07-29
US20100324025A1 (en) 2010-12-23
IL169475A (en) 2012-04-30
KR101076018B1 (ko) 2011-10-21
KR20110022732A (ko) 2011-03-07
JP2006519772A (ja) 2006-08-31
EA011808B1 (ru) 2009-06-30
AU2004204760B2 (en) 2009-06-04

Similar Documents

Publication Publication Date Title
ES2552247T3 (es) Agentes antibacterianos
AU2004281536B9 (en) Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases
AU2004281959B9 (en) Novel dipeptidyl peptidase IV inhibitors used for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases
JP2768554B2 (ja) 金属タンパク質加水分解酵素阻害剤であるヒドロキサム酸誘導体
JP2006519772A5 (es)
CA2476065A1 (en) Inhibitors of histone deacetylase
US20230105108A1 (en) Compounds for the treatment of bacterial infections and potentiation of antibiotics
JPH09508363A (ja) アミノ酸誘導体およびそのホスホリパーゼａ▲下２▼阻害剤としての用途
EP2326619B1 (en) Methionine analogs and methods of using same
MXPA01002563A (es) Derivados de benceno y uso mecinal de los mismos