PE20081692A1 - Nuevo derivado de heterocicliden acetamida - Google Patents

Nuevo derivado de heterocicliden acetamida

Info

Publication number
PE20081692A1
PE20081692A1 PE2008000171A PE2008000171A PE20081692A1 PE 20081692 A1 PE20081692 A1 PE 20081692A1 PE 2008000171 A PE2008000171 A PE 2008000171A PE 2008000171 A PE2008000171 A PE 2008000171A PE 20081692 A1 PE20081692 A1 PE 20081692A1
Authority
PE
Peru
Prior art keywords
substituted
halogen
heterocicliden
acetamida
hydrocarbon
Prior art date
Application number
PE2008000171A
Other languages
English (en)
Inventor
Hideharu Uchida
Shinichi Ogawa
Muneyoshi Makabe
Yoshitaka Maeda
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39644589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081692(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Publication of PE20081692A1 publication Critical patent/PE20081692A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE k, m, n, Y p SON CADA UNO 0-2; j Y q SON CADA UNO 0-1; R1 ES HALOGENO, HIDROCARBURO SUSTITUIDO O NO, HETEROCICLICO SUSTITUIDO, ENTRE OTROS; R2 ES HALOGENO, AMINO SUSTITUIDO O NO, OXO, ENTRE OTROS; X1 ES O, -NH, S, ENTRE OTROS; X2 ES METILENO, O, -NH-, SO2, ENTRE OTROS; W ES METILENO, CARBONILO, SULFONILO; R7 ES H, HIDROCARBURO SUSTITUIDO O NO, HETEROCICLO SUSTITUIDO O NO, ACILO SUSTITUIDO O NO; R8 ES H, HALOGENO, HIDROCARBURO SUSTITUIDO O NO, ALCOXI C1-C6 SUSTITUIDO O NO, ENTRE OTROS; L1 Y L2 SON CADA UNO O, NH, SO, SO2, ENTRE OTROS; LA PORCION CICLO ES ARILO O HETEROARILO DE 5-6 ELEMENTOS. UN COMPUESTO ES: (E)-2-(8-TRIFLUOROMETIL-3,4-DIHIDROBENZO[b]OXEPIN-5(2H)-ILIDEN)-N-(2,2-DIMETIL-4H-BENZO[1,4]OXAZIN-3-ON-6-IL)ACETAMIDA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE TIPO I POTENCIAL DEL RECEPTOR TEMPORAL (TRVP1) UTILES EN EL TRATAMIENTO DE DOLOR NEUROPATICO, DOLOR INFLAMATORIO, ENTRE OTROS
PE2008000171A 2007-01-24 2008-01-23 Nuevo derivado de heterocicliden acetamida PE20081692A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007014372 2007-01-24

Publications (1)

Publication Number Publication Date
PE20081692A1 true PE20081692A1 (es) 2008-12-18

Family

ID=39644589

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000171A PE20081692A1 (es) 2007-01-24 2008-01-23 Nuevo derivado de heterocicliden acetamida

Country Status (14)

Country Link
EP (1) EP2128157A4 (es)
JP (1) JPWO2008091021A1 (es)
KR (1) KR20090107068A (es)
CN (1) CN101589038A (es)
AR (1) AR065014A1 (es)
AU (1) AU2008208224A1 (es)
CA (1) CA2676020A1 (es)
CL (1) CL2008000202A1 (es)
CO (1) CO6210825A2 (es)
MX (1) MX2009007954A (es)
PA (1) PA8766901A1 (es)
PE (1) PE20081692A1 (es)
TW (1) TW200902002A (es)
WO (1) WO2008091021A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007010383A1 (ja) 2005-07-22 2007-01-25 Mochida Pharmaceutical Co., Ltd. 新規なヘテロシクリデンアセトアミド誘導体
CN101426498A (zh) * 2006-04-18 2009-05-06 艾博特公司 香草素受体亚型1（vr1）的拮抗剂及其用途
JP2011201776A (ja) * 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ヘテロシクリデン−ｎ−（３，４−ジヒドロ−２（１ｈ）−キナゾリノン−５−イル）アセトアミド誘導体
AU2009269720A1 (en) 2008-06-17 2012-01-19 Glenmark Pharmaceuticals S.A. Chromane derivatives as TRPV3 modulators
JP2011201778A (ja) * 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ｐ−置換アリールアセトアミドを有するヘテロシクリデン誘導体
JP2011201777A (ja) * 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd 光学活性なヘテロシクリデン−ｎ−アリールアセトアミド誘導体
CA2831146C (en) 2011-03-25 2019-06-04 Abbvie Inc. Trpv1 antagonists
US8859584B2 (en) 2011-12-19 2014-10-14 Abbvie, Inc. TRPV1 antagonists
US8969325B2 (en) 2011-12-19 2015-03-03 Abbvie Inc. TRPV1 antagonists
US8796328B2 (en) 2012-06-20 2014-08-05 Abbvie Inc. TRPV1 antagonists
AU2020335426A1 (en) * 2019-08-23 2022-03-10 Mochida Pharmaceutical Co., Ltd. Method for producing heterocyclidene acetamide derivative
KR102334947B1 (ko) * 2020-04-22 2021-12-06 주식회사 제이맥켐 Trpv1 길항제로서 벤즈이미다졸론계 시남아마이드 유도체 및 이를 유효성분으로 함유하는 통증의 치료 또는 예방용 약학적 조성물
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9309621D0 (en) 1993-05-11 1993-06-23 Wellcome Found Amide derivatives and their therapeutic use
AU684537B2 (en) 1993-08-26 1997-12-18 Yamanouchi Pharmaceutical Co., Ltd. Benzazepine derivative, pharmaceutical composition containing the same, and intermediate for the same
DE19620170A1 (de) 1996-05-20 1997-11-27 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
AR011913A1 (es) 1997-03-06 2000-09-13 Yamano Masaki Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
WO2001036381A1 (fr) 1999-11-15 2001-05-25 Nissan Chemical Industries, Ltd. Composes hydrazone et pesticides
US6120964A (en) 1999-12-15 2000-09-19 Eastman Kodak Company 2-(1,2-benzisothiazol-3(2H)-ylidene 1,1-dioxide)acetamides negative charge control agents for electrostatographic toners and developers
ATE438626T1 (de) 2001-11-16 2009-08-15 Astellas Pharma Inc 4,4-difluor-1,2,3,4-tetrahydro-5h-1- benzazepinderivate und deren salze
JP2005518371A (ja) * 2001-12-10 2005-06-23 アムジエン・インコーポレーテツド バニロイド受容体リガンド及び治療に於けるこれらの使用
EP1480954B1 (en) * 2002-02-15 2008-12-03 Glaxo Group Limited Vanilloid receptor modulators
EP1507776B1 (en) * 2002-05-29 2007-02-28 Amgen Inc. 2-oxo-1,3,4-trihydroquinazolinyl derivatives for the treatment of cell proliferation-related disorders
EP1575918A2 (en) 2002-12-19 2005-09-21 Neurogen Corporation Substituted biaryl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
EP1603883B1 (en) 2003-02-03 2012-03-28 Janssen Pharmaceutica NV Quinoline-derived amide modulators of vanilloid vr1 receptor
SE0301446D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
US7585878B2 (en) 2003-06-12 2009-09-08 Astellas Pharma Inc. Benzamide derivative or salt thereof
GB0319151D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
ES2309564T3 (es) 2003-09-22 2008-12-16 Euro-Celtique S.A. Compuestos de fenil-carboxamida utiles para el tratamiento del dolor.
US7432281B2 (en) 2003-10-07 2008-10-07 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP1678123A1 (en) * 2003-10-15 2006-07-12 Bayer HealthCare AG Tetrahydro-naphthalene and urea derivatives
US7037927B2 (en) 2003-10-16 2006-05-02 Abbott Laboratories Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
WO2005044802A2 (en) 2003-11-08 2005-05-19 Bayer Healthcare Ag Tetrahydro-quinolinylurea derivatives as vrl antagonists
WO2005070885A1 (en) 2004-01-23 2005-08-04 Amgen Inc. Bis bicyclic amides as vanilloid receptor ligands and their use in treatments of inflammatory and neuropatic pain
WO2005095329A1 (en) 2004-03-31 2005-10-13 Pfizer Japan Inc. Substituted benzamide compounds as vr1 receptor antagonists
BRPI0513286A (pt) 2004-07-15 2008-05-06 Japan Tobacco Inc compostos de benzamida condensada e inibidores de atividade de receptor vanilóide subtipo (vr1), suas composições farmacêuticas, pacote comercial, fármaco e respectivos usos
US20080070946A1 (en) 2004-10-08 2008-03-20 Astrazeneca Ab Hydroxymethylbenzothiazoles Amides
WO2006058338A2 (en) 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
ES2255848B1 (es) 2004-12-16 2007-07-01 Consejo Superior Investig. Cientificas Derivados de isoquinolina como inhibidores de calpaina.
JP2007014372A (ja) 2005-07-05 2007-01-25 Kariya Mokuzai Kogyo Kk 椅子
WO2007010383A1 (ja) * 2005-07-22 2007-01-25 Mochida Pharmaceutical Co., Ltd. 新規なヘテロシクリデンアセトアミド誘導体

Also Published As

Publication number Publication date
PA8766901A1 (es) 2009-06-23
EP2128157A4 (en) 2010-03-17
EP2128157A1 (en) 2009-12-02
KR20090107068A (ko) 2009-10-12
MX2009007954A (es) 2009-08-07
CN101589038A (zh) 2009-11-25
TW200902002A (en) 2009-01-16
AR065014A1 (es) 2009-05-13
CA2676020A1 (en) 2008-07-31
AU2008208224A1 (en) 2008-07-31
JPWO2008091021A1 (ja) 2010-05-20
CL2008000202A1 (es) 2009-10-02
CO6210825A2 (es) 2010-10-20
WO2008091021A1 (ja) 2008-07-31

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