BRPI0709581A8 - compostos de bicicloeteroarila como moduladores de px27 e seu uso - Google Patents
compostos de bicicloeteroarila como moduladores de px27 e seu usoInfo
- Publication number
- BRPI0709581A8 BRPI0709581A8 BRPI0709581A BRPI0709581A BRPI0709581A8 BR PI0709581 A8 BRPI0709581 A8 BR PI0709581A8 BR PI0709581 A BRPI0709581 A BR PI0709581A BR PI0709581 A BRPI0709581 A BR PI0709581A BR PI0709581 A8 BRPI0709581 A8 BR PI0709581A8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- bicycloetheroyl
- modulators
- inflammation
- pain
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000008736 traumatic injury Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
<b>compostos de bicicloeteroarila como moduladores de px2~ 7~ e seu uso.<d> compostos de bicicloeteroarila são descritas os quais possuem uma fórmula representada pela seguinte fórmula (i): os compostos podem ser preparados como composições farmacêuticas, e podem ser usados para a prevenção e tratamento de uma variedade de condições em mamíferos incluindo seres humanos, abrangendo por meio de exemplo não-limitativo, dor, inflamação, lesão traumática, e outros.
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78312106P | 2006-03-16 | 2006-03-16 | |
US78292306P | 2006-03-16 | 2006-03-16 | |
US78359006P | 2006-03-16 | 2006-03-16 | |
US60/783,121 | 2006-03-16 | ||
US60/783,590 | 2006-03-16 | ||
US83141606P | 2006-07-17 | 2006-07-17 | |
US60/831,416 | 2006-07-17 | ||
US90604907P | 2007-03-09 | 2007-03-09 | |
US60/782,923 | 2007-03-16 | ||
PCT/US2007/006735 WO2007109192A2 (en) | 2006-03-16 | 2007-03-16 | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0709581A2 BRPI0709581A2 (pt) | 2011-07-19 |
BRPI0709581A8 true BRPI0709581A8 (pt) | 2018-12-11 |
Family
ID=38523012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0709581A BRPI0709581A8 (pt) | 2006-03-16 | 2007-03-16 | compostos de bicicloeteroarila como moduladores de px27 e seu uso |
Country Status (13)
Country | Link |
---|---|
US (2) | US7816371B2 (pt) |
EP (1) | EP1933622B1 (pt) |
JP (1) | JP5240941B2 (pt) |
CN (1) | CN101442909B (pt) |
AR (1) | AR059920A1 (pt) |
BR (1) | BRPI0709581A8 (pt) |
CA (1) | CA2645568C (pt) |
DK (1) | DK1933622T3 (pt) |
ES (1) | ES2569352T3 (pt) |
HK (1) | HK1133787A1 (pt) |
MX (1) | MX2008011922A (pt) |
TW (1) | TWI464148B (pt) |
WO (1) | WO2007109192A2 (pt) |
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CA2680275C (en) * | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
AU2008319735A1 (en) | 2007-10-31 | 2009-05-07 | Nissan Chemical Industries, Ltd. | Pyridazinone derivatives and use thereof as P2X7 receptor inhibitors |
JP5506776B2 (ja) | 2008-03-25 | 2014-05-28 | アフェクティス ファーマシューティカルズ アーゲー | 新規p2x7r拮抗薬及びその使用法 |
EP2331525A4 (en) * | 2008-08-11 | 2013-01-02 | Harvard College | HALOFUGINONE ANALOGUES FOR THE INHIBITION OF ARNT SYNTHÉTASES AND USES THEREOF |
GB0906274D0 (en) | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
MX2011010810A (es) | 2009-04-14 | 2012-01-12 | Affectis Pharmaceuticals Ag | Nuevos antagonistas de p2x7r y su uso. |
CN102858741A (zh) | 2010-05-14 | 2013-01-02 | 阿费克蒂斯制药股份公司 | 制备p2x7r拮抗剂的新方法 |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
JP5955957B2 (ja) | 2011-07-22 | 2016-07-20 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | P2x7受容体アンタゴニストとしての複素環アミド誘導体 |
US10155742B2 (en) | 2012-01-13 | 2018-12-18 | President And Fellows Of Harvard College | Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions |
EP2804865B1 (en) | 2012-01-20 | 2015-12-23 | Actelion Pharmaceuticals Ltd. | Heterocyclic amide derivatives as p2x7 receptor antagonists |
WO2014091415A1 (en) | 2012-12-12 | 2014-06-19 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
EP2935211B1 (en) | 2012-12-18 | 2016-11-09 | Actelion Pharmaceuticals Ltd. | Indole carboxamide derivatives as p2x7 receptor antagonists |
EP2956135B1 (en) | 2013-01-22 | 2016-11-16 | Actelion Pharmaceuticals Ltd. | Heterocyclic amide derivatives as p2x7 receptor antagonists |
CA2897459C (en) | 2013-01-22 | 2021-03-02 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
KR101910724B1 (ko) * | 2014-03-24 | 2018-10-22 | 광동 쫑성 파마세티컬 컴패니, 리미티드 | Smo 억제제로서의 퀴놀린 유도체 |
CN106604918B (zh) * | 2014-04-17 | 2019-09-27 | 诺华股份有限公司 | 多环hERG激活剂 |
CN105596301A (zh) * | 2016-01-29 | 2016-05-25 | 中国药科大学 | 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法 |
WO2019099509A1 (en) * | 2017-11-14 | 2019-05-23 | Second Genome, Inc. | Use of a p2x7 receptor antagonist to treat an inflammatory disease or disorder |
US11708353B2 (en) | 2018-06-08 | 2023-07-25 | The General Hospital Corporation | Inhibitors of prolyl-tRNA-synthetase |
US20230128348A1 (en) | 2020-03-31 | 2023-04-27 | Djohan HASAN | Treatment of hyperinflammatory syndrome |
WO2022109268A1 (en) * | 2020-11-20 | 2022-05-27 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
TWI825637B (zh) | 2021-03-31 | 2023-12-11 | 美商輝瑞股份有限公司 | 啶-1,6(2h,7h)-二酮 |
GB2607584A (en) * | 2021-06-03 | 2022-12-14 | Stichting Medische Kliniek Velsen | Composition and method of treatment |
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-
2007
- 2007-03-14 TW TW096108752A patent/TWI464148B/zh active
- 2007-03-16 ES ES07753368.5T patent/ES2569352T3/es active Active
- 2007-03-16 JP JP2009500521A patent/JP5240941B2/ja active Active
- 2007-03-16 DK DK07753368.5T patent/DK1933622T3/en active
- 2007-03-16 EP EP07753368.5A patent/EP1933622B1/en not_active Not-in-force
- 2007-03-16 AR ARP070101082A patent/AR059920A1/es not_active Application Discontinuation
- 2007-03-16 BR BRPI0709581A patent/BRPI0709581A8/pt not_active IP Right Cessation
- 2007-03-16 WO PCT/US2007/006735 patent/WO2007109192A2/en active Application Filing
- 2007-03-16 CN CN2007800170265A patent/CN101442909B/zh active Active
- 2007-03-16 MX MX2008011922A patent/MX2008011922A/es active IP Right Grant
- 2007-03-16 US US11/725,153 patent/US7816371B2/en not_active Expired - Fee Related
- 2007-03-16 CA CA2645568A patent/CA2645568C/en not_active Expired - Fee Related
-
2009
- 2009-11-25 HK HK09110995.5A patent/HK1133787A1/xx unknown
-
2010
- 2010-10-18 US US12/925,297 patent/US20110092476A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20070225324A1 (en) | 2007-09-27 |
TW200800904A (en) | 2008-01-01 |
EP1933622B1 (en) | 2016-03-09 |
EP1933622A2 (en) | 2008-06-25 |
US7816371B2 (en) | 2010-10-19 |
WO2007109192A3 (en) | 2007-11-22 |
BRPI0709581A2 (pt) | 2011-07-19 |
CA2645568C (en) | 2014-11-18 |
HK1133787A1 (en) | 2010-04-09 |
WO2007109192A2 (en) | 2007-09-27 |
US20110092476A1 (en) | 2011-04-21 |
CN101442909B (zh) | 2013-03-27 |
MX2008011922A (es) | 2008-11-28 |
JP5240941B2 (ja) | 2013-07-17 |
AR059920A1 (es) | 2008-05-07 |
EP1933622A4 (en) | 2010-03-10 |
TWI464148B (zh) | 2014-12-11 |
JP2009530304A (ja) | 2009-08-27 |
DK1933622T3 (en) | 2016-05-02 |
ES2569352T3 (es) | 2016-05-10 |
CN101442909A (zh) | 2009-05-27 |
CA2645568A1 (en) | 2007-09-27 |
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