BR112017024517A2 - compostos de tetraidroquinolinona como moduladores ror gama - Google Patents

compostos de tetraidroquinolinona como moduladores ror gama

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Publication number
BR112017024517A2
BR112017024517A2 BR112017024517A BR112017024517A BR112017024517A2 BR 112017024517 A2 BR112017024517 A2 BR 112017024517A2 BR 112017024517 A BR112017024517 A BR 112017024517A BR 112017024517 A BR112017024517 A BR 112017024517A BR 112017024517 A2 BR112017024517 A2 BR 112017024517A2
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Prior art keywords
compounds
tetrahydroquinolinone
modulators
receptor
disorders
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BR112017024517A
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English (en)
Inventor
Ravi KOTRABASAIAH UJJINAMATADA
Chetan Pandit
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Aurigene Discovery Technologies Limited
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Publication of BR112017024517A2 publication Critical patent/BR112017024517A2/pt

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

a presente invenção fornece tetraidroquinolinona substituída e compostos relacionados da fórmula (i), que são úteis terapeuticamente como moduladores de receptores órfãos relacionados ao receptor ácido retinóico (rors), mais particularmente como moduladores ror¿. estes compostos são úteis no tratamento e prevenção de doenças e/ou disfunções, em particular o seu uso em doenças e/ou disfunções mediadas pelo receptor ror¿. a presente invenção também fornece o preparo dos compostos e formulações farmacêuticas compreendendo pelo menos tetraidroquinolinona substituída ou um dos seus compostos relacionados da fórmula (i), juntamente com um veículo, diluente ou excipiente destes farmaceuticamente aceitáveis.
BR112017024517A 2015-05-15 2016-05-13 compostos de tetraidroquinolinona como moduladores ror gama BR112017024517A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2448CH2015 2015-05-15
PCT/IB2016/052773 WO2016185342A1 (en) 2015-05-15 2016-05-13 Substituted tetrahydroquinolinone compounds as ror gamma modulators

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BR112017024517A2 true BR112017024517A2 (pt) 2018-07-24

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US (3) US20180200247A1 (pt)
EP (2) EP3845526A1 (pt)
JP (2) JP6684516B2 (pt)
KR (1) KR20180029971A (pt)
CN (2) CN108026045B (pt)
AU (2) AU2016262969C1 (pt)
BR (1) BR112017024517A2 (pt)
CA (1) CA2985547C (pt)
CU (1) CU24487B1 (pt)
CY (1) CY1124129T1 (pt)
DK (1) DK3294713T5 (pt)
EA (1) EA036679B1 (pt)
ES (1) ES2868175T3 (pt)
HK (1) HK1255229A1 (pt)
HR (1) HRP20210745T1 (pt)
HU (1) HUE054009T2 (pt)
IL (2) IL255522B (pt)
LT (1) LT3294713T (pt)
MX (2) MX2017014621A (pt)
MY (1) MY189194A (pt)
PH (1) PH12017502052A1 (pt)
PL (1) PL3294713T4 (pt)
PT (1) PT3294713T (pt)
RS (1) RS62016B1 (pt)
SI (1) SI3294713T1 (pt)
WO (1) WO2016185342A1 (pt)

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AR117169A1 (es) 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
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