MX2017014621A - Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma. - Google Patents

Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma.

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Publication number
MX2017014621A
MX2017014621A MX2017014621A MX2017014621A MX2017014621A MX 2017014621 A MX2017014621 A MX 2017014621A MX 2017014621 A MX2017014621 A MX 2017014621A MX 2017014621 A MX2017014621 A MX 2017014621A MX 2017014621 A MX2017014621 A MX 2017014621A
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Mexico
Prior art keywords
compounds
modulators
ror
substituted tetrahydroquinolinone
ror gamma
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Application number
MX2017014621A
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English (en)
Inventor
Kotrabasaiah Ujjinamatada Ravi
Pandit Chetan
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Aurigene Discovery Tech Ltd
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Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of MX2017014621A publication Critical patent/MX2017014621A/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

La presente invención proporciona tetrahidroquinolinona sustituida y compuestos relacionados de la fórmula (I), que son terapéuticamente útiles como moduladores de receptores huérfanos (ROR) relacionados con receptores de ácido retinoico, más particularmente como moduladores de ROR?. Estos compuestos son útiles en el tratamiento y la prevención de enfermedades y / o trastornos, en particular su uso en enfermedades y / o trastornos mediados por el receptor ROR?. La presente invención también proporciona la preparación de los compuestos y formulaciones farmacéuticas que comprenden al menos una de las tetrahidroquinolinonas sustituidas o compuestos relacionados de la fórmula (I), junto con un vehículo, diluyente o excipiente farmacéuticamente aceptable para la misma.
MX2017014621A 2015-05-15 2016-05-13 Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma. MX2017014621A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2448CH2015 2015-05-15
PCT/IB2016/052773 WO2016185342A1 (en) 2015-05-15 2016-05-13 Substituted tetrahydroquinolinone compounds as ror gamma modulators

Publications (1)

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MX2017014621A true MX2017014621A (es) 2018-06-28

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MX2017014621A MX2017014621A (es) 2015-05-15 2016-05-13 Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma.
MX2021009561A MX2021009561A (es) 2015-05-15 2016-05-13 Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma.

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US (3) US20180200247A1 (es)
EP (2) EP3294713B1 (es)
JP (2) JP6684516B2 (es)
CN (2) CN108026045B (es)
AU (2) AU2016262969C1 (es)
BR (1) BR112017024517A2 (es)
CA (1) CA2985547C (es)
CU (1) CU24487B1 (es)
CY (1) CY1124129T1 (es)
DK (1) DK3294713T5 (es)
EA (1) EA036679B1 (es)
ES (1) ES2868175T3 (es)
HK (1) HK1255229A1 (es)
HR (1) HRP20210745T1 (es)
HU (1) HUE054009T2 (es)
IL (2) IL255522B (es)
LT (1) LT3294713T (es)
MX (2) MX2017014621A (es)
MY (1) MY189194A (es)
PH (1) PH12017502052A1 (es)
PL (1) PL3294713T3 (es)
PT (1) PT3294713T (es)
RS (1) RS62016B1 (es)
SI (1) SI3294713T1 (es)
WO (1) WO2016185342A1 (es)

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AR117169A1 (es) 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
KR20210106492A (ko) 2018-12-20 2021-08-30 바이엘 악티엔게젤샤프트 살진균 화합물로서의 헤테로시클릴 피리다진
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WO2021136339A1 (zh) * 2019-12-31 2021-07-08 广东东阳光药业有限公司 具有双环结构的酰胺类化合物及其在药物中的应用
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