PL3294713T4 - Podstawione związki tetrahydrochinolinonowe jako modulatory ror gamma - Google Patents

Podstawione związki tetrahydrochinolinonowe jako modulatory ror gamma

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Publication number
PL3294713T4
PL3294713T4 PL16795974T PL16795974T PL3294713T4 PL 3294713 T4 PL3294713 T4 PL 3294713T4 PL 16795974 T PL16795974 T PL 16795974T PL 16795974 T PL16795974 T PL 16795974T PL 3294713 T4 PL3294713 T4 PL 3294713T4
Authority
PL
Poland
Prior art keywords
ror gamma
gamma modulators
compounds
substituted tetrahydroquinolinone
substituted
Prior art date
Application number
PL16795974T
Other languages
English (en)
Other versions
PL3294713T3 (pl
Inventor
Ravi KOTRABASAIAH UJJINAMATADA
Chetan Pandit
Original Assignee
Aurigene Discovery Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Technologies Limited filed Critical Aurigene Discovery Technologies Limited
Publication of PL3294713T3 publication Critical patent/PL3294713T3/pl
Publication of PL3294713T4 publication Critical patent/PL3294713T4/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D239/84—Nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL16795974T 2015-05-15 2016-05-13 Podstawione związki tetrahydrochinolinonowe jako modulatory ror gamma PL3294713T4 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2448CH2015 2015-05-15
PCT/IB2016/052773 WO2016185342A1 (en) 2015-05-15 2016-05-13 Substituted tetrahydroquinolinone compounds as ror gamma modulators
EP16795974.1A EP3294713B1 (en) 2015-05-15 2016-05-13 Substituted tetrahydroquinolinone compounds as ror gamma modulators

Publications (2)

Publication Number Publication Date
PL3294713T3 PL3294713T3 (pl) 2021-07-26
PL3294713T4 true PL3294713T4 (pl) 2021-07-26

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PL16795974T PL3294713T4 (pl) 2015-05-15 2016-05-13 Podstawione związki tetrahydrochinolinonowe jako modulatory ror gamma

Country Status (26)

Country Link
US (3) US20180200247A1 (pl)
EP (2) EP3845526A1 (pl)
JP (2) JP6684516B2 (pl)
KR (1) KR20180029971A (pl)
CN (2) CN108026045B (pl)
AU (2) AU2016262969C1 (pl)
BR (1) BR112017024517A2 (pl)
CA (1) CA2985547C (pl)
CU (1) CU24487B1 (pl)
CY (1) CY1124129T1 (pl)
DK (1) DK3294713T5 (pl)
EA (1) EA036679B1 (pl)
ES (1) ES2868175T3 (pl)
HK (1) HK1255229A1 (pl)
HR (1) HRP20210745T1 (pl)
HU (1) HUE054009T2 (pl)
IL (2) IL255522B (pl)
LT (1) LT3294713T (pl)
MX (2) MX2017014621A (pl)
MY (1) MY189194A (pl)
PH (1) PH12017502052A1 (pl)
PL (1) PL3294713T4 (pl)
PT (1) PT3294713T (pl)
RS (1) RS62016B1 (pl)
SI (1) SI3294713T1 (pl)
WO (1) WO2016185342A1 (pl)

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CN108218845B (zh) * 2016-12-21 2022-11-29 江苏柯菲平医药股份有限公司 一类色满-6-磺酰胺RORγ调节剂及其用途
WO2018136892A1 (en) 2017-01-23 2018-07-26 Magic Leap, Inc. Eyepiece for virtual, augmented, or mixed reality systems
CN107129488A (zh) * 2017-04-21 2017-09-05 湖南博奥德生物医药技术开发有限公司 一种艾乐替尼的制备方法
JP2020524660A (ja) 2017-06-14 2020-08-20 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｒｏｒ−ガンマモジュレーターとして有用な２，３−ジヒドロイソインドール−１−カルボキサミド
CN109111418B (zh) * 2017-06-23 2022-10-11 江苏柯菲平医药股份有限公司 一类2，3-二氢-1H-茚-4-磺酰胺RORγ调节剂及其用途
EP3581565A1 (en) * 2018-06-14 2019-12-18 Beijing Zhibo Bio-Medical Technology Co., Ltd. Phenyl benzyl ether derivative and preparation method and application thereof
CN109232416B (zh) * 2018-10-24 2021-09-24 福州大学 一种合成4-三氟甲基-2-吡喃酮/吡啶酮化合物的方法
AR117169A1 (es) 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas
BR112021010152A2 (pt) 2018-12-20 2021-11-09 Bayer Ag Heterociclil piridazina como compostos fungicidas
EP3927329A4 (en) * 2019-02-20 2022-11-23 The Regents of the University of California TREATMENT OF CANCERS DEPENDENT ON THE ORPHAN RECEPTOR BOUND ON THE RETINOIC ACID y (RORy) RECEPTOR
CN109970631A (zh) * 2019-03-26 2019-07-05 上海吉奉生物科技有限公司 一种5-碘-2-吡啶乙酸的合成方法
CN113121463A (zh) * 2019-12-31 2021-07-16 广东东阳光药业有限公司 具有双环结构的酰胺类化合物及其在药物中的应用
WO2021239766A1 (en) 2020-05-27 2021-12-02 Bayer Aktiengesellschaft Active compound combinations
JP2023532222A (ja) 2020-06-18 2023-07-27 バイエル、アクチエンゲゼルシャフト 活性化合物組み合わせ
CN112724089B (zh) * 2021-01-05 2022-08-26 烟台皓元生物医药科技有限公司 一种2-氨基-3-溴-6-氯吡嗪的合成工艺
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