EA201691491A1 - Арильные и гетероарильные эфиры в качестве модуляторов ror-гамма - Google Patents

Арильные и гетероарильные эфиры в качестве модуляторов ror-гамма

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Publication number
EA201691491A1
EA201691491A1 EA201691491A EA201691491A EA201691491A1 EA 201691491 A1 EA201691491 A1 EA 201691491A1 EA 201691491 A EA201691491 A EA 201691491A EA 201691491 A EA201691491 A EA 201691491A EA 201691491 A1 EA201691491 A1 EA 201691491A1
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EA
Eurasian Patent Office
Prior art keywords
rorγt
heteroaril
ror
ethers
aryl
Prior art date
Application number
EA201691491A
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English (en)
Inventor
Сачин Сундарлал Чаудхари
Абрахам Томас
Ашок Бхаусахеб Кадам
Сачин Васантрао Дхон
Бхарат Гангадхар Адик
Неелима Каираткар-Джоши
Дайси Маниш Шах
Малини Бажпай
Original Assignee
Гленмарк Фармасьютикалс С.А.
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Application filed by Гленмарк Фармасьютикалс С.А. filed Critical Гленмарк Фармасьютикалс С.А.
Publication of EA201691491A1 publication Critical patent/EA201691491A1/ru

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    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Изобретение относится к соединениям формулы (I) и их фармацевтически приемлемым солям, где кольцо А, кольцо В, R, R, R, n и p соответствуют приведенным в настоящем документе определениям, которые обладают активностью модуляторов ретиноидного орфанного рецептора гамма t (RORγt). Эти соединения предотвращают, ингибируют или подавляют действие RORγt и, соответственно, могут применяться в лечении опосредуемых RORγt заболеваний, нарушений, синдромов или состояний, таких как, например, боль, воспаление, ХОБЛ, астма, ревматоидный артрит, колит, рассеянный склероз, псориаз, нейродегенеративные заболевания и рак.
EA201691491A 2014-04-16 2015-04-15 Арильные и гетероарильные эфиры в качестве модуляторов ror-гамма EA201691491A1 (ru)

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