MX2016013518A - Compuestos de aril y heteroaril eter como moduladores de ror gamma. - Google Patents

Compuestos de aril y heteroaril eter como moduladores de ror gamma.

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Publication number
MX2016013518A
MX2016013518A MX2016013518A MX2016013518A MX2016013518A MX 2016013518 A MX2016013518 A MX 2016013518A MX 2016013518 A MX2016013518 A MX 2016013518A MX 2016013518 A MX2016013518 A MX 2016013518A MX 2016013518 A MX2016013518 A MX 2016013518A
Authority
MX
Mexico
Prior art keywords
aryl
roryt
ether compounds
ror gamma
gamma modulators
Prior art date
Application number
MX2016013518A
Other languages
English (en)
Inventor
Sundarlal Chaudhari Sachin
Thomas Abraham
Khairatkar-Joshi Neelima
Manish Shah Daisy
Bajpai Malini
Bhausaheb Kadam Ashok
Vasantrao Dhone Sachin
Gangadhar Adik Bharat
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of MX2016013518A publication Critical patent/MX2016013518A/es

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    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

?La presente invención se refiere a compuestos de Fórmula (I) y sales de los mismos farmacéuticamente aceptables, en donde el Anillo A, el anillo B, R, R2, R3, n, y p son como se definen en la presente, los cuales son activos como moduladores del receptor gamma t huérfano relacionado con retinoides (RO?Rt). Estos compuestos previenen, inhiben, o suprimen la acción de ROR?t y son, por lo tanto, útiles en el tratamiento de enfermedades, trastornos, síndromes o condiciones mediadas por ROR?t tales como, por ejemplo, dolor, inflamación, COPD, asma, artritis reumatoide, colitis, esclerosis múltiple, psoriasis, enfermedades neurodegenerativas, y cáncer. (ver Fórmula).
MX2016013518A 2014-04-16 2015-04-15 Compuestos de aril y heteroaril eter como moduladores de ror gamma. MX2016013518A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1376MU2014 2014-04-16
IN2696MU2014 2014-08-22
IN545MU2015 2015-02-20
PCT/IB2015/052745 WO2015159233A1 (en) 2014-04-16 2015-04-15 Aryl and heteroaryl ether compounds as ror gamma modulators

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MX2016013518A true MX2016013518A (es) 2017-01-23

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