PL3102576T3 - Dihydropirolopirydynowe inhibitory ror-gamma - Google Patents

Dihydropirolopirydynowe inhibitory ror-gamma

Info

Publication number
PL3102576T3
PL3102576T3 PL15705744T PL15705744T PL3102576T3 PL 3102576 T3 PL3102576 T3 PL 3102576T3 PL 15705744 T PL15705744 T PL 15705744T PL 15705744 T PL15705744 T PL 15705744T PL 3102576 T3 PL3102576 T3 PL 3102576T3
Authority
PL
Poland
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
Prior art date
Application number
PL15705744T
Other languages
English (en)
Inventor
David A. Claremon
Lawrence Wayne Dillard
Chengguo DONG
Yi Fan
Lanqi Jia
Zhijie Liu
Stephen D. Lotesta
Andrew Marcus
Suresh B. Singh
Colin M. Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3102576(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vitae Pharmaceuticals, Llc filed Critical Vitae Pharmaceuticals, Llc
Publication of PL3102576T3 publication Critical patent/PL3102576T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
PL15705744T 2014-02-03 2015-01-30 Dihydropirolopirydynowe inhibitory ror-gamma PL3102576T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26
EP15705744.9A EP3102576B8 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma
PCT/US2015/013699 WO2015116904A1 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

Publication Number Publication Date
PL3102576T3 true PL3102576T3 (pl) 2019-12-31

Family

ID=52544571

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15705744T PL3102576T3 (pl) 2014-02-03 2015-01-30 Dihydropirolopirydynowe inhibitory ror-gamma

Country Status (26)

Country Link
US (6) US9266886B2 (pl)
EP (2) EP3102576B8 (pl)
JP (1) JP6466461B2 (pl)
KR (1) KR102408261B1 (pl)
CN (1) CN105940002B (pl)
AU (1) AU2015210833B2 (pl)
CA (1) CA2938311C (pl)
CL (1) CL2016001947A1 (pl)
DK (1) DK3102576T3 (pl)
EA (1) EA031804B1 (pl)
EC (1) ECSP16071151A (pl)
ES (1) ES2735099T3 (pl)
HU (1) HUE045511T2 (pl)
IL (1) IL246902B (pl)
LT (1) LT3102576T (pl)
MX (1) MX371017B (pl)
PE (1) PE20161372A1 (pl)
PH (1) PH12016501457B1 (pl)
PL (1) PL3102576T3 (pl)
PT (1) PT3102576T (pl)
RS (1) RS59007B1 (pl)
SG (1) SG11201606080SA (pl)
SI (1) SI3102576T1 (pl)
TW (1) TWI658041B (pl)
UA (1) UA121309C2 (pl)
WO (1) WO2015116904A1 (pl)

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MX371017B (es) * 2014-02-03 2020-01-13 Vitae Pharmaceuticals Llc Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma.
EP3180349A4 (en) 2014-08-12 2018-08-22 Monash University Lymph directing prodrugs
TWI675032B (zh) 2014-10-14 2019-10-21 美商維它藥物公司 ＲＯＲ-γ之二氫吡咯并吡啶抑制劑
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
WO2016145298A1 (en) 2015-03-12 2016-09-15 The Regents Of The University Of California METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS
CN108026045B (zh) * 2015-05-15 2021-04-27 奥瑞基尼探索技术有限公司 用作RORγ调节剂的经过取代的四氢喹啉酮化合物
RS59934B1 (sr) 2015-06-09 2020-03-31 Abbvie Inc Modulatori nuklearnih receptora (ror) za lečenje inflamatornih i autoimunih oboljenja
WO2017010399A1 (ja) * 2015-07-10 2017-01-19 塩野義製薬株式会社 ＲＯＲγｔ阻害作用を有する化合物およびそれらを含有する医薬組成物
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
JP7118888B2 (ja) 2015-09-08 2022-08-16 モナッシュ ユニバーシティ リンパ指向性プロドラッグ
EP3356366B1 (en) * 2015-10-01 2019-08-28 Boehringer Ingelheim International GmbH Pteridine derivatives as modulators of ror gamma
BR112018010018A2 (pt) 2015-11-20 2018-11-21 Vitae Pharmaceuticals Inc moduladores de ror-gama
CR20180328A (es) 2015-12-15 2018-08-09 Astrazeneca Ab Compuestos de isoindol
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN106632313B (zh) * 2016-03-04 2021-04-09 上海贤鼎生物科技有限公司 一种抗癌药帕博昔布重要中间体及合成工艺
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2018011747A1 (en) 2016-07-14 2018-01-18 Cadila Healthcare Limited Polycyclic compounds as ror-gamma modulators
MX2019000276A (es) 2016-07-14 2019-09-09 Cadila Healthcare Ltd Nuevos derivados ciclopropílicos.
WO2018042342A1 (en) * 2016-08-30 2018-03-08 Glenmark Pharmaceuticals S.A. 1,2,3-benzotriazole derivatives as ror gamma t modulators
TWI705958B (zh) 2016-12-05 2020-10-01 荷蘭商領導醫藥控股責任有限公司 ＲＯＲγ調節子
US11730819B2 (en) 2016-12-23 2023-08-22 Bicycletx Limited Peptide derivatives having novel linkage structures
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
US11339144B2 (en) 2017-04-10 2022-05-24 Navitor Pharmaceuticals, Inc. Heteroaryl Rheb inhibitors and uses thereof
WO2018197893A1 (en) 2017-04-27 2018-11-01 Bicycletx Limited Bicyclic peptide ligands and uses thereof
TW201900617A (zh) * 2017-05-23 2019-01-01 大陸商江蘇恆瑞醫藥股份有限公司 螺環甲醯胺類衍生物、其製備方法及其在醫藥上的應用
EP3638661A1 (en) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
CN109111418B (zh) * 2017-06-23 2022-10-11 江苏柯菲平医药股份有限公司 一类2，3-二氢-1H-茚-4-磺酰胺RORγ调节剂及其用途
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