CU24487B1 - Compuestos de tetrahidroquinolinona sustituidos como moduladores de gamma ror - Google Patents

Compuestos de tetrahidroquinolinona sustituidos como moduladores de gamma ror

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Publication number
CU24487B1
CU24487B1 CU2017000144A CU20170144A CU24487B1 CU 24487 B1 CU24487 B1 CU 24487B1 CU 2017000144 A CU2017000144 A CU 2017000144A CU 20170144 A CU20170144 A CU 20170144A CU 24487 B1 CU24487 B1 CU 24487B1
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gamma
compounds
modulators
ror
formula
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CU2017000144A
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English (en)
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CU20170144A7 (es
Inventor
Ujjinamatada Ravi Kotrabasaiah
Chetan Pandit
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Aurigene Discovery Tech Ltd
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Publication of CU20170144A7 publication Critical patent/CU20170144A7/es
Publication of CU24487B1 publication Critical patent/CU24487B1/es

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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

<p>La presente invención proporciona tetrahidroquinolinona sustituida y compuestos relacionados de la fórmula (I)</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>que son terapéuticamente útiles como moduladores de receptores huérfanos (ROR) relacionados con receptores de ácido retinoico, más particularmente como moduladores de ROR gamma. Estos compuestos son útiles en el tratamiento y la prevención de enfermedades y/o trastornos, en particular su uso en enfermedades y/o trastornos madiados por el receptor ROR gamma. La presente invención también proporciona la preparación de los compuestos y formulaciones farmacéuticas que comprenden al menos una de las tetrahidroquinolinonas sustituidas o compuestos relacionados de la fórmula (I), junto con un vehículo, diluyente o excipiente farmacéuticamente aceptable para la misma.</p>
CU2017000144A 2015-05-15 2016-05-13 Compuestos de tetrahidroquinolinona sustituidos como moduladores de gamma ror CU24487B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2448CH2015 2015-05-15
PCT/IB2016/052773 WO2016185342A1 (en) 2015-05-15 2016-05-13 Substituted tetrahydroquinolinone compounds as ror gamma modulators

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CU20170144A7 CU20170144A7 (es) 2018-04-03
CU24487B1 true CU24487B1 (es) 2020-11-30

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US (3) US20180200247A1 (es)
EP (2) EP3294713B1 (es)
JP (2) JP6684516B2 (es)
KR (1) KR20180029971A (es)
CN (2) CN113121497A (es)
AU (2) AU2016262969C1 (es)
BR (1) BR112017024517A2 (es)
CA (1) CA2985547C (es)
CU (1) CU24487B1 (es)
CY (1) CY1124129T1 (es)
DK (1) DK3294713T5 (es)
EA (1) EA036679B1 (es)
ES (1) ES2868175T3 (es)
HK (1) HK1255229A1 (es)
HR (1) HRP20210745T1 (es)
HU (1) HUE054009T2 (es)
IL (2) IL255522B (es)
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MX (2) MX2021009561A (es)
MY (1) MY189194A (es)
PH (1) PH12017502052A1 (es)
PL (1) PL3294713T4 (es)
PT (1) PT3294713T (es)
RS (1) RS62016B1 (es)
SI (1) SI3294713T1 (es)
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