CO7111268A2 - Compuestos novedosos - Google Patents

Compuestos novedosos

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Publication number
CO7111268A2
CO7111268A2 CO14237467A CO14237467A CO7111268A2 CO 7111268 A2 CO7111268 A2 CO 7111268A2 CO 14237467 A CO14237467 A CO 14237467A CO 14237467 A CO14237467 A CO 14237467A CO 7111268 A2 CO7111268 A2 CO 7111268A2
Authority
CO
Colombia
Prior art keywords
novel compounds
ror
modulators
metabolic
inflammatory
Prior art date
Application number
CO14237467A
Other languages
English (en)
Inventor
Veronique Birault
Amanda Jennifer Campbell
Stephen Harrison
Joelle Le
Lena Shukla
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1207403.5A external-priority patent/GB201207403D0/en
Priority claimed from GB201304596A external-priority patent/GB201304596D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO7111268A2 publication Critical patent/CO7111268A2/es

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract

La presente invención se refiere a moduladores novedosos del receptor huérfano retinoideo gamma (RORγ), procedimientos para su preparación, composiciones farmacéuticas que contienen estos moduladores y a su uso en el tratamiento de enfermedades inflamatorias, metabólicas y autoinmunitarias mediadas por el RORγ
CO14237467A 2012-04-27 2014-10-27 Compuestos novedosos CO7111268A2 (es)

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