SG11201609722UA - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SG11201609722UA
SG11201609722UA SG11201609722UA SG11201609722UA SG11201609722UA SG 11201609722U A SG11201609722U A SG 11201609722UA SG 11201609722U A SG11201609722U A SG 11201609722UA SG 11201609722U A SG11201609722U A SG 11201609722UA SG 11201609722U A SG11201609722U A SG 11201609722UA
Authority
SG
Singapore
Prior art keywords
novel compounds
novel
compounds
Prior art date
Application number
SG11201609722UA
Inventor
Hui Lei
Xin Ma
Feng Ren
Xichen Lin
Robert W Marquis Jr
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of SG11201609722UA publication Critical patent/SG11201609722UA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
SG11201609722UA 2014-05-28 2015-05-26 Novel compounds SG11201609722UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014078701 2014-05-28
PCT/CN2015/079755 WO2015180614A1 (en) 2014-05-28 2015-05-26 Novel compounds

Publications (1)

Publication Number Publication Date
SG11201609722UA true SG11201609722UA (en) 2016-12-29

Family

ID=54698095

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201609722UA SG11201609722UA (en) 2014-05-28 2015-05-26 Novel compounds

Country Status (18)

Country Link
US (1) US9868724B2 (en)
EP (1) EP3148987B1 (en)
JP (1) JP6522665B2 (en)
KR (1) KR20170008852A (en)
CN (1) CN107001342B (en)
AU (1) AU2015267911B2 (en)
CA (1) CA2953637C (en)
CL (1) CL2016003023A1 (en)
CR (1) CR20160549A (en)
DO (1) DOP2016000311A (en)
EA (1) EA032272B1 (en)
ES (1) ES2716966T3 (en)
IL (1) IL248983A0 (en)
MX (1) MX2016015631A (en)
PE (1) PE20170137A1 (en)
PH (1) PH12016502331A1 (en)
SG (1) SG11201609722UA (en)
WO (1) WO2015180614A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6279605B2 (en) 2012-12-06 2018-02-14 グラクソ グループ リミテッドGlaxo Group Limited Modulators of retinoid-related orphan receptor gamma (RORγ) for use in the treatment of autoimmune and inflammatory diseases
KR20170012388A (en) 2014-05-28 2017-02-02 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Novel compounds
AU2015267909B2 (en) 2014-05-28 2018-03-22 Glaxosmithkline Intellectual Property Development Limited Novel compounds
SG11201609722UA (en) 2014-05-28 2016-12-29 Glaxosmithkline Ip Dev Ltd Novel compounds
US10662181B2 (en) * 2016-07-13 2020-05-26 Leo Pharma A/S Heteroaromatic modulators of the retinoid-related orphan receptor gamma
CN109134476B (en) * 2017-06-15 2021-03-19 复旦大学 Bridged ring piperazine derivative or salt thereof, and preparation method and application thereof

Family Cites Families (26)

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US7790726B2 (en) 2005-08-16 2010-09-07 Chemocentryx, Inc. Monocyclic and bicyclic compounds and methods of use
US20070208000A1 (en) 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
US7825120B2 (en) 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
WO2007078839A2 (en) 2005-12-19 2007-07-12 Cytokinetics, Inc. Compounds, compositions and methods
WO2012028100A1 (en) 2010-09-01 2012-03-08 Glaxo Group Limited Novel compounds
WO2012027965A1 (en) 2010-09-01 2012-03-08 Glaxo Group Limited Novel compounds
WO2012100734A1 (en) 2011-01-24 2012-08-02 Glaxo Group Limited Compounds useful as retinoid-related orphan receptor gamma modulators
WO2012100732A1 (en) 2011-01-24 2012-08-02 Glaxo Group Limited Retinoid-related orphan receptor gamma modulators, composition containing them and uses thereof
EP2511263A1 (en) 2011-04-14 2012-10-17 Phenex Pharmaceuticals AG Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
WO2012145254A2 (en) 2011-04-16 2012-10-26 Board Of Regents, The University Of Texas System Methods of using inhibitors of rorϒt to treat disease
US8604069B2 (en) 2011-04-28 2013-12-10 Japan Tobacco Inc. Amide compound and medicinal use thereof
WO2012158784A2 (en) * 2011-05-16 2012-11-22 Theodore Mark Kamenecka Modulators of the nuclear hormone receptor ror
CA2847563A1 (en) * 2011-09-09 2013-03-14 New York University Amido compounds as ror.gamma.t modulators and uses thereof
GB201116641D0 (en) 2011-09-27 2011-11-09 Glaxo Group Ltd Novel compounds
WO2013100027A1 (en) * 2011-12-28 2013-07-04 武田薬品工業株式会社 Heterocyclic compound
GB201207406D0 (en) 2012-04-27 2012-06-13 Glaxo Group Ltd Novel compounds
JP6182594B2 (en) 2012-04-27 2017-08-16 グラクソ グループ リミテッドGlaxo Group Limited New compounds
JO3215B1 (en) * 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag Carboxamide or Sulfonamide Substituted Nitrogen-Containing 5-Membered Heterocycles as Modulators for the Orphan Nuclear Receptor RORy
NZ706775A (en) * 2012-10-16 2018-10-26 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of ror-gamma-t
JP6279605B2 (en) * 2012-12-06 2018-02-14 グラクソ グループ リミテッドGlaxo Group Limited Modulators of retinoid-related orphan receptor gamma (RORγ) for use in the treatment of autoimmune and inflammatory diseases
WO2013171729A2 (en) 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
US20160257664A1 (en) 2013-10-25 2016-09-08 Glaxosmithkline Llc Novel compounds
US10286000B2 (en) 2013-10-25 2019-05-14 St. Jude Children's Research Hospital, Inc. Retinoid X receptor-gamma agonists and retinoid X receptor-alpha antagonists for treatment of cancer
AU2015267909B2 (en) 2014-05-28 2018-03-22 Glaxosmithkline Intellectual Property Development Limited Novel compounds
SG11201609722UA (en) 2014-05-28 2016-12-29 Glaxosmithkline Ip Dev Ltd Novel compounds
KR20170012388A (en) 2014-05-28 2017-02-02 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Novel compounds

Also Published As

Publication number Publication date
AU2015267911B2 (en) 2017-10-26
US20170101399A1 (en) 2017-04-13
EA201692395A1 (en) 2017-03-31
ES2716966T3 (en) 2019-06-18
IL248983A0 (en) 2017-01-31
KR20170008852A (en) 2017-01-24
CA2953637C (en) 2022-11-29
CR20160549A (en) 2017-04-28
CL2016003023A1 (en) 2017-04-21
EP3148987B1 (en) 2019-01-02
AU2015267911A1 (en) 2016-12-01
WO2015180614A1 (en) 2015-12-03
PE20170137A1 (en) 2017-03-05
CN107001342A (en) 2017-08-01
DOP2016000311A (en) 2017-02-28
US9868724B2 (en) 2018-01-16
PH12016502331A1 (en) 2017-02-06
JP2017519738A (en) 2017-07-20
CA2953637A1 (en) 2015-12-03
JP6522665B2 (en) 2019-05-29
CN107001342B (en) 2020-02-07
MX2016015631A (en) 2017-04-25
EP3148987A4 (en) 2017-11-15
EA032272B1 (en) 2019-05-31
EP3148987A1 (en) 2017-04-05

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