EA201491973A1 - Новые соединения - Google Patents

Новые соединения

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Publication number
EA201491973A1
EA201491973A1 EA201491973A EA201491973A EA201491973A1 EA 201491973 A1 EA201491973 A1 EA 201491973A1 EA 201491973 A EA201491973 A EA 201491973A EA 201491973 A EA201491973 A EA 201491973A EA 201491973 A1 EA201491973 A1 EA 201491973A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new connections
rorγ
modulators
retinoid
metabolic
Prior art date
Application number
EA201491973A
Other languages
English (en)
Other versions
EA026102B1 (ru
Inventor
Вероник Биро
Аманда Дженнифер Кэмпбелл
Стефен Харрисон
Жоэлль Ле
Лена Шукла
Original Assignee
Глэксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1207403.5A external-priority patent/GB201207403D0/en
Priority claimed from GB201304596A external-priority patent/GB201304596D0/en
Application filed by Глэксо Груп Лимитед filed Critical Глэксо Груп Лимитед
Publication of EA201491973A1 publication Critical patent/EA201491973A1/ru
Publication of EA026102B1 publication Critical patent/EA026102B1/ru

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract

Настоящее изобретение относится к новым модуляторам связанного с ретиноидом сиротского рецептора гамма (RORγ), способам их получения, к фармацевтическим композициям, содержащим эти модуляторы, и к их применению для лечения воспалительных, метаболических и аутоиммунных заболеваний, опосредуемых RORγ.
EA201491973A 2012-04-27 2013-04-25 МОДУЛЯТОРЫ СВЯЗАННОГО С РЕТИНОИДОМ СИРОТСКОГО РЕЦЕПТОРА ГАММА (RORγ) EA026102B1 (ru)

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PCT/EP2013/058666 WO2013160418A1 (en) 2012-04-27 2013-04-25 Novel compounds

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US9428452B2 (en) 2016-08-30
BR112014026881A2 (pt) 2017-06-27
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CO7111268A2 (es) 2014-11-10
US20150080369A1 (en) 2015-03-19
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UY34765A (es) 2013-11-29
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CN104379559B (zh) 2016-11-09
AR090847A1 (es) 2014-12-10
PH12014502414A1 (en) 2015-01-12
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CN104379559A (zh) 2015-02-25
EP2841416A1 (en) 2015-03-04
WO2013160418A1 (en) 2013-10-31
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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU