UY36709A - Moduladores de ror gamma (ror¿) - Google Patents

Moduladores de ror gamma (ror¿)

Info

Publication number
UY36709A
UY36709A UY0001036709A UY36709A UY36709A UY 36709 A UY36709 A UY 36709A UY 0001036709 A UY0001036709 A UY 0001036709A UY 36709 A UY36709 A UY 36709A UY 36709 A UY36709 A UY 36709A
Authority
UY
Uruguay
Prior art keywords
ror
gamma modulators
diseases
compounds
sulfonylphenyl
Prior art date
Application number
UY0001036709A
Other languages
English (en)
Inventor
Cals Joseph Maria Gerardus Barbara
De Kimpe Vera
Nabuurs Sander Bernardus
Original Assignee
Lead Pharma Cel Models Ip B V
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Pharma Cel Models Ip B V, Sanofi Sa filed Critical Lead Pharma Cel Models Ip B V
Publication of UY36709A publication Critical patent/UY36709A/es

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    • A61K31/10Sulfides; Sulfoxides; Sulfones
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    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Abstract

La presente invención se refiere a nuevos compuestos modulares de ROR¿ que contienen un armazón de 4-[2-(4-sulfonilfenil)acetamido]benzamida, según la Fórmula I: o una sal farmacéuticamente aceptable de los mismos. Estos compuestos pueden usarse como inhibidores de ROR¿ y son útiles para el tratamiento de enfermedades o trastornos mediados por ROR¿, en particular enfermedades autoinmunitarias y enfermedades inflamatorias.
UY0001036709A 2015-06-05 2016-06-03 Moduladores de ror gamma (ror¿) UY36709A (es)

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EP3101009A1 (en) 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
US10011566B2 (en) 2015-12-15 2018-07-03 Astrazeneca Ab Compounds
WO2017199103A1 (en) * 2016-05-18 2017-11-23 Glenmark Pharmaceuticals S.A. Benzamide compounds as ror gamma modulators
MX2019000276A (es) 2016-07-14 2019-09-09 Cadila Healthcare Ltd Nuevos derivados ciclopropílicos.
AR109042A1 (es) 2016-07-14 2018-10-24 Cadila Healthcare Ltd COMPUESTOS MODULARES DE RORg
US10196350B2 (en) 2016-12-05 2019-02-05 Lead Pharma Holding B.V. ROR gamma (RORγ) modulators
WO2018229155A1 (en) 2017-06-14 2018-12-20 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
CN112830893A (zh) * 2019-10-28 2021-05-25 成都倍特药业股份有限公司 一类RORγ抑制剂、其制备方法及其在医药上的应用
TW202136238A (zh) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 RORγt抑制劑及其製備方法和用途
CN114685363A (zh) 2020-12-31 2022-07-01 上海医药集团股份有限公司 一类RORγt调节剂、其制备方法及应用
WO2023192988A2 (en) * 2022-04-01 2023-10-05 President And Fellows Of Harvard College Immune modulatory agents

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WO2013171729A2 (en) * 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
WO2014125426A1 (en) * 2013-02-15 2014-08-21 Aurigene Discovery Technologies Limited Trisubstituted heterocyclic derivatives as ror gamma modulators
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US10428018B2 (en) 2019-10-01
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