SV2016005293A - Compuestos de azol amido-sustituidos como inhibidores de tnks1 y/o tnks2 - Google Patents
Compuestos de azol amido-sustituidos como inhibidores de tnks1 y/o tnks2Info
- Publication number
- SV2016005293A SV2016005293A SV2016005293A SV2016005293A SV2016005293A SV 2016005293 A SV2016005293 A SV 2016005293A SV 2016005293 A SV2016005293 A SV 2016005293A SV 2016005293 A SV2016005293 A SV 2016005293A SV 2016005293 A SV2016005293 A SV 2016005293A
- Authority
- SV
- El Salvador
- Prior art keywords
- compounds
- tnks1
- tnks2
- inhibitors
- amido
- Prior art date
Links
- 101000663006 Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1 Proteins 0.000 title abstract 2
- 101000662592 Homo sapiens Poly [ADP-ribose] polymerase tankyrase-2 Proteins 0.000 title abstract 2
- 102100037664 Poly [ADP-ribose] polymerase tankyrase-1 Human genes 0.000 title abstract 2
- 102100037477 Poly [ADP-ribose] polymerase tankyrase-2 Human genes 0.000 title abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C07D487/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
COMPUESTOS DE AZOL SUSTITUIDOS CON AMIDA DE FÓRMULA GENERAL (I): (VER FORMULA); EN DONDE X1, X2, R1, R2, R4, R5, R7 Y R8 SON COMO SE DEFINE EN LAS REIVINDICACIONES LOS CUALES SON INHIBIDORES DE TNKS1 Y/O TNKS2, MÉTODOS PARA PREPARAR DICHOS COMPUESTOS, COMPUESTOS INTERMEDIARIOS ÚTILES PARA PREPARAR DICHOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS Y COMBINACIONES QUE COMPRENDEN DICHOS COMPUESTOS Y USO DE DICHOS COMPUESTOS PARA FABRICAR UNA COMPOSICIÓN FARMACÉUTICA PARA EL TRATAMIENTO O PROFILAXIS DE UNA ENFERMEDAD, EN PARTICULAR DE NEOPLASMAS, COMO UN AGENTE ÚNICO O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201461973925P | 2014-04-02 | 2014-04-02 | |
EP14163261 | 2014-04-02 |
Publications (1)
Publication Number | Publication Date |
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SV2016005293A true SV2016005293A (es) | 2018-04-30 |
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ID=53724279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SV2016005293A SV2016005293A (es) | 2014-04-02 | 2016-09-30 | Compuestos de azol amido-sustituidos como inhibidores de tnks1 y/o tnks2 |
Country Status (25)
Country | Link |
---|---|
US (1) | US9884063B2 (es) |
EP (1) | EP3126337A2 (es) |
JP (1) | JP2017512806A (es) |
KR (1) | KR20160133001A (es) |
CN (1) | CN106459015A (es) |
AP (1) | AP2016009476A0 (es) |
AU (1) | AU2015239548A1 (es) |
BR (1) | BR112016022749A2 (es) |
CA (1) | CA2944370A1 (es) |
CL (1) | CL2016002482A1 (es) |
CR (1) | CR20160462A (es) |
CU (1) | CU20160148A7 (es) |
DO (1) | DOP2016000268A (es) |
EA (1) | EA201691962A1 (es) |
HK (1) | HK1231484A1 (es) |
IL (1) | IL247678A0 (es) |
MA (1) | MA39824A (es) |
MX (1) | MX2016012937A (es) |
PE (1) | PE20161386A1 (es) |
PH (1) | PH12016501932A1 (es) |
SG (1) | SG11201607735TA (es) |
SV (1) | SV2016005293A (es) |
TW (1) | TW201623249A (es) |
UY (1) | UY36060A (es) |
WO (1) | WO2015150449A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017055313A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
WO2017055316A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
WO2018078005A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted azaspiro derivatives as tankyrase inhibitors |
WO2018078009A1 (en) | 2016-10-29 | 2018-05-03 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives |
WO2018087126A1 (en) | 2016-11-09 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives as inhibitors of tankyrase |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5616489A (en) * | 1979-07-20 | 1981-02-17 | Ajinomoto Co Inc | Imidazolecarboxylic acid derivative |
KR20020016839A (ko) | 1999-06-24 | 2002-03-06 | 무라타 도시카즈 | 복소환 디카르복실산 디아미드 유도체, 농원예용 살충제및 그것의 사용 방법 |
DE102004058062A1 (de) * | 2004-12-02 | 2006-06-08 | Bayer Healthcare Ag | Cyclische Iminocarbamate und ihre Verwendung |
JP2010504980A (ja) * | 2006-09-28 | 2010-02-18 | エグゼリクシス, インコーポレイテッド | Jak−2モジュレーターおよび使用方法 |
US7562189B2 (en) | 2006-09-28 | 2009-07-14 | Network Appliance, Inc. | Write-in-place within a write-anywhere filesystem |
US20100267626A1 (en) | 2007-11-05 | 2010-10-21 | Novartis Ag | Methods and compositions for measuring wnt activation and for treating wnt-related cancers |
US8440710B2 (en) | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
US9725479B2 (en) | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
RU2013128448A (ru) | 2010-12-08 | 2015-01-20 | Осло Юниверсити Хоспитал Хф | Производные триазола в качестве ингибиторов сигнального пути wnt |
US8722721B2 (en) | 2011-03-16 | 2014-05-13 | Hoffmann-La Roche Inc. | SEC-hydroxycyclohexyl derivatives |
US9227982B2 (en) | 2011-07-13 | 2016-01-05 | Novartis Ag | 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors |
WO2013012723A1 (en) | 2011-07-13 | 2013-01-24 | Novartis Ag | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
PE20141371A1 (es) | 2011-08-29 | 2014-10-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
WO2013093508A2 (en) * | 2011-12-22 | 2013-06-27 | Oslo University Hospital Hf | Wnt pathway inhibitors |
US9340549B2 (en) | 2012-03-05 | 2016-05-17 | Amgen Inc. | Oxazolidinone compounds and derivatives thereof |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN104271580B (zh) | 2012-05-04 | 2017-02-22 | 默克专利股份公司 | 吡咯并三嗪酮衍生物 |
WO2013177349A2 (en) | 2012-05-25 | 2013-11-28 | Glaxosmithkline Llc | Quinazolinediones as tankyrase inhibitors |
EP2858994A1 (en) | 2012-06-07 | 2015-04-15 | F. Hoffmann-La Roche AG | Pyrazolopyrimidone and pyrazolopyridone inhibitors of tankyrase |
BR112014030674A2 (pt) | 2012-06-20 | 2017-06-27 | Hoffmann La Roche | compostos n-ariltriazol como antagonistas do lpar |
RU2014152790A (ru) | 2012-06-20 | 2016-08-10 | Ф. Хоффманн-Ля Рош Аг | Пирролопиразоновые ингибиторы танкиразы |
RU2654216C2 (ru) | 2012-08-08 | 2018-05-17 | Мерк Патент Гмбх | Производные (аза-)изохинолинона |
JP6497520B2 (ja) | 2013-05-23 | 2019-04-10 | 日産化学株式会社 | 液晶配向処理剤、液晶配向膜および液晶表示素子 |
CN103923237B (zh) | 2013-10-31 | 2017-01-25 | 北京利和知信科技有限公司 | 用于烯烃聚合的催化剂组分及其应用 |
US10100027B2 (en) | 2014-09-26 | 2018-10-16 | Changzhou Yinsheng Pharmaceutical Co., Ltd. | Benzofuran analogue as NS4B inhibitor |
EP3292107A1 (en) | 2015-05-05 | 2018-03-14 | Bayer Pharma Aktiengesellschaft | Amido-substituted cyclohexane derivatives |
WO2017055313A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
WO2017055316A1 (en) | 2015-10-01 | 2017-04-06 | Bayer Pharma Aktiengesellschaft | Amido-substituted azole compounds |
-
2015
- 2015-03-27 UY UY0001036060A patent/UY36060A/es not_active Application Discontinuation
- 2015-03-30 TW TW104110344A patent/TW201623249A/zh unknown
- 2015-04-01 CR CR20160462A patent/CR20160462A/es unknown
- 2015-04-01 PE PE2016001850A patent/PE20161386A1/es not_active Application Discontinuation
- 2015-04-01 US US15/301,443 patent/US9884063B2/en not_active Expired - Fee Related
- 2015-04-01 SG SG11201607735TA patent/SG11201607735TA/en unknown
- 2015-04-01 EA EA201691962A patent/EA201691962A1/ru unknown
- 2015-04-01 WO PCT/EP2015/057167 patent/WO2015150449A2/en active Application Filing
- 2015-04-01 AP AP2016009476A patent/AP2016009476A0/en unknown
- 2015-04-01 EP EP15741893.0A patent/EP3126337A2/en not_active Withdrawn
- 2015-04-01 CA CA2944370A patent/CA2944370A1/en not_active Abandoned
- 2015-04-01 CN CN201580029154.6A patent/CN106459015A/zh active Pending
- 2015-04-01 MA MA039824A patent/MA39824A/fr unknown
- 2015-04-01 MX MX2016012937A patent/MX2016012937A/es unknown
- 2015-04-01 AU AU2015239548A patent/AU2015239548A1/en not_active Abandoned
- 2015-04-01 BR BR112016022749A patent/BR112016022749A2/pt not_active IP Right Cessation
- 2015-04-01 KR KR1020167030262A patent/KR20160133001A/ko unknown
- 2015-04-01 JP JP2016559907A patent/JP2017512806A/ja not_active Withdrawn
-
2016
- 2016-09-07 IL IL247678A patent/IL247678A0/en unknown
- 2016-09-29 PH PH12016501932A patent/PH12016501932A1/en unknown
- 2016-09-30 CU CUP2016000148A patent/CU20160148A7/es unknown
- 2016-09-30 CL CL2016002482A patent/CL2016002482A1/es unknown
- 2016-09-30 SV SV2016005293A patent/SV2016005293A/es unknown
- 2016-09-30 DO DO2016000268A patent/DOP2016000268A/es unknown
-
2017
- 2017-05-25 HK HK17105307.8A patent/HK1231484A1/zh unknown
Also Published As
Publication number | Publication date |
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PH12016501932A1 (en) | 2016-12-19 |
DOP2016000268A (es) | 2016-10-31 |
HK1231484A1 (zh) | 2017-12-22 |
MA39824A (fr) | 2017-02-08 |
MX2016012937A (es) | 2017-03-31 |
UY36060A (es) | 2015-10-30 |
AP2016009476A0 (en) | 2016-09-30 |
KR20160133001A (ko) | 2016-11-21 |
JP2017512806A (ja) | 2017-05-25 |
BR112016022749A2 (pt) | 2019-09-24 |
US20170020886A1 (en) | 2017-01-26 |
AU2015239548A1 (en) | 2016-09-29 |
CU20160148A7 (es) | 2017-02-02 |
TW201623249A (zh) | 2016-07-01 |
CA2944370A1 (en) | 2015-10-08 |
CR20160462A (es) | 2016-12-06 |
SG11201607735TA (en) | 2016-11-29 |
WO2015150449A3 (en) | 2016-01-14 |
WO2015150449A2 (en) | 2015-10-08 |
EA201691962A1 (ru) | 2017-04-28 |
CN106459015A (zh) | 2017-02-22 |
EP3126337A2 (en) | 2017-02-08 |
CL2016002482A1 (es) | 2017-03-17 |
US9884063B2 (en) | 2018-02-06 |
IL247678A0 (en) | 2016-11-30 |
PE20161386A1 (es) | 2017-01-15 |
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