UY37098A - Moduladores de ror-gamma - Google Patents
Moduladores de ror-gammaInfo
- Publication number
- UY37098A UY37098A UY0001037098A UY37098A UY37098A UY 37098 A UY37098 A UY 37098A UY 0001037098 A UY0001037098 A UY 0001037098A UY 37098 A UY37098 A UY 37098A UY 37098 A UY37098 A UY 37098A
- Authority
- UY
- Uruguay
- Prior art keywords
- ror
- gamma modulators
- diseases
- formula
- treatment
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Compuestos novedosos de fórmula I: sales aceptables farmacéuticamente de los mismos, y composiciones farmacéuticas de los mismos, que son útiles en el tratamiento de enfermedades y trastornos mediados por ROR¿. También se proveen composiciones farmacéuticas que comprenden los compuestos novedosos de fórmula I y métodos para su uso en el tratamiento de una o más enfermedades o trastornos inflamatorios, metabólicos, autoinmunes y otros.
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CN112679467A (zh) | 2015-03-11 | 2021-04-20 | Fmc公司 | 杂环取代的二环唑杀有害生物剂 |
ES2856931T3 (es) | 2015-08-05 | 2021-09-28 | Vitae Pharmaceuticals Llc | Moduladores de ROR-gamma |
RU2018121946A (ru) | 2015-11-20 | 2019-12-23 | Вайтаи Фармасьютиклз, Ллк | Модуляторы ror-гамма |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
-
2017
- 2017-01-26 TW TW111104096A patent/TW202220968A/zh unknown
- 2017-01-26 TW TW106103216A patent/TWI757266B/zh active
- 2017-01-27 KR KR1020187024271A patent/KR20180100697A/ko active Search and Examination
- 2017-01-27 BR BR112018015273A patent/BR112018015273A2/pt not_active Application Discontinuation
- 2017-01-27 RU RU2021133444A patent/RU2021133444A/ru unknown
- 2017-01-27 US US16/073,503 patent/US10829481B2/en active Active
- 2017-01-27 AU AU2017212577A patent/AU2017212577B2/en active Active
- 2017-01-27 CA CA3011838A patent/CA3011838A1/en active Pending
- 2017-01-27 CN CN202111366970.XA patent/CN114230523A/zh active Pending
- 2017-01-27 JP JP2018539070A patent/JP6948333B2/ja active Active
- 2017-01-27 MA MA045646A patent/MA45646A/fr unknown
- 2017-01-27 MA MA055328A patent/MA55328A/fr unknown
- 2017-01-27 UY UY0001037098A patent/UY37098A/es not_active Application Discontinuation
- 2017-01-27 CN CN201780009016.0A patent/CN109071509B/zh active Active
- 2017-01-27 EP EP17703628.2A patent/EP3408268B8/en active Active
- 2017-01-27 EP EP21184347.9A patent/EP3939974A1/en not_active Withdrawn
- 2017-01-27 MX MX2018009257A patent/MX2018009257A/es unknown
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- 2017-01-27 WO PCT/US2017/015220 patent/WO2017132432A1/en active Application Filing
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2018
- 2018-07-28 SA SA518392101A patent/SA518392101B1/ar unknown
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2020
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2021
- 2021-09-16 JP JP2021150729A patent/JP2021193131A/ja active Pending
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BR112018015273A2 (pt) | 2018-12-18 |
MA55328A (fr) | 2022-01-19 |
RU2018127360A (ru) | 2020-03-02 |
JP2021193131A (ja) | 2021-12-23 |
US10829481B2 (en) | 2020-11-10 |
EP3939974A1 (en) | 2022-01-19 |
CN109071509B (zh) | 2021-11-30 |
AU2017212577B2 (en) | 2021-05-13 |
EP3408268B8 (en) | 2023-12-06 |
RU2018127360A3 (es) | 2020-04-06 |
JP2019503385A (ja) | 2019-02-07 |
RU2760366C2 (ru) | 2021-11-24 |
TW201734001A (zh) | 2017-10-01 |
SA518392101B1 (ar) | 2022-03-16 |
RU2021133444A (ru) | 2021-11-29 |
TWI757266B (zh) | 2022-03-11 |
AU2017212577A1 (en) | 2018-08-02 |
JP6948333B2 (ja) | 2021-10-13 |
MX2018009257A (es) | 2018-11-09 |
CN114230523A (zh) | 2022-03-25 |
US20190352286A1 (en) | 2019-11-21 |
CN109071509A (zh) | 2018-12-21 |
CA3011838A1 (en) | 2017-08-03 |
WO2017132432A8 (en) | 2017-08-31 |
KR20180100697A (ko) | 2018-09-11 |
TW202220968A (zh) | 2022-06-01 |
EP3408268B1 (en) | 2021-08-04 |
MA45646A (fr) | 2021-03-24 |
EP3408268A1 (en) | 2018-12-05 |
WO2017132432A1 (en) | 2017-08-03 |
US20210094940A1 (en) | 2021-04-01 |
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