UY38001A - Compuestos que inhiben las proteínas ras mutantes g12c - Google Patents

Compuestos que inhiben las proteínas ras mutantes g12c

Info

Publication number
UY38001A
UY38001A UY0001038001A UY38001A UY38001A UY 38001 A UY38001 A UY 38001A UY 0001038001 A UY0001038001 A UY 0001038001A UY 38001 A UY38001 A UY 38001A UY 38001 A UY38001 A UY 38001A
Authority
UY
Uruguay
Prior art keywords
compounds
inhibit
mutant ras
ras proteins
refers
Prior art date
Application number
UY0001038001A
Other languages
English (en)
Inventor
Grant Kettle Jason
Kaur Bagal Sharanjeet
Richard Robb Graeme
Michael Smith James
Joseph CASSAR Doyle
Lyman Feron James
Woolf Goldberg Frederick
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY38001A publication Critical patent/UY38001A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Abstract

La memoria descriptiva se refiere a compuestos de Fórmula (I) (I) y sales farmacéuticamente aceptables de los mismos. La memoria descriptiva también se refiere a procesos e intermedios usados para su preparación, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos proliferativos celulares.
UY0001038001A 2017-12-08 2018-12-07 Compuestos que inhiben las proteínas ras mutantes g12c UY38001A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762596331P 2017-12-08 2017-12-08
US201862678418P 2018-05-31 2018-05-31

Publications (1)

Publication Number Publication Date
UY38001A true UY38001A (es) 2019-05-31

Family

ID=64664739

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038001A UY38001A (es) 2017-12-08 2018-12-07 Compuestos que inhiben las proteínas ras mutantes g12c

Country Status (4)

Country Link
US (1) US10597405B2 (es)
TW (1) TW201938561A (es)
UY (1) UY38001A (es)
WO (1) WO2019110751A1 (es)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2863873T3 (es) 2016-05-18 2021-10-11 Mirati Therapeutics Inc Inhibidores de KRAS G12C
EP3710439B1 (en) 2017-11-15 2023-02-15 Mirati Therapeutics, Inc. Kras g12c inhibitors
US10647715B2 (en) 2017-11-15 2020-05-12 Mirati Therapeutics, Inc. KRas G12C inhibitors
TW202012415A (zh) 2018-05-08 2020-04-01 瑞典商阿斯特捷利康公司 化學化合物
EP3924053A1 (en) 2019-02-12 2021-12-22 Novartis AG Pharmaceutical combination comprising tno155 and a krasg12c inhibitor
CN113993860B (zh) * 2019-06-25 2023-08-01 正大天晴药业集团股份有限公司 作为kras g12c突变蛋白抑制剂的七元杂环类衍生物
CN112300196A (zh) * 2019-07-30 2021-02-02 上海凌达生物医药有限公司 一类哌啶稠环类化合物、制备方法和用途
CN112300173B (zh) * 2019-07-30 2021-10-01 上海凌达生物医药有限公司 一类含氮多环类化合物、制备方法和用途
US20220389029A1 (en) * 2019-09-20 2022-12-08 Shanghai Jemincare Pharmaceuticals Co., Ltd Fused pyridone compound, and preparation method therefor and use thereof
CN112574224A (zh) * 2019-09-30 2021-03-30 上海迪诺医药科技有限公司 Kras g12c抑制剂及其应用
CN112707905A (zh) * 2019-10-25 2021-04-27 武汉誉祥医药科技有限公司 一种三并杂环化合物及其制备方法和用途
IL292438A (en) 2019-10-28 2022-06-01 Merck Sharp & Dohme Small molecules that inhibit the g12c mutant of kras
CN115057872A (zh) * 2019-10-30 2022-09-16 劲方医药科技(上海)有限公司 取代的杂环并环类化合物，其制法与医药上的用途
CA3159559A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
TW202132314A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
JP2023505100A (ja) * 2019-11-27 2023-02-08 レボリューション メディシンズ インコーポレイテッド 共有ｒａｓ阻害剤及びその使用
WO2021150613A1 (en) * 2020-01-20 2021-07-29 Incyte Corporation Spiro compounds as inhibitors of kras
GB202001344D0 (en) 2020-01-31 2020-03-18 Redx Pharma Plc Ras Inhibitors
CN113321654B (zh) * 2020-02-28 2022-05-03 上海济煜医药科技有限公司 作为激酶抑制剂的稠合吡啶酮类化合物
AU2021248363B2 (en) 2020-04-03 2024-02-15 Medshine Discovery Inc. Octahydropyrazinodiazanaphthyridine dione compounds
CN113527299B (zh) * 2020-04-18 2023-12-29 上海凌达生物医药有限公司 一类含氮稠环类化合物、制备方法和用途
KR20230019101A (ko) * 2020-04-29 2023-02-07 상하이 린진 바이오파마 씨오., 엘티디. 벤조티아졸릴 비아릴 화합물, 제조 방법 및 용도
TW202202493A (zh) * 2020-05-06 2022-01-16 美商默沙東藥廠 Il4i1抑制劑及使用方法
US11739102B2 (en) 2020-05-13 2023-08-29 Incyte Corporation Fused pyrimidine compounds as KRAS inhibitors
TWI799871B (zh) * 2020-05-27 2023-04-21 大陸商勁方醫藥科技(上海)有限公司 三環并環類化合物，其製法與醫藥上的用途
TW202210633A (zh) 2020-06-05 2022-03-16 法商昂席歐公司 用於治療癌症之dbait分子與kras抑制劑的組合
CN115916194A (zh) 2020-06-18 2023-04-04 锐新医药公司 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
US20230295163A1 (en) * 2020-08-21 2023-09-21 Zhejiang Hisun Pharmaceutical Co., Ltd. Tetracyclic derivative, method for preparing same and use thereof in medicine
AU2021344830A1 (en) 2020-09-03 2023-04-06 Revolution Medicines, Inc. Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
KR20230067635A (ko) 2020-09-15 2023-05-16 레볼루션 메디슨즈, 인크. 암의 치료에서 ras 억제제로서 인돌 유도체
WO2022072783A1 (en) 2020-10-02 2022-04-07 Incyte Corporation Bicyclic dione compounds as inhibitors of kras
TW202233188A (zh) 2020-11-06 2022-09-01 大陸商泰勵生物科技（上海）有限公司 用於癌症治療的ｋｒａｓ抑制劑
US20230107642A1 (en) 2020-12-18 2023-04-06 Erasca, Inc. Tricyclic pyridones and pyrimidones
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN116670136A (zh) * 2020-12-31 2023-08-29 正大天晴药业集团股份有限公司 四环类化合物及其医药用途
WO2022161489A1 (zh) * 2021-02-01 2022-08-04 上海艾力斯医药科技股份有限公司 五并杂环类化合物、其制备方法及其应用
CN116964056A (zh) * 2021-03-25 2023-10-27 上海济煜医药科技有限公司 稠合吡啶酮类化合物盐型、晶型及其应用
CR20230570A (es) 2021-05-05 2024-01-22 Revolution Medicines Inc Inhibidores de ras
WO2022235870A1 (en) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Ras inhibitors for the treatment of cancer
WO2022266206A1 (en) 2021-06-16 2022-12-22 Erasca, Inc. Kras inhibitor conjugates
WO2022271658A1 (en) * 2021-06-23 2022-12-29 Erasca, Inc. Tricyclic kras inhibitors
TW202317100A (zh) 2021-06-23 2023-05-01 瑞士商諾華公司 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途
CN116249683A (zh) * 2021-07-06 2023-06-09 浙江海正药业股份有限公司 氘甲基取代吡嗪并吡嗪并喹啉酮类衍生物、其制备方法及其在医药上的应用
CA3226720A1 (en) * 2021-07-23 2023-01-26 Suzhou Zanrong Pharma Limited Kras g12d inhibitors and uses thereof
CN117677398A (zh) 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品
CA3224341A1 (en) 2021-09-01 2023-03-09 Novartis Ag Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
WO2023030517A1 (en) * 2021-09-06 2023-03-09 Suzhou Zanrong Pharma Limited Kras g12c inhibitors and uses thereof
WO2023041059A1 (zh) * 2021-09-18 2023-03-23 南京明德新药研发有限公司 八氢吡嗪并二氮杂萘啶二酮化合物及其晶型
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
CA3235146A1 (en) 2021-10-14 2023-04-20 Incyte Corporation Quinoline compounds as inhibitors of kras
TW202325298A (zh) * 2021-11-01 2023-07-01 大陸商江蘇恆瑞醫藥股份有限公司 含氮的四環化合物、其製備方法及其在醫藥上的應用
TW202340214A (zh) 2021-12-17 2023-10-16 美商健臻公司 做為shp2抑制劑之吡唑并吡𠯤化合物
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
WO2023183755A1 (en) * 2022-03-21 2023-09-28 Erasca, Inc. Tricyclic pyrimidones
CN114605409B (zh) * 2022-04-01 2024-04-02 苏州睿尔思科技有限公司 一种4-羟基-1,5-萘啶类配体的生产制备方法
WO2023199180A1 (en) 2022-04-11 2023-10-19 Novartis Ag Therapeutic uses of a krasg12c inhibitor
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
CN115784954A (zh) * 2022-07-15 2023-03-14 温州奥洋科技有限公司 一种不含肼结构的脂溶性金属离子钝化剂兼三聚乙二硫醇二甲醚的结构及其合成路线
CN115745854A (zh) * 2022-07-15 2023-03-07 浙江奥洋新材料有限公司 一种不含肼结构的脂溶性金属离子钝化剂三聚乙二硫醇二苄醚的结构及其合成路线
GB202212641D0 (en) 2022-08-31 2022-10-12 Jazz Pharmaceuticals Ireland Ltd Novel compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160076519A (ko) 2013-10-10 2016-06-30 아락세스 파마 엘엘씨 Kras g12c 억제제
WO2016049524A1 (en) * 2014-09-25 2016-03-31 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10428064B2 (en) * 2015-04-15 2019-10-01 Araxes Pharma Llc Fused-tricyclic inhibitors of KRAS and methods of use thereof
MX2018000777A (es) 2015-07-22 2018-03-23 Araxes Pharma Llc Compuestos de quinazolina sustituido y su uso como inhibidores de proteinas kras, hras y/o nras mutantes g12c.
US10882847B2 (en) * 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058768A1 (en) * 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10730867B2 (en) * 2015-09-28 2020-08-04 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
JP7015059B2 (ja) 2015-11-16 2022-02-15 アラクセス ファーマ エルエルシー 置換複素環式基を含む２－置換キナゾリン化合物およびその使用方法
ES2863873T3 (es) 2016-05-18 2021-10-11 Mirati Therapeutics Inc Inhibidores de KRAS G12C

Also Published As

Publication number Publication date
US10597405B2 (en) 2020-03-24
TW201938561A (zh) 2019-10-01
WO2019110751A1 (en) 2019-06-13
US20190177338A1 (en) 2019-06-13

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Effective date: 20231114