CO2019011546A2 - Compuestos y métodos para el tratamiento de enfermedades parasitarias - Google Patents

Compuestos y métodos para el tratamiento de enfermedades parasitarias

Info

Publication number
CO2019011546A2
CO2019011546A2 CONC2019/0011546A CO2019011546A CO2019011546A2 CO 2019011546 A2 CO2019011546 A2 CO 2019011546A2 CO 2019011546 A CO2019011546 A CO 2019011546A CO 2019011546 A2 CO2019011546 A2 CO 2019011546A2
Authority
CO
Colombia
Prior art keywords
treatment
compounds
methods
parasitic diseases
diseases
Prior art date
Application number
CONC2019/0011546A
Other languages
English (en)
Inventor
Eamon Comer
Nobutaka Kato
Marshall Morningstar
Bruno Melillo
Original Assignee
Broad Inst Inc
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Broad Inst Inc, Harvard College filed Critical Broad Inst Inc
Publication of CO2019011546A2 publication Critical patent/CO2019011546A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

COMPUESTOS Y MÉTODOS PARA EL TRATAMIENTO DE ENFERMEDADES PARASITARIAS RESUMEN En este documento se proporcionan compuestos útiles para el tratamiento de diversas enfermedades parasitarias. Estos compuestos, así como las sales farmacéuticamente aceptables de los mismos, pueden formularse en composiciones farmacéuticas o composiciones veterinarias, y pueden utilizarse en métodos de tratamiento y/o profilaxis de enfermedades propagadas por parásitos, incluyendo malaria y criptosporidiosis.
CONC2019/0011546A 2017-03-20 2019-10-17 Compuestos y métodos para el tratamiento de enfermedades parasitarias CO2019011546A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762473771P 2017-03-20 2017-03-20
PCT/US2018/023270 WO2018175385A1 (en) 2017-03-20 2018-03-20 Compounds and methods for the treatment of parasitic diseases

Publications (1)

Publication Number Publication Date
CO2019011546A2 true CO2019011546A2 (es) 2020-02-28

Family

ID=63586520

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0011546A CO2019011546A2 (es) 2017-03-20 2019-10-17 Compuestos y métodos para el tratamiento de enfermedades parasitarias

Country Status (17)

Country Link
US (2) US11174260B2 (es)
EP (1) EP3600286B1 (es)
JP (1) JP7306997B2 (es)
KR (1) KR20190129968A (es)
CN (1) CN110650738B (es)
AU (1) AU2018240031B2 (es)
BR (1) BR112019019494A2 (es)
CA (1) CA3057087A1 (es)
CO (1) CO2019011546A2 (es)
ES (1) ES2966369T3 (es)
IL (1) IL269390B (es)
MX (1) MX2019011271A (es)
MY (1) MY197171A (es)
PH (1) PH12019502150A1 (es)
SG (1) SG11201908691PA (es)
WO (1) WO2018175385A1 (es)
ZA (1) ZA201906213B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110650738B (zh) 2017-03-20 2023-05-09 博德研究所 用于治疗寄生虫病的化合物和方法
CN110168093B (zh) * 2017-09-12 2023-08-15 中科蓝华(广州)生物医药技术有限公司 一种转染细胞内寄生虫的试剂盒及其应用
WO2020041384A1 (en) * 2018-08-20 2020-02-27 The Broad Institute, Inc. 3-phenyl-2-cyano-azetidine derivatives, inhibitors of rna-guided nuclease activity
WO2020061167A1 (en) * 2018-09-18 2020-03-26 Washington University Treatment of infections of toxoplasma gondii and closely related parasites
JP2022516798A (ja) * 2019-01-09 2022-03-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 ジアザビシクロ［６．２．０］デカン関連化合物の合成のための方法
US20230009323A1 (en) * 2019-10-25 2023-01-12 The Broad Institute, Inc. Compounds and methods for the treatment of cryptosporidiosis
WO2022067060A1 (en) * 2020-09-24 2022-03-31 The Broad Institute, Inc. Apicomplexan parasite inhibition

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3176017A (en) * 1963-02-26 1965-03-30 American Home Prod Aroylalkyl derivatives of diazabicyclo-nonanes and-decanes
US3542780A (en) 1967-07-25 1970-11-24 American Home Prod 2-amidino-1,2,3,4-tetrahydropyrazine(1,2-a)indoles
US3531485A (en) 1967-08-14 1970-09-29 American Home Prod Aryl-substituted diazabicycloalkanes
RU2236413C2 (ru) 1998-07-14 2004-09-20 Байер Акциенгезельшафт Производные артемизинина, способ их получения, фармацевтическая композиция на их основе и способ лечения
UA77515C2 (en) 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
US7511159B2 (en) 2003-12-25 2009-03-31 Ono Pharmaceutical Co., Ltd. Azetidine ring compounds and drugs comprising the same
PT2925757T (pt) * 2012-11-19 2018-01-09 Novartis Ag Compostos e composições para o tratamento de doenças parasitárias
TR201809140T4 (tr) 2012-12-20 2018-07-23 Katholieke Univ Leuven K U Leuven R&D Terapötik olarak aktif pirazolo-pirimidin türevleri.
UY35772A (es) 2013-10-14 2015-05-29 Bayer Cropscience Ag Nuevos compuestos plaguicidas
GB2533536B (en) 2013-10-24 2021-05-19 Toyota Motor Co Ltd Cathode active material for sodium batteries, and sodium battery
WO2015070204A1 (en) 2013-11-11 2015-05-14 The Broad Institute, Inc. Compounds and methods for the treatment of malaria
US20160326157A1 (en) 2014-01-06 2016-11-10 President And Fellows Of Harvard College Monobactams and methods of their synthesis and use
AU2015236369B2 (en) 2014-03-24 2017-02-16 Novartis Ag Monobactam organic compounds for the treatment of bacterial infections
MY183209A (en) 2014-10-24 2021-02-18 Takeda Pharmaceuticals Co Heterocyclic compound
WO2016172631A2 (en) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
CN110650738B (zh) 2017-03-20 2023-05-09 博德研究所 用于治疗寄生虫病的化合物和方法
WO2020061167A1 (en) 2018-09-18 2020-03-26 Washington University Treatment of infections of toxoplasma gondii and closely related parasites
WO2020219610A1 (en) 2019-04-23 2020-10-29 Washington University Compounds and methods for the treatment of parasitic diseases

Also Published As

Publication number Publication date
US20200095253A1 (en) 2020-03-26
CN110650738A (zh) 2020-01-03
CA3057087A1 (en) 2018-09-27
CN110650738B (zh) 2023-05-09
ZA201906213B (en) 2022-03-30
JP2020514381A (ja) 2020-05-21
JP7306997B2 (ja) 2023-07-11
WO2018175385A1 (en) 2018-09-27
ES2966369T3 (es) 2024-04-22
PH12019502150A1 (en) 2020-07-06
US20220162211A1 (en) 2022-05-26
US11866441B2 (en) 2024-01-09
US11174260B2 (en) 2021-11-16
MY197171A (en) 2023-05-28
IL269390B (en) 2022-08-01
EP3600286B1 (en) 2023-08-16
EP3600286A1 (en) 2020-02-05
KR20190129968A (ko) 2019-11-20
EP3600286A4 (en) 2020-12-02
SG11201908691PA (en) 2019-10-30
RU2019132950A3 (es) 2021-06-29
BR112019019494A2 (pt) 2020-04-28
AU2018240031B2 (en) 2022-07-14
MX2019011271A (es) 2020-01-20
AU2018240031A1 (en) 2019-10-10
IL269390A (en) 2019-11-28
RU2019132950A (ru) 2021-04-21

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