UY36215A - Espirocicloheptanos como inhibidores de rock - Google Patents

Espirocicloheptanos como inhibidores de rock

Info

Publication number
UY36215A
UY36215A UY0001036215A UY36215A UY36215A UY 36215 A UY36215 A UY 36215A UY 0001036215 A UY0001036215 A UY 0001036215A UY 36215 A UY36215 A UY 36215A UY 36215 A UY36215 A UY 36215A
Authority
UY
Uruguay
Prior art keywords
disorders
compounds
rock inhibitors
espirocicloheptanos
present
Prior art date
Application number
UY0001036215A
Other languages
English (en)
Inventor
Ladziata Vladimir
Peter W Glunz
Hu Zilun
Wang Yufeng
Original Assignee
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Company Una Corporación Del Estado De Delaware filed Critical Bristol Myers Squibb Company Una Corporación Del Estado De Delaware
Publication of UY36215A publication Critical patent/UY36215A/es

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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

La presente invención proporciona compuestos de la Fórmula (I):o estereoisómeros, tautómeros o sales de aquellos aceptables desde el punto de vista farmacéutico, en donde todas las variables son como se definen en la presente. Estos compuestos son inhibidores de ROCK selectivos. La presente invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a métodos para tratar trastornos cardiovasculares, trastornos relacionados con el músculo liso, trastornos oncológicos, trastorno neuropatológicos, trastornos autoinmunitarios, trastornos fibróticos y/o trastornos inflamatorios mediante su uso.
UY0001036215A 2014-07-15 2015-07-14 Espirocicloheptanos como inhibidores de rock UY36215A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462024555P 2014-07-15 2014-07-15
US14/797,414 US9902702B2 (en) 2014-07-15 2015-07-13 Spirocycloheptanes as inhibitors of rock

Publications (1)

Publication Number Publication Date
UY36215A true UY36215A (es) 2016-01-29

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ID=55073996

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036215A UY36215A (es) 2014-07-15 2015-07-14 Espirocicloheptanos como inhibidores de rock

Country Status (24)

Country Link
US (2) US9902702B2 (es)
EP (1) EP3169682B1 (es)
JP (2) JP6499749B2 (es)
KR (1) KR102420938B1 (es)
CN (1) CN106817899B (es)
AR (1) AR101208A1 (es)
AU (1) AU2015289897B2 (es)
BR (1) BR112017000808A2 (es)
CA (1) CA2954976A1 (es)
CL (1) CL2017000089A1 (es)
CO (1) CO2017001152A2 (es)
EA (1) EA033061B1 (es)
ES (1) ES2716415T3 (es)
IL (1) IL250046B (es)
MA (1) MA39554B1 (es)
MX (1) MX2017000485A (es)
PE (1) PE20170672A1 (es)
PH (1) PH12017500072A1 (es)
SG (1) SG11201700251PA (es)
TN (1) TN2017000009A1 (es)
TW (1) TW201607933A (es)
UY (1) UY36215A (es)
WO (1) WO2016010950A1 (es)
ZA (1) ZA201700304B (es)

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KR102457933B1 (ko) 2016-05-27 2022-10-24 브리스톨-마이어스 스큅 컴퍼니 Rock의 억제제로서의 트리아졸론 및 테트라졸론
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