UY35972A - Inhibidores macrocíclicos de fxia que tienen grupos heterocíclicos - Google Patents
Inhibidores macrocíclicos de fxia que tienen grupos heterocíclicosInfo
- Publication number
- UY35972A UY35972A UY0001035972A UY35972A UY35972A UY 35972 A UY35972 A UY 35972A UY 0001035972 A UY0001035972 A UY 0001035972A UY 35972 A UY35972 A UY 35972A UY 35972 A UY35972 A UY 35972A
- Authority
- UY
- Uruguay
- Prior art keywords
- fxia
- heterocyclic groups
- compounds
- inhibitors
- macrocyclic inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Abstract
La presente invención proporciona compuestos de la Fórmula (Ia): o estereoisómeros, tautómeros o sales de aquellos aceptables desde el punto de vista farmacéutico, en donde todas las variables son como se definen en la presente. Estos compuestos son inhibidores selectivos del factor XIa o inhibidores duales de FXIa y calicreína plasmática. La pres ente invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos y a métodos para tratar trastornos tromboembólicos y/o inflamatorios mediante su uso.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461933948P | 2014-01-31 | 2014-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY35972A true UY35972A (es) | 2015-07-31 |
Family
ID=52484569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001035972A UY35972A (es) | 2014-01-31 | 2015-01-30 | Inhibidores macrocíclicos de fxia que tienen grupos heterocíclicos |
Country Status (23)
Country | Link |
---|---|
US (3) | US20170057961A1 (es) |
EP (1) | EP3099688B1 (es) |
JP (1) | JP6419836B2 (es) |
CN (1) | CN106459051B (es) |
AR (1) | AR099228A1 (es) |
BR (1) | BR112016016741B1 (es) |
CA (1) | CA2937738C (es) |
CY (1) | CY1120534T1 (es) |
DK (1) | DK3099688T3 (es) |
EA (1) | EA032650B1 (es) |
ES (1) | ES2655540T3 (es) |
HR (1) | HRP20172002T1 (es) |
HU (1) | HUE038060T2 (es) |
LT (1) | LT3099688T (es) |
MX (1) | MX2016009385A (es) |
NO (1) | NO2760821T3 (es) |
PL (1) | PL3099688T3 (es) |
PT (1) | PT3099688T (es) |
RS (1) | RS56785B1 (es) |
SI (1) | SI3099688T1 (es) |
TW (1) | TWI703144B (es) |
UY (1) | UY35972A (es) |
WO (1) | WO2015116882A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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LT2766346T (lt) | 2011-10-14 | 2017-06-12 | Bristol-Myers Squibb Company | Pakeistieji tetrahidroizochinolino junginiai, kaip faktoriaus xia inhibitoriai |
US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
NO2760821T3 (es) | 2014-01-31 | 2018-03-10 | ||
NZ723762A (en) | 2014-01-31 | 2023-03-31 | Bristol Myers Squibb Co | Macrocycles with hetrocyclic p2’ groups as factor xia inhibitors |
CN107074821B (zh) | 2014-09-04 | 2020-05-22 | 百时美施贵宝公司 | 为fxia抑制剂的二酰胺大环化合物 |
NO2721243T3 (es) * | 2014-10-01 | 2018-10-20 | ||
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
US10160750B2 (en) | 2015-06-19 | 2018-12-25 | Bristol-Myers Squibb Company | Diamide macrocycles as factor XIa inhibitors |
US10287288B2 (en) | 2015-07-29 | 2019-05-14 | Bristol-Myers Squibb | Factor XIa macrocyclic inhibitors bearing alkyl or cycloalkyl P2' moieties |
CN114805365A (zh) | 2015-07-29 | 2022-07-29 | 百时美施贵宝公司 | 携带非芳族p2,基团的因子xia新大环 |
KR20180073602A (ko) * | 2015-10-29 | 2018-07-02 | 머크 샤프 앤드 돔 코포레이션 | 인자 XIa 억제제 |
EP3371162B1 (en) | 2015-10-29 | 2022-01-26 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
JP2019507167A (ja) | 2016-03-02 | 2019-03-14 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 第xia因子阻害活性を有するジアミド大員環 |
US10143681B2 (en) | 2016-08-22 | 2018-12-04 | Merck Sharp & Dohme Corp. | Factor XIa inhibitors |
KR20190084310A (ko) | 2016-11-23 | 2019-07-16 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 살충제로서의 2-[3-(알킬술포닐)-2H-인다졸-2-일]-3H-이미다조[4,5-b]피리딘 유도체 및 유사한 화합물 |
US11083199B2 (en) | 2017-01-10 | 2021-08-10 | Bayer Aktiengesellschaft | Heterocycle derivatives as pesticides |
JP7101177B2 (ja) | 2017-01-10 | 2022-07-14 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としてのヘテロサイクレン誘導体 |
CN110062757B (zh) * | 2017-01-18 | 2022-03-04 | 广东东阳光药业有限公司 | 凝血因子XIa抑制剂及其用途 |
CN110922412A (zh) * | 2018-09-20 | 2020-03-27 | 复旦大学 | 具有抗精神病作用药物化合物的不对称合成方法 |
US20220204508A1 (en) * | 2019-04-16 | 2022-06-30 | Medshine Discovery Inc. | Macrocyclic derivatives acting as xia factor inhibitor |
WO2021013209A1 (zh) * | 2019-07-23 | 2021-01-28 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
WO2022222960A1 (zh) * | 2021-04-21 | 2022-10-27 | 上海美悦生物科技发展有限公司 | FXIa抑制剂及其药物组合物、制备方法和用途 |
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WO2015160636A1 (en) | 2014-04-16 | 2015-10-22 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
US9808445B2 (en) | 2014-04-16 | 2017-11-07 | Merck Sharp & Dohme Corp. | Factor IXa inhibitors |
KR20150136294A (ko) | 2014-05-27 | 2015-12-07 | 주식회사 레고켐 바이오사이언스 | 인자 XIa 억제 활성을 가지는 신규한 화합물 |
RU2016150410A (ru) | 2014-05-28 | 2018-06-28 | Мерк Шарп И Доум Корп. | Ингибиторы фактора xia |
EP3197891B1 (de) | 2014-09-24 | 2018-11-21 | Bayer Pharma Aktiengesellschaft | Faktor xia hemmende pyridobenzazepin- und pyridobenzazocin-derivate |
NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
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NZ733574A (en) | 2014-12-10 | 2024-03-22 | Ono Pharmaceutical Co | Dihydroindolizinone derivative |
US10160750B2 (en) | 2015-06-19 | 2018-12-25 | Bristol-Myers Squibb Company | Diamide macrocycles as factor XIa inhibitors |
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2012
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2015
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- 2015-01-30 HU HUE15705427A patent/HUE038060T2/hu unknown
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- 2015-01-30 ES ES15705427.1T patent/ES2655540T3/es active Active
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- 2015-01-30 US US15/115,319 patent/US20170057961A1/en not_active Abandoned
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PL3099688T3 (pl) | 2018-03-30 |
EA201691561A1 (ru) | 2017-01-30 |
PT3099688T (pt) | 2018-01-15 |
EP3099688B1 (en) | 2017-10-18 |
CA2937738C (en) | 2023-01-17 |
CY1120534T1 (el) | 2019-07-10 |
NO2760821T3 (es) | 2018-03-10 |
JP6419836B2 (ja) | 2018-11-07 |
US20170342071A1 (en) | 2017-11-30 |
CA2937738A1 (en) | 2015-08-06 |
EP3099688A1 (en) | 2016-12-07 |
TWI703144B (zh) | 2020-09-01 |
US10273236B2 (en) | 2019-04-30 |
BR112016016741B1 (pt) | 2023-01-17 |
TW201615640A (zh) | 2016-05-01 |
US20180222907A1 (en) | 2018-08-09 |
AR099228A1 (es) | 2016-07-06 |
RS56785B1 (sr) | 2018-04-30 |
BR112016016741A2 (es) | 2017-08-08 |
CN106459051A (zh) | 2017-02-22 |
JP2017504640A (ja) | 2017-02-09 |
MX2016009385A (es) | 2016-09-16 |
DK3099688T3 (en) | 2018-01-15 |
CN106459051B (zh) | 2018-10-16 |
LT3099688T (lt) | 2017-12-27 |
EA032650B1 (ru) | 2019-06-28 |
US20170057961A1 (en) | 2017-03-02 |
SI3099688T1 (sl) | 2017-12-29 |
WO2015116882A1 (en) | 2015-08-06 |
HRP20172002T1 (hr) | 2018-02-09 |
ES2655540T3 (es) | 2018-02-20 |
HUE038060T2 (hu) | 2018-09-28 |
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