RS56785B1 - Makrociklični inhibitori faktora xia kondenzovani sa heterociklusima - Google Patents

Makrociklični inhibitori faktora xia kondenzovani sa heterociklusima

Info

Publication number
RS56785B1
RS56785B1 RS20180033A RSP20180033A RS56785B1 RS 56785 B1 RS56785 B1 RS 56785B1 RS 20180033 A RS20180033 A RS 20180033A RS P20180033 A RSP20180033 A RS P20180033A RS 56785 B1 RS56785 B1 RS 56785B1
Authority
RS
Serbia
Prior art keywords
heterocycles
condensed
factor xia
xia inhibitors
macrocyclic
Prior art date
Application number
RS20180033A
Other languages
English (en)
Inventor
William R Ewing
Yufeng Wang
Andrew K Dilger
Tianan Fang
Donald J P Pinto
Ruth R Wexler
Yeheng Zhu
Kumar Balashanmuga Pabbisetty
Lucca Indawati De
Michael J Orwat
Ii Leon M Smith
James R Corte
Wu Yang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of RS56785B1 publication Critical patent/RS56785B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RS20180033A 2014-01-31 2015-01-30 Makrociklični inhibitori faktora xia kondenzovani sa heterociklusima RS56785B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461933948P 2014-01-31 2014-01-31
PCT/US2015/013647 WO2015116882A1 (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles
EP15705427.1A EP3099688B1 (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles

Publications (1)

Publication Number Publication Date
RS56785B1 true RS56785B1 (sr) 2018-04-30

Family

ID=52484569

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180033A RS56785B1 (sr) 2014-01-31 2015-01-30 Makrociklični inhibitori faktora xia kondenzovani sa heterociklusima

Country Status (23)

Country Link
US (3) US20170057961A1 (sr)
EP (1) EP3099688B1 (sr)
JP (1) JP6419836B2 (sr)
CN (1) CN106459051B (sr)
AR (1) AR099228A1 (sr)
BR (1) BR112016016741B1 (sr)
CA (1) CA2937738C (sr)
CY (1) CY1120534T1 (sr)
DK (1) DK3099688T3 (sr)
EA (1) EA032650B1 (sr)
ES (1) ES2655540T3 (sr)
HR (1) HRP20172002T1 (sr)
HU (1) HUE038060T2 (sr)
LT (1) LT3099688T (sr)
MX (1) MX2016009385A (sr)
NO (1) NO2760821T3 (sr)
PL (1) PL3099688T3 (sr)
PT (1) PT3099688T (sr)
RS (1) RS56785B1 (sr)
SI (1) SI3099688T1 (sr)
TW (1) TWI703144B (sr)
UY (1) UY35972A (sr)
WO (1) WO2015116882A1 (sr)

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WO2020211781A1 (zh) * 2019-04-16 2020-10-22 南京明德新药研发有限公司 作为XIa因子抑制剂的大环衍生物
CN114008047B (zh) * 2019-07-23 2023-03-21 南京明德新药研发有限公司 作为XIa因子抑制剂的大环衍生物
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CY1120534T1 (el) 2019-07-10
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