EA201691561A1 - Макроциклические ингибиторы фактора xia, конденсированные с гетероциклами - Google Patents

Макроциклические ингибиторы фактора xia, конденсированные с гетероциклами

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Publication number
EA201691561A1
EA201691561A1 EA201691561A EA201691561A EA201691561A1 EA 201691561 A1 EA201691561 A1 EA 201691561A1 EA 201691561 A EA201691561 A EA 201691561A EA 201691561 A EA201691561 A EA 201691561A EA 201691561 A1 EA201691561 A1 EA 201691561A1
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EA
Eurasian Patent Office
Prior art keywords
heterocycles
condensed
compounds
present
macrocyclic inhibitors
Prior art date
Application number
EA201691561A
Other languages
English (en)
Other versions
EA032650B1 (ru
Inventor
Эндрю К. Дилгер
Джеймс Р. Корте
Лукка Индавати Де
Тианан Фан
Ву Ян
Юфэн ВАН
Кумар Балашанмуга Паббисетти
Уильям Р. Эвинг
Ехэн Чжу
Рут Р. Векслер
Дональд Дж. П. Пинто
Майкл Дж. Орват
II Леон М. Смит
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201691561A1 publication Critical patent/EA201691561A1/ru
Publication of EA032650B1 publication Critical patent/EA032650B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (Ia)или их стереоизомерам, таутомерам или фармацевтически приемлемым солям, где все переменные определены в настоящем описании. Эти соединения представляют собой селективные ингибиторы фактора XIa или двойные ингибиторы FXIa и калликреина плазмы. Настоящее изобретение также относится к фармацевтическим композициям, содержащим указанные соединения, и к способам лечения тромбоэмболических и/или воспалительных заболеваний с их использованием.
EA201691561A 2014-01-31 2015-01-30 Макроциклические ингибиторы фактора xia, конденсированные с гетероциклами EA032650B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461933948P 2014-01-31 2014-01-31
PCT/US2015/013647 WO2015116882A1 (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles

Publications (2)

Publication Number Publication Date
EA201691561A1 true EA201691561A1 (ru) 2017-01-30
EA032650B1 EA032650B1 (ru) 2019-06-28

Family

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Country Status (23)

Country Link
US (3) US20170057961A1 (ru)
EP (1) EP3099688B1 (ru)
JP (1) JP6419836B2 (ru)
CN (1) CN106459051B (ru)
AR (1) AR099228A1 (ru)
BR (1) BR112016016741B1 (ru)
CA (1) CA2937738C (ru)
CY (1) CY1120534T1 (ru)
DK (1) DK3099688T3 (ru)
EA (1) EA032650B1 (ru)
ES (1) ES2655540T3 (ru)
HR (1) HRP20172002T1 (ru)
HU (1) HUE038060T2 (ru)
LT (1) LT3099688T (ru)
MX (1) MX2016009385A (ru)
NO (1) NO2760821T3 (ru)
PL (1) PL3099688T3 (ru)
PT (1) PT3099688T (ru)
RS (1) RS56785B1 (ru)
SI (1) SI3099688T1 (ru)
TW (1) TWI703144B (ru)
UY (1) UY35972A (ru)
WO (1) WO2015116882A1 (ru)

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KR102709654B1 (ko) * 2019-04-16 2024-09-26 차이나 리소어시즈 바이오파마슈티컬 컴퍼니 리미티드 XIa 인자 억제제로서의 거대고리 유도체
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AR099228A1 (es) 2016-07-06
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