TR200101903T2 - Yeni malonik asit türevleri, bunların preparasyon işlemleri. - Google Patents
Yeni malonik asit türevleri, bunların preparasyon işlemleri.Info
- Publication number
- TR200101903T2 TR200101903T2 TR2001/01903T TR200101903T TR200101903T2 TR 200101903 T2 TR200101903 T2 TR 200101903T2 TR 2001/01903 T TR2001/01903 T TR 2001/01903T TR 200101903 T TR200101903 T TR 200101903T TR 200101903 T2 TR200101903 T2 TR 200101903T2
- Authority
- TR
- Turkey
- Prior art keywords
- compounds
- formula
- acid derivatives
- malonic acid
- prevention
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
Abstract
Mevcut bulus, kan pihtilastirma proteinlerinin önlenmesine yönelik yeni bilesiklerle ve daha özel olarak R(1), R(2), R(3), R(4), R(5) ve R(6)'nin istemlerden belirtilen anlamlara geldigi formül (I)'e ait malonik asit türevleriyle ilgilidir. Formül (I)'e ait bilesikler, kan pihtilastirici enzim faktör Xa'nin önleyicileridir. Bulus, formül (I)'e ait bilesiklerin preparasyon islemleriyle, faktör Xa aktivitesinin önlenmesine ve kan pihtilasmasinin önlenmesine yönelik metotlar, tromboembolik hastaliklar gibi faktör Xa aktivitesinin önlenmesiyle tedavi edilebilen veya engellenebilen hastaliklarin tedavisinde ve profilaksisinde formül (I)'e ait bilesiklerin kullanilmasiyla, ve formül (I)'e ait bilesiklerin, bu hastaliklarda uygulanabilecek ilaçlarin preparasyonunda kullanilmasiyla da ilgilidir
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100002A EP1016663A1 (en) | 1999-01-02 | 1999-01-02 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
EP99119537 | 1999-10-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200101903T2 true TR200101903T2 (tr) | 2001-11-21 |
Family
ID=26152843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/01903T TR200101903T2 (tr) | 1999-01-02 | 1999-12-23 | Yeni malonik asit türevleri, bunların preparasyon işlemleri. |
Country Status (17)
Country | Link |
---|---|
US (1) | US6395737B1 (tr) |
EP (1) | EP1140878A1 (tr) |
JP (1) | JP2002534420A (tr) |
KR (1) | KR20010101355A (tr) |
CN (1) | CN1332734A (tr) |
AU (1) | AU3043100A (tr) |
BR (1) | BR9916732A (tr) |
CA (1) | CA2358578A1 (tr) |
CZ (1) | CZ20012379A3 (tr) |
HK (1) | HK1041700A1 (tr) |
HU (1) | HUP0105437A3 (tr) |
ID (1) | ID29979A (tr) |
IL (1) | IL144096A0 (tr) |
NO (1) | NO20012983D0 (tr) |
PL (1) | PL349343A1 (tr) |
TR (1) | TR200101903T2 (tr) |
WO (1) | WO2000040571A1 (tr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2239478T3 (es) | 1999-01-02 | 2005-09-16 | Aventis Pharma Deutschland Gmbh | Derivados de arilalcanoilo, procedimientos para su preparacion, su uso y composiciones farmaceuticas que los contienen. |
EP1127884A1 (en) * | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them |
FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
JP4744149B2 (ja) | 2002-12-03 | 2011-08-10 | ファーマサイクリックス インコーポレイテッド | 第viia因子阻害剤としての2−(2−ヒドロキシビフェニル−3−イル)−1h−ベンゾイミダゾール−5−カルボキサミジン誘導体 |
US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
CN105949358A (zh) | 2010-10-20 | 2016-09-21 | 瑟拉斯公司 | 基本不含杂质的亚甲基丙二酸酯的合成 |
US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
EP2899183B1 (en) | 2011-10-14 | 2018-09-19 | Bristol-Myers Squibb Company | Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors |
IN2014CN02805A (tr) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
AR088456A1 (es) | 2011-10-14 | 2014-06-11 | Bristol Myers Squibb Co | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor xia |
CA2853079A1 (en) | 2011-10-19 | 2013-05-10 | Bioformix Inc. | Methylene beta-ketoester monomers, methods for making methylene beta-ketoester monomers, polymerizable compositions and products formed therefrom |
EP3848402A1 (en) | 2012-03-30 | 2021-07-14 | Sirrus, Inc. | Ink and coating formulations and polymerizable systems for producing the same |
WO2013149165A1 (en) | 2012-03-30 | 2013-10-03 | Bioformix Inc. | Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby |
EP3153530B1 (en) | 2012-03-30 | 2021-02-24 | Sirrus, Inc. | Composite and laminate articles and polymerizable systems for producing the same |
WO2013181600A2 (en) | 2012-06-01 | 2013-12-05 | Bioformix Inc. | Optical material and articles formed therefrom |
EP2906541B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
US9920034B2 (en) | 2012-10-12 | 2018-03-20 | Bristol-Myers Squibb Company | Crystalline forms of a factor XIa inhibitor |
WO2014059202A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
EP2920231B1 (en) | 2012-11-16 | 2020-05-06 | Sirrus, Inc. | Plastics bonding systems and methods |
CN105164797B (zh) | 2012-11-30 | 2019-04-19 | 瑟拉斯公司 | 用于电子应用的复合组合物 |
EP2943462B1 (en) | 2013-01-11 | 2018-06-27 | Sirrus, Inc. | Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway |
WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
NO2760821T3 (tr) | 2014-01-31 | 2018-03-10 | ||
US9777001B2 (en) | 2014-01-31 | 2017-10-03 | Bristol-Myers Squibb Company | Macrocycles with aromatic P2′ groups as factor xia inhibitors |
EP3164406A4 (en) | 2014-07-01 | 2018-04-04 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Fxia阻害剤であるジアミドマクロ環 |
US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE242404C (tr) | ||||
DE235866C (tr) | ||||
US4504492A (en) * | 1981-09-25 | 1985-03-12 | Burroughs Wellcome Co. | Pharmaceutical amides, and preparation, formulations and use thereof |
EP0511347A1 (de) | 1990-11-15 | 1992-11-04 | Pentapharm A.G. | Meta-substituierte phenylalanin-derivate |
IT1254883B (it) * | 1992-04-16 | 1995-10-11 | Italfarmaco Spa | Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva. |
JPH07509731A (ja) | 1993-02-10 | 1995-10-26 | ペンタファルム アクチェンゲゼルシャフト | トロンビン阻害剤としての置換されたフェニルアラニン誘導体のピペラジド |
US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
EP0758341B1 (en) * | 1994-04-26 | 2004-03-24 | Aventis Pharmaceuticals, Inc. | FACTOR Xa INHIBITORS |
AU3107795A (en) * | 1994-08-09 | 1996-03-07 | Pentapharm Ag | Inhibitors of the benzamidine type |
GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
CZ295362B6 (cs) * | 1995-12-20 | 2005-07-13 | Aventis Pharmaceuticals Inc. | Způsob přípravy N-acetyl-(L)-4-kyanofenylalaninu Ac-(L)-Phe(4-CN)-OH a N-acetyl-(L)-p-amidinofenylalanincyklohexylglycin-beta-(3-N-methylpyridinium)-alaninu Ac-(L)-pAph-Chg-PalMe(3)-NH2 |
PT979240E (pt) | 1997-05-02 | 2004-08-31 | Akzo Nobel Nv | Inibidores de serina-protease |
SI1042287T1 (en) | 1997-12-24 | 2005-10-31 | Aventis Pharma Deutschland Gmbh | Indole derivatives as inhibitors of factor xa |
EP1016663A1 (en) | 1999-01-02 | 2000-07-05 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
-
1999
- 1999-12-23 WO PCT/EP1999/010340 patent/WO2000040571A1/en not_active Application Discontinuation
- 1999-12-23 IL IL14409699A patent/IL144096A0/xx unknown
- 1999-12-23 ID IDW00200101430A patent/ID29979A/id unknown
- 1999-12-23 BR BR9916732-8A patent/BR9916732A/pt not_active IP Right Cessation
- 1999-12-23 KR KR1020017008429A patent/KR20010101355A/ko not_active Application Discontinuation
- 1999-12-23 PL PL99349343A patent/PL349343A1/xx not_active Application Discontinuation
- 1999-12-23 HU HU0105437A patent/HUP0105437A3/hu unknown
- 1999-12-23 TR TR2001/01903T patent/TR200101903T2/tr unknown
- 1999-12-23 CA CA002358578A patent/CA2358578A1/en not_active Abandoned
- 1999-12-23 CZ CZ20012379A patent/CZ20012379A3/cs unknown
- 1999-12-23 EP EP99964667A patent/EP1140878A1/en not_active Withdrawn
- 1999-12-23 JP JP2000592279A patent/JP2002534420A/ja not_active Abandoned
- 1999-12-23 AU AU30431/00A patent/AU3043100A/en not_active Abandoned
- 1999-12-23 CN CN99815372A patent/CN1332734A/zh active Pending
- 1999-12-28 US US09/473,053 patent/US6395737B1/en not_active Expired - Lifetime
-
2001
- 2001-06-15 NO NO20012983A patent/NO20012983D0/no not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103402.4A patent/HK1041700A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU3043100A (en) | 2000-07-24 |
JP2002534420A (ja) | 2002-10-15 |
ID29979A (id) | 2001-10-25 |
KR20010101355A (ko) | 2001-11-14 |
BR9916732A (pt) | 2001-09-25 |
NO20012983L (no) | 2001-06-15 |
CA2358578A1 (en) | 2000-07-13 |
CZ20012379A3 (cs) | 2001-09-12 |
IL144096A0 (en) | 2002-05-23 |
EP1140878A1 (en) | 2001-10-10 |
NO20012983D0 (no) | 2001-06-15 |
HK1041700A1 (zh) | 2002-07-19 |
HUP0105437A3 (en) | 2003-03-28 |
WO2000040571A1 (en) | 2000-07-13 |
PL349343A1 (en) | 2002-07-15 |
CN1332734A (zh) | 2002-01-23 |
HUP0105437A2 (hu) | 2002-05-29 |
US6395737B1 (en) | 2002-05-28 |
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