BR9916732A - Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa) - Google Patents
Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa)Info
- Publication number
- BR9916732A BR9916732A BR9916732-8A BR9916732A BR9916732A BR 9916732 A BR9916732 A BR 9916732A BR 9916732 A BR9916732 A BR 9916732A BR 9916732 A BR9916732 A BR 9916732A
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- factor
- inhibition
- activity
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
Abstract
Patente de Invenção: <B>"DERIVADOS DE áCIDO MALÈNICO, PROCESSO PARA A SUA PREPARAçãO, SEU USO E COMPOSIçõES FARMACêUTICAS CONTENDO-OS (INIBIçãO DA ATIVIDADE DO FATOR XA)"<D>. A presente invenção refere-se a novos compostos para a inibição de proteínas de coagulação do sangue, e mais particularmente, a derivados de ácido malónico da fórmula (I), em que R(1), R(2), R(3), R(4), R(5) e R(6) têm os significados indicados nas reivindicações. Os compostos de fórmula I são inibidores do fator Xa da enzima de coagulação do sangue. A invenção também refere-se a processos para a preparação dos compostos de fórmula I, a métodos de inibição da atividade do fator Xa e de inibição da coagulação do sangue, ao uso dos compostos de fórmula I no tratamento e profilaxia de doenças, que podem ser tratadas ou prevenidas pela inibição da atividade do fator Xa tais como doenças tromboembólicas, e ao uso dos compostos de fórmula I na preparação de medicamentos a serem aplicados em tais doenças. A invenção ainda refere-se a composições contendo um composto de fórmula I em mistura ou de outro modo em associação com um veículo inerte, em particular composições farmacêuticas contendo um composto de fórmula I juntamente com substâncias veículose substâncias auxiliares farmaceuticamente aceitáveis.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100002A EP1016663A1 (en) | 1999-01-02 | 1999-01-02 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
EP99119537 | 1999-10-01 | ||
PCT/EP1999/010340 WO2000040571A1 (en) | 1999-01-02 | 1999-12-23 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9916732A true BR9916732A (pt) | 2001-09-25 |
Family
ID=26152843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9916732-8A BR9916732A (pt) | 1999-01-02 | 1999-12-23 | Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa) |
Country Status (17)
Country | Link |
---|---|
US (1) | US6395737B1 (pt) |
EP (1) | EP1140878A1 (pt) |
JP (1) | JP2002534420A (pt) |
KR (1) | KR20010101355A (pt) |
CN (1) | CN1332734A (pt) |
AU (1) | AU3043100A (pt) |
BR (1) | BR9916732A (pt) |
CA (1) | CA2358578A1 (pt) |
CZ (1) | CZ20012379A3 (pt) |
HK (1) | HK1041700A1 (pt) |
HU (1) | HUP0105437A3 (pt) |
ID (1) | ID29979A (pt) |
IL (1) | IL144096A0 (pt) |
NO (1) | NO20012983D0 (pt) |
PL (1) | PL349343A1 (pt) |
TR (1) | TR200101903T2 (pt) |
WO (1) | WO2000040571A1 (pt) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL144095A0 (en) | 1999-01-02 | 2002-05-23 | Aventis Pharma Gmbh | Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them |
EP1127884A1 (en) | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them |
FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
WO2004050637A2 (en) | 2002-12-03 | 2004-06-17 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
JP2014503474A (ja) | 2010-10-20 | 2014-02-13 | バイオフオーミツクス・インコーポレイテツド | エネルギー移動手段の存在下での急速回収を用いたメチレンマロナートの合成 |
ES2699226T3 (es) | 2011-10-14 | 2019-02-08 | Bristol Myers Squibb Co | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa |
HUE034857T2 (en) | 2011-10-14 | 2018-03-28 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds are inhibitors of factor XIA |
ES2579832T3 (es) | 2011-10-14 | 2016-08-17 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa |
JP6267643B2 (ja) | 2011-10-19 | 2018-01-24 | シラス・インコーポレイテッド | 多官能性モノマー、多官能性モノマーを製造する方法、これらから形成された重合性組成物および製品 |
JP6188252B2 (ja) | 2012-03-30 | 2017-08-30 | シラス・インコーポレイテッド | 重合性組成物の活性化方法、重合系およびこれにより形成される製品 |
US9234107B2 (en) | 2012-03-30 | 2016-01-12 | Sirrus, Inc. | Ink coating formulations and polymerizable systems for producing the same |
JP6553505B2 (ja) | 2012-03-30 | 2019-07-31 | シラス・インコーポレイテッド | 複合材およびラミネート物品ならびにこれらを作製するための重合系 |
US10047192B2 (en) | 2012-06-01 | 2018-08-14 | Sirrus, Inc. | Optical material and articles formed therefrom |
TR201807316T4 (tr) | 2012-10-12 | 2018-06-21 | Squibb Bristol Myers Co | Bir faktör XIa inhibitörünün kristalli formları. |
EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
EP2906541B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
WO2014078689A1 (en) | 2012-11-16 | 2014-05-22 | Bioformix Inc. | Plastics bonding systems and methods |
WO2014085570A1 (en) | 2012-11-30 | 2014-06-05 | Bioformix, Inc. | Composite compositions for electronics applications |
EP2943462B1 (en) | 2013-01-11 | 2018-06-27 | Sirrus, Inc. | Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway |
ES2712699T3 (es) | 2013-03-25 | 2019-05-14 | Bristol Myers Squibb Co | Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa |
MY190429A (en) | 2014-01-31 | 2022-04-21 | Bristol Myers Squibb Co | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
NO2760821T3 (pt) | 2014-01-31 | 2018-03-10 | ||
AU2015284307A1 (en) | 2014-07-01 | 2017-02-02 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Fxia阻害剤であるジアミドマクロ環 |
US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE235866C (pt) | ||||
DE242404C (pt) | ||||
DE3269422D1 (en) * | 1981-09-25 | 1986-04-03 | Wellcome Found | Pharmaceutical amides, and preparation, formulations and use thereof |
WO1992008709A1 (de) * | 1990-11-15 | 1992-05-29 | Pentapharm Ag | Meta-substituierte phenylalanin-derivate |
IT1254883B (it) * | 1992-04-16 | 1995-10-11 | Italfarmaco Spa | Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva. |
JPH07509731A (ja) * | 1993-02-10 | 1995-10-26 | ペンタファルム アクチェンゲゼルシャフト | トロンビン阻害剤としての置換されたフェニルアラニン誘導体のピペラジド |
US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
AU707653B2 (en) * | 1994-04-26 | 1999-07-15 | Selectide Corporation | Factor Xa inhibitors |
WO1996005189A1 (de) * | 1994-08-09 | 1996-02-22 | Pentapharm Ag | Neue inhibitoren vom benzamidintyp |
GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
DK0868526T3 (da) * | 1995-12-20 | 2002-12-02 | Aventis Pharma Inc | Fremgangsmåde til fremstilling af N-acetyl(L)-4-cyanophenylalanin Ac-(L)-Phe(4-CN)-OH og N-acetyl-(L)-p-amidinophenylalanincyclohexylglycin-beta-(3-N-methylpyridinium)-alanin Ac-(L)-pAph-Chg-PalMe(3)-NH2 |
BR9809342A (pt) | 1997-05-02 | 2000-07-04 | Akzo Nobel Nv | Composto, composição farmacêutica, e, uso do composto |
DE69829879T2 (de) | 1997-12-24 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Indolderivate als faktor xa inhibitoren |
EP1016663A1 (en) | 1999-01-02 | 2000-07-05 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
-
1999
- 1999-12-23 WO PCT/EP1999/010340 patent/WO2000040571A1/en not_active Application Discontinuation
- 1999-12-23 HU HU0105437A patent/HUP0105437A3/hu unknown
- 1999-12-23 CZ CZ20012379A patent/CZ20012379A3/cs unknown
- 1999-12-23 IL IL14409699A patent/IL144096A0/xx unknown
- 1999-12-23 ID IDW00200101430A patent/ID29979A/id unknown
- 1999-12-23 KR KR1020017008429A patent/KR20010101355A/ko not_active Application Discontinuation
- 1999-12-23 AU AU30431/00A patent/AU3043100A/en not_active Abandoned
- 1999-12-23 TR TR2001/01903T patent/TR200101903T2/xx unknown
- 1999-12-23 JP JP2000592279A patent/JP2002534420A/ja not_active Abandoned
- 1999-12-23 EP EP99964667A patent/EP1140878A1/en not_active Withdrawn
- 1999-12-23 CN CN99815372A patent/CN1332734A/zh active Pending
- 1999-12-23 PL PL99349343A patent/PL349343A1/xx not_active Application Discontinuation
- 1999-12-23 CA CA002358578A patent/CA2358578A1/en not_active Abandoned
- 1999-12-23 BR BR9916732-8A patent/BR9916732A/pt not_active IP Right Cessation
- 1999-12-28 US US09/473,053 patent/US6395737B1/en not_active Expired - Lifetime
-
2001
- 2001-06-15 NO NO20012983A patent/NO20012983D0/no not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103402.4A patent/HK1041700A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2000040571A1 (en) | 2000-07-13 |
TR200101903T2 (tr) | 2001-11-21 |
HK1041700A1 (zh) | 2002-07-19 |
NO20012983L (no) | 2001-06-15 |
CN1332734A (zh) | 2002-01-23 |
KR20010101355A (ko) | 2001-11-14 |
US6395737B1 (en) | 2002-05-28 |
NO20012983D0 (no) | 2001-06-15 |
EP1140878A1 (en) | 2001-10-10 |
HUP0105437A3 (en) | 2003-03-28 |
PL349343A1 (en) | 2002-07-15 |
JP2002534420A (ja) | 2002-10-15 |
CZ20012379A3 (cs) | 2001-09-12 |
CA2358578A1 (en) | 2000-07-13 |
HUP0105437A2 (hu) | 2002-05-29 |
IL144096A0 (en) | 2002-05-23 |
AU3043100A (en) | 2000-07-24 |
ID29979A (id) | 2001-10-25 |
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Legal Events
Date | Code | Title | Description |
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FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11N | Dismissal: publication cancelled [chapter 11.14 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O, 6O E 7O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |