BR0316234A - Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos - Google Patents

Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos

Info

Publication number
BR0316234A
BR0316234A BR0316234-6A BR0316234A BR0316234A BR 0316234 A BR0316234 A BR 0316234A BR 0316234 A BR0316234 A BR 0316234A BR 0316234 A BR0316234 A BR 0316234A
Authority
BR
Brazil
Prior art keywords
phosphodiesterase
inhibitors
processes
preparation
compounds
Prior art date
Application number
BR0316234-6A
Other languages
English (en)
Inventor
Norbert H Fgen
Hildegard Kuss
Ute Egerland
Chris Rundfeldt
Helge Hartenhauer
Antje Gasparic
Original Assignee
Elbion Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elbion Ag filed Critical Elbion Ag
Publication of BR0316234A publication Critical patent/BR0316234A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"HIDROXIINDóIS, SEU USO COMO INIBIDORES DE FOSFODIESTERASE 4 E PROCESSOS PARA A PREPARAçãO DOS MESMOS". A presente invenção refere-se a 4- e/ou 7-hidroxiindóis substituídos, a processos para a preparação dos mesmos, a preparações farmacêuticas as quais compreendem esses compostos e ao uso farmacêutico desses compostos, os quais são inibidores de fosfodiesterase 4, como compostos ativos para o tratamento de doenças as quais podem ser influenciadas pelo uso dos compostos de acordo com a invenção para inibir a atividade da fosfodiesterase 4 em células imunocompetentes (por exemplo, macrófagos e linfócitos).
BR0316234-6A 2002-11-15 2003-11-14 Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos BR0316234A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10253426A DE10253426B4 (de) 2002-11-15 2002-11-15 Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
PCT/EP2003/012742 WO2004045607A1 (de) 2002-11-15 2003-11-14 Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
BR0316234A true BR0316234A (pt) 2005-10-11

Family

ID=32240098

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316234-6A BR0316234A (pt) 2002-11-15 2003-11-14 Hidroxiindóis, seu uso como inibidores de fosfodiesterase 4 e processos para a preparação dos mesmos

Country Status (19)

Country Link
US (2) US7166637B2 (pt)
EP (1) EP1562584A1 (pt)
JP (1) JP2006508141A (pt)
KR (1) KR20050075014A (pt)
CN (1) CN1711082A (pt)
AR (1) AR042053A1 (pt)
AU (1) AU2003283400A1 (pt)
BR (1) BR0316234A (pt)
CA (1) CA2505988A1 (pt)
DE (1) DE10253426B4 (pt)
HR (1) HRP20050542A2 (pt)
MX (1) MXPA05005138A (pt)
NO (1) NO20052864L (pt)
PL (1) PL376524A1 (pt)
RU (1) RU2005118409A (pt)
TW (1) TW200510306A (pt)
UA (1) UA80567C2 (pt)
WO (1) WO2004045607A1 (pt)
ZA (2) ZA200503399B (pt)

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Also Published As

Publication number Publication date
NO20052864L (no) 2005-06-13
EP1562584A1 (de) 2005-08-17
AR042053A1 (es) 2005-06-08
US20070093531A1 (en) 2007-04-26
US7166637B2 (en) 2007-01-23
ZA200507002B (en) 2006-06-28
WO2004045607A1 (de) 2004-06-03
AU2003283400A1 (en) 2004-06-15
MXPA05005138A (es) 2005-07-22
KR20050075014A (ko) 2005-07-19
TW200510306A (en) 2005-03-16
PL376524A1 (pl) 2006-01-09
DE10253426B4 (de) 2005-09-22
DE10253426A1 (de) 2004-06-03
CN1711082A (zh) 2005-12-21
HRP20050542A2 (en) 2005-08-31
CA2505988A1 (en) 2004-06-03
UA80567C2 (en) 2007-10-10
RU2005118409A (ru) 2006-01-20
ZA200503399B (en) 2006-06-28
JP2006508141A (ja) 2006-03-09
US20040147759A1 (en) 2004-07-29

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