EP2185560A4 - Heteroaryl amide analogues - Google Patents

Heteroaryl amide analogues

Info

Publication number
EP2185560A4
EP2185560A4 EP08797591A EP08797591A EP2185560A4 EP 2185560 A4 EP2185560 A4 EP 2185560A4 EP 08797591 A EP08797591 A EP 08797591A EP 08797591 A EP08797591 A EP 08797591A EP 2185560 A4 EP2185560 A4 EP 2185560A4
Authority
EP
European Patent Office
Prior art keywords
heteroaryl amide
amide analogues
analogues
heteroaryl
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08797591A
Other languages
German (de)
French (fr)
Other versions
EP2185560A1 (en
Inventor
Rajagopal Bakthavatchalam
David C Ihle
Scott M Capitosti
David J Wustrow
Jun Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of EP2185560A1 publication Critical patent/EP2185560A1/en
Publication of EP2185560A4 publication Critical patent/EP2185560A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
EP08797591A 2007-08-10 2008-08-11 Heteroaryl amide analogues Withdrawn EP2185560A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95525007P 2007-08-10 2007-08-10
PCT/US2008/072760 WO2009023623A1 (en) 2007-08-10 2008-08-11 Heteroaryl amide analogues

Publications (2)

Publication Number Publication Date
EP2185560A1 EP2185560A1 (en) 2010-05-19
EP2185560A4 true EP2185560A4 (en) 2011-10-05

Family

ID=40351102

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08797591A Withdrawn EP2185560A4 (en) 2007-08-10 2008-08-11 Heteroaryl amide analogues

Country Status (14)

Country Link
EP (1) EP2185560A4 (en)
JP (2) JP2010535816A (en)
KR (1) KR20100066422A (en)
CN (1) CN101778850A (en)
AU (1) AU2008286946B2 (en)
BR (1) BRPI0812594A2 (en)
CA (1) CA2691512A1 (en)
CO (1) CO6251319A2 (en)
EA (1) EA020332B1 (en)
IL (1) IL202550A0 (en)
NZ (1) NZ582056A (en)
SG (1) SG183699A1 (en)
UA (1) UA99729C2 (en)
WO (1) WO2009023623A1 (en)

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WO2012110190A1 (en) * 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
PL2707101T3 (en) * 2011-05-12 2019-10-31 Proteostasis Therapeutics Inc Proteostasis regulators
WO2012163792A1 (en) * 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) * 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2013014587A1 (en) 2011-07-22 2013-01-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
TWI576347B (en) * 2012-01-20 2017-04-01 艾克泰聯製藥有限公司 Heterocyclic amide derivatives as p2x7 receptor antagonists
JOP20130213B1 (en) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co 5-ht3 receptor antagonists
SG11201504369SA (en) * 2012-12-12 2015-07-30 Actelion Pharmaceuticals Ltd Indole carboxamide derivatives as p2x7 receptor antagonists
KR102232744B1 (en) * 2012-12-18 2021-03-26 이도르시아 파마슈티컬스 리미티드 Indole carboxamide derivatives as p2x7 receptor antagonists
KR102220847B1 (en) * 2013-01-22 2021-02-26 이도르시아 파마슈티컬스 리미티드 Heterocyclic amide derivatives as p2x7 receptor antagonists
EP2956135B1 (en) 2013-01-22 2016-11-16 Actelion Pharmaceuticals Ltd. Heterocyclic amide derivatives as p2x7 receptor antagonists
ES2638850T3 (en) 2013-02-19 2017-10-24 Pfizer Inc. Azabenzimidazole compounds as inhibitors of PDE4 isoenzymes for the treatment of CNS disorders and other disorders
US9604982B2 (en) 2013-03-14 2017-03-28 Janssen Pharmaceutica Nv P2X7 modulators
TWI644671B (en) * 2013-03-14 2018-12-21 比利時商健生藥品公司 P2x7 modulators
JP6467404B2 (en) 2013-03-14 2019-02-13 ヤンセン ファーマシューティカ エヌ．ベー． P2X7 modulator
JO3509B1 (en) 2013-03-14 2020-07-05 Janssen Pharmaceutica Nv P2x7 modulators
ES2644025T3 (en) * 2013-07-17 2017-11-27 Global Alliance For Tb Drug Development Azaindole compounds, synthesis thereof, and methods of use thereof
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
SG11201700243YA (en) 2014-08-06 2017-02-27 Pfizer Imidazopyridazine compounds
CA2960968A1 (en) 2014-09-12 2016-03-17 Janssen Pharmaceutica Nv P2x7 modulators
CN106795172B (en) 2014-09-29 2020-07-28 武田药品工业株式会社 Crystalline forms of 1- (1-methyl-1H-pyrazol-4-yl) -N- ((1R,5S,7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] non-7-yl) -1H-indole-3-carboxamide
EP3233841A1 (en) 2014-12-15 2017-10-25 Merck Patent GmbH Indole and azaindoles derivatives and their use in neurodegenerative diseases
JP6462493B2 (en) 2015-05-29 2019-01-30 株式会社デンソー Approach determination device, approach determination method
CA3010615C (en) 2016-01-14 2024-02-20 Beth Israel Deaconess Medical Center, Inc. Mast-cell modulators and uses thereof
TW201819361A (en) 2016-09-03 2018-06-01 印度商托仁特生技有限公司 Novel indazole compounds
US20200102303A1 (en) 2018-09-28 2020-04-02 Janssen Pharmaceutica Nv Monoacylglycerol Lipase Modulators
BR112021005936A2 (en) 2018-09-28 2021-06-29 Janssen Pharmaceutica Nv monoacylglycerol lipase modulators
US11839663B2 (en) 2019-09-30 2023-12-12 Janssen Pharmaceutica Nv Radiolabelled MGL pet ligands
US11891387B2 (en) 2020-03-26 2024-02-06 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
CN116323581A (en) * 2020-09-22 2023-06-23 苏州恩华生物医药科技有限公司 Indole derivatives and use thereof
WO2023198199A1 (en) * 2022-04-15 2023-10-19 先声再明医药有限公司 Myt1 kinase inhibitor

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US4803198A (en) * 1981-08-08 1989-02-07 Kali-Chemie Pharma Gmbh 1-Phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
US5399559A (en) * 1992-06-05 1995-03-21 Shell Research Limited Fungicidal indole derivatives
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
EP1310488A1 (en) * 2000-08-09 2003-05-14 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
US20030199689A1 (en) * 2001-11-22 2003-10-23 Marc Nazare New indole derivatives as factor Xa inhibitors
WO2004056768A2 (en) * 2002-12-20 2004-07-08 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
WO2005009947A2 (en) * 2003-07-24 2005-02-03 Aventis Pharma S.A. Aryl heteroaromatic products, compositions comprising the same and use thereof
WO2005014529A1 (en) * 2003-08-08 2005-02-17 Astrazeneca Ab 2- adamantyl derivatives as p2x7 receptor antagonists.
US20050165049A1 (en) * 2004-01-23 2005-07-28 Christopher Hulme Vanilloid receptor ligands and their use in treatments
WO2006072736A1 (en) * 2005-01-07 2006-07-13 Sanofi-Aventis N- (heteroaryl) -1h-indole-2-carb0xamide derivatives and their use as vanilloid trpv1 receptor ligands
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US4803198A (en) * 1981-08-08 1989-02-07 Kali-Chemie Pharma Gmbh 1-Phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them
US5399559A (en) * 1992-06-05 1995-03-21 Shell Research Limited Fungicidal indole derivatives
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
EP1310488A1 (en) * 2000-08-09 2003-05-14 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
US20030199689A1 (en) * 2001-11-22 2003-10-23 Marc Nazare New indole derivatives as factor Xa inhibitors
WO2004056768A2 (en) * 2002-12-20 2004-07-08 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
WO2005009947A2 (en) * 2003-07-24 2005-02-03 Aventis Pharma S.A. Aryl heteroaromatic products, compositions comprising the same and use thereof
WO2005014529A1 (en) * 2003-08-08 2005-02-17 Astrazeneca Ab 2- adamantyl derivatives as p2x7 receptor antagonists.
US20050165049A1 (en) * 2004-01-23 2005-07-28 Christopher Hulme Vanilloid receptor ligands and their use in treatments
US20070149602A1 (en) * 2004-08-05 2007-06-28 Sanofi-Aventis N-(1h-indolyl)-1h-indole-2-carboxamide derivatives, their preparation and their therapeutic use
WO2006072736A1 (en) * 2005-01-07 2006-07-13 Sanofi-Aventis N- (heteroaryl) -1h-indole-2-carb0xamide derivatives and their use as vanilloid trpv1 receptor ligands
WO2006100208A1 (en) * 2005-03-21 2006-09-28 N.V. Organon 1-benzylindole-2-carboxamide derivatives

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CONNOR ET AL.: "Novel Benzothiophene-, Benzofuran-, and Naphthalenecarboxamidotetraz oles as Potential Antiallergy Agents", J. MED. CHEM., vol. 35, 1 January 1992 (1992-01-01), pages 958 - 965, XP002303235, ISSN: 0022-2623, DOI: 10.1021/JM00083A023 *
NAZARE ET AL.: "Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents", BIOORG. MED. CHEM. LETT., vol. 14, no. 16, 1 May 2004 (2004-05-01), pages 4191 - 4195, XP002546716, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2004.06.020 *
NAZARE ET AL.: "Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography", J. MED. CHEM., vol. 48, no. 14, 1 January 2005 (2005-01-01), pages 4511 - 4525, XP002546715, ISSN: 0022-2623, [retrieved on 20050611], DOI: 10.1021/JM0490540 *
OELGEN ET AL.: "Synthesis and antioxidant properties of novel N-substituted indole-2-carboxamide and indole-3-acetamide derivatives", ARCHIV DER PHARMAZIE, vol. 7, 1 January 2002 (2002-01-01), pages 331 - 338, XP002275101, ISSN: 0365-6233, DOI: 10.1002/1521-4184(200209)335:7<331::AID-ARDP331>3.0.CO;2-7 *
See also references of WO2009023623A1 *

Also Published As

Publication number Publication date
CO6251319A2 (en) 2011-02-21
BRPI0812594A2 (en) 2015-06-23
AU2008286946A1 (en) 2009-02-19
CA2691512A1 (en) 2009-02-19
AU2008286946B2 (en) 2013-11-21
EA020332B1 (en) 2014-10-30
EA200971085A1 (en) 2010-06-30
SG183699A1 (en) 2012-09-27
JP2010535816A (en) 2010-11-25
WO2009023623A1 (en) 2009-02-19
KR20100066422A (en) 2010-06-17
IL202550A0 (en) 2010-06-30
NZ582056A (en) 2012-08-31
CN101778850A (en) 2010-07-14
UA99729C2 (en) 2012-09-25
JP2015110566A (en) 2015-06-18
EP2185560A1 (en) 2010-05-19

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Inventor name: YUAN, JUN

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