NO20052864L - Nye hydroksyindoler, deres anvendelse som fosfordiesterase 4 inhibitorer samt fremstilling av forbindelser - Google Patents
Nye hydroksyindoler, deres anvendelse som fosfordiesterase 4 inhibitorer samt fremstilling av forbindelserInfo
- Publication number
- NO20052864L NO20052864L NO20052864A NO20052864A NO20052864L NO 20052864 L NO20052864 L NO 20052864L NO 20052864 A NO20052864 A NO 20052864A NO 20052864 A NO20052864 A NO 20052864A NO 20052864 L NO20052864 L NO 20052864L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- inhibitors
- preparation
- new hydroxy
- hydroxy indoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Det beskrives substituerte 4- og/eller 7-hydroksyindoler med formel (1) samt fremgangsmåter for deres fremstilling, farmasøytiske preparater inneholdende forbindelsene samt den farmasøytiske anvendelse av disse forbindelser. Forbindelsene er inhibitorer av fosfodiesterase 4 og finner anvendelse som aktive forbindelser for behandling av sykdommer som kan påvirkes ved en inhibering av fosfodiesterase 4 aktiviteten i immunokompetente celler (for eksempel makrofager og lymfocytter).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10253426A DE10253426B4 (de) | 2002-11-15 | 2002-11-15 | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
PCT/EP2003/012742 WO2004045607A1 (de) | 2002-11-15 | 2003-11-14 | Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20052864L true NO20052864L (no) | 2005-06-13 |
Family
ID=32240098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20052864A NO20052864L (no) | 2002-11-15 | 2005-06-13 | Nye hydroksyindoler, deres anvendelse som fosfordiesterase 4 inhibitorer samt fremstilling av forbindelser |
Country Status (19)
Country | Link |
---|---|
US (2) | US7166637B2 (no) |
EP (1) | EP1562584A1 (no) |
JP (1) | JP2006508141A (no) |
KR (1) | KR20050075014A (no) |
CN (1) | CN1711082A (no) |
AR (1) | AR042053A1 (no) |
AU (1) | AU2003283400A1 (no) |
BR (1) | BR0316234A (no) |
CA (1) | CA2505988A1 (no) |
DE (1) | DE10253426B4 (no) |
HR (1) | HRP20050542A2 (no) |
MX (1) | MXPA05005138A (no) |
NO (1) | NO20052864L (no) |
PL (1) | PL376524A1 (no) |
RU (1) | RU2005118409A (no) |
TW (1) | TW200510306A (no) |
UA (1) | UA80567C2 (no) |
WO (1) | WO2004045607A1 (no) |
ZA (2) | ZA200503399B (no) |
Families Citing this family (68)
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EP1483283A4 (en) | 2002-03-13 | 2007-04-11 | Signum Biosciences Inc | MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE |
DE10253426B4 (de) * | 2002-11-15 | 2005-09-22 | Elbion Ag | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
DE10318609A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
DE10318611A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
TW200517381A (en) * | 2003-08-01 | 2005-06-01 | Genelabs Tech Inc | Bicyclic heteroaryl derivatives |
EP1670787B1 (en) | 2003-09-11 | 2012-05-30 | iTherX Pharma, Inc. | Cytokine inhibitors |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
RU2007130896A (ru) * | 2005-01-14 | 2009-02-20 | Дженелэбс Текнолоджиз, Инк. (Us) | Индольные производные для лечения вирусных инфекций |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
EP1843734A4 (en) | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
TW200738677A (en) * | 2005-06-27 | 2007-10-16 | Elbion Ag | Nitro-substituted hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them |
KR101461263B1 (ko) | 2005-10-21 | 2014-11-17 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
PL2013211T3 (pl) | 2006-04-21 | 2012-08-31 | Novartis Ag | Pochodne puryny do zastosowania jako agoniści receptora adenozyny A2A |
JPWO2008026687A1 (ja) | 2006-09-01 | 2010-01-21 | 杏林製薬株式会社 | ピラゾロピリジンカルボキサミド誘導体及びそれらを含有するホスホジエステラーゼ(pde)阻害剤 |
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EP2089151B1 (de) * | 2006-10-31 | 2016-05-25 | Basf Se | Regelung eines verfahrens zur herstellung wasserabsorbierender polymerpartikel in einer erwärmten gasphase |
EP2104535B9 (en) | 2007-01-10 | 2011-06-15 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
EP2332933A1 (en) | 2007-05-07 | 2011-06-15 | Novartis AG | Epithelial sodium channel (ENaC) inhibitors |
CN101778850A (zh) * | 2007-08-10 | 2010-07-14 | H.隆德贝克有限公司 | 杂芳基酰胺类似物 |
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US20150297604A1 (en) | 2012-04-03 | 2015-10-22 | Novartis Ag | Combination Products with Tyrosine Kinase Inhibitors and their Use |
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JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
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CN106458966B (zh) | 2014-04-24 | 2019-05-07 | 诺华股份有限公司 | 作为磷脂酰肌醇3-激酶抑制剂的吡嗪衍生物 |
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CN105832724B (zh) * | 2015-10-16 | 2018-07-03 | 北京冠瑞金生物科技有限公司 | 吲哚醇在制备抗抑郁症药物中的用途 |
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NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
MX9304801A (es) * | 1992-08-06 | 1997-06-28 | Warner Lambert Co | 2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales. |
CA2140440A1 (en) * | 1992-08-06 | 1994-02-17 | Ellen M. Dobrusin | 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties |
US5567711A (en) * | 1995-04-19 | 1996-10-22 | Abbott Laboratories | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
DE19818964A1 (de) * | 1998-04-28 | 1999-11-04 | Dresden Arzneimittel | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung |
SK286192B6 (sk) * | 1998-04-28 | 2008-05-06 | Elbion Ag | Hydroxyindol, spôsob jeho prípravy a jeho použitie ako inhibítora fosfodiesterázy 4 |
DE19917504A1 (de) * | 1999-04-17 | 2000-10-19 | Dresden Arzneimittel | Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen |
DE10053275A1 (de) | 2000-10-27 | 2002-05-02 | Dresden Arzneimittel | Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
TW200402417A (en) | 2002-06-21 | 2004-02-16 | Akzo Nobel Nv | 1-[(Indol-3-yl)carbonyl]piperazine derivatives |
DE10253426B4 (de) * | 2002-11-15 | 2005-09-22 | Elbion Ag | Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung |
-
2002
- 2002-11-15 DE DE10253426A patent/DE10253426B4/de not_active Expired - Fee Related
-
2003
- 2003-11-13 US US10/714,568 patent/US7166637B2/en not_active Expired - Fee Related
- 2003-11-13 TW TW092131851A patent/TW200510306A/zh unknown
- 2003-11-14 EP EP03775355A patent/EP1562584A1/de not_active Withdrawn
- 2003-11-14 PL PL376524A patent/PL376524A1/pl unknown
- 2003-11-14 RU RU2005118409/04A patent/RU2005118409A/ru not_active Application Discontinuation
- 2003-11-14 AU AU2003283400A patent/AU2003283400A1/en not_active Abandoned
- 2003-11-14 KR KR1020057008684A patent/KR20050075014A/ko not_active Application Discontinuation
- 2003-11-14 WO PCT/EP2003/012742 patent/WO2004045607A1/de active Application Filing
- 2003-11-14 BR BR0316234-6A patent/BR0316234A/pt not_active IP Right Cessation
- 2003-11-14 CN CNA200380103190XA patent/CN1711082A/zh active Pending
- 2003-11-14 AR ARP030104219A patent/AR042053A1/es not_active Application Discontinuation
- 2003-11-14 UA UAA200504467A patent/UA80567C2/uk unknown
- 2003-11-14 JP JP2004552596A patent/JP2006508141A/ja not_active Withdrawn
- 2003-11-14 MX MXPA05005138A patent/MXPA05005138A/es active IP Right Grant
- 2003-11-14 CA CA002505988A patent/CA2505988A1/en not_active Abandoned
-
2005
- 2005-04-28 ZA ZA200503399A patent/ZA200503399B/en unknown
- 2005-06-13 NO NO20052864A patent/NO20052864L/no not_active Application Discontinuation
- 2005-06-14 HR HR20050542A patent/HRP20050542A2/hr not_active Application Discontinuation
- 2005-09-01 ZA ZA200507002A patent/ZA200507002B/en unknown
-
2006
- 2006-11-30 US US11/606,696 patent/US20070093531A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20050075014A (ko) | 2005-07-19 |
UA80567C2 (en) | 2007-10-10 |
AR042053A1 (es) | 2005-06-08 |
US20040147759A1 (en) | 2004-07-29 |
PL376524A1 (pl) | 2006-01-09 |
DE10253426A1 (de) | 2004-06-03 |
DE10253426B4 (de) | 2005-09-22 |
EP1562584A1 (de) | 2005-08-17 |
ZA200503399B (en) | 2006-06-28 |
RU2005118409A (ru) | 2006-01-20 |
US20070093531A1 (en) | 2007-04-26 |
CA2505988A1 (en) | 2004-06-03 |
TW200510306A (en) | 2005-03-16 |
AU2003283400A1 (en) | 2004-06-15 |
HRP20050542A2 (en) | 2005-08-31 |
WO2004045607A1 (de) | 2004-06-03 |
JP2006508141A (ja) | 2006-03-09 |
MXPA05005138A (es) | 2005-07-22 |
BR0316234A (pt) | 2005-10-11 |
US7166637B2 (en) | 2007-01-23 |
ZA200507002B (en) | 2006-06-28 |
CN1711082A (zh) | 2005-12-21 |
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