NO20012983L - Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet) - Google Patents
Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet)Info
- Publication number
- NO20012983L NO20012983L NO20012983A NO20012983A NO20012983L NO 20012983 L NO20012983 L NO 20012983L NO 20012983 A NO20012983 A NO 20012983A NO 20012983 A NO20012983 A NO 20012983A NO 20012983 L NO20012983 L NO 20012983L
- Authority
- NO
- Norway
- Prior art keywords
- inhibition
- factor
- activity
- preparation
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100002A EP1016663A1 (en) | 1999-01-02 | 1999-01-02 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
| EP99119537 | 1999-10-01 | ||
| PCT/EP1999/010340 WO2000040571A1 (en) | 1999-01-02 | 1999-12-23 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012983D0 NO20012983D0 (no) | 2001-06-15 |
| NO20012983L true NO20012983L (no) | 2001-06-15 |
Family
ID=26152843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012983A NO20012983L (no) | 1999-01-02 | 2001-06-15 | Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet) |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6395737B1 (tr) |
| EP (1) | EP1140878A1 (tr) |
| JP (1) | JP2002534420A (tr) |
| KR (1) | KR20010101355A (tr) |
| CN (1) | CN1332734A (tr) |
| AU (1) | AU3043100A (tr) |
| BR (1) | BR9916732A (tr) |
| CA (1) | CA2358578A1 (tr) |
| CZ (1) | CZ20012379A3 (tr) |
| HK (1) | HK1041700A1 (tr) |
| HU (1) | HUP0105437A3 (tr) |
| ID (1) | ID29979A (tr) |
| IL (1) | IL144096A0 (tr) |
| NO (1) | NO20012983L (tr) |
| PL (1) | PL349343A1 (tr) |
| TR (1) | TR200101903T2 (tr) |
| WO (1) | WO2000040571A1 (tr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9916733A (pt) | 1999-01-02 | 2001-09-25 | Aventis Pharma Gmbh | Derivados de arilalcanoìla, processos para sua preparação, seu uso e composições farmacêuticas que os contêm |
| EP1127884A1 (en) | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them |
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
| US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
| US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
| US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
| US8884051B2 (en) | 2010-10-20 | 2014-11-11 | Bioformix Inc. | Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent |
| ES2699226T3 (es) | 2011-10-14 | 2019-02-08 | Bristol Myers Squibb Co | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa |
| CA2851810C (en) | 2011-10-14 | 2020-01-07 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| ES2579832T3 (es) | 2011-10-14 | 2016-08-17 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa |
| MX360463B (es) | 2011-10-19 | 2018-11-05 | Sirrus Inc | Monomeros de beta-cetoester de metileno, procedimientos de fabricación de monomeros de beta-cetoester de metileno, composiciones polimerizables y productos formados a partir de las mismas. |
| CA2869108A1 (en) | 2012-03-30 | 2013-10-03 | Bioformix Inc. | Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby |
| JP6345644B2 (ja) | 2012-03-30 | 2018-06-20 | シラス・インコーポレイテッド | インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系 |
| EP3153530B1 (en) | 2012-03-30 | 2021-02-24 | Sirrus, Inc. | Composite and laminate articles and polymerizable systems for producing the same |
| US10047192B2 (en) | 2012-06-01 | 2018-08-14 | Sirrus, Inc. | Optical material and articles formed therefrom |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9403774B2 (en) | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| BR112015007937A2 (pt) | 2012-10-12 | 2017-07-04 | Bristol Myers Squibb Co | formas cristalinas de um inibidor de fator xia |
| WO2014078689A1 (en) | 2012-11-16 | 2014-05-22 | Bioformix Inc. | Plastics bonding systems and methods |
| US10607910B2 (en) | 2012-11-30 | 2020-03-31 | Sirrus, Inc. | Composite compositions for electronics applications |
| EP2943462B1 (en) | 2013-01-11 | 2018-06-27 | Sirrus, Inc. | Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway |
| WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| RS57659B1 (sr) | 2014-01-31 | 2018-11-30 | Bristol Myers Squibb Co | Makrociklusi sa heterocikličnim p2' grupama kao inhibitori faktora xia |
| NO2760821T3 (tr) | 2014-01-31 | 2018-03-10 | ||
| EP3164406A4 (en) | 2014-07-01 | 2018-04-04 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10081623B2 (en) | 2014-09-04 | 2018-09-25 | Bristol-Myers Squibb Company | Diamide macrocycles that are FXIa inhibitors |
| US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
| US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
| US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
| US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
| US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
| US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
| US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE242404C (tr) | ||||
| DE235866C (tr) | ||||
| DE3269422D1 (en) * | 1981-09-25 | 1986-04-03 | Wellcome Found | Pharmaceutical amides, and preparation, formulations and use thereof |
| EP0511347A1 (de) | 1990-11-15 | 1992-11-04 | Pentapharm A.G. | Meta-substituierte phenylalanin-derivate |
| IT1254883B (it) * | 1992-04-16 | 1995-10-11 | Italfarmaco Spa | Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva. |
| HUT68042A (en) * | 1993-02-10 | 1995-03-22 | Pentapharm Ag | Piperazides of substituted phenylalanine derivates as thrombin inhibitors |
| US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
| EP0758341B1 (en) * | 1994-04-26 | 2004-03-24 | Aventis Pharmaceuticals, Inc. | FACTOR Xa INHIBITORS |
| AU3107795A (en) * | 1994-08-09 | 1996-03-07 | Pentapharm Ag | Inhibitors of the benzamidine type |
| GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
| JP4044614B2 (ja) * | 1995-12-20 | 2008-02-06 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | Ｎ―アセチル―（Ｌ）―４―シアノフェニルアラニンＡｃ―（Ｌ）―Ｐｈｅ（４―ＣＮ）―ＯＨおよびＮ―アセチル―（Ｌ）―ｐ―アミジノフェニルアラニン―シクロヘキシルグリシン―β―（３―Ｎ―メチルピリジニウム）―アラニン Ａｃ―（Ｌ）―ｐＡｐｈ―Ｃｈｇ―ＰａｌＭｅ（３）―ＮＨ２の新規な製法 |
| RU2183642C2 (ru) | 1997-05-02 | 2002-06-20 | Акцо Нобель Н.В. | Ингибиторы сериновых протеаз |
| ATE293599T1 (de) | 1997-12-24 | 2005-05-15 | Aventis Pharma Gmbh | Indolderivate als faktor xa inhibitoren |
| EP1016663A1 (en) | 1999-01-02 | 2000-07-05 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
-
1999
- 1999-12-23 CA CA002358578A patent/CA2358578A1/en not_active Abandoned
- 1999-12-23 HU HU0105437A patent/HUP0105437A3/hu unknown
- 1999-12-23 JP JP2000592279A patent/JP2002534420A/ja not_active Abandoned
- 1999-12-23 PL PL99349343A patent/PL349343A1/xx not_active Application Discontinuation
- 1999-12-23 AU AU30431/00A patent/AU3043100A/en not_active Abandoned
- 1999-12-23 TR TR2001/01903T patent/TR200101903T2/tr unknown
- 1999-12-23 WO PCT/EP1999/010340 patent/WO2000040571A1/en not_active Application Discontinuation
- 1999-12-23 CZ CZ20012379A patent/CZ20012379A3/cs unknown
- 1999-12-23 IL IL14409699A patent/IL144096A0/xx unknown
- 1999-12-23 CN CN99815372A patent/CN1332734A/zh active Pending
- 1999-12-23 EP EP99964667A patent/EP1140878A1/en not_active Withdrawn
- 1999-12-23 ID IDW00200101430A patent/ID29979A/id unknown
- 1999-12-23 KR KR1020017008429A patent/KR20010101355A/ko not_active Application Discontinuation
- 1999-12-23 BR BR9916732-8A patent/BR9916732A/pt not_active IP Right Cessation
- 1999-12-28 US US09/473,053 patent/US6395737B1/en not_active Expired - Lifetime
-
2001
- 2001-06-15 NO NO20012983A patent/NO20012983L/no not_active Application Discontinuation
-
2002
- 2002-05-04 HK HK02103402.4A patent/HK1041700A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL349343A1 (en) | 2002-07-15 |
| NO20012983D0 (no) | 2001-06-15 |
| HK1041700A1 (zh) | 2002-07-19 |
| TR200101903T2 (tr) | 2001-11-21 |
| CN1332734A (zh) | 2002-01-23 |
| KR20010101355A (ko) | 2001-11-14 |
| BR9916732A (pt) | 2001-09-25 |
| HUP0105437A3 (en) | 2003-03-28 |
| AU3043100A (en) | 2000-07-24 |
| US6395737B1 (en) | 2002-05-28 |
| CA2358578A1 (en) | 2000-07-13 |
| IL144096A0 (en) | 2002-05-23 |
| ID29979A (id) | 2001-10-25 |
| EP1140878A1 (en) | 2001-10-10 |
| WO2000040571A1 (en) | 2000-07-13 |
| JP2002534420A (ja) | 2002-10-15 |
| CZ20012379A3 (cs) | 2001-09-12 |
| HUP0105437A2 (hu) | 2002-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |