NO20013878L - (1-fenacy-3-fenyl-3-piperidylety)piperidinderivater, fremgangsmåte for fremstilling derav og farmasöytiske preparaterinneholdende de samme - Google Patents
(1-fenacy-3-fenyl-3-piperidylety)piperidinderivater, fremgangsmåte for fremstilling derav og farmasöytiske preparaterinneholdende de sammeInfo
- Publication number
- NO20013878L NO20013878L NO20013878A NO20013878A NO20013878L NO 20013878 L NO20013878 L NO 20013878L NO 20013878 A NO20013878 A NO 20013878A NO 20013878 A NO20013878 A NO 20013878A NO 20013878 L NO20013878 L NO 20013878L
- Authority
- NO
- Norway
- Prior art keywords
- phenacy
- piperidylethyl
- phenyl
- preparation
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9901593A FR2789389B3 (fr) | 1999-02-10 | 1999-02-10 | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
FR9904429A FR2789390B3 (fr) | 1999-02-10 | 1999-04-07 | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
PCT/FR2000/000284 WO2000047572A1 (fr) | 1999-02-10 | 2000-02-08 | Derives de (1-phenacy-3-phenyl-3-piperidylethyl)piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20013878D0 NO20013878D0 (no) | 2001-08-08 |
NO20013878L true NO20013878L (no) | 2001-10-10 |
NO321149B1 NO321149B1 (no) | 2006-03-27 |
Family
ID=26234812
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20013878A NO321149B1 (no) | 1999-02-10 | 2001-08-08 | (1-fenacy-3-fenyl-3-piperidylety)piperidinderivater, fremgangsmate for fremstilling derav og farmasoytiske preparater inneholdende de samme samt anvendelse |
NO20051958A NO20051958L (no) | 1999-02-10 | 2005-04-21 | Forbindelser |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051958A NO20051958L (no) | 1999-02-10 | 2005-04-21 | Forbindelser |
Country Status (37)
Country | Link |
---|---|
US (2) | US6642233B1 (no) |
EP (1) | EP1150970B1 (no) |
JP (1) | JP4648544B2 (no) |
KR (1) | KR100611261B1 (no) |
CN (1) | CN1273463C (no) |
AR (1) | AR028813A1 (no) |
AT (1) | ATE370942T1 (no) |
AU (1) | AU763716B2 (no) |
BG (1) | BG65031B1 (no) |
BR (1) | BR0008067A (no) |
CA (1) | CA2360894C (no) |
CO (1) | CO4980896A1 (no) |
CZ (1) | CZ300765B6 (no) |
DE (1) | DE60036081T2 (no) |
DK (1) | DK1150970T3 (no) |
EE (1) | EE04437B1 (no) |
ES (1) | ES2291187T3 (no) |
FR (1) | FR2789390B3 (no) |
HK (1) | HK1038927A1 (no) |
HR (1) | HRP20010566A2 (no) |
HU (1) | HUP0201281A3 (no) |
ID (1) | ID29219A (no) |
IL (2) | IL144363A0 (no) |
ME (1) | MEP11908A (no) |
NO (2) | NO321149B1 (no) |
NZ (1) | NZ513053A (no) |
PE (1) | PE20001463A1 (no) |
PL (1) | PL198561B1 (no) |
PT (1) | PT1150970E (no) |
RS (1) | RS50210B (no) |
RU (1) | RU2220956C2 (no) |
SI (1) | SI1150970T1 (no) |
SK (1) | SK286401B6 (no) |
TR (1) | TR200102331T2 (no) |
TW (1) | TWI254712B (no) |
UA (1) | UA70986C2 (no) |
WO (1) | WO2000047572A1 (no) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050009798A1 (en) * | 2002-02-20 | 2005-01-13 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists |
AU2003217535A1 (en) * | 2002-02-20 | 2003-09-09 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids |
BRPI0507301A (pt) * | 2004-01-30 | 2007-06-26 | Pfizer Prod Inc | composições farmacêuticas de antagonistas do receptor de nuerocinina e ciclodextrina e métodos para melhor toleráncia no local de injeção |
FR2873373B1 (fr) * | 2004-07-23 | 2006-09-08 | Sanofi Synthelabo | Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique |
GB2452696B (en) * | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
DE102008015426A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid zu Reduktion von Hautrötungen |
DE102008015428A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende Zubereitungen für den humanen Haut- und/oder Schleimhautkontakt mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid |
DE102008015425A1 (de) * | 2008-03-20 | 2010-01-21 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen zur Verringerung von Juckreiz und anderen dermatologischen Missempfindungen, die insbesondere bei Altershaut auftreten können, mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US512901A (en) * | 1894-01-16 | Folding bed | ||
GB821012A (en) * | 1957-01-15 | 1959-09-30 | Rhone Poulenc Sa | New phenthiazine derivatives and processes for their preparation |
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
ES2132709T3 (es) | 1994-08-25 | 1999-08-16 | Merrell Pharma Inc | Nuevas piperidinas substituidas utiles para el tratamiento de las enfermedades alergicas. |
CA2162786A1 (en) * | 1994-11-22 | 1996-05-23 | Philip Arthur Hipskind | Heterocyclic tachykinin receptor antagonists |
-
1999
- 1999-04-07 FR FR9904429A patent/FR2789390B3/fr not_active Expired - Lifetime
-
2000
- 2000-02-08 WO PCT/FR2000/000284 patent/WO2000047572A1/fr active IP Right Grant
- 2000-02-08 PL PL350243A patent/PL198561B1/pl not_active IP Right Cessation
- 2000-02-08 HU HU0201281A patent/HUP0201281A3/hu unknown
- 2000-02-08 EE EEP200100417A patent/EE04437B1/xx not_active IP Right Cessation
- 2000-02-08 US US09/913,106 patent/US6642233B1/en not_active Expired - Fee Related
- 2000-02-08 ES ES00903744T patent/ES2291187T3/es not_active Expired - Lifetime
- 2000-02-08 PT PT00903744T patent/PT1150970E/pt unknown
- 2000-02-08 CA CA002360894A patent/CA2360894C/en not_active Expired - Fee Related
- 2000-02-08 RU RU2001121989/04A patent/RU2220956C2/ru not_active IP Right Cessation
- 2000-02-08 SI SI200030968T patent/SI1150970T1/sl unknown
- 2000-02-08 KR KR1020017009983A patent/KR100611261B1/ko not_active IP Right Cessation
- 2000-02-08 AU AU25531/00A patent/AU763716B2/en not_active Ceased
- 2000-02-08 DE DE60036081T patent/DE60036081T2/de not_active Expired - Lifetime
- 2000-02-08 BR BR0008067-5A patent/BR0008067A/pt not_active Application Discontinuation
- 2000-02-08 EP EP00903744A patent/EP1150970B1/fr not_active Expired - Lifetime
- 2000-02-08 SK SK1139-2001A patent/SK286401B6/sk not_active IP Right Cessation
- 2000-02-08 IL IL14436300A patent/IL144363A0/xx not_active IP Right Cessation
- 2000-02-08 CZ CZ20012888A patent/CZ300765B6/cs not_active IP Right Cessation
- 2000-02-08 UA UA2001075184A patent/UA70986C2/uk unknown
- 2000-02-08 DK DK00903744T patent/DK1150970T3/da active
- 2000-02-08 RS YUP-564/01A patent/RS50210B/sr unknown
- 2000-02-08 ID IDW00200101651A patent/ID29219A/id unknown
- 2000-02-08 JP JP2000598492A patent/JP4648544B2/ja not_active Expired - Fee Related
- 2000-02-08 TR TR2001/02331T patent/TR200102331T2/xx unknown
- 2000-02-08 ME MEP-119/08A patent/MEP11908A/xx unknown
- 2000-02-08 CN CNB008058261A patent/CN1273463C/zh not_active Expired - Fee Related
- 2000-02-08 AT AT00903744T patent/ATE370942T1/de not_active IP Right Cessation
- 2000-02-08 NZ NZ513053A patent/NZ513053A/xx not_active IP Right Cessation
- 2000-02-09 TW TW089102106A patent/TWI254712B/zh active
- 2000-02-09 AR ARP000100555A patent/AR028813A1/es active IP Right Grant
- 2000-02-10 CO CO00008757A patent/CO4980896A1/es unknown
- 2000-02-10 PE PE2000000102A patent/PE20001463A1/es not_active Application Discontinuation
-
2001
- 2001-07-26 HR HR20010566A patent/HRP20010566A2/hr not_active Application Discontinuation
- 2001-08-08 BG BG105794A patent/BG65031B1/bg unknown
- 2001-08-08 NO NO20013878A patent/NO321149B1/no not_active IP Right Cessation
-
2002
- 2002-01-29 HK HK02100715A patent/HK1038927A1/xx not_active IP Right Cessation
-
2003
- 2003-09-16 US US10/663,124 patent/US6951940B2/en not_active Expired - Fee Related
-
2005
- 2005-04-21 NO NO20051958A patent/NO20051958L/no unknown
-
2007
- 2007-01-07 IL IL180579A patent/IL180579A0/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |