ES2132709T3 - Nuevas piperidinas substituidas utiles para el tratamiento de las enfermedades alergicas. - Google Patents

Nuevas piperidinas substituidas utiles para el tratamiento de las enfermedades alergicas.

Info

Publication number
ES2132709T3
ES2132709T3 ES95931551T ES95931551T ES2132709T3 ES 2132709 T3 ES2132709 T3 ES 2132709T3 ES 95931551 T ES95931551 T ES 95931551T ES 95931551 T ES95931551 T ES 95931551T ES 2132709 T3 ES2132709 T3 ES 2132709T3
Authority
ES
Spain
Prior art keywords
treatment
allergic diseases
useful
piperidines substituted
new piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95931551T
Other languages
English (en)
Inventor
Timothy P Burkholder
Larry D Bratton
Elizabeth M Kudlacz
George D Maynard
John M Kane
Braulio Santiago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2132709T3 publication Critical patent/ES2132709T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS DE PIPERIDINA SUSTITUIDA DE FORMULA (1), ESTEREOISOMEROS DE LOS MISMOS, Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE SON UTILES COMO ANTAGONISTAS DEL RECEPTOR DE HISTAMINA Y ANTAGONISTAS DEL RECEPTOR DE TAQUIQUININA. DICHOS ANTAGONISTAS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES ALERGICAS INCLUYENDO: RINITIS ESTACIONAL, RINITIS ALERGICA Y SINUSITIS.
ES95931551T 1994-08-25 1995-08-17 Nuevas piperidinas substituidas utiles para el tratamiento de las enfermedades alergicas. Expired - Lifetime ES2132709T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29596094A 1994-08-25 1994-08-25
US50191495A 1995-07-13 1995-07-13

Publications (1)

Publication Number Publication Date
ES2132709T3 true ES2132709T3 (es) 1999-08-16

Family

ID=26969426

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95931551T Expired - Lifetime ES2132709T3 (es) 1994-08-25 1995-08-17 Nuevas piperidinas substituidas utiles para el tratamiento de las enfermedades alergicas.

Country Status (20)

Country Link
US (1) US6329392B1 (es)
EP (1) EP0777666B1 (es)
JP (1) JPH10504580A (es)
KR (1) KR100362620B1 (es)
CN (1) CN1067385C (es)
AT (1) ATE177095T1 (es)
AU (1) AU693936B2 (es)
CA (1) CA2198084C (es)
DE (1) DE69508093T2 (es)
DK (1) DK0777666T3 (es)
ES (1) ES2132709T3 (es)
FI (1) FI114470B (es)
GR (1) GR3030253T3 (es)
HU (1) HU221434B (es)
IL (1) IL115040A (es)
MX (1) MX9701305A (es)
NO (1) NO313237B1 (es)
NZ (1) NZ292683A (es)
TW (1) TW430663B (es)
WO (1) WO1996006094A1 (es)

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US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
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Also Published As

Publication number Publication date
CA2198084A1 (en) 1996-02-29
KR100362620B1 (ko) 2003-02-14
HU221434B (en) 2002-10-28
AU693936B2 (en) 1998-07-09
CA2198084C (en) 2000-03-28
NO313237B1 (no) 2002-09-02
AU3492895A (en) 1996-03-14
EP0777666A1 (en) 1997-06-11
EP0777666B1 (en) 1999-03-03
TW430663B (en) 2001-04-21
KR970705556A (ko) 1997-10-09
NZ292683A (en) 1998-07-28
DE69508093T2 (de) 1999-07-15
FI970771A (fi) 1997-02-24
DK0777666T3 (da) 1999-09-27
WO1996006094A1 (en) 1996-02-29
CN1067385C (zh) 2001-06-20
DE69508093D1 (de) 1999-04-08
IL115040A0 (en) 1995-12-08
US6329392B1 (en) 2001-12-11
MX9701305A (es) 1998-05-31
NO970831L (no) 1997-04-18
ATE177095T1 (de) 1999-03-15
FI970771A0 (fi) 1997-02-24
IL115040A (en) 2000-02-29
GR3030253T3 (en) 1999-08-31
FI114470B (fi) 2004-10-29
NO970831D0 (no) 1997-02-24
CN1158612A (zh) 1997-09-03
JPH10504580A (ja) 1998-05-06
HUT76644A (en) 1997-10-28

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