HUP0401544A2 - Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0401544A2
HUP0401544A2 HU0401544A HUP0401544A HUP0401544A2 HU P0401544 A2 HUP0401544 A2 HU P0401544A2 HU 0401544 A HU0401544 A HU 0401544A HU P0401544 A HUP0401544 A HU P0401544A HU P0401544 A2 HUP0401544 A2 HU P0401544A2
Authority
HU
Hungary
Prior art keywords
modulators
group
nr18r19
compounds useful
compounds
Prior art date
Application number
HU0401544A
Other languages
English (en)
Inventor
Guixue Yu
John Macor
Timothy Herpin
R. Michael Lawrence
George C. Morton
Rejean Ruel
Graham S. Poindexter
Edward H. Ruediger
Carl Thibault
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HUP0401544A2 publication Critical patent/HUP0401544A2/hu

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A találmány tárgya melanokortin receptor modulátoraiként hasznosvegyületek, amelyek (I) általános képletében E jelentése E1, E2, E3vagy E4 képletű csoport; G jelentése új oldallánc, amely lehet 2-6szénatomos alkenil-, A3-aril-, -OR18, heteroaril-, A1-ciano-, A2-OR17,A1-C(=O)R18, A1-CO2R18, A1-CO2R18, A1-C(=O)NR18R19, A1-OC(=O)R18, A1-NR18C(=O)R19, A1-OC(=O)NR18R19, A1-NR18CO2R19, A1-NR18SO2R17, A1-SO2R17, A1-NR20C(=O)NR18R19 vagy A1-SR18; vagy ha y értéke 0 vagy ha Wjelentése NHR22-től eltérő, akkor G lehet A1-heterociklusos csoport,ahol A1 jelentése vegyértékvonal, 1-6 szénatomos alkilén- vagy 2-6szénatomos alkeniléncsoport, A2 jelentése 1-6 szénatomos alkilén- vagy2-6 szénatomos alkeniléncsoport, és A3 jelentése 2-6 szénatomosalkeniléncsoport; W jelentése -NR21R22, -OR23, -NR21C(=O)R24, -NR21CO2R24, amidino-, guanidino- vagy heteroaril-, heterociklusos vagy3-7 szénatomos cikloalkilcsoport a leírás szerint; és X és R1-R24jelentése a leírásban megadott. A vegyületek hatásos melanokortinreceptor, különösen MC-1R és MC-4R modulátorok. A találmány kiterjed avegyületeket tartalmazó gyógyszerkészítményekre is. Ó
HU0401544A 2001-03-02 2002-03-02 Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények HUP0401544A2 (hu)

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CA2438272A1 (en) 2002-10-10
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US20030096827A1 (en) 2003-05-22
US7067525B2 (en) 2006-06-27
EP1363898A4 (en) 2004-12-08
WO2002070511A1 (en) 2002-09-12
EP1363898A1 (en) 2003-11-26
US20040229882A1 (en) 2004-11-18
EP1363631A2 (en) 2003-11-26
WO2002079146A2 (en) 2002-10-10
US20030092732A1 (en) 2003-05-15
JP2005511475A (ja) 2005-04-28
WO2002079146A3 (en) 2003-02-06
HUP0303484A2 (hu) 2004-01-28
US6979691B2 (en) 2005-12-27
CA2437594A1 (en) 2002-09-12
US6713487B2 (en) 2004-03-30
US20060025403A1 (en) 2006-02-02

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