HUP0303484A2 - Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303484A2 HUP0303484A2 HU0303484A HUP0303484A HUP0303484A2 HU P0303484 A2 HUP0303484 A2 HU P0303484A2 HU 0303484 A HU0303484 A HU 0303484A HU P0303484 A HUP0303484 A HU P0303484A HU P0303484 A2 HUP0303484 A2 HU P0303484A2
- Authority
- HU
- Hungary
- Prior art keywords
- modulators
- pharmaceutical compositions
- same
- compounds
- compounds useful
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000004378 Melanocortin Receptors Human genes 0.000 title abstract 3
- 108090000950 Melanocortin Receptors Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract
A találmány tárgya (I) általános képletű vegyületek, gyógyászatilagelfogadható sói, hidrátjai és prodrugjai, amelyek melanokortinreceptorok, különösen MC-1R és MC-4R receptorok modulátoraikénthasznosak. Az (I) általános képletben E jelentése (II) általánosképletű csoport, X jelentése nitrogénatom vagy CH, W jelentése -NR16R17, -NR16C(=O)R22, -NR16CO2R22, -OR23 vagy a leírásban definiáltheteroaril- vagy heterociklusos csoport, valamint R1 - R12, R16, R17,R22, R23, x, y és z jelentése a leírás szerinti. A találmány kiterjeda vegyületeket tartalmazó gyógyszerkészítményekre és a vegyületekalkalmazására melanokortin receptorral összefüggő állapot kezelésére. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US27320601P | 2001-03-02 | 2001-03-02 | |
US27329101P | 2001-03-02 | 2001-03-02 | |
PCT/US2002/006581 WO2002079146A2 (en) | 2001-03-02 | 2002-03-02 | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
Publications (1)
Publication Number | Publication Date |
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HUP0303484A2 true HUP0303484A2 (hu) | 2004-01-28 |
Family
ID=26956008
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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HU0401544A HUP0401544A2 (hu) | 2001-03-02 | 2002-03-02 | Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények |
HU0303484A HUP0303484A2 (hu) | 2001-03-02 | 2002-03-02 | Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények |
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Application Number | Title | Priority Date | Filing Date |
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HU0401544A HUP0401544A2 (hu) | 2001-03-02 | 2002-03-02 | Melanokortin receptor modulátoraiként hasznos vegyületek és a vegyületeket tartalmazó gyógyszerkészítmények |
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US (4) | US6979691B2 (hu) |
EP (2) | EP1363898A4 (hu) |
JP (2) | JP2005511475A (hu) |
CA (2) | CA2437594A1 (hu) |
HU (2) | HUP0401544A2 (hu) |
WO (2) | WO2002070511A1 (hu) |
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PT3245203T (pt) | 2015-01-15 | 2019-02-08 | Idorsia Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como modeladores do recetor cxcr3 |
AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
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US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
ATE177095T1 (de) * | 1994-08-25 | 1999-03-15 | Merrell Pharma Inc | Substituierte piperidine für die behandlung von allergischen krankheiten |
US5559128A (en) | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
WO1996035713A1 (en) * | 1995-05-08 | 1996-11-14 | Pfizer, Inc. | Dipeptides which promote release of growth hormone |
ATE288444T1 (de) * | 1995-05-29 | 2005-02-15 | Pfizer | Dipeptide, die die ausschüttung von wachstumshormonen stimulieren |
US5804578A (en) * | 1996-04-03 | 1998-09-08 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
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US6303620B1 (en) * | 1998-05-11 | 2001-10-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
DE69941255D1 (de) | 1998-05-11 | 2009-09-24 | Novo Nordisk As | Verbindungen mit wachstumshormon freisetzenden eigenschaften |
US6294534B1 (en) * | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
WO1999064002A1 (en) * | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
GB9819860D0 (en) | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
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WO2000074679A1 (en) * | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
CA2403686C (en) | 2000-03-23 | 2010-01-26 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
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WO2002015909A1 (en) | 2000-08-23 | 2002-02-28 | Merck & Co., Inc. | Substituted piperidines as melanocortin receptor agonists |
ES2247298T3 (es) | 2001-01-23 | 2006-03-01 | Eli Lilly And Company | Derivados de piperazina y piperidina como agonistas del receptor de melanocortina. |
EP1368339A1 (en) | 2001-01-23 | 2003-12-10 | Eli Lilly & Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
-
2002
- 2002-03-02 EP EP02723310A patent/EP1363898A4/en not_active Withdrawn
- 2002-03-02 CA CA002437594A patent/CA2437594A1/en not_active Abandoned
- 2002-03-02 HU HU0401544A patent/HUP0401544A2/hu unknown
- 2002-03-02 WO PCT/US2002/006479 patent/WO2002070511A1/en not_active Application Discontinuation
- 2002-03-02 EP EP02741644A patent/EP1363631A4/en not_active Withdrawn
- 2002-03-02 HU HU0303484A patent/HUP0303484A2/hu unknown
- 2002-03-02 JP JP2002569831A patent/JP2005511475A/ja active Pending
- 2002-03-02 WO PCT/US2002/006581 patent/WO2002079146A2/en active Application Filing
- 2002-03-02 CA CA002438272A patent/CA2438272A1/en not_active Abandoned
- 2002-03-02 JP JP2002577773A patent/JP2004532838A/ja active Pending
- 2002-03-04 US US10/090,582 patent/US6979691B2/en not_active Expired - Lifetime
- 2002-03-04 US US10/090,288 patent/US6713487B2/en not_active Expired - Lifetime
-
2003
- 2003-10-29 US US10/696,761 patent/US7067525B2/en not_active Expired - Lifetime
-
2005
- 2005-08-08 US US11/199,464 patent/US20060025403A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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WO2002079146A2 (en) | 2002-10-10 |
EP1363898A4 (en) | 2004-12-08 |
JP2004532838A (ja) | 2004-10-28 |
WO2002070511A1 (en) | 2002-09-12 |
HUP0401544A2 (hu) | 2004-12-28 |
US6713487B2 (en) | 2004-03-30 |
US7067525B2 (en) | 2006-06-27 |
CA2438272A1 (en) | 2002-10-10 |
WO2002079146A3 (en) | 2003-02-06 |
JP2005511475A (ja) | 2005-04-28 |
EP1363898A1 (en) | 2003-11-26 |
US6979691B2 (en) | 2005-12-27 |
CA2437594A1 (en) | 2002-09-12 |
US20060025403A1 (en) | 2006-02-02 |
US20030096827A1 (en) | 2003-05-22 |
EP1363631A2 (en) | 2003-11-26 |
EP1363631A4 (en) | 2005-11-16 |
US20040229882A1 (en) | 2004-11-18 |
US20030092732A1 (en) | 2003-05-15 |
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