EA201792536A1 - Триазоловые агонисты рецептора apj - Google Patents

Триазоловые агонисты рецептора apj

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Publication number
EA201792536A1
EA201792536A1 EA201792536A EA201792536A EA201792536A1 EA 201792536 A1 EA201792536 A1 EA 201792536A1 EA 201792536 A EA201792536 A EA 201792536A EA 201792536 A EA201792536 A EA 201792536A EA 201792536 A1 EA201792536 A1 EA 201792536A1
Authority
EA
Eurasian Patent Office
Prior art keywords
apj receptor
formula
agonists
triazole
compounds
Prior art date
Application number
EA201792536A
Other languages
English (en)
Other versions
EA034776B1 (ru
Inventor
Нин Чэнь
Сяоци Чэнь
Иньхун Чэнь
Алан К. Чэн
Ричард В. Коннорс
Джеффри Дейгнан
Пол Джон Дрэнсфилд
Сяохой Ду
Цзыцэ Фу
Джули Энн Хит
Дэниел Б. Хорн
Джонатан Хаузе
Мэттью Р. Кэллер
Аариф Юсуф Кхакоо
Дэвид Джон Копески
Су-Джень Лай
Чжихуа Ма
Лоуренс Р. Макги
Хулио К. Медина
Джеффри Т. Михалик
Нобуко Нисимура
Стивен Х. Олсон
Ватее Паттаропон
Гаятри Сваминат
Сяодун Ван
Кевин Ян
Вэнь-Чэнь Ех
Миккель В. Дебенедетто
Роберт П. Фаррелл
Саймон Дж. Хедли
Тед К. Джадд
Франк Кайзер
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201792536A1 publication Critical patent/EA201792536A1/ru
Publication of EA034776B1 publication Critical patent/EA034776B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Соединения формулы I и формулы II, их фармацевтически приемлемые соли, их стереоизомеры или их смеси являются агонистами рецептора APJ, их можно применять для лечения сердечно-сосудистых и других состояний. Соединения формулы I и формулы II имеют следующие структуры:где определения переменных приведены в описании изобретения.
EA201792536A 2015-05-20 2016-05-18 Триазоловые агонисты рецептора apj EA034776B1 (ru)

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