SI3099688T1 - S heterocikli kondenzirani makrociklični factor xia inhibitorji - Google Patents
S heterocikli kondenzirani makrociklični factor xia inhibitorjiInfo
- Publication number
- SI3099688T1 SI3099688T1 SI201530121T SI201530121T SI3099688T1 SI 3099688 T1 SI3099688 T1 SI 3099688T1 SI 201530121 T SI201530121 T SI 201530121T SI 201530121 T SI201530121 T SI 201530121T SI 3099688 T1 SI3099688 T1 SI 3099688T1
- Authority
- SI
- Slovenia
- Prior art keywords
- heterocycles
- condensed
- factor xia
- xia inhibitors
- macrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461933948P | 2014-01-31 | 2014-01-31 | |
PCT/US2015/013647 WO2015116882A1 (en) | 2014-01-31 | 2015-01-30 | Macrocyclic factor xia inhibitors condensed with heterocycles |
EP15705427.1A EP3099688B1 (en) | 2014-01-31 | 2015-01-30 | Macrocyclic factor xia inhibitors condensed with heterocycles |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3099688T1 true SI3099688T1 (sl) | 2017-12-29 |
Family
ID=52484569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201530121T SI3099688T1 (sl) | 2014-01-31 | 2015-01-30 | S heterocikli kondenzirani makrociklični factor xia inhibitorji |
Country Status (23)
Country | Link |
---|---|
US (3) | US20170057961A1 (sl) |
EP (1) | EP3099688B1 (sl) |
JP (1) | JP6419836B2 (sl) |
CN (1) | CN106459051B (sl) |
AR (1) | AR099228A1 (sl) |
BR (1) | BR112016016741B1 (sl) |
CA (1) | CA2937738C (sl) |
CY (1) | CY1120534T1 (sl) |
DK (1) | DK3099688T3 (sl) |
EA (1) | EA032650B1 (sl) |
ES (1) | ES2655540T3 (sl) |
HR (1) | HRP20172002T1 (sl) |
HU (1) | HUE038060T2 (sl) |
LT (1) | LT3099688T (sl) |
MX (1) | MX2016009385A (sl) |
NO (1) | NO2760821T3 (sl) |
PL (1) | PL3099688T3 (sl) |
PT (1) | PT3099688T (sl) |
RS (1) | RS56785B1 (sl) |
SI (1) | SI3099688T1 (sl) |
TW (1) | TWI703144B (sl) |
UY (1) | UY35972A (sl) |
WO (1) | WO2015116882A1 (sl) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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HUE034857T2 (en) | 2011-10-14 | 2018-03-28 | Bristol Myers Squibb Co | Substituted tetrahydroisoquinoline compounds are inhibitors of factor XIA |
JP6479763B2 (ja) | 2013-03-25 | 2019-03-06 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 第xia因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン |
NO2760821T3 (sl) | 2014-01-31 | 2018-03-10 | ||
CN106132962B (zh) | 2014-01-31 | 2018-09-07 | 百时美施贵宝公司 | 作为凝血因子xia抑制剂的具有芳族p2’基团的大环化合物 |
ES2714283T3 (es) | 2014-09-04 | 2019-05-28 | Bristol Myers Squibb Co | Macrociclos de diamida que son inhibidores de FXIa |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
NO2721243T3 (sl) * | 2014-10-01 | 2018-10-20 | ||
ES2762987T3 (es) | 2015-06-19 | 2020-05-26 | Bristol Myers Squibb Co | Macrociclos de diamida como inhibidores del factor XIA |
WO2017019821A1 (en) | 2015-07-29 | 2017-02-02 | Bristol-Myers Squibb Company | Factor xia new macrocycle bearing a non-aromatic p2' group |
KR102086934B1 (ko) * | 2015-07-29 | 2020-03-09 | 브리스톨-마이어스 스큅 컴퍼니 | 알킬 또는 시클로알킬 P2' 모이어티를 갖는 인자 XIa 마크로시클릭 억제제 |
AU2016344476B2 (en) * | 2015-10-29 | 2020-08-13 | Merck Sharp & Dohme Llc | Factor XIa inhibitors |
EP3371162B1 (en) | 2015-10-29 | 2022-01-26 | Merck Sharp & Dohme Corp. | Macrocyclic spirocarbamate derivatives as factor xia inhibitors, pharmaceutically acceptable compositions and their use |
KR20180117156A (ko) | 2016-03-02 | 2018-10-26 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제 활성을 갖는 디아미드 마크로사이클 |
EP3500556B1 (en) | 2016-08-22 | 2023-08-02 | Merck Sharp & Dohme LLC | Pyridine-1-oxide derivatives and their use as factor xia inhibitors |
KR20190084310A (ko) | 2016-11-23 | 2019-07-16 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 살충제로서의 2-[3-(알킬술포닐)-2H-인다졸-2-일]-3H-이미다조[4,5-b]피리딘 유도체 및 유사한 화합물 |
AR113206A1 (es) | 2017-01-10 | 2020-02-19 | Bayer Cropscience Ag | Derivados heterocíclicos como pesticidas |
AU2018207776B2 (en) | 2017-01-10 | 2021-06-17 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
CN110062757B (zh) * | 2017-01-18 | 2022-03-04 | 广东东阳光药业有限公司 | 凝血因子XIa抑制剂及其用途 |
CN110922412A (zh) * | 2018-09-20 | 2020-03-27 | 复旦大学 | 具有抗精神病作用药物化合物的不对称合成方法 |
WO2020211781A1 (zh) * | 2019-04-16 | 2020-10-22 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
CN114008047B (zh) * | 2019-07-23 | 2023-03-21 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
WO2022222960A1 (zh) * | 2021-04-21 | 2022-10-27 | 上海美悦生物科技发展有限公司 | FXIa抑制剂及其药物组合物、制备方法和用途 |
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2012
- 2012-08-31 NO NO12780535A patent/NO2760821T3/no unknown
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2015
- 2015-01-30 PT PT157054271T patent/PT3099688T/pt unknown
- 2015-01-30 AR ARP150100295A patent/AR099228A1/es unknown
- 2015-01-30 LT LTEP15705427.1T patent/LT3099688T/lt unknown
- 2015-01-30 EA EA201691561A patent/EA032650B1/ru not_active IP Right Cessation
- 2015-01-30 CN CN201580017759.3A patent/CN106459051B/zh active Active
- 2015-01-30 EP EP15705427.1A patent/EP3099688B1/en active Active
- 2015-01-30 WO PCT/US2015/013647 patent/WO2015116882A1/en active Application Filing
- 2015-01-30 MX MX2016009385A patent/MX2016009385A/es active IP Right Grant
- 2015-01-30 CA CA2937738A patent/CA2937738C/en active Active
- 2015-01-30 PL PL15705427T patent/PL3099688T3/pl unknown
- 2015-01-30 TW TW104103315A patent/TWI703144B/zh active
- 2015-01-30 BR BR112016016741-4A patent/BR112016016741B1/pt active IP Right Grant
- 2015-01-30 HU HUE15705427A patent/HUE038060T2/hu unknown
- 2015-01-30 DK DK15705427.1T patent/DK3099688T3/en active
- 2015-01-30 UY UY0001035972A patent/UY35972A/es active IP Right Grant
- 2015-01-30 JP JP2016549270A patent/JP6419836B2/ja active Active
- 2015-01-30 SI SI201530121T patent/SI3099688T1/sl unknown
- 2015-01-30 ES ES15705427.1T patent/ES2655540T3/es active Active
- 2015-01-30 RS RS20180033A patent/RS56785B1/sr unknown
- 2015-01-30 US US15/115,319 patent/US20170057961A1/en not_active Abandoned
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2017
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- 2017-12-29 CY CY20171101357T patent/CY1120534T1/el unknown
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2018
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EA201691561A1 (ru) | 2017-01-30 |
EP3099688A1 (en) | 2016-12-07 |
US20170342071A1 (en) | 2017-11-30 |
ES2655540T3 (es) | 2018-02-20 |
MX2016009385A (es) | 2016-09-16 |
TW201615640A (zh) | 2016-05-01 |
JP2017504640A (ja) | 2017-02-09 |
LT3099688T (lt) | 2017-12-27 |
CA2937738A1 (en) | 2015-08-06 |
CY1120534T1 (el) | 2019-07-10 |
BR112016016741B1 (pt) | 2023-01-17 |
CN106459051A (zh) | 2017-02-22 |
RS56785B1 (sr) | 2018-04-30 |
UY35972A (es) | 2015-07-31 |
AR099228A1 (es) | 2016-07-06 |
US10273236B2 (en) | 2019-04-30 |
EA032650B1 (ru) | 2019-06-28 |
PL3099688T3 (pl) | 2018-03-30 |
CA2937738C (en) | 2023-01-17 |
EP3099688B1 (en) | 2017-10-18 |
US20170057961A1 (en) | 2017-03-02 |
NO2760821T3 (sl) | 2018-03-10 |
WO2015116882A1 (en) | 2015-08-06 |
DK3099688T3 (en) | 2018-01-15 |
HUE038060T2 (hu) | 2018-09-28 |
HRP20172002T1 (hr) | 2018-02-09 |
BR112016016741A2 (sl) | 2017-08-08 |
PT3099688T (pt) | 2018-01-15 |
TWI703144B (zh) | 2020-09-01 |
CN106459051B (zh) | 2018-10-16 |
US20180222907A1 (en) | 2018-08-09 |
JP6419836B2 (ja) | 2018-11-07 |
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