BR112017000808A2 - espirociclo-heptanos como inibidores de rock - Google Patents

espirociclo-heptanos como inibidores de rock

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Publication number
BR112017000808A2
BR112017000808A2 BR112017000808A BR112017000808A BR112017000808A2 BR 112017000808 A2 BR112017000808 A2 BR 112017000808A2 BR 112017000808 A BR112017000808 A BR 112017000808A BR 112017000808 A BR112017000808 A BR 112017000808A BR 112017000808 A2 BR112017000808 A2 BR 112017000808A2
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BR
Brazil
Prior art keywords
rock inhibitors
compounds
spirocycloheptanes
neuropathological
fibrotic
Prior art date
Application number
BR112017000808A
Other languages
English (en)
Inventor
W Glunz Peter
Ladziata Vladimir
Wang Yufeng
Hu Zilun
Original Assignee
Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR112017000808A2 publication Critical patent/BR112017000808A2/pt

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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

a presente invenção fornece compostos de fórmula (i): (i) ou estereoisômeros, tautômeros, ou sais farmaceuticamente acetáveis dos mesmos, em que todas as variáveis são como definidas aqui. estes compostos são inibidores de rock seletivos. esta invenção também se refere às composições farmacêuticas compreendendo estes compostos e métodos de tratar distúrbios cardiovasculares, de músculo liso, oncológicos, neuropatológicos, autoimunes, fibróticos, e/ou inflamatórios usando as mesmas.
BR112017000808A 2014-07-15 2015-07-14 espirociclo-heptanos como inibidores de rock BR112017000808A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024555P 2014-07-15 2014-07-15
US14/797,414 US9902702B2 (en) 2014-07-15 2015-07-13 Spirocycloheptanes as inhibitors of rock
PCT/US2015/040254 WO2016010950A1 (en) 2014-07-15 2015-07-14 Spirocycloheptanes as inhibitors of rock

Publications (1)

Publication Number Publication Date
BR112017000808A2 true BR112017000808A2 (pt) 2017-12-05

Family

ID=55073996

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017000808A BR112017000808A2 (pt) 2014-07-15 2015-07-14 espirociclo-heptanos como inibidores de rock

Country Status (24)

Country Link
US (2) US9902702B2 (pt)
EP (1) EP3169682B1 (pt)
JP (2) JP6499749B2 (pt)
KR (1) KR102420938B1 (pt)
CN (1) CN106817899B (pt)
AR (1) AR101208A1 (pt)
AU (1) AU2015289897B2 (pt)
BR (1) BR112017000808A2 (pt)
CA (1) CA2954976A1 (pt)
CL (1) CL2017000089A1 (pt)
CO (1) CO2017001152A2 (pt)
EA (1) EA033061B1 (pt)
ES (1) ES2716415T3 (pt)
IL (1) IL250046B (pt)
MA (1) MA39554B1 (pt)
MX (1) MX2017000485A (pt)
PE (1) PE20170672A1 (pt)
PH (1) PH12017500072A1 (pt)
SG (1) SG11201700251PA (pt)
TN (1) TN2017000009A1 (pt)
TW (1) TW201607933A (pt)
UY (1) UY36215A (pt)
WO (1) WO2016010950A1 (pt)
ZA (1) ZA201700304B (pt)

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