ATE124408T1 - Heterozyklische aminderivate, deren herstellung und deren verwendung. - Google Patents
Heterozyklische aminderivate, deren herstellung und deren verwendung.Info
- Publication number
- ATE124408T1 ATE124408T1 AT91117442T AT91117442T ATE124408T1 AT E124408 T1 ATE124408 T1 AT E124408T1 AT 91117442 T AT91117442 T AT 91117442T AT 91117442 T AT91117442 T AT 91117442T AT E124408 T1 ATE124408 T1 AT E124408T1
- Authority
- AT
- Austria
- Prior art keywords
- stands
- compound
- ring
- heterocyclic amine
- formula
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- -1 heterocyclic amine Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27803890 | 1990-10-16 | ||
| JP23798391 | 1991-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE124408T1 true ATE124408T1 (de) | 1995-07-15 |
Family
ID=26533468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91117442T ATE124408T1 (de) | 1990-10-16 | 1991-10-12 | Heterozyklische aminderivate, deren herstellung und deren verwendung. |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US5198462A (de) |
| EP (1) | EP0481383B1 (de) |
| AT (1) | ATE124408T1 (de) |
| CA (1) | CA2053477C (de) |
| DE (1) | DE69110828T2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW241258B (de) * | 1992-04-15 | 1995-02-21 | Takeda Pharm Industry Co Ltd | |
| ATE161530T1 (de) * | 1992-09-04 | 1998-01-15 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische verbindungen, deren herstellung und verwendung |
| EP0634402A1 (de) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinon-Derivate, ihre Herstellung und Verwendung |
| TW263498B (de) * | 1993-11-10 | 1995-11-21 | Takeda Pharm Industry Co Ltd | |
| AU8862298A (en) | 1997-07-22 | 1999-02-16 | Basf Coatings Aktiengesellschaft | Coating agent and method for producing same |
| FR2772761B1 (fr) | 1997-12-23 | 2000-05-26 | Lipha | Nouveaux derives de n-phenylamide et n-pyridylamide, leur procede de preparation et compositions pharmaceutiques les contenant |
| US6169185B1 (en) | 1999-02-25 | 2001-01-02 | Day-Glo Color Corp. | Ink jet printing inks |
| DE60132606T2 (de) * | 2000-09-20 | 2009-02-19 | Merck & Co., Inc. | Isochinolinone als kalium-kanal-inhibitoren |
| AU2003211931A1 (en) * | 2002-02-13 | 2003-09-04 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| AU2004276267B2 (en) | 2003-09-23 | 2010-08-19 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| NZ563009A (en) * | 2005-04-19 | 2011-05-27 | Surface Logix Inc | Inhibitors of microsomal triglyceride transfer protein and Apo-B secretion |
| US9221767B2 (en) | 2013-01-18 | 2015-12-29 | Bristol-Myers Squibb Company | Substituted phthalazinones as rock inhibitors |
| US9902702B2 (en) | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| US12453728B1 (en) | 2024-08-08 | 2025-10-28 | Redux Therapeutics, Llc | Compositions comprising inhibitors of microsomal triglyceride transfer protein and Apo-B secretion |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3247212A (en) * | 1963-03-19 | 1966-04-19 | Dow Chemical Co | Thio substituted 3 amino isoquinolines |
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| DE2030675A1 (en) * | 1969-06-23 | 1971-02-11 | Arthur D Little, Inc , Cambridge, Mass (V St A) | 3-amino-4-phenyl-isoquinoline derivs |
| NO133758C (de) * | 1970-04-04 | 1976-06-23 | Takeda Chemical Industries Ltd | |
| JPS555502B1 (de) * | 1971-07-31 | 1980-02-07 | ||
| US3870722A (en) * | 1973-11-02 | 1975-03-11 | Sandoz Ag | 2-Methyl-3-substituted-4-aryl isoquinolines |
| US4078075A (en) * | 1976-09-20 | 1978-03-07 | Ciba-Geigy Corporation | Insecticidally active 3-N-(4-trifluoromethylphenyl)-carbamoyl-4-hydroxy-coumarin |
| US4596822A (en) * | 1984-08-20 | 1986-06-24 | Georgia Tech Research Corporation | Heterocyclic inhibitors of serine proteases |
| KR890011876A (ko) * | 1988-01-27 | 1989-08-23 | 메이 앤드 베이커 리미팃드 | 신규한 이소퀴놀린 유도체 그의 제조방법 및 그를 함유하는 제약학적 조성물 |
| US4868210A (en) * | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4994465A (en) * | 1989-02-17 | 1991-02-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds |
| CA2028538A1 (en) * | 1989-10-27 | 1991-04-28 | Hideaki Natsugari | 4-substituted isoquinolone derivatives, their production and use |
| US5278186A (en) * | 1990-02-10 | 1994-01-11 | Takeda Chemical Industries, Ltd. | Chromene derivatives, their production and use |
-
1991
- 1991-10-12 EP EP91117442A patent/EP0481383B1/de not_active Expired - Lifetime
- 1991-10-12 DE DE69110828T patent/DE69110828T2/de not_active Expired - Fee Related
- 1991-10-12 AT AT91117442T patent/ATE124408T1/de not_active IP Right Cessation
- 1991-10-15 CA CA002053477A patent/CA2053477C/en not_active Expired - Fee Related
- 1991-10-16 US US07/777,169 patent/US5198462A/en not_active Expired - Fee Related
-
1992
- 1992-12-22 US US07/995,016 patent/US5300646A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5198462A (en) | 1993-03-30 |
| DE69110828D1 (de) | 1995-08-03 |
| CA2053477A1 (en) | 1992-04-17 |
| CA2053477C (en) | 2002-01-29 |
| EP0481383A1 (de) | 1992-04-22 |
| US5300646A (en) | 1994-04-05 |
| EP0481383B1 (de) | 1995-06-28 |
| DE69110828T2 (de) | 1995-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |