DK3102576T3 - Dihydropyrrolopyridininhibitorer af ror-gamma - Google Patents

Dihydropyrrolopyridininhibitorer af ror-gamma Download PDF

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Publication number
DK3102576T3
DK3102576T3 DK15705744.9T DK15705744T DK3102576T3 DK 3102576 T3 DK3102576 T3 DK 3102576T3 DK 15705744 T DK15705744 T DK 15705744T DK 3102576 T3 DK3102576 T3 DK 3102576T3
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Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
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DK15705744.9T
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English (en)
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Zhijie Liu
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Yajun Zheng
Linghang Zhuang
Wei Zhao
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Vitae Pharmaceuticals Llc
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Application filed by Vitae Pharmaceuticals Llc filed Critical Vitae Pharmaceuticals Llc
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Publication of DK3102576T3 publication Critical patent/DK3102576T3/da

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DK15705744.9T 2014-02-03 2015-01-30 Dihydropyrrolopyridininhibitorer af ror-gamma DK3102576T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26
PCT/US2015/013699 WO2015116904A1 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

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DK3102576T3 true DK3102576T3 (da) 2019-07-22

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DK15705744.9T DK3102576T3 (da) 2014-02-03 2015-01-30 Dihydropyrrolopyridininhibitorer af ror-gamma

Country Status (26)

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US (6) US9266886B2 (da)
EP (2) EP3102576B8 (da)
JP (1) JP6466461B2 (da)
KR (1) KR102408261B1 (da)
CN (1) CN105940002B (da)
AU (1) AU2015210833B2 (da)
CA (1) CA2938311C (da)
CL (1) CL2016001947A1 (da)
DK (1) DK3102576T3 (da)
EA (1) EA031804B1 (da)
EC (1) ECSP16071151A (da)
ES (1) ES2735099T3 (da)
HU (1) HUE045511T2 (da)
IL (1) IL246902B (da)
LT (1) LT3102576T (da)
MX (1) MX371017B (da)
PE (1) PE20161372A1 (da)
PH (1) PH12016501457B1 (da)
PL (1) PL3102576T3 (da)
PT (1) PT3102576T (da)
RS (1) RS59007B1 (da)
SG (1) SG11201606080SA (da)
SI (1) SI3102576T1 (da)
TW (1) TWI658041B (da)
UA (1) UA121309C2 (da)
WO (1) WO2015116904A1 (da)

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CN117164657A (zh) 2014-08-12 2023-12-05 莫纳什大学 定向淋巴的前药
CN107074852B (zh) 2014-10-14 2019-08-16 生命医药有限责任公司 ROR-γ的二氢吡咯并吡啶抑制剂
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) * 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
JP2018513123A (ja) 2015-03-12 2018-05-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｒｏｒガンマ阻害剤を用いてがんを治療するための方法
US20180200247A1 (en) 2015-05-15 2018-07-19 Aurigene Discovery Technologies Limited Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators
MX2017015980A (es) 2015-06-09 2018-04-20 Abbvie Inc Moduladores de receptor nuclear.
WO2017010399A1 (ja) * 2015-07-10 2017-01-19 塩野義製薬株式会社 ＲＯＲγｔ阻害作用を有する化合物およびそれらを含有する医薬組成物
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US10450314B2 (en) * 2015-10-01 2019-10-22 Boehringer Ingelheim International Gmbh Pteridine derivatives as modulators of ROR gamma
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TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN106632313B (zh) * 2016-03-04 2021-04-09 上海贤鼎生物科技有限公司 一种抗癌药帕博昔布重要中间体及合成工艺
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3481809A1 (en) 2016-07-14 2019-05-15 Cadila Healthcare Limited Cyclopropyl derivatives as ror-gamma modulators
TW201815388A (zh) 2016-07-14 2018-05-01 印度商卡迪拉保健有限公司 作為ＲＯＲγ調節劑之新穎化合物
WO2018042342A1 (en) * 2016-08-30 2018-03-08 Glenmark Pharmaceuticals S.A. 1,2,3-benzotriazole derivatives as ror gamma t modulators
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CN110603261A (zh) 2016-12-23 2019-12-20 拜斯科阿迪有限公司 具有新型键结构的肽衍生物
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
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TW201900617A (zh) * 2017-05-23 2019-01-01 大陸商江蘇恆瑞醫藥股份有限公司 螺環甲醯胺類衍生物、其製備方法及其在醫藥上的應用
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