DK3442972T3 - Bromdomænehæmmere - Google Patents

Bromdomænehæmmere Download PDF

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Publication number
DK3442972T3
DK3442972T3 DK17781931.5T DK17781931T DK3442972T3 DK 3442972 T3 DK3442972 T3 DK 3442972T3 DK 17781931 T DK17781931 T DK 17781931T DK 3442972 T3 DK3442972 T3 DK 3442972T3
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Prior art keywords
bromdomain
inhibitors
bromdomain inhibitors
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DK17781931.5T
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English (en)
Inventor
Steven D Fidanze
Lisa A Hasvold
Dachun Liu
Keith F Mcdaniel
John PRATT
Michael Schrimpf
George S Sheppard
Le Wang
Bing Li
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Abbvie Inc
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Publication of DK3442972T3 publication Critical patent/DK3442972T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DK17781931.5T 2016-04-15 2017-04-14 Bromdomænehæmmere DK3442972T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016079362 2016-04-15
PCT/CN2017/080511 WO2017177955A1 (en) 2016-04-15 2017-04-14 Bromodomain inhibitors

Publications (1)

Publication Number Publication Date
DK3442972T3 true DK3442972T3 (da) 2020-04-27

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Country Status (38)

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US (3) US10633379B2 (da)
EP (2) EP3693369A3 (da)
JP (2) JP6978424B2 (da)
KR (1) KR102250415B1 (da)
CN (1) CN109071534B (da)
AR (1) AR108207A1 (da)
AU (2) AU2017251537B2 (da)
BR (1) BR112018071216A2 (da)
CA (1) CA3018802A1 (da)
CL (1) CL2018002924A1 (da)
CO (1) CO2018011064A2 (da)
CR (1) CR20180541A (da)
CY (1) CY1123025T1 (da)
DK (1) DK3442972T3 (da)
DO (1) DOP2018000227A (da)
EC (1) ECSP18083519A (da)
ES (1) ES2793239T3 (da)
HR (1) HRP20200728T1 (da)
HU (1) HUE050217T2 (da)
IL (1) IL261586B (da)
LT (1) LT3442972T (da)
MA (2) MA44674B1 (da)
MD (1) MD3442972T2 (da)
ME (1) ME03759B (da)
MX (1) MX2018012541A (da)
MY (1) MY190795A (da)
PE (1) PE20190472A1 (da)
PH (1) PH12018501920B1 (da)
PL (1) PL3442972T3 (da)
PT (1) PT3442972T (da)
RS (1) RS60302B1 (da)
RU (1) RU2741808C2 (da)
SG (1) SG11201808003RA (da)
SI (1) SI3442972T1 (da)
TW (3) TW202304907A (da)
UA (1) UA124764C2 (da)
UY (1) UY37205A (da)
WO (1) WO2017177955A1 (da)

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JP6978424B2 (ja) * 2016-04-15 2021-12-08 アッヴィ・インコーポレイテッド ブロモドメイン阻害剤
JP2019534264A (ja) * 2016-10-14 2019-11-28 アッヴィ・インコーポレイテッド ブロモドメイン阻害剤
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
KR20210038921A (ko) 2018-07-25 2021-04-08 치아타이 티안큉 파마수티컬 그룹 주식회사 브로모도메인 단백질 억제제로서의 설폭시민 화합물과 약학적 조성물 및 이의 의학적 용도
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
WO2020063976A1 (zh) * 2018-09-29 2020-04-02 如东凌达生物医药科技有限公司 一类稠杂环联芳基苄醇类化合物、制备方法和用途
CA3116931A1 (en) 2018-10-30 2020-05-07 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
EP3967690A4 (en) 2019-03-17 2023-04-12 Shanghai Ringene BioPharma Co., Ltd. PYRROLE AMIDOPYRIDONE COMPOUND, METHOD FOR PREPARING IT AND ITS USE
GB201905721D0 (en) * 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020232214A1 (en) * 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
WO2021003310A1 (en) 2019-07-02 2021-01-07 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
GB202016977D0 (en) 2020-10-26 2020-12-09 In4Derm Ltd Compounds
EP4183785A1 (en) 2020-12-01 2023-05-24 Chengdu Easton Biopharmaceuticals Co., Ltd. Novel n-heterocyclic bet bromodomain inhibitor, and preparation method therefor and medical use thereof
WO2022228421A1 (zh) * 2021-04-30 2022-11-03 成都苑东生物制药股份有限公司 一种新型brd4溴结构域protac蛋白降解剂、其制备方法及医药用途
GB2621505A (en) 2021-06-29 2024-02-14 Tay Therapeutics Ltd Pyrrolopyridone derivatives useful in the treatment of cancer
CN115611890A (zh) * 2021-07-15 2023-01-17 成都苑东生物制药股份有限公司 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途

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