MX2016013851A - 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). - Google Patents

1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet).

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Publication number
MX2016013851A
MX2016013851A MX2016013851A MX2016013851A MX2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A
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Mexico
Prior art keywords
pyridin
ones
inhibitors
pyrazolo
pyrrolo
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MX2016013851A
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English (en)
Inventor
P Combs Andrew
Falahatpisheh Nikoo
P Maduskuie Thomas Jr
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Incyte Corp
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Publication date
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Publication of MX2016013851A publication Critical patent/MX2016013851A/es

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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

La presente invención se relaciona con pirrolopiridinonas sustituidas y pirazolopiridinonas sustituidas que constituyen inhibidores de proteínas BET tales como BRD2, BRD3, BRD4 y BRD-t y son útiles en el tratamiento de las enfermedades como el cáncer.
MX2016013851A 2014-04-23 2015-04-22 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). MX2016013851A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983289P 2014-04-23 2014-04-23
PCT/US2015/027047 WO2015164480A1 (en) 2014-04-23 2015-04-22 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS

Publications (1)

Publication Number Publication Date
MX2016013851A true MX2016013851A (es) 2017-07-14

Family

ID=53055117

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016013851A MX2016013851A (es) 2014-04-23 2015-04-22 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet).
MX2020011035A MX2020011035A (es) 2014-04-23 2016-10-21 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7 (6h)-onas como inhibidores de proteinas de bromodominio y extra terminal (bet).

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MX2020011035A MX2020011035A (es) 2014-04-23 2016-10-21 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7 (6h)-onas como inhibidores de proteinas de bromodominio y extra terminal (bet).

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JP (2) JP6572237B2 (es)
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CN (1) CN106414442B (es)
AR (1) AR100160A1 (es)
AU (3) AU2015249810B2 (es)
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CA (1) CA2946731C (es)
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CR (2) CR20200231A (es)
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DK (2) DK3134403T3 (es)
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MA (1) MA39985B1 (es)
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MX (2) MX2016013851A (es)
MY (1) MY180775A (es)
NZ (3) NZ725930A (es)
PE (1) PE20170144A1 (es)
PH (1) PH12016502115A1 (es)
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