MX2016013851A - 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). - Google Patents

1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet).

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Publication number
MX2016013851A
MX2016013851A MX2016013851A MX2016013851A MX2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A MX 2016013851 A MX2016013851 A MX 2016013851A
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Mexico
Prior art keywords
pyridin
ones
inhibitors
pyrazolo
pyrrolo
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MX2016013851A
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English (en)
Inventor
P Combs Andrew
Falahatpisheh Nikoo
P Maduskuie Thomas Jr
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Incyte Corp
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Publication of MX2016013851A publication Critical patent/MX2016013851A/es

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Abstract

La presente invención se relaciona con pirrolopiridinonas sustituidas y pirazolopiridinonas sustituidas que constituyen inhibidores de proteínas BET tales como BRD2, BRD3, BRD4 y BRD-t y son útiles en el tratamiento de las enfermedades como el cáncer.
MX2016013851A 2014-04-23 2015-04-22 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet). MX2016013851A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983289P 2014-04-23 2014-04-23
PCT/US2015/027047 WO2015164480A1 (en) 2014-04-23 2015-04-22 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS

Publications (1)

Publication Number Publication Date
MX2016013851A true MX2016013851A (es) 2017-07-14

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ID=53055117

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Application Number Title Priority Date Filing Date
MX2016013851A MX2016013851A (es) 2014-04-23 2015-04-22 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7(6h) -onas como inhibidores de proteinas de bromodominio y extra terminal (bet).
MX2020011035A MX2020011035A (es) 2014-04-23 2016-10-21 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7 (6h)-onas como inhibidores de proteinas de bromodominio y extra terminal (bet).

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MX2020011035A MX2020011035A (es) 2014-04-23 2016-10-21 1h-pirrolo[2,3-c]piridin-7(6h)-onas y pirazolo[3,4-c]piridin-7 (6h)-onas como inhibidores de proteinas de bromodominio y extra terminal (bet).

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US9290514B2 (en) 2013-07-08 2016-03-22 Incyte Holdings Corporation Tricyclic heterocycles as BET protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
EA039678B1 (ru) 2014-04-23 2022-02-24 Инсайт Корпорейшн 1H-ПИРРОЛО[2,3-c]ПИРИДИН-7(6H)-ОНЫ И ПИРАЗОЛО[3,4-c]ПИРИДИН-7(6H)-ОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕЛКОВ BET
TWI712603B (zh) 2014-09-15 2020-12-11 美商英塞特公司 作為ｂｅｔ蛋白抑制劑之三環雜環
MA40940A (fr) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
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MA40943A (fr) * 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
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