HUE049627T2 - 1H-pirrolo[2,3-C]piridin-7(6H)-onok és pirazolo[3,4-C]piridin-7(6H)-onok, mint BET fehérjék inhibitorai - Google Patents
1H-pirrolo[2,3-C]piridin-7(6H)-onok és pirazolo[3,4-C]piridin-7(6H)-onok, mint BET fehérjék inhibitoraiInfo
- Publication number
- HUE049627T2 HUE049627T2 HUE15721085A HUE15721085A HUE049627T2 HU E049627 T2 HUE049627 T2 HU E049627T2 HU E15721085 A HUE15721085 A HU E15721085A HU E15721085 A HUE15721085 A HU E15721085A HU E049627 T2 HUE049627 T2 HU E049627T2
- Authority
- HU
- Hungary
- Prior art keywords
- pyridin
- ones
- pyrazolo
- pyrrolo
- inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461983289P | 2014-04-23 | 2014-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE049627T2 true HUE049627T2 (hu) | 2020-09-28 |
Family
ID=53055117
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE15721085A HUE049627T2 (hu) | 2014-04-23 | 2015-04-22 | 1H-pirrolo[2,3-C]piridin-7(6H)-onok és pirazolo[3,4-C]piridin-7(6H)-onok, mint BET fehérjék inhibitorai |
HUE20156599A HUE061770T2 (hu) | 2014-04-23 | 2015-04-22 | 1H-pirrolo[2,3-C]piridin-7(6H)-onok és pirazolo[3,4-C]piridin-7(6H)-onok mint BET fehérjék gátlószerei |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE20156599A HUE061770T2 (hu) | 2014-04-23 | 2015-04-22 | 1H-pirrolo[2,3-C]piridin-7(6H)-onok és pirazolo[3,4-C]piridin-7(6H)-onok mint BET fehérjék gátlószerei |
Country Status (36)
Country | Link |
---|---|
US (7) | US9540368B2 (hu) |
EP (3) | EP4218766A1 (hu) |
JP (2) | JP6572237B2 (hu) |
KR (2) | KR102430144B1 (hu) |
CN (1) | CN106414442B (hu) |
AR (1) | AR100160A1 (hu) |
AU (3) | AU2015249810B2 (hu) |
BR (1) | BR112016024626B1 (hu) |
CA (1) | CA2946731C (hu) |
CL (1) | CL2016002681A1 (hu) |
CR (2) | CR20160542A (hu) |
CY (2) | CY1122948T1 (hu) |
DK (2) | DK3134403T3 (hu) |
EA (2) | EA039678B1 (hu) |
EC (1) | ECSP16088983A (hu) |
ES (2) | ES2784846T3 (hu) |
FI (1) | FI3674302T3 (hu) |
HR (2) | HRP20230340T1 (hu) |
HU (2) | HUE049627T2 (hu) |
IL (3) | IL248415B (hu) |
LT (2) | LT3134403T (hu) |
MA (1) | MA39985B1 (hu) |
ME (1) | ME03763B (hu) |
MX (2) | MX2016013851A (hu) |
MY (1) | MY180775A (hu) |
NZ (3) | NZ763737A (hu) |
PE (1) | PE20170144A1 (hu) |
PH (1) | PH12016502115A1 (hu) |
PL (2) | PL3134403T3 (hu) |
PT (2) | PT3674302T (hu) |
RS (2) | RS60139B1 (hu) |
SG (2) | SG11201608843TA (hu) |
SI (2) | SI3674302T1 (hu) |
TW (2) | TWI735002B (hu) |
UA (1) | UA119870C2 (hu) |
WO (1) | WO2015164480A1 (hu) |
Families Citing this family (46)
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WO2014143768A1 (en) | 2013-03-15 | 2014-09-18 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
AR096837A1 (es) | 2013-07-08 | 2016-02-03 | Incyte Corp | Heterociclos tricíclicos como inhibidores de proteínas bet |
WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
FI3674302T3 (fi) | 2014-04-23 | 2023-04-27 | Incyte Holdings Corp | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONEJA JA PYRATSOLO[3,4-c]PYRIDIN-7(6H)-ONEJA BET-PROTEIINIEN INHIBIITTOREINA |
ES2855225T3 (es) | 2014-09-15 | 2021-09-23 | Incyte Corp | Heterociclos tricíclicos para su uso como inhibidores de proteínas BET |
MA40943A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
MA40940A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
JP6639497B2 (ja) | 2014-11-10 | 2020-02-05 | ジェネンテック, インコーポレイテッド | ブロモドメインインヒビターおよびその使用 |
CN107531692B (zh) | 2015-01-29 | 2020-12-25 | 基因泰克公司 | 治疗化合物及其用途 |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
WO2017024408A1 (en) * | 2015-08-11 | 2017-02-16 | Neomed Institute | Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals |
US10836742B2 (en) | 2015-08-11 | 2020-11-17 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
EP3334719B1 (en) | 2015-08-12 | 2021-09-15 | Neomed Institute | Substituted benzimidazoles, their preparation and their use as pharmaceuticals |
WO2017066876A1 (en) | 2015-10-21 | 2017-04-27 | Neomed Institute | Substituted imidazopyridines, their preparation and their use as pharmaceuticals |
TW201722966A (zh) | 2015-10-29 | 2017-07-01 | 英塞特公司 | Bet蛋白質抑制劑之非晶固體形式 |
US10519151B2 (en) | 2016-01-28 | 2019-12-31 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals |
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AU2018302178A1 (en) | 2017-07-18 | 2020-02-13 | Nuvation Bio Inc. | 1,8-naphthyridinone compounds and uses thereof |
CA3070273A1 (en) | 2017-07-18 | 2019-01-24 | Nuvation Bio Inc. | Heterocyclic compounds as adenosine antagonists |
JP7254075B2 (ja) * | 2017-11-06 | 2023-04-07 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | キサンチン誘導体及びbetタンパク質のブロモドメインの阻害剤としてのその使用 |
CN111712496B (zh) | 2017-12-20 | 2023-05-02 | 贝达药业股份有限公司 | 作为溴结构域蛋白质抑制剂的化合物和组合物 |
MX2020006365A (es) | 2017-12-21 | 2020-10-12 | Ribon Therapeutics Inc | Quinazolinonas como inhibidores de poli(adenosin difosfato-ribosa)polimerasa 14 (parp14). |
WO2019154329A1 (zh) * | 2018-02-06 | 2019-08-15 | 上海海和药物研究开发有限公司 | 具有bet抑制活性的化合物及其制备方法和用途 |
CN110776508B (zh) * | 2018-07-27 | 2021-07-16 | 海创药业股份有限公司 | 一种brd4抑制剂及其制备方法和用途 |
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