MX2016007346A - Derivados de dihidropiridinona y dihidropiridazinona utiles como inhibidores de bromodominio. - Google Patents
Derivados de dihidropiridinona y dihidropiridazinona utiles como inhibidores de bromodominio.Info
- Publication number
- MX2016007346A MX2016007346A MX2016007346A MX2016007346A MX2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A MX 2016007346 A MX2016007346 A MX 2016007346A
- Authority
- MX
- Mexico
- Prior art keywords
- dihydropyridinone
- derivatives useful
- bromodomain inhibitors
- dihydropyridazinone derivatives
- dihydropyridazinone
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
La presente invención, proporciona compuestos de la fórmula (I) (ver Fórmula) en donde Y1, Y2, R1, R2, R3, A1, A2, A3, y A4, tienen cualquiera de los valores definidos en la especificación, y las sales farmacéuticamente aceptables de los mismos, que son útiles como agentes para el tratamiento de enfermedades y condiciones, incluyendo enfermedades inflamatorias, cáncer y SIDA. También se proporcionan las composiciones farmacéuticas comprendidas de uno o más compuestos de la fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013088844 | 2013-12-09 | ||
PCT/US2014/069350 WO2015089075A1 (en) | 2013-12-09 | 2014-12-09 | Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors |
Publications (1)
Publication Number | Publication Date |
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MX2016007346A true MX2016007346A (es) | 2016-09-13 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MX2016007346A MX2016007346A (es) | 2013-12-09 | 2014-12-09 | Derivados de dihidropiridinona y dihidropiridazinona utiles como inhibidores de bromodominio. |
Country Status (8)
Country | Link |
---|---|
US (3) | US9428514B2 (es) |
EP (1) | EP3089970B1 (es) |
JP (1) | JP2016539970A (es) |
CN (1) | CN105939996A (es) |
AU (1) | AU2014363989A1 (es) |
CA (1) | CA2932030A1 (es) |
MX (1) | MX2016007346A (es) |
WO (1) | WO2015089075A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3581576B1 (en) | 2013-03-15 | 2022-01-26 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors for use in the treatment of a proliferative disease in combination with a janus kinase inhibitor |
JP2016523964A (ja) | 2013-07-08 | 2016-08-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Betタンパク質阻害剤としての三環式複素環 |
WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
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BR112014031068A2 (pt) * | 2012-06-12 | 2017-06-27 | Abbvie Inc | derivados piridinona e piridazinona |
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AU2014363989A1 (en) * | 2013-12-09 | 2016-06-16 | Abbvie Inc. | Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors |
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2014
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- 2014-12-09 CA CA2932030A patent/CA2932030A1/en not_active Abandoned
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- 2014-12-09 JP JP2016537524A patent/JP2016539970A/ja active Pending
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2018
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US20160331749A1 (en) | 2016-11-17 |
US10085985B2 (en) | 2018-10-02 |
CN105939996A (zh) | 2016-09-14 |
US20150158873A1 (en) | 2015-06-11 |
AU2014363989A1 (en) | 2016-06-16 |
EP3089970A1 (en) | 2016-11-09 |
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