MX2014012695A - Derivados de isoindolona. - Google Patents

Derivados de isoindolona.

Info

Publication number
MX2014012695A
MX2014012695A MX2014012695A MX2014012695A MX2014012695A MX 2014012695 A MX2014012695 A MX 2014012695A MX 2014012695 A MX2014012695 A MX 2014012695A MX 2014012695 A MX2014012695 A MX 2014012695A MX 2014012695 A MX2014012695 A MX 2014012695A
Authority
MX
Mexico
Prior art keywords
compounds
formula
isoindolone derivatives
diseases
isoindolone
Prior art date
Application number
MX2014012695A
Other languages
English (en)
Inventor
John K Pratt
Le Wang
Chang H Park
George S Sheppard
Lisa A Hasvold
Dachun Liu
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2014012695A publication Critical patent/MX2014012695A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/4164—1,3-Diazoles
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

La presente invención provee compuestos de fórmula (I) en donde A, Y, J, R1, R2 y R3 tienen cualquiera de los valores definidos para los mismos en la especificación, y sales farmacéuticamente aceptables de los mismos, que son útiles como agentes en el tratamiento de enfermedades y afecciones que incluyen enfermedades inflamatorias, diabetes, obesidad, cáncer y SIDA. También se proveen composiciones farmacéuticas que comprenden uno o más compuestos de fórmula (I). (ver Fórmula).
MX2014012695A 2012-04-20 2013-04-19 Derivados de isoindolona. MX2014012695A (es)

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PCT/CN2012/074411 WO2013155695A1 (en) 2012-04-20 2012-04-20 Isoindolone derivatives
US13/796,731 US9776990B2 (en) 2012-04-20 2013-03-12 Isoindolone derivatives
PCT/US2013/037297 WO2013158952A1 (en) 2012-04-20 2013-04-19 Isoindolone derivatives

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MX2014012635A (es) 2015-05-15
JP2015514725A (ja) 2015-05-21
US20150111890A1 (en) 2015-04-23
EP2838881B1 (en) 2018-08-08
CA2870446A1 (en) 2013-10-24
WO2013155695A1 (en) 2013-10-24
JP5989229B2 (ja) 2016-09-07
US9776990B2 (en) 2017-10-03
EP2838881A4 (en) 2015-10-28
WO2013158952A1 (en) 2013-10-24
JP2015514780A (ja) 2015-05-21
CN104334526A (zh) 2015-02-04
EP2850071A1 (en) 2015-03-25

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