EA201690087A1 - Новые квиназолиноны как ингибиторы бромодомена - Google Patents

Новые квиназолиноны как ингибиторы бромодомена

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Publication number
EA201690087A1
EA201690087A1 EA201690087A EA201690087A EA201690087A1 EA 201690087 A1 EA201690087 A1 EA 201690087A1 EA 201690087 A EA201690087 A EA 201690087A EA 201690087 A EA201690087 A EA 201690087A EA 201690087 A1 EA201690087 A1 EA 201690087A1
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EA
Eurasian Patent Office
Prior art keywords
quinazolinons
bromomodenial
inhibitors
new
therapy
Prior art date
Application number
EA201690087A
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English (en)
Inventor
Джон Фредерик Квинн
Владимир Хлебников
Original Assignee
Зенит Эпидженетикс Корп.
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Publication date
Application filed by Зенит Эпидженетикс Корп. filed Critical Зенит Эпидженетикс Корп.
Publication of EA201690087A1 publication Critical patent/EA201690087A1/ru

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Данное изобретение относится к соединениям, которые применяют для ингибирования функции белка BET посредством связывания с бромодоменами, а также их применению в терапии.
EA201690087A 2013-07-31 2014-07-30 Новые квиназолиноны как ингибиторы бромодомена EA201690087A1 (ru)

Applications Claiming Priority (2)

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US201361860403P 2013-07-31 2013-07-31
PCT/IB2014/002510 WO2015015318A2 (en) 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors

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EA201690087A1 true EA201690087A1 (ru) 2016-08-31

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US (2) US9855271B2 (ru)
EP (1) EP3027604B1 (ru)
JP (1) JP6542212B2 (ru)
KR (1) KR20160038008A (ru)
CN (1) CN105593224B (ru)
AU (1) AU2014298051B2 (ru)
CA (1) CA2919948C (ru)
EA (1) EA201690087A1 (ru)
HK (1) HK1218547A1 (ru)
IL (1) IL243479B (ru)
WO (1) WO2015015318A2 (ru)

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PT3010503T (pt) 2013-06-21 2020-06-16 Zenith Epigenetics Corp Novos inibidores bicíclicos de bromodomínios
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
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