HK1218547A1 - 作為溴結構域抑制劑的新型喹唑啉酮類化合物 - Google Patents

作為溴結構域抑制劑的新型喹唑啉酮類化合物

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Publication number
HK1218547A1
HK1218547A1 HK16106581.4A HK16106581A HK1218547A1 HK 1218547 A1 HK1218547 A1 HK 1218547A1 HK 16106581 A HK16106581 A HK 16106581A HK 1218547 A1 HK1218547 A1 HK 1218547A1
Authority
HK
Hong Kong
Prior art keywords
bromodomain inhibitors
quinazolinones
novel
novel quinazolinones
bromodomain
Prior art date
Application number
HK16106581.4A
Other languages
English (en)
Inventor
John Frederick Quinn
Vladimir Khlebnikov
Original Assignee
Zenith Epigenetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenith Epigenetics Corp filed Critical Zenith Epigenetics Corp
Publication of HK1218547A1 publication Critical patent/HK1218547A1/zh

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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HK16106581.4A 2013-07-31 2016-06-08 作為溴結構域抑制劑的新型喹唑啉酮類化合物 HK1218547A1 (zh)

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Application Number Priority Date Filing Date Title
US201361860403P 2013-07-31 2013-07-31
PCT/IB2014/002510 WO2015015318A2 (en) 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors

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US (2) US9855271B2 (zh)
EP (1) EP3027604B1 (zh)
JP (1) JP6542212B2 (zh)
KR (1) KR20160038008A (zh)
CN (1) CN105593224B (zh)
AU (1) AU2014298051B2 (zh)
CA (1) CA2919948C (zh)
EA (1) EA201690087A1 (zh)
HK (1) HK1218547A1 (zh)
IL (1) IL243479B (zh)
WO (1) WO2015015318A2 (zh)

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WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
MX367420B (es) 2013-03-14 2019-08-21 Convergene Llc Metodos y composiciones para inhibicion de proteinas que contienen bromodominio.
ES2661437T3 (es) 2013-06-21 2018-04-02 Zenith Epigenetics Corp. Nuevos compuestos bicíclicos sustituidos como inhibidores de bromodominio
MX365864B (es) 2013-06-21 2019-06-18 Zenith Epigenetics Ltd Inhibidores de bromodominio biciclicos novedosos.
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
CN105593224B (zh) 2013-07-31 2021-05-25 恒元生物医药科技(苏州)有限公司 作为溴结构域抑制剂的新型喹唑啉酮类化合物
US20170027955A1 (en) * 2014-04-04 2017-02-02 Constellation Pharmaceuticals, Inc. Expression levels of bcl-xl, bcl2, bcl-w, and bad and cancer therapies
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