MX365864B - Inhibidores de bromodominio biciclicos novedosos. - Google Patents
Inhibidores de bromodominio biciclicos novedosos.Info
- Publication number
- MX365864B MX365864B MX2015017045A MX2015017045A MX365864B MX 365864 B MX365864 B MX 365864B MX 2015017045 A MX2015017045 A MX 2015017045A MX 2015017045 A MX2015017045 A MX 2015017045A MX 365864 B MX365864 B MX 365864B
- Authority
- MX
- Mexico
- Prior art keywords
- bromodomain inhibitors
- novel bicyclic
- terminal domain
- inhibitors
- bet
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title abstract 2
- 108050009021 Bromodomains Proteins 0.000 title abstract 2
- 125000002619 bicyclic group Chemical group 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000004853 protein function Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
La invención proporciona compuestos bicíclicos sustituidos novedosos que son útiles como inhibidores de la función de las proteínas del dominio extra terminal BET mediante la unión a bromodominios. Las composiciones farmacéuticas que comprenden los compuestos se utilizan para la prevención y el tratamiento de enfermedades y afecciones asociadas con las proteínas de bromodominio y de dominio extra terminal (BET).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361837841P | 2013-06-21 | 2013-06-21 | |
PCT/US2014/043423 WO2015002754A2 (en) | 2013-06-21 | 2014-06-20 | Novel bicyclic bromodomain inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015017045A MX2015017045A (es) | 2016-08-03 |
MX365864B true MX365864B (es) | 2019-06-18 |
Family
ID=52144263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015017045A MX365864B (es) | 2013-06-21 | 2014-06-20 | Inhibidores de bromodominio biciclicos novedosos. |
Country Status (23)
Country | Link |
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US (5) | US9663520B2 (es) |
EP (2) | EP3010503B1 (es) |
JP (4) | JP6461121B2 (es) |
KR (1) | KR102307566B1 (es) |
CN (2) | CN109939113B (es) |
AU (2) | AU2014284616B2 (es) |
BR (1) | BR112015031073B1 (es) |
CA (2) | CA3190653A1 (es) |
DK (1) | DK3010503T3 (es) |
EA (1) | EA035601B1 (es) |
ES (1) | ES2806135T3 (es) |
HK (2) | HK1216722A1 (es) |
HR (1) | HRP20200854T1 (es) |
HU (1) | HUE049469T2 (es) |
IL (1) | IL242844B (es) |
MX (1) | MX365864B (es) |
NZ (2) | NZ754629A (es) |
PL (1) | PL3010503T3 (es) |
PT (1) | PT3010503T (es) |
SG (2) | SG10201710705UA (es) |
SI (1) | SI3010503T1 (es) |
WO (1) | WO2015002754A2 (es) |
ZA (2) | ZA201600272B (es) |
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