ATE367814T1 - Hiv hemmende pyrazinon-derivate - Google Patents

Hiv hemmende pyrazinon-derivate

Info

Publication number
ATE367814T1
ATE367814T1 AT02740421T AT02740421T ATE367814T1 AT E367814 T1 ATE367814 T1 AT E367814T1 AT 02740421 T AT02740421 T AT 02740421T AT 02740421 T AT02740421 T AT 02740421T AT E367814 T1 ATE367814 T1 AT E367814T1
Authority
AT
Austria
Prior art keywords
sub
sup
alkyl
het
alkyloxy
Prior art date
Application number
AT02740421T
Other languages
English (en)
Inventor
Paul Janssen
Aken Koen Van
Paulus Lewi
Lucien Koymans
Jonge Marc De
Jan Heeres
Frederik Daeyaert
Georges Hoornaert
Frans Compernolle
Amuri Kilonda
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE367814T1 publication Critical patent/ATE367814T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
AT02740421T 2001-03-15 2002-03-13 Hiv hemmende pyrazinon-derivate ATE367814T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01200971 2001-03-15

Publications (1)

Publication Number Publication Date
ATE367814T1 true ATE367814T1 (de) 2007-08-15

Family

ID=8180016

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02740421T ATE367814T1 (de) 2001-03-15 2002-03-13 Hiv hemmende pyrazinon-derivate

Country Status (8)

Country Link
US (1) US7105522B2 (de)
EP (1) EP1370265B8 (de)
JP (1) JP4251438B2 (de)
AT (1) ATE367814T1 (de)
CA (1) CA2437785C (de)
DE (1) DE60221368T2 (de)
ES (1) ES2290313T3 (de)
WO (1) WO2002078708A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004074266A1 (en) * 2003-02-07 2004-09-02 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazines
CA2575002C (en) 2004-08-10 2015-01-20 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazin-6-one derivatives
WO2007044565A2 (en) * 2005-10-06 2007-04-19 University Of Massachusetts Composition and synthesis of new reagents for inhibition of hiv replication
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
EP3010918B1 (de) 2013-06-21 2018-08-15 Zenith Epigenetics Ltd. Neuartige substituierte bicyclische verbindungen als bromdomänenhemmer
EP3674300B1 (de) 2013-06-21 2022-10-12 Zenith Epigenetics Ltd. Neuartige bicyclische bromdomänenhemmer
KR20160038008A (ko) 2013-07-31 2016-04-06 제니쓰 에피제네틱스 코포레이션 브로모도메인 억제제로서 신규 퀴나졸리논
EP3227280B1 (de) 2014-12-01 2019-04-24 Zenith Epigenetics Ltd. Substituierte pyridine als bromdomänenhemmer
WO2016087936A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridinones as bromodomain inhibitors
WO2016092375A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Substituted heterocycles as bromodomain inhibitors
CN107406438B (zh) 2014-12-17 2021-05-14 恒翼生物医药科技(上海)有限公司 溴结构域的抑制剂
MX2021011775A (es) 2017-04-26 2023-01-10 Basilea Pharm Int Ag Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos.
WO2023128786A1 (en) * 2021-12-30 2023-07-06 Collaborations Pharmaceuticals, Inc New antiviral triazole derivatives, their synthesis and their use for treatment of mammalian viral infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238576A (en) 1990-06-18 1994-12-22 Merck & Co Inc Pyridinone derivatives, preparation and pharmaceutical compositions thereof
GB2266716A (en) 1992-05-05 1993-11-10 Merck & Co Inc Inhibitors of HIV reverse transcriptase
CA2265672C (en) * 1996-09-16 2008-12-02 Du Pont Pharmaceuticals Company Pyrazinones and triazinones and their derivatives thereof

Also Published As

Publication number Publication date
EP1370265B1 (de) 2007-07-25
US20040102456A1 (en) 2004-05-27
DE60221368D1 (de) 2007-09-06
WO2002078708A1 (en) 2002-10-10
JP2004519512A (ja) 2004-07-02
US7105522B2 (en) 2006-09-12
CA2437785C (en) 2009-05-12
EP1370265B8 (de) 2013-10-30
CA2437785A1 (en) 2002-10-10
EP1370265A1 (de) 2003-12-17
ES2290313T3 (es) 2008-02-16
DE60221368T2 (de) 2008-04-17
JP4251438B2 (ja) 2009-04-08

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