MX2021011775A - Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. - Google Patents
Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos.Info
- Publication number
- MX2021011775A MX2021011775A MX2021011775A MX2021011775A MX2021011775A MX 2021011775 A MX2021011775 A MX 2021011775A MX 2021011775 A MX2021011775 A MX 2021011775A MX 2021011775 A MX2021011775 A MX 2021011775A MX 2021011775 A MX2021011775 A MX 2021011775A
- Authority
- MX
- Mexico
- Prior art keywords
- processes
- sup
- formula
- compound
- furazanobenzimidazoles
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La presente invención proporciona procesos para preparar un compuesto de fórmula (I) y sales farmacéuticamente aceptables de este, (ver Fórmula) (I) que comprenden desproteger un compuesto de fórmula (II) (ver Fórmula) (II) donde cada R3 representa independientemente un grupo alquilo terciario, preferentemente donde cada R3 es butilo terciario. La invención también proporciona intermedios útiles para preparar compuestos de fórmula (I) y procesos para preparar estos intermedios. Además, la invención proporciona formas polimórficas de la sal de tipo dicloruro del compuesto de fórmula (I) y su uso en el tratamiento de trastornos proliferativos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17168283 | 2017-04-26 | ||
EP17172753 | 2017-05-24 | ||
PCT/EP2018/060454 WO2018197475A1 (en) | 2017-04-26 | 2018-04-24 | Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021011775A true MX2021011775A (es) | 2023-01-10 |
Family
ID=62028032
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021011775A MX2021011775A (es) | 2017-04-26 | 2018-04-24 | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
MX2019012257A MX2019012257A (es) | 2017-04-26 | 2018-04-24 | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019012257A MX2019012257A (es) | 2017-04-26 | 2018-04-24 | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US11891382B2 (es) |
EP (1) | EP3615529A1 (es) |
JP (2) | JP7191298B2 (es) |
KR (2) | KR102648947B1 (es) |
CN (2) | CN110536890B (es) |
BR (1) | BR112019021400A2 (es) |
CA (1) | CA3058695A1 (es) |
MX (2) | MX2021011775A (es) |
TW (2) | TW202300489A (es) |
WO (1) | WO2018197475A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018210868A1 (en) | 2017-05-16 | 2018-11-22 | Basilea Pharmaceutica International AG | Novel dosage principle for drugs useful for treating neoplastic diseases |
EP3713565A1 (en) | 2017-11-20 | 2020-09-30 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
WO2021048135A1 (en) | 2019-09-09 | 2021-03-18 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
WO2022053549A1 (en) | 2020-09-10 | 2022-03-17 | Basilea Pharmaceutica International AG | Use of c-myc as a biomarker of drug response |
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CN105753863B (zh) | 2015-09-11 | 2018-07-31 | 东莞市真兴贝特医药技术有限公司 | 氧代二氢咪唑并吡啶类化合物及其应用 |
US20180306790A1 (en) | 2015-10-22 | 2018-10-25 | Basilea Pharmaceutica International AG | Use of eb1 as a biomarker of drug response |
WO2017127637A1 (en) | 2016-01-22 | 2017-07-27 | Chevron Oronite Company Llc | Synergistic lubricating oil composition containing a mixture of olefin copolymer dispersant-type viscosity improver and amine compound |
WO2018055235A1 (en) | 2016-09-21 | 2018-03-29 | University Of Helsinki | Isoxazole-amides for treating cardiac diseases |
JP7046968B2 (ja) | 2017-03-02 | 2022-04-04 | 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | 2-(置換フェニルヘテロ)芳香族カルボン酸系fto阻害剤、その製造方法およびその使用 |
WO2018210868A1 (en) | 2017-05-16 | 2018-11-22 | Basilea Pharmaceutica International AG | Novel dosage principle for drugs useful for treating neoplastic diseases |
WO2019018119A1 (en) | 2017-07-18 | 2019-01-24 | Pairnomix, Llc | METHODS FOR TREATING EPILEPSY AND DISORDERS ASSOCIATED WITH KCNTI |
EP3713565A1 (en) | 2017-11-20 | 2020-09-30 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
-
2018
- 2018-04-24 CN CN201880025871.5A patent/CN110536890B/zh active Active
- 2018-04-24 JP JP2019556655A patent/JP7191298B2/ja active Active
- 2018-04-24 CA CA3058695A patent/CA3058695A1/en active Pending
- 2018-04-24 KR KR1020197030486A patent/KR102648947B1/ko active IP Right Grant
- 2018-04-24 US US16/606,397 patent/US11891382B2/en active Active
- 2018-04-24 WO PCT/EP2018/060454 patent/WO2018197475A1/en unknown
- 2018-04-24 MX MX2021011775A patent/MX2021011775A/es unknown
- 2018-04-24 MX MX2019012257A patent/MX2019012257A/es unknown
- 2018-04-24 KR KR1020247008492A patent/KR20240038149A/ko active Application Filing
- 2018-04-24 CN CN202310915136.4A patent/CN116947836A/zh active Pending
- 2018-04-24 BR BR112019021400A patent/BR112019021400A2/pt active Search and Examination
- 2018-04-24 EP EP18719174.7A patent/EP3615529A1/en active Pending
- 2018-04-25 TW TW111131870A patent/TW202300489A/zh unknown
- 2018-04-25 TW TW107113946A patent/TWI776885B/zh active
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2022
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WO2018197475A1 (en) | 2018-11-01 |
KR20240038149A (ko) | 2024-03-22 |
JP7191298B2 (ja) | 2022-12-19 |
KR102648947B1 (ko) | 2024-03-18 |
US11891382B2 (en) | 2024-02-06 |
KR20190141147A (ko) | 2019-12-23 |
TWI776885B (zh) | 2022-09-11 |
US20210115032A1 (en) | 2021-04-22 |
CN116947836A (zh) | 2023-10-27 |
CN110536890A (zh) | 2019-12-03 |
CN110536890B (zh) | 2023-08-15 |
BR112019021400A2 (pt) | 2020-04-28 |
JP2023018078A (ja) | 2023-02-07 |
TW201900641A (zh) | 2019-01-01 |
JP2020517620A (ja) | 2020-06-18 |
MX2019012257A (es) | 2019-12-16 |
TW202300489A (zh) | 2023-01-01 |
EP3615529A1 (en) | 2020-03-04 |
CA3058695A1 (en) | 2018-11-01 |
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