DE60221368D1 - Hiv hemmende pyrazinon-derivate - Google Patents

Hiv hemmende pyrazinon-derivate

Info

Publication number
DE60221368D1
DE60221368D1 DE60221368T DE60221368T DE60221368D1 DE 60221368 D1 DE60221368 D1 DE 60221368D1 DE 60221368 T DE60221368 T DE 60221368T DE 60221368 T DE60221368 T DE 60221368T DE 60221368 D1 DE60221368 D1 DE 60221368D1
Authority
DE
Germany
Prior art keywords
sub
sup
alkyl
het
alkyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60221368T
Other languages
English (en)
Other versions
DE60221368T2 (de
Inventor
Paul Adriaan Janssen
Aken Koen Jeanne Van
Paulus Joannes Lewi
Lucien Maria Koymans
Jonge Marc Rene De
Jan Janssen Phar Heeres
Frederik Frans Daeyaert
Georges J Hoornaert
Frans J Compernolle
Amuri K U Leuven R Kilonda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE60221368D1 publication Critical patent/DE60221368D1/de
Application granted granted Critical
Publication of DE60221368T2 publication Critical patent/DE60221368T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60221368T 2001-03-15 2002-03-13 Hiv hemmende pyrazinon-derivate Expired - Lifetime DE60221368T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01200971 2001-03-15
EP01200971 2001-03-15
PCT/EP2002/002806 WO2002078708A1 (en) 2001-03-15 2002-03-13 Hiv inhibiting pyrazinone derivatives

Publications (2)

Publication Number Publication Date
DE60221368D1 true DE60221368D1 (de) 2007-09-06
DE60221368T2 DE60221368T2 (de) 2008-04-17

Family

ID=8180016

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60221368T Expired - Lifetime DE60221368T2 (de) 2001-03-15 2002-03-13 Hiv hemmende pyrazinon-derivate

Country Status (8)

Country Link
US (1) US7105522B2 (de)
EP (1) EP1370265B8 (de)
JP (1) JP4251438B2 (de)
AT (1) ATE367814T1 (de)
CA (1) CA2437785C (de)
DE (1) DE60221368T2 (de)
ES (1) ES2290313T3 (de)
WO (1) WO2002078708A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004213173B2 (en) * 2003-02-07 2010-07-29 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazines
US7923554B2 (en) 2004-08-10 2011-04-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
EP1945208A4 (de) * 2005-10-06 2011-08-03 Univ Massachusetts Zusammensetzung und synthese von neuen reagenzien zur hemmung der hiv-replikation
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
MX2015007921A (es) * 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
WO2015002754A2 (en) 2013-06-21 2015-01-08 Zenith Epigenetics Corp. Novel bicyclic bromodomain inhibitors
WO2015004534A2 (en) 2013-06-21 2015-01-15 Zenith Epigenetics Corp. Novel substituted bicyclic compounds as bromodomain inhibitors
US9855271B2 (en) 2013-07-31 2018-01-02 Zenith Epigenetics Ltd. Quinazolinones as bromodomain inhibitors
EP3227281A4 (de) 2014-12-01 2018-05-30 Zenith Epigenetics Ltd. Substituierte pyridinone als bromodomain-inhibitoren
CA2966303A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
JP2017537946A (ja) 2014-12-11 2017-12-21 ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． ブロモドメイン阻害剤としての置換複素環
CA2966450A1 (en) 2014-12-17 2016-06-23 Olesya KHARENKO Inhibitors of bromodomains
CA3058695A1 (en) 2017-04-26 2018-11-01 Basilea Pharmaceutica International AG Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof
WO2023128786A1 (en) * 2021-12-30 2023-07-06 Collaborations Pharmaceuticals, Inc New antiviral triazole derivatives, their synthesis and their use for treatment of mammalian viral infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98526A0 (en) 1990-06-18 1992-07-15 Merck & Co Inc Pyridones,processes for their preparation and pharmaceutical compositions containing them
GB2266716A (en) 1992-05-05 1993-11-10 Merck & Co Inc Inhibitors of HIV reverse transcriptase
EP0927171B1 (de) * 1996-09-16 2002-02-20 Du Pont Pharmaceuticals Company Eine resorbierbare röntgenopake markierung enthaltendes chirurgisches implantat und verfahren zum verriegeln desselben in einem körper

Also Published As

Publication number Publication date
US7105522B2 (en) 2006-09-12
EP1370265B1 (de) 2007-07-25
CA2437785A1 (en) 2002-10-10
JP4251438B2 (ja) 2009-04-08
ES2290313T3 (es) 2008-02-16
EP1370265B8 (de) 2013-10-30
CA2437785C (en) 2009-05-12
ATE367814T1 (de) 2007-08-15
EP1370265A1 (de) 2003-12-17
DE60221368T2 (de) 2008-04-17
US20040102456A1 (en) 2004-05-27
WO2002078708A1 (en) 2002-10-10
JP2004519512A (ja) 2004-07-02

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: JANSSEN, PAUL ADRIAAN, BEERSE, BE

Inventor name: VAN AKEN, KOEN JEANNE, KORTRIJK, BE

Inventor name: LEWI, PAULUS JOANNES, BEERSE, BE

Inventor name: KOYMANS, LUCIEN MARIA, BEERSE, BE

Inventor name: DE JONGE, MARC RENE, BEERSE, BE

Inventor name: HEERES, JAN, BEERSE, BE

Inventor name: DAEYAERT, FREDERIK FRANS, BEERSE, BE

Inventor name: HOORNAERT, GEORGES J.C., LEUVEN, BE

Inventor name: COMPERNOLLE, FRANS J., LEUVEN, BE

Inventor name: KILONDA, AMURI, LEUVEN, BE

8364 No opposition during term of opposition