MX371017B - Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma. - Google Patents

Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma.

Info

Publication number
MX371017B
MX371017B MX2016010034A MX2016010034A MX371017B MX 371017 B MX371017 B MX 371017B MX 2016010034 A MX2016010034 A MX 2016010034A MX 2016010034 A MX2016010034 A MX 2016010034A MX 371017 B MX371017 B MX 371017B
Authority
MX
Mexico
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
diseases
Prior art date
Application number
MX2016010034A
Other languages
English (en)
Other versions
MX2016010034A (es
Inventor
Jing Yuan
Wei Zhao
Suresh B Singh
Linghang Zhuang
Lanqi Jia
Yajun Zheng
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
A Claremon David
Liu Zhijie
D Lotesta Stephen
Marcus Andrew
m tice Colin
Original Assignee
Vitae Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX371017(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vitae Pharmaceuticals Llc filed Critical Vitae Pharmaceuticals Llc
Publication of MX2016010034A publication Critical patent/MX2016010034A/es
Publication of MX371017B publication Critical patent/MX371017B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de Fórmula (I): (ver Fórmula) sales farmacéuticamente aceptables de los mismos, y composiciones de los mismos, los cuales son útiles en el tratamiento de enfermedades y trastornos mediados por ROR?; también se proporcionan composiciones farmacéuticas que comprenden los nuevos compuestos de Fórmula (I) y métodos para su uso en el tratamiento de uno o más trastornos o enfermedades inflamatorios, metabólicos, autoinmunes y otros.
MX2016010034A 2014-02-03 2015-01-30 Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma. MX371017B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26
PCT/US2015/013699 WO2015116904A1 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
MX2016010034A MX2016010034A (es) 2016-11-15
MX371017B true MX371017B (es) 2020-01-13

Family

ID=52544571

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010034A MX371017B (es) 2014-02-03 2015-01-30 Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma.

Country Status (26)

Country Link
US (6) US9266886B2 (es)
EP (2) EP3102576B8 (es)
JP (1) JP6466461B2 (es)
KR (1) KR102408261B1 (es)
CN (1) CN105940002B (es)
AU (1) AU2015210833B2 (es)
CA (1) CA2938311C (es)
CL (1) CL2016001947A1 (es)
DK (1) DK3102576T3 (es)
EA (1) EA031804B1 (es)
EC (1) ECSP16071151A (es)
ES (1) ES2735099T3 (es)
HU (1) HUE045511T2 (es)
IL (1) IL246902B (es)
LT (1) LT3102576T (es)
MX (1) MX371017B (es)
PE (1) PE20161372A1 (es)
PH (1) PH12016501457A1 (es)
PL (1) PL3102576T3 (es)
PT (1) PT3102576T (es)
RS (1) RS59007B1 (es)
SG (1) SG11201606080SA (es)
SI (1) SI3102576T1 (es)
TW (1) TWI658041B (es)
UA (1) UA121309C2 (es)
WO (1) WO2015116904A1 (es)

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CN117164657A (zh) 2014-08-12 2023-12-05 莫纳什大学 定向淋巴的前药
SI3207043T1 (sl) * 2014-10-14 2019-04-30 Vitae Pharmaceuticals, Inc. Dihidropirolopiridinovi inhibitorji za ROR-gama
NZ731185A (en) 2014-10-29 2024-03-22 Bicyclerd Ltd Bicyclic peptide ligands specific for mt1-mmp
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US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
CN107614062A (zh) 2015-03-12 2018-01-19 加利福尼亚大学董事会 用RORγ抑制剂治疗癌症的方法
KR102702236B1 (ko) 2015-05-15 2024-09-04 오리진 온콜로지 리미티드 Ror 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물
JP6549735B2 (ja) 2015-06-09 2019-07-24 アッヴィ・インコーポレイテッド 核内受容体調節剤
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CN118063537A (zh) 2015-09-08 2024-05-24 莫纳什大学 定向淋巴的前药
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TWI757266B (zh) * 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN106632313B (zh) * 2016-03-04 2021-04-09 上海贤鼎生物科技有限公司 一种抗癌药帕博昔布重要中间体及合成工艺
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